This research centers on exploring the challenges faced by LGBTQ college students, employing a causal-comparative research design. The study aims to describe these challenges and investigate potential significant differences based on factors such as sex, sexual identity, and sexual orientation. The primary objectives include identifying and understanding challenges encountered by LGBTQ college students, examining variations in challenges concerning sex, sexual identity, and sexual orientation, and providing insights into the experiences of this demographic. The research is guided by a causal-comparative framework, aiming to unveil causal relationships between variables and shed light on differences in challenges faced by LGBTQ students. Utilizing a causal-comparative approach, this study systematically examines and compares challenges experienced by LGBTQ college students, aiming to derive meaningful insights into their diverse experiences. The study focuses on 30 LGBTQ students enrolled at Notre Dame of Midsayap College during the second semester of the A.Y. 2022-2023. The site selection is deliberate, aiming to capture a specific demographic within a defined educational context. In the context of stigmatization and unique challenges faced by LGBTQ individuals, snowball sampling can be more appropriate, allowing for more organic and connected approach in reaching respondence. The sample size of 30 was deemed sufficient to provide meaningful insights into the challenges faced by this demographic. The collected data was analyzed to discern patterns and variations in challenges experienced by LGBTQ students, with a focus on sex, sexual identity, and sexual orientation as potential differentiators. Majority of respondents were 20 years old or younger, predominantly male, with females having a significant presence in terms of sexual identity. Challenges included mental health, prejudice, victimization, discrimination, harassment, and self-identity. Males experienced higher levels of challenges, and transgender individuals, as well as bisexuals, faced heightened difficulties based on sexual identity and orientation. The research concludes by summarizing key findings, emphasizing the distinctive challenges faced by LGBTQ college students, and highlighting areas for further investigation and support. This study contributes valuable insights into the nuanced challenges confronted by LGBTQ college students, offering a foundation for future research and advocating for targeted support initiatives within educational institutions.