Polymer-coated steel (PCS) is a new type of metal packaging material under development, which has better performance in saving resources, energy, and environmental protection. The lamination process has an important influence on the bonding quality of the PCS interface. PCS samples under different lamination temperatures and lamination speeds were prepared through experiments. A binding rate is defined to represent the real bonding area of the PCS interface. The micro-scratch tester and scanner are used to study the influence of the lamination process on the bonding rate and bonding strength of the PCS interface. It is proposed that the bonding rate and bonding strength of the PCS interface increases with the increase of lamination temperature and increases with the decrease of lamination speed. The PCS interface bonding rate and bonding strength are positively correlated. SEM and DSC experiments revealed the cause of bubbles on the PCS surface. It is proposed that controlling the uniformity of the TFS surface temperature can reduce the quality defects of PCS surface bubbles. Relevant research results bring guiding significance for the formation of enterprises.