Cause Of Gastritis Research Articles

The Relationship between Diet and Stress with Gastritis Symptoms in Adolescents at Integrated Agricultural Vocational Schools

Adolescence is a productive age that can experience lifestyle changes that don't pay attention to health, making them susceptible to gastritis symptoms. Common causes of gastritis include improper eating patterns, such as inappropriate frequency or timing of meals, eating excessively and quickly, or consuming foods that are stimulating (too spiced and spicy). Gastritis can easily attack individuals who have irregular eating patterns. Stress affects changes in physiological functions in the body's systems, one of which is the digestive system. Stress can cause decreased appetite, stomach emptying, increased stomach acid, resulting in pain in the stomach. This study aims to determine the relationship between diet and stress and symptoms of gastritis in adolescents. This research is a cross sectional study conducted on 271 teenagers at the Integrated Agricultural Vocational School, Riau Province. The data collection tool is a questionnaire that is valid and has high reliability. The results of the analysis carried out using the chi square test showed that there was a significant relationship between diet and stress and symptoms of gastritis in adolescents as evidenced by a correlation value of 0.000 α 0.05. After conducting research, the results showed that poor eating patterns and high levels of stress can result in symptoms of gastritis.

Systematic optimization of UCNPs-LFA for Helicobacter pylori nucleic acid detection at point-of-care.

Helicobacter pylori (Hp) prevail globally as the primary cause of gastritis, gastric ulcer, and potential gastric cancer, highlighting the need for rapid and precise point-of-care (POC) detection of Hp nucleic acid. Upconversion nanoparticle-based lateral flow assay (UCNPs-LFA) exhibit great potential in POC detection, due to their high optical stability and absence of background fluorescence. However, insufficient sensitivity for nucleic acid detection remains a key challenge. This study systematically optimizes UCNPs-LFA by focusing on target capture, signal transduction, signal separation, and signal analysis, to enhance its detection capabilities for Hp nucleic acid. The optimized UCNPs-LFA platform features a significantly decreased detection limit, a broadened detection range, and high reliability. Results demonstrate that the limit of detection (LOD) is 25 fM, a 105-fold improvement over the initial platform. This systematic optimization strategy is versatile and can be applied to optimize other nanoparticle-based LFAs.

Introducing HeliEns: A Novel Hybrid Ensemble Learning Algorithm for Early Diagnosis of Helicobacter pylori Infection

The Gram-negative bacterium Helicobacter pylori (H. infection) infects the human stomach and is a major cause of gastritis, peptic ulcers, and gastric cancer. With over 50% of the global population affected, early and accurate diagnosis of H. infection infection is crucial for effective treatment and prevention of severe complications. Traditional diagnostic methods, such as endoscopy with biopsy, serology, urea breath tests, and stool antigen tests, are often invasive, costly, and can lack precision. Recent advancements in machine learning (ML) and quantum machine learning (QML) offer promising non-invasive alternatives capable of analyzing complex datasets to identify patterns not easily discernible by human analysis. This research aims to develop and evaluate HeliEns, a novel quantum hybrid ensemble learning algorithm designed for the early and accurate diagnosis of H. infection infection. HeliEns combines the strengths of multiple quantum machine learning models, specifically Quantum K-Nearest Neighbors (QKNN), Quantum Naive Bayes (QNB), and Quantum Logistic Regression (QLR), to enhance diagnostic accuracy and reliability. The development of HeliEns involved rigorous data preprocessing steps, including data cleaning, encoding of categorical variables, and feature scaling, to ensure the dataset’s suitability for quantum machine learning algorithms. Individual models (QKNN, QNB, and QLR) were trained and evaluated using metrics such as accuracy, precision, recall, and F1-score. The ensemble model was then constructed by integrating these quantum models using a hybrid approach that leverages their diverse strengths. The HeliEns model demonstrated superior performance compared to individual models, achieving an accuracy of 94%, precision of 97%, recall of 92%, and an F1-score of 94% in detecting H. infection infection. The quantum ensemble approach effectively mitigated the limitations of individual models, providing a robust and reliable diagnostic tool. HeliEns significantly improved diagnostic accuracy and reliability for early H. infection detection. The integration of multiple quantum ML algorithms within the HeliEns framework enhanced overall model performance. The non-invasive nature of the HeliEns model offers a cost-effective and user-friendly alternative to traditional diagnostic methods. This research underscores the transformative potential of quantum machine learning in healthcare, particularly in enhancing diagnostic efficiency and patient outcomes. HeliEns represents a significant advancement in the early diagnosis of H. infection infection, leveraging quantum machine learning to provide a non-invasive, accurate, and reliable diagnostic tool. This research highlights the importance of QML-driven solutions in healthcare and sets the stage for future research to further refine and validate the HeliEns model in real-world clinical settings.

Types Of Food That Cause Gastritis (A Systematic Review)

Gastritis is one of the non-communicable diseases that occurs due to an unhealthy and irregular lifestyle. Gastritis is a disease of the stomach due to inflammation or swelling of the gastric mucosa area. Gastritis can cause discomfort in the upper abdomen, resulting in headaches and reduced appetite than before. Gastritis can occur due to the relationship between wounds in the gastric mucosa and the inflammatory process of the gastric lining epithelium. The purpose of this study was to determine the types of foods that can cause gastritis. The method in this Literature Review using 5 databases, which are Google Scholar, PubMed, EBSCo, Sciencedirect, and Scopus. The results of this study obtained 4 articles that were reviewed where milk consumption, chili sauce consumption, tea consumption, spicy consumption, acid consumption, instant noodle consumption, white bread consumption, chicken soup consumption, and risky food consumption could be the cause of gastritis. The conclusion of this study Gastritis can also cause other symptoms, namely the onset of complaints of pain in the solar plexus, symptoms of nausea and vomiting, feeling of tightness, bloating, and weakness. To prevent gastritis, it is necessary to have good food consumption habits

Probing the expression and adhesion of glycans involved in Helicobacter pylori infection

Helicobacter pylori infects approximately half the human population and has an unusual infective niche of the human stomach. Helicobacter pylori is a major cause of gastritis and has been classified as a group 1 carcinogen by the WHO. Treatment involves triple or quadruple antibiotic therapy, but antibiotic resistance is becoming increasingly prevalent. Helicobacter pylori expresses certain blood group related antigens (Lewis system) as a part of its lipopolysaccharide (LPS), which is thought to assist in immune evasion. Additionally, H. pylori LPS participates in adhesion to host cells alongside several adhesion proteins. This study profiled the carbohydrates of H. pylori reference strains (SS1 and 26695) using monoclonal antibodies (mAbs) and lectins, identifying interactions between two carbohydrate-targeting mAbs and multiple lectins. Atomic force microscopy (AFM) scans were used to probe lectin and antibody interactions with the bacterial surfaces. The selected mAb and lectins displayed an increased adhesive force over the surface of the curved H. pylori rods. Furthermore, this study demonstrates the ability of anti-carbohydrate antibodies to reduce the adhesion of H. pylori 26695 to human gastric adenocarcinoma cells via AFM. Targeting bacterial carbohydrates to disrupt crucial adhesion and immune evasion mechanisms represents a promising strategy for combating H. pylori infection.

The Effect of 131I Therapy on the Eradication of Helicobacter pylori in Patients with Thyroid Disorders: A Preliminary Study.

The leading cause of gastritis and its complications is Helicobacter pylori Radioactive iodine (131I) accumulates significantly in the stomach after consumption. On this basis, we decided to determine whether different doses of 131I in the stomach would be effective in eradicating the infection. Methods: All patients with hyperthyroidism or differentiated thyroid carcinoma who were referred for 131I treatment were invited to the study. A stool antigen test was conducted before consumption of 131I (0.15-5.5 GBq) and was repeated 2 mo later to detect H. pylori infection. Results: H. pylori positivity was found in 51.8% (14/27) of the patients. At 2 mo after treatment, 13 of the 14 patients with differentiated thyroid carcinoma or hyperthyroidism who had been identified as positive for H. pylori stool antigen before 131I administration were still positive, representing a nonsignificant eradication rate of 7.1%. Conclusion: Administration of 131I to patients with H. pylori did not show potential to eliminate the infection.

Gastritis in Northeast India and North India: A Regional Comparison of Prevalence and Associated Risk Factors

Background: Gastritis is one of the most prevalent disorders affecting individuals. Helicobacter pylori infection, along with other factors such as lifestyle, gender, alcohol drinking, and smoking are causes of gastritis. Northeast Indian population is geographically, ethnically, culturally, and linguistically a blend of its surrounding nations, being different from the North Indian population. The objective of the study was to predict the prevalence and risk factors of gastritis in Northeast India and compare it with North India. Methods: A total of 909 dyspeptic patients (Northeast India: 362 and North India: 547) were enrolled and had undergone endoscopy. H. pylori status was identified, determined, and genotyped. They were divided into gastritis and nongastritis samples based on the presence or absence of gastric ulcerations and erosion. The risk factors for gastritis in Northeast and North India were estimated with Chi-square analysis, odds ratios, and 95% confidence intervals using multiple logistic regression analysis. Results: The prevalence of gastritis and H. pylori infection was higher in Northeast India than North India. The risk factors significantly associated with gastritis in Northeast region were H. pylori infection, increased smoking, and alcohol drinking and in North region were smoking and body mass index. Conclusion: Although our study found the risk factors associated with gastritis in Northeast India, the available data do not provide sufficient evidence. Further studies are recommended.

Coffee Consumption With The Incident Of Gastritis: Literature Review

Background: Gastritis is a stomach health problem that begins with inflammation of the gastric mucosa caused by infection with the Helicobacter pylori germ and is the most common disease. One cause of gastritis is the habit of drinking coffee. The habit of drinking coffee (caffeine) for a long period with a frequent frequency, namely > three glasses/day, can trigger an increase in stomach acid, irritating the mucosa or the stomach wall. This literature review aims to analyze the relationship between coffee consumption and the incidence of gastritis Methods: Literature obtained from SINTA, PUBMED, Garuda, and Google Scholar databases. Nine literature reviews used several designs, namely descriptive exploratory, cross-sectional, descriptive cross-sectional study, case-control, descriptive-analytical, and descriptive from 2013-2023; then PICO analysis was carried out. Results: The caffeine content in coffee can stimulate the production of stomach acid, which can trigger gastritis. Inflammation will occur continuously if the stomach is frequently exposed to irritants such as coffee. The inflamed tissue is then filled with fibrin tissue, which can cause loss of the gastric mucosal layer and atrophy. Conclusion: The study showed that coffee influenced the incidence of gastritis.

Assessing the Efficacy of a Modified Triple Drug Regimen Supplemented with Mastic Gum in the Eradication of Helicobacter pylori Infection

Abstract Introduction/Objective Helicobacter pylori (H. pylori) is a bacterium that infects the stomach and small intestine. It is known to be the main cause of gastritis and peptic ulcers. The infection is common worldwide, with a prevalence rate of 50% in many countries. Eradication of H. pylori infection is crucial, as failure to do so can lead to serious complications such as gastric cancer. Treatment for H. pylori infection involves a combination of antibiotics, proton pump inhibitors (PPIs), and bismuth compounds. However, due to the emergence of antibiotic resistance, there is a need for alternative treatments. Methods/Case Report This study had been a randomized controlled trial involving 180 patients with H. pylori infection. The patients had been divided into two groups: Group A received the standard triple-drug regimen (clarithromycin, amoxicillin, and omeprazole), while Group B received the triple-drug regimen along with mastic gum. The treatment duration was 14 days for both groups. Baseline demographics and clinical characteristics had been collected for all patients. The presence of H. pylori infection had been confirmed by a urea breath test and fecal antigen test. Results (if a Case Study enter NA) This study has investigated the effects of mastic gum on H. pylori infection. In a randomized controlled trial of 180 H. pylori-positive patients, mastic gum was found to be effective in eradicating the bacteria in 83 of 90 patients (92.2%) who received the supplementation Group B received the triple-drug regimen along with mastic gum, compared to only 57 of 90 patients (63.3%) in the group A (p < 0.001). Thus, a randomized controlled trial of 90 patients with H. pylori infection found that combination therapy of mastic gum and a triple-drug regimen resulted in a significantly higher eradication rate (92.2%) compared to a triple-drug regimen only (63.3%). Conclusion The current study investigated the adding mastic gum to the standard triple-drug regimen can improve the eradication rate of H. pylori infection. This could potentially offer an alternative treatment option for patients with H. pylori infection, especially those with antibiotic resistance. Applying the mastic gum has approved its effectiveness, and it could reduce the reliance on antibiotics and minimize the risk of resistance development.

Investigating associations between HLA DQA1 ~ DQB1 haplotypes, H. pylori infection, metaplasia, and anti-CagA IgA seropositivity in a Turkish gastritis cohort.

Helicobacter pylori was reported as an important cause of gastritis, and gastric ulcers and CagA oncoprotein-producing H. pylori subgroups were blamed to increase the severity of gastritis. Disparities were reported in that the presence of serum anti-CagA IgA was not parallel with CagA-positive H. pylori cohabitation. We hypothesized that the HLA-DQA1 ~ DQB1 haplotypes in human populations include protective haplotypes that more effectively present immunogenic CagA peptides and susceptible haplotypes with an impaired capacity to present CagA peptides. We recruited patients (n = 201) admitted for gastroendoscopy procedures and performed high-resolution HLA-DQA1 and DQB1 typing. Serum anti-CagA IgA levels were analyzed by ELISA (23.0% positive), and H. pylori was classified as positive or negative in gastric mucosal tissue slides (72.6% positive). The HLA DQA1*05:05 allele (29.1%) and HLA DQB1*03:01 allele (32.8%) were found at the highest frequency among gastritis patients of Turkish descent. In HLA DQA1*05:05 ~ DQB1*03:01 double homozygous (7.3%) and heterozygous (40.7%) haplotype carriers, the presence of anti-CagA IgA decreased dramatically, the presence of H. pylori increased, and the presence of metaplasia followed a decreasing trend. The DQ protein encoded by HLA DQA1*05:05-DQ*03:01 showed a low binding affinity to the CagA peptide when binding capacity was analyzed by the NetMHCIIPan 4.0 prediction method. In conclusion, HLA DQA1 ~ DQB1 polymorphisms are crucial as host defense mechanisms against CagA H. pylori since antigen binding capacity plays a crucial role in anti-CagA IgA production.

A Case of Helicobacter heilmannii Gastritis in a Patient With Human Immunodeficiency Virus

Abstract Helicobacter heilmannii is an uncommon Helicobacter that is a cause of gastritis in humans similar to Helicobacter pylori (H. pylori). Treatment of H. heilmannii is not well studied, but traditional H. pylori regimens have shown success in case reports. Most case reports are in immunocompetent hosts, so little is known about the interplay between H. heilmannii and the immune system. We report a case of H. heilmannii infection in a patient with well-controlled human immunodeficiency virus infection who was treated with quadruple therapy (tetracycline, metronidazole, bismuth, and proton pump inhibitor) and had successful eradication of his infection.

Morphological Spectrum of Gastritis in Endoscopic Biopsies and Its Association With Helicobacter pylori Infection.

Introduction Helicobacter pylori(H. pylori)infection is the most common cause of gastritis. The consequences of the persistent infection range from acute ulceration to the development of gastric neoplasia. The purpose of the study is to determine the histopathological pattern of gastritis in gastric biopsies and its association with H. pylori. Materials and methods This is a retrospective study of all the gastric biopsies received in the Department of Histopathology, Chughtai Institute of Pathology, Lahore, Pakistan from January 12, 2021 to April 10, 2021. Sections were cut from formalin-fixed, paraffin-embedded (FFPE) tissue blocks. Slides were stained with routine, special and immunohistochemical stains. The cases were then blindly reviewed by two pathologists with a special interest in Gastrointestinal Pathology. Microscopic features based on updated Sydney classification were recorded. The collected data were then analyzed by using SPSS version 20(IBM Corp., Armonk, NY). Results A total of 429 gastric biopsies were examined. Out of which, 202 (47.1%) were male and 227 (52.9%) were female with a female-to-male ratio of 1.2:1. Their ages ranged from 12 to 100 years and a peak in the fourth decade of life with a mean age of 43 years (median age 49 years). Among gastritis, activity was seen in 194 (45%) and chronicity in 237 (55%) cases. H. pylori was seen in 174 (40.5%) cases and there was a strong statistically significant association between H. pylori infection and severity of gastritis (p<0.001). Other parameters of Sydney classification, such as atrophic changes, were seen in 144 (33%) cases, and intestinal metaplasia in 10 (2.3%) cases. Conclusion H. pylori organism was the most common cause of gastritis in our environment. The severity of gastritis is directly related to the H. pylori infection. If neutrophils are identified on surface epithelium, then H. pylori should be searched with increased attention on morphology and/or on immunohistochemical stain of H. pylori. Chronic inflammation and H. pylori density can also guide treatment which is necessary to avoid complications.

Factors Associated with the Incidence of Gastritis in Patients at Faisal Islamic Hospital Makassar

Gastritis is known in the community as heartburn or heartburn. It is an inflammation of the mucosal wall. It can occur suddenly and is usually characterized by nausea and vomiting, pain, bleeding, weakness, decreased appetite, or headache. It can be caused by habitual consumption of sensitive foods, or often by a frivolous diet. The individual overeats, eats foods that are overly seasoned or contain microorganisms. Other causes of gastritis include alcohol, smoking, age, aspirin, bile reflux or radiation therapy. The purpose of this study was to determine the factors associated with the incidence of gastritis in patients at Faisal Makassar Islamic Hospital and to determine the relationship between the patient's diet and smoking history with the incidence of gastritis in patients. This study is a type of retrospective Exposfacto research with the design / design of Crossectional Study, by obtaining primary data (data obtained directly from patients) and secondary data (data obtained from the medica record of Faisal Makassar Islamic Hospital and obtained from family or people closest to the patient). The population in this study were all patients suffering from gastrointestinal diseases at Faisal Islamic Hospital Makassar. The sample in this study were all patients suffering from gastritis disease at Faisal Islamic Hospital Makassar. Chi-Square test P value = 0.003 &lt; α = 0.05. This means that a person's irregular diet is very influential on the occurrence of gastritis. the results of bivariate analysis showed that there was no relationship between smoking history and the incidence of gastritis at Faisal Islamic Hospital Makassar with Chi-Square test P=0.117 and &lt; α = 0.05.

Evaluation of serum levels of Proinflammatory Cytokines IL-8, IL-17, and IL-22 in Helicobacter pylori infection and their association with the degree of gastritis histopathology in a sample of Iraqi patients

Gastritis can be defined as histological inflammation of the gastric mucosa. It can be classified according to the time course of the disease as acute or chronic, histological findings, anatomic location, and pathological mechanisms. The objective of this study was to evaluation of serum levels of the proinflammatory cytokines IL-8, IL-17 and IL-22 in Helicobacter pylori infection and their association with the degree of gastritis histopathology in a sample of Iraqi patients. The case-control prospective study consists of 60 patients who attended the Gastrointestinal Tract Center at Al-Kindy Teaching Hospital during the period from December 2019 to April 2020. In addition, the control group included 60 apparently healthy individuals. Biopsies from the gastric antrum and/or body mucosa were used to assess the severity of chronic inflammation, neutrophil infiltration, atrophy, intestinal metaplasia. Serum samples were obtained to determine H. pylori infection, circulating interleukin (IL)-8, IL-17, and IL-22. Results showed that the Patients’ ages with gastritis ranged from 18-75 years. The body mass index revealed that 33.33% of the patients were obese and 35% of them were overweight. Most of the patients with active chronic gastritis and superficial chronic gastritis had positive titers for anti-H. pylori IgG antibody (167.89 ± 3.18 IU/ml) and (150.74± 1.45 IU/ml) respectively, which was significantly different from the control group (4.36 ± 0.29 IU/ml) (P=0.0001). Histopathological analysis showed that all subjects experienced chronic inflammation, while neutrophil infiltration was found 36.66% and there was significant association between serum levels of IL-8, IL-17, and IL-22 with a degree of chronic inflammation and neutrophils infiltration. In conclusion, the most common cause of gastritis was H. pylori with histopathological lesions, showing neutrophils infiltration and chronic gastric mucosal inflammation associated with increased levels of IL-8, IL-17, and IL-22 in serum.

Hubungan Tingkat Kecemasan Terhadap Kekambuhan Gastritis Pada Mahasiswa Tingkat Akhir

Health problrms are often underestimated by society, especially ypung people, especially among students. This matter because their daily livers are busy with their daily activities for example school acyivities, therefore starr to feel anxious so they don’t pay much attention to the type of food they eat, common causes of gastritis include pattern improper eating,such as the frequency or timing of eating at inappropriate times appropriate, gastritis can easily attack individuals who having an irregular eating pattern.one of the diseases currently common among people experienced by students is gastirits.apart from that, there are various life problems the unresolved makes them range against gastritis. The aim of this research is to determine the level anxiety and the relationship between anxiety levels and recurrence gastritis. this research is quantitative research with a cross sectional approach at IKB St. Fatimah Mamuju. Sample used in this research were 33 people who had meet the inclusion and exclusion criteria. The data that is measured is level of anxiety and recurrence of gastritis. univariate analysis on this research are gender, age, history of gastritis, educations, the biavariate analysis used was the chi square test. Kolmogrov smirnov test for the relationship between anxiety and gastritis recurrence. The bivariate analysis used was the chi square test. Kolmogrov smirnov test for the relationship between anxiety and gastritis recurrence. The results of bivariate analysis show that the level of anxiety not associated with gastritis recurrence (p value 0,0995). So it can be concluded from this research that there is no relationship significant relationship between the level of anxiety and the recurrence of gastritis.

Application of biomaterials in the eradication of Helicobacter pylori: A bibliometric analysis and overview.

Helicobacter pylori is a prominent cause of gastritis, peptic ulcer, and gastric cancer. It is naturally colonized on the surface of the mucus layer and mucosal epithelial cells of the gastric sinus, surrounded not only by mucus layer with high viscosity that prevents the contact of drug molecules with bacteria but also by multitudinous gastric acid and pepsin, inactivating the antibacterial drug. With high-performance biocompatibility and biological specificity, biomaterials emerge as promising prospects closely associated with H. pylori eradication recently. Aiming to thoroughly summarize the progressing research in this field, we have screened 101 publications from the web of science database and then a bibliometric investigation was performed on the research trends of the application of biomaterials in eradicating H. pylori over the last decade utilizing VOSviewer and CiteSpace to establish the relationship between the publications, countries, institutions, authors, and most relevant topics. Keyword analysis illustrates biomaterials including nanoparticles (NPs), metallic materials, liposomes, and polymers are employed most frequently. Depending on their constituent materials and characterized structures, biomaterials exhibit diverse prospects in eradicating H. pylori regarding extending drug delivery time, avoiding drug inactivation, target response, and addressing drug resistance. Furthermore, we overviewed the challenges and forthcoming research perspective of high-performance biomaterials in H. pylori eradication based on recent studies.

LITERASI KESEHATAN: MENGENAL LEBIH DEKAT TENTANG PENCEGAHAN DAN PENANGANAN GASTRITIS PADA MAHASISWA STKIP HAMZAR

The condition that is often experienced by students is gastritis. Gastritis is one of the disorders of the digestive system that occurs due to an imbalance of stomach acid; gastritis often occurs if the diet is irregular, such as in students who have to go to college every morning. Some students sometimes don't have time to have breakfast which causes a person to experience stomach ache or gastritis. Gastritis can be a serious problem for students/adolescents, be it acute gastritis or chronic gastritis that students can experience. One of the causes of gastritis is a poor diet, not having breakfast before going to college. To minimize gastric disturbances or gastritis, of course, the role of health workers is required to provide health education or health literacy so that students understand what must be done to prevent gastritis. The purpose of this PKM is to prevent and minimize the occurrence of gastritis in students/adolescents. The method used in this service is in the form of health education or health counseling aimed at students, how to measure the level of understanding of the material provided is then carried out pretest and posttest. The results of community service in the form of an increase in the level of student knowledge about gastritis were strengthened by the results of the Wilcoxon test p value 0.001, p value &lt;0.05, there was an effect of health literacy about gastritis on the level of student knowledge about gastritis.

Current Understanding of the Transmission, Diagnosis, and Treatment of H. pylori Infection: A Comprehensive Review

H. pylori infection is a prevalent bacterial infection that affects the gastric mucosa of humans, with a prevalence ranging from 30% to 90%, depending on the region. The infection is a significant cause of gastritis, peptic ulcer disease, and gastric cancer. In this comprehensive review, we discuss the current understanding of the transmission, diagnosis, and treatment of H. pylori infection. We describe the risk factors and epidemiology of the infection, along with its pathogenesis, which involves multiple virulence factors that contribute to the colonization and survival of the bacteria in the acidic stomach environment. Diagnostic tests for H. pylori infection include invasive and non-invasive methods, with the choice of test depending on several factors. Treatment of H. pylori infection is aimed at eradicating the bacteria and preventing complications. Antibiotic-based triple or quadruple therapy, in combination with acid-suppressing agents, is the standard treatment, but antibiotic resistance is an emerging problem that needs to be addressed. This comprehensive review provides a useful resource for clinicians, researchers, and public health officials involved in managing H. pylori infection and its associated complications.

Analysis of Images of Neutrophil Lymphocyte Ratio and Bacteria Density Level of Helicobacter Pylori in Tissue in Gastritis Patients

Gastritis is an inflammatory disease that can last for a long time. Helicobacter pylori infection is known as the main cause of peptic ulcer and the most common cause of gastritis. Helicobacter Pylori infection will cause mononuclear (MN) and polymorphonuclear (PMN) cell infiltration and will increase the production of proinflammatory cytokines in the gastric mucosa compared to non-Helicobacter Pylori gastritis. Helicobacter Pylori with histopathological examination diagnosis. This type of research is descriptive observational with purposive sampling data collection technique at the Anatomical Pathology Laboratory Installation, RSPAL dr. Ramelan Surabaya. The data used are the results of a biopsy of 60 samples that were determined as gastritis with histopathological examination of the identification of Helicobacter Pylori bacteria in gastric tissue classified by the level of bacterial density using The Updated Sydney System, as well as haemogram data for complete blood examination to further calculate the neutrophil lymphocyte ratio (NLR). The data were processed using descriptive statistical tests to determine the average neutrophil lymphocyte ratio (NLR). Based on the statistics of the r-Spearman test, the density of Helicobacter Pylori, (Pν = 0.000) below &lt; 0.005 indicates that there is a strong relationship between the neutrophil lymphocyte ratio (NLR) and the density of Helicobacter Pylori bacteria.

The tibetan medicine Zuozhu-Daxi can prevent Helicobacter pylori induced-gastric mucosa inflammation by inhibiting lipid metabolism

BackgroundTibetan medicine has been used in clinical practice for more than 3800 years. Zuozhu-Daxi (ZZDX), a classic traditional Tibetan medicine, has been proved to be effective in the treatment of digestive diseases, such as chronic gastritis, gastric ulcer, etc. Helicobacter pylori (H. pylori), one of the most common pathogenic microbes, is regarded as the most common cause of gastritis. Researching on the effects of ZZDX on H. pylori-induced gastric mucosa inflammation could provide more evidences on H. pylori treatment and promote the development of Tibetan medicine. This study aimed to explore whether ZZDX could rescue H. pylori-induced gastric mucosa inflammation and its mechanism.MethodsMale C57BL/6 mice were infected with H. pylori, and orally treated with ZZDX to rescue gastric mucosa inflammation induced by H. pylori infection. Pathology of gastric mucosa inflammation was evaluated under microscopy by hematoxylin–eosin (HE) staining. The infection status of H. pylori was evaluated by immunohistochemical (IHC) staining. The reactive oxygen species (ROS) level in serum was evaluated using a detection kit. IL-1α, IL-6, and PGE2 expression levels in serum were measured using ELISA. IL-1α, IL-8, TNF-α, and NOD1 expression levels in gastric tissues were measured using real-time PCR. RNA sequencing and gene certification of interest were performed to explore the mechanisms in vivo and in vitro.ResultsThe results showed that ZZDX could significantly inhibit H. pylori-induced gastric mucosa inflammation using HE staining. IL-1α, IL-6, and PGE2 expression levels in serum were significantly decreased after treatment with ZZDX. ZZDX treatment significantly decreased the mRNA expression of IL-8 induced by H. pylori infection in gastric tissues. Elovl4, Acot1 and Scd1 might be involved in the mechanisms of ZZDX treatment. However, the H. pylori infection status in the gastric mucosa was not reduced after ZZDX treatment.ConclusionsZZDX reversed gastric mucosal injury and alleviated gastric mucosa inflammation induced by H. pylori infection.