Caudal Inferior Parietal Lobule Research Articles

An evolutionary gap in primate default mode network organization

SUMMARYThe human default mode network (DMN) is engaged at rest and in cognitive states such as self-directed thoughts. Interconnected homologous cortical areas in primates constitute a network considered as the equivalent. Here, based on a cross-species comparison of the DMN between humans and non-hominoid primates (macaques, marmosets, and mouse lemurs), we report major dissimilarities in connectivity profiles. Most importantly, the medial prefrontal cortex (mPFC) of non-hominoid primates is poorly engaged with the posterior cingulate cortex (PCC), though strong correlated activity between the human PCC and the mPFC is a key feature of the human DMN. Instead, a fronto-temporal resting-state network involving the mPFC was detected consistently across non-hominoid primate species. These common functional features shared between non-hominoid primates but not with humans suggest a substantial gap in the organization of the primate’s DMN and its associated cognitive functions.

Convergence of prefrontal and parietal anatomical projections in a connectional hub in the striatum

Visual attentional bias forms for rewarding and punishing stimuli in the environment. While this attentional bias is adaptive in healthy situations, it is maladaptive in disorders such as drug addiction or PTSD. In both these disorders, the ability to exert control over this attentional bias is associated with drug abstinence rates or reduced PTSD symptoms, indicating the interaction of visual attention, cognitive control, and stimulus association. The inferior parietal lobule (IPL) is central to attention, while the prefrontal cortex (PFC) is critical for reward, cognitive control, and attention. Importantly, regions of the IPL and PFC commonly project to the rostral dorsal caudate (rdCaud) of the striatum. We propose an anatomical network architecture in which IPL projections converge with PFC projections in a connectional hub in the rdCaud, providing an anatomical substrate for the interaction of these projections and their competitive influence on striatal processing. To investigate this, we mapped the dense projections from the caudal IPL and prefrontal (dlPFC, vlPFC, OFC, dACC, and dmPFC) regions that project to the medial rdCaud with anatomical tract-tracing tracer injections in monkeys. These inputs converge in a precise site in the medial rdCaud, rostral to the anterior commissure. Small retrograde tracer injections confirmed these inputs to the medial rdCaud and showed that a proximal ventral striatal location has a very different pattern of cortical inputs. We next used human resting-state functional connectivity MRI (fcMRI) to examine whether a striatal hub exists in the human medial rdCaud. Seed regions in the human medial rdCaud revealed cortical correlation maps similar to the monkey retrograde injection results. A subsequent analysis of these correlated cortical regions showed that their peak correlation within the striatum is in the medial rdCaud, indicating that this is a connectional hub. In contrast, this peak striatal correlation was not found in the ventral striatal location, suggesting that this site is not a connectional hub of cortical regions. Taken together, this work uses the precision of monkey anatomy to identify a connectional hub of IPL and PFC projections in the medial rdCaud. It also translates this anatomical precision to humans, demonstrating that, guided by anatomy, connectional hubs can be identified in humans with fcMRI. These connectional hubs provide more specific treatment targets for drug addiction, PTSD, and other neurological and psychiatric disorders involving the striatum.

Scene selectivity and retinotopy in medial parietal cortex

Functional imaging studies in human reliably identify a trio of scene-selective regions, one on each of the lateral (occipital place area, OPA), ventral (parahippocampal place area, PPA), and medial (retrosplenial complex, RSC) cortical surfaces. Recently, we demonstrated differential retinotopic biases for the contralateral lower and upper visual fields within OPA and PPA, respectively. Here, using fMRI, we combine detailed mapping of both population receptive fields (pRF) and category-selectivity, with independently acquired resting-state functional connectivity analyses, to examine scene and retinotopic processing within medial parietal cortex. We identified a medial scene-selective region, which was contained largely within the posterior and ventral bank of the parieto-occipital sulcus (POS). While this region is typically referred to as RSC, the spatial extent of our scene-selective region typically did not extend into retrosplenial cortex, and thus we adopt the term medial place area (MPA) to refer to this visually defined scene-selective region. Intriguingly MPA co-localized with a region identified solely on the basis of retinotopic sensitivity using pRF analyses. We found that MPA demonstrates a significant contralateral visual field bias, coupled with large pRF sizes. Unlike OPA and PPA, MPA did not show a consistent bias to a single visual quadrant. MPA also co-localized with a region identified by strong differential functional connectivity with PPA and FFA, commensurate with its functional selectivity. Functional connectivity with OPA was much weaker than with PPA, and similar to that with face-selective OFA, suggesting a closer link with ventral then lateral cortex. Consistent with prior research, we also observed differential functional connectivity in medial parietal cortex for anterior over posterior PPA, as well as a region on the lateral surface, the caudal inferior parietal lobule (cIPL). However, the differential connectivity in medial parietal cortex was found principally anterior of MPA. We suggest that there is posterior-anterior gradient within medial parietal cortex, with posterior regions in the POS showing retinotopically-based scene-selectivity and more anterior regions showing connectivity that may be more reflective of abstract, navigationally pertinent and possibly mnemonic representations.

Two Distinct Scene-Processing Networks Connecting Vision and Memory.

A number of regions in the human brain are known to be involved in processing natural scenes, but the field has lacked a unifying framework for understanding how these different regions are organized and interact. We provide evidence from functional connectivity and meta-analyses for a new organizational principle, in which scene processing relies upon two distinct networks that split the classically defined parahippocampal place area (PPA). The first network of strongly connected regions consists of the occipital place area/transverse occipital sulcus and posterior PPA, which contain retinotopic maps and are not strongly coupled to the hippocampus at rest. The second network consists of the caudal inferior parietal lobule, retrosplenial complex, and anterior PPA, which connect to the hippocampus (especially anterior hippocampus), and are implicated in both visual and nonvisual tasks, including episodic memory and navigation. We propose that these two distinct networks capture the primary functional division among scene-processing regions, between those that process visual features from the current view of a scene and those that connect information from a current scene view with a much broader temporal and spatial context. This new framework for understanding the neural substrates of scene-processing bridges results from many lines of research, and makes specific functional predictions.

Scene-Selectivity and Retinotopy in Medial Parietal Cortex.

Functional imaging studies in human reliably identify a trio of scene-selective regions, one on each of the lateral [occipital place area (OPA)], ventral [parahippocampal place area (PPA)], and medial [retrosplenial complex (RSC)] cortical surfaces. Recently, we demonstrated differential retinotopic biases for the contralateral lower and upper visual fields within OPA and PPA, respectively. Here, using functional magnetic resonance imaging, we combine detailed mapping of both population receptive fields (pRF) and category-selectivity, with independently acquired resting-state functional connectivity analyses, to examine scene and retinotopic processing within medial parietal cortex. We identified a medial scene-selective region, which was contained largely within the posterior and ventral bank of the parieto-occipital sulcus (POS). While this region is typically referred to as RSC, the spatial extent of our scene-selective region typically did not extend into retrosplenial cortex, and thus we adopt the term medial place area (MPA) to refer to this visually defined scene-selective region. Intriguingly MPA co-localized with a region identified solely on the basis of retinotopic sensitivity using pRF analyses. We found that MPA demonstrates a significant contralateral visual field bias, coupled with large pRF sizes. Unlike OPA and PPA, MPA did not show a consistent bias to a single visual quadrant. MPA also co-localized with a region identified by strong differential functional connectivity with PPA and the human face-selective fusiform face area (FFA), commensurate with its functional selectivity. Functional connectivity with OPA was much weaker than with PPA, and similar to that with face-selective occipital face area (OFA), suggesting a closer link with ventral than lateral cortex. Consistent with prior research, we also observed differential functional connectivity in medial parietal cortex for anterior over posterior PPA, as well as a region on the lateral surface, the caudal inferior parietal lobule (cIPL). However, the differential connectivity in medial parietal cortex was found principally anterior of MPA. We suggest that there is posterior–anterior gradient within medial parietal cortex, with posterior regions in the POS showing retinotopically based scene-selectivity and more anterior regions showing connectivity that may be more reflective of abstract, navigationally pertinent and possibly mnemonic representations.

Two distinct scene processing networks connecting vision and memory

Research on visual scene understanding has identified a number of regions involved in processing natural scenes, but has lacked a unifying framework for understanding how these different regions are organized and interact. We propose a new organizational principle, in which scene processing relies on two distinct networks at the edge of visual cortex. The first network consists of the Transverse Occipital Sulcus (TOS, or the Occipital Place Area) and the posterior portion of the Parahippocampal Place Area (PPA). These regions have a well-defined retinotopic organization and do not show strong memory or context effects, suggesting that this network primarily processes visual features from the current view of a scene. The second network consists of the caudal Inferior Parietal Lobule (cIPL), Retrosplenial Cortex (RSC), and the anterior portion of the PPA. These regions are involved in a wide range of both visual and non-visual tasks involving episodic memory, navigation, imagination, and default mode processing, and connect information about a current scene view with a much broader temporal and spatial context. We provide evidence for this division from a diverse set of sources. Using a data-driven approach to parcellate resting-state fMRI data, we identify coherent functional regions corresponding to scene-processing areas. We then show that a network clustering analysis separates these scene-related regions into two adjacent networks, which exhibit sharp changes in connectivity properties across their narrow border. Additionally, we argue that the cIPL has been previously overlooked as a critical region for full scene understanding, based on a meta-analysis of previous functional studies as well as diffusion tractography results showing that cIPL is well-positioned to connect visual cortex with many other cortical systems. This new framework for understanding the neural substrates of scene processing bridges results from many lines of research, and makes specific predictions about functional properties of these regions. Meeting abstract presented at VSS 2015

Cortico-cortical connections of areas 44 and 45B in the macaque monkey

In the human brain, areas 44 and 45 constitute Broca’s region, the ventrolateral frontal region critical for language production. The homologues of these areas in the macaque monkey brain have been established by direct cytoarchitectonic comparison with the human brain. The cortical areas that project monosynaptically to areas 44 and 45B in the macaque monkey brain require clarification. Fluorescent retrograde tracers were placed in cytoarchitectonic areas 44 and 45B of the macaque monkey, as well as in the anterior part of the inferior parietal lobule and the superior temporal gyrus. The results demonstrate that ipsilateral afferent connections of area 44 arise from local frontal areas, including rostral premotor cortical area 6, from secondary somatosensory cortex, the caudal insula, and the cingulate motor region. Area 44 is strongly linked with the anterior inferior parietal lobule (particularly area PFG and the adjacent anterior intraparietal sulcus). Input from the temporal lobe is limited to the fundus of the superior temporal sulcus extending caudal to the central sulcus. There is also input from the sulcal part of area Tpt in the upper bank of the superior temporal sulcus. Area 45B shares some of the connections of area 44, but can be distinguished from area 44 by input from the caudal inferior parietal lobule (area PG) and significant input from the part of the superior temporal sulcus that extends anterior to the central sulcus. Area 45B also receives input from visual association cortex that is not observed in area 44. The results have provided a clarification of the relative connections of areas 44 and 45B of the ventrolateral frontal region which, in the human brain, subserves certain aspects of language processing.

Probabilistic fibre tract analysis of cytoarchitectonically defined human inferior parietal lobule areas reveals similarities to macaques.

The human inferior parietal lobule (IPL) is a multimodal brain region, subdivided in several cytoarchitectonic areas which are involved in neural networks related to spatial attention, language, and higher motor processing. Tracer studies in macaques revealed differential connectivity patterns of IPL areas as the respective structural basis. Evidence for comparable differential fibre tracts of human IPL is lacking. Here, anatomical connectivity of five cytoarchitectonic human IPL areas to 64 cortical targets was investigated using probabilistic tractography. Connection likelihood was assessed by evaluating the number of traces between seed and target against the distribution of traces from that seed to voxels in the same distance as the target. The main fibre tract pattern shifted gradually from rostral to caudal IPL: Rostral areas were predominantly connected to somatosensory and superior parietal areas while caudal areas more strongly connected with auditory, anterior temporal and higher visual cortices. All IPL areas were strongly connected with inferior frontal, insular and posterior temporal areas. These results showed striking similarities with connectivity patterns in macaques, providing further evidence for possible homologies between these two species. This shift in fibre tract pattern supports a differential functional involvement of rostral (higher motor functions) and caudal IPL (spatial attention), with probable overlapping language involvement. The differential functional involvement of IPL areas was further supported by hemispheric asymmetries of connection patterns which showed left-right differences especially with regard to connections to sensorimotor, inferior frontal and temporal areas.

Architectonics and cortical connections of the upper bank of the superior temporal sulcus in the rhesus monkey: an analysis in the tangential plane.

Area TPO in the upper bank of the superior temporal sulcus (STS) of macaque monkeys is thought to correspond to the superior temporal polysensory (STP) cortex, but has been shown to have neurochemical/connectional subdivisions. To examine directly the relationship between chemoarchitecture and cortical connections of area TPO, the upper bank of the STS was sectioned tangential to the cortical surface. Three subdivisions of area TPO (TPOr, TPOi, and TPOc) were examined with cytochrome oxidase (CO) histochemistry and neurofilament protein (NF) immunoreactivity and architectonic patterns were compared with connections on the same or adjacent sections. Area TPOc, which may partly overlap with the location of the medial superior temporal area MST, exhibited regular patchy staining for CO in layers III/IV and a complementary pattern in the NF stain. Area TPOr, but not TPOi, also had a patchy pattern of complementary staining in CO and neurofilament similar to TPOc, although not as distinct. Tracer injections within cortex including the frontal eye fields (areas 46 and 8) labeled areas TPOc, TPOi, and TPOr. The caudal inferior parietal lobule (IPL) projected to all three areas. The projections from prearcuate and posterior parietal cortices showed both overlap and nonoverlap with each other within TPOc, TPOi, and TPOr. Projections were to all neurochemical components within the subdivisions of TPO. The findings support the parcellation of area TPO into three subdivisions and extend findings of chemoarchitectonic modules within high-order association cortices.

Overlapping and nonoverlapping cortical projections to cortex of the superior temporal sulcus in the rhesus monkey: Double anterograde tracer studies

To examine how fibers from functionally distinct cortical zones interrelate within their target areas of the superior temporal sulcus (STS) in the rhesus monkey, separate anterograde tracers were injected in two different regions of the same hemisphere known to project to the STS. Paired injections were placed in dorsal prearcuate cortex and the caudal inferior parietal lobule (IPL), interconnected regions that are part of a hypothesized distributed network concerned with visuospatial analysis or directed attention; in a presumed auditory region of the superior temporal gyrus (STG) and in extrastriate visual cortex, the caudal IPL and lower rim of the intraparietal sulcus; and in dorsal prearcuate cortex and the STG. Overlapping and nonoverlapping projections were then examined in STS visual and polysensory areas. Prefrontal and parietal fibers directly overlapped extensively in area MST and all subdivisions of presumed polysensory cortex (areas TPOc, TPOi, and TPOr), although nonoverlapping connections were also found. Although STG and IPL fibers targeted all TPO subdivisions, connections were to nonoverlapping, but often adjacent, columns. Paired prefrontal and STG injections revealed largely nonoverlapping vertical columns of connections but substantial overlap within layers VI and I or areas TPOc and TPOi. The findings suggest that area TPO contains differently connected modules that may maintain at least initial segregation of visual versus auditory inputs. Other modules within area TPO receive directly converging input from the posterior parietal and the prefrontal cortices and may participate in a distributed cortical network concerned with visuospatial functions.

Chemoarchitectonics and corticocortical terminations within the superior temporal sulcus of the rhesus monkey: Evidence for subdivisions of superior temporal polysensory cortex

Cortex of the upper bank of the superior temporal sulcus (STS) in macaque monkeys, termed the superior temporal polysensory (STP) region, corresponds largely to architectonic area TPO and is connectionally distinct from adjacent visual areas. To investigate whether or not the STP region contains separate subdivisions, immunostaining for parvalbumin and neurofilament protein (using the SMI-32 antibody) was compared with patterns of corticocortical terminations in the STS. Chemoarchitectonic results provided evidence for three caudal-to-rostral subdivisions: TPOc, TPOi, and TPOr. Area TPOc was characterized by patchy staining for parvalbumin and SMI-32 in cortical layers IV/III and III, respectively. Area TPOi had more uniform chemoarchitectonic staining, whereas area TPOr had a thicker layer IV than TPOi. The connectional results showed prefrontal cortex in the location of the frontal eye fields (area 8) and dorsal area 46 projected in a columnar pattern to all cortical layers of area TPOc, to layer IV of TPOi, and in a columnar fashion, with a moderate increase in density in layer IV, to TPOr. In TPOc, columns of frontal connections showed a periodicity similar to that of the SMI-32 staining. The caudal inferior parietal lobule (area 7a) and superior temporal gyrus projected to each subdivision of area TPO, displaying either panlaminar or fourth-layer terminations. In addition to STP cortex, parvalbumin and SMI-32 immunostaining allowed identification of caudal visual areas of the STS, including MT, MST, FST, and V4t. These areas received first- and sixth-layer projections from prefrontal cortex and area 7a.

The effects of lesions of superior temporal gyrus and inferior parietal lobe on temporal and vertex components of the human AEP

We recorded auditory evoked potentials (AEPs) to 1 kHz tone bursts in controls and patients with unilateral lesions centered in posterior superior temporal gyrus and adjacent caudal inferior parietal lobule (STG) or in rostral inferior parietal lobule (IPL). Controls generated a vertex maximal N94 (N1b) and P200 (P2) and additional P45, N78 and N127 temporal AEP components (P45, N1a, N1c). Similar to prior reports, in controls the N1a was most prominent over the left temporal lobe and the P45 was largest over the right temporal lobe consistent with behavioral and anatomical data indicating differential organization of left and right human temporal lobe. The N1c was recorded equally from both T 3 and T 4 electrodes and was enhanced in the temporal site contralateral to the ear of stimulation. The patient groups had differenti al effects on AEPs. Unilateral STG lesions resulted in bilateral reductions of the N1b and P45 and marked unilateral reductions of the N1a and N1c over lesioned hemisphere. IPL lesions resulted in bilateral but non-significant reductions of the N1b and N1c. The scalp topography results in normal subjects combined with the effects of unilateral STG lesions provide supportive evidence that the temporal maximal components of the human AEP (P45, N1a, N1c) are generated by radially oriented neuronal dipole sources located in STG. The bilateral reduction of the N1b vertex response by unilateral STG lesions is compatible with a unilateral disruption of a vertically oriented dipole situated in the posterior superior temporal plane. The results emphasize the critical role of the superior temporal plane and lateral superior temporal gyrus in generation of human long latency AEPs.

Posterior parietal projections to the intraparietal sulcus of the rhesus monkey

A cyto- and myeloarchitectonic parcellation of the intraparietal sulcus in the rhesus monkey was correlated with the pattern of afferent connections from the parietal lobe as determined by autoradiographic techniques. Area PEa in the upper bank receives topographically-organized input from the ventral and caudal superior parietal lobule and the medial surface of the parietal lobe. Area POa in the lower bank is the recipient of a projection from the rostral inferior parietal lobule. Area IPd, situated in the depth of the intraparietal sulcus, receives converging input from the caudal superior parietal lobule, medial surface of the parietal lobe, and mid- and caudal inferior parietal lobule. Finally, intrinsic sequences of connections, directed from rostral to caudal and caudal to rostral, exist within both areas PEa and POa, each having a distinctive laminar pattern of origins and terminations.

The thalamic relations of the caudal inferior parietal lobule and the lateral prefrontal cortex in monkeys: divergent cortical projections from cell clusters in the medial pulvinar nucleus.

The thalamic relations of the caudal inferior parietal lobule and the dorsolateral prefrontal cortex in monkeys have been investigated with both anterograde and retrograde neuroanatomical tracing techniques. The results of these experiments indicate that the medial pulvinar nucleus (Pul.m.) is the principal thalamic relay to the gyral surface of the caudal inferior parietal lobule (area 7a). Within the Pul.m. there are two or three disklike aggregates of neurons which project to area 7a; these disklike neuronal aggregates are oriented from dorsomedial to ventrolateral and extend over most of the rostrocaudal extent of the nucleus. Within these disks there are rodlike clusters of neurons which are elongated in the rostrocaudal dimension of the thalamus, and which project in a topographically ordered manner to area 7a. Thus, the more rostrally located neurons within the Pul.m. disks project to more rostral parts of area 7a and, conversely, the more caudally located neurons project to the caudal part of this cortical field. Similarly, the medial part of each disk projects to the lateral part of area 7a while the laterally placed neurons project to the medial part of the cortical field. In addition to its input from the Pul.m., area 7a is also reciprocally connected with the magnocellular division of the nucleus ventralis anterior, with the nuclei which abut upon the medullary capsule of the laterodorsal nucleus, and with the suprageniculate nucleus and the nucleus limitans. The cortex on the lateral bank of the intraparietal sulcus (the so-called lateral intraparietal area, LIP) projects principally to the lateral pulvinar nucleus (Pul.l) of the thalamus rather than to Pul.m. Area LIP has been found to project to the pregeniculate nucleus, the zona incerta, the anterior pretectal nucleus, and the superior colliculus. Area 7a projects to none of these structures, but it does project to the posterior pretectal nucleus. The thalamic relations of the neighboring cortical regions, such as the prelunate gyrus and area 7b, are also distinct from those of area 7a. It thus seems that the prelunate gyrus is primarily interconnected with the Pul.l., and area 7b with the oral pulvinar nucleus. Taken together these different subcortical relationships provide further evidence for the view that the caudal inferior parietal lobule is not a homogeneous cortical area, but is composed of a number of subsidiary fields. The projection from the Pul.m. to the lateral prefrontal cortex arises from disklike aggregates of neurons, similar in their orientation to the neuronal disks that project to area 7a.(ABSTRACT TRUNCATED AT 400 WORDS)

The distribution of posterior parietal fibers in the corpus callosum of the rhesus monkey.

The distribution of posterior parietal fibers in the corpus callosum of the rhesus monkey was analyzed using autoradiographic techniques. Posterior parietal fibers are located in the posterior half of the body of the corpus callosum. There is some segregation of fibers with respect to their place of origin within the posterior parietal lobe. However, there is also overlap, particularly between fibers coming from the caudal inferior parietal lobule and the medial parietal lobe.

Intrinsic connections and architectonics of posterior parietal cortex in the rhesus monkey

By means of autoradiographic and ablation-degeneration techniques, the intrinsic cortical connections of the posterior parietal cortex in the rhesus monkey were traced and correlated with a reappraisal of cerebral architectonics. Two major rostral-to-caudal connectional sequences exist. One begins in the dorsal postcentral gyrus (area 2) and proceeds, through architectonic divisions of the superior parietal lobule (areas PE and PEc), to a cortical region on the medial surface of the parietal lobe (area PGm). This area has architectonic features similar to those of the caudal inferior parietal lobule (area PG). The second sequence begins in the ventral post/central gyrus (area 2) and passes through the rostral inferior parietal lobule (areas PG and PFG) to reach the caudal inferior parietal lobule (area PG). Both the superior parietal lobule and the rostral inferior parietal lobule also send projections to various other zones located in the parietal opercular region, the intraparietal sulcus, and the caudalmost portion of the cingulate sulcus. Areas PGm and PG, on the other hand, project to each other, to the cingulate region, to the caudalmost portion of the superior temporal gyrus, and to the upper bank of the superior temporal sulcus. Finally, a reciprocal sequence of connections, directed from caudal to rostral, links together many of the above-mentioned parietal zones. With regard to the laminar pattern of termination, the rostral-to-caudal connections are primarily distributed in the form of cortical "columns" while the caudal-to-rostral connections are found mainly over the first cortical cell layer.

Homotopic and heterotopic callosal afferents of caudal inferior parietal lobule in Macaca mulatta.

We have examined callosal-axon neurons giving rise to homotopic and heterotopic callosal projections to caudal inferior parietal lobule (area PG) in Macaca mulatta, identifying these neurons by means of retrograde axonal transport of horseradish peroxidase. The labeled neurons in the homotopic region occur predominantly in layers IIIB and V.A moderate number are also seen in layer VI, a smaller number of layer IV, and rare cells occur in layer II. These neurons occupy a region very similar in outline to the injection area, and though variable in density in the horizontal plane, are continuously distributed in this plane. The heterotopic neurons are seen in the contralateral cingulate gyrus, continuing caudally into medial parietal cortex, in the cortex of the superior temporal and occipitotemporal sulci, in the caudal superior temporal gyrus, and in the caudal inferior parietal lobule, behind the homotopic area. These same regions on the ipsilateral side contain labeled neurons of origin of ipsilateral association projections to area PG. For other ipsilateral labeling was found. A review of the literature on heterotopic callosal connections of a particular generalization of this conclusion: The callosal heterotopic connections of a particular cortical area are made with regions which on the ipsilateral side have associated connections with that area, though usually not with all of such regions.

Some cortical projections to the parahippocampal area in the rhesus monkey

Using silver impregnation techniques to trace cortical connections in rhesus monkeys subject to ablations of various parts of posterior “association” cortex, several specific projections to sectors of the parahippocampal area have been found. Area TF is the recipient of projections from the caudal inferior parietal lobule; area TH has afferent connections with the rostroventral superior temporal gyrus; both areas TF and TH together receive input from the lateral and ventral peristriate belt. In addition, the inferior temporal gyrus also projects to areas TF-TH of von Bonin and Bailey as well as the cortex in the banks of the rhinal fissure. The possible significance of these projections in terms of sensory-limbic connections and sensory convergence is discussed.

INTERCORTICAL CONNECTIONS OF CORPUS CALLOSUM AS INDICATED BY EVOKED POTENTIALS

INTERCORTICAL CONNECTIONS OF CORPUS CALLOSUM AS INDICATED BY EVOKED POTENTIALS