While it is known that one can consider the Cauchy problem for evolution equations with Caputo derivatives, the situation for the initial value problems for the Riemann–Liouville derivatives is less understood. In this paper, we propose new type initial, inner, and inner-boundary value problems for fractional differential equations with the Riemann–Liouville derivatives. The results on the existence and uniqueness are proved, and conditions on the solvability are found. The well-posedness of the new type of initial, inner, and inner-boundary conditions is also discussed. Moreover, we give explicit formulas for the solutions. As an application fractional partial differential equations for general positive operators are studied.