Aim. The aim of the study was to determine the relationship between missing teeth in the oral cavity and upper face wrinkles.Material and methods. The research consisted of two stages – a retrospective and a current study, in a retrospective study documentation of 100 patients was obtained, in a current study took part 50 patients. Extraoral and intraoral medical photographs of the patient`s faces were taken. Photographs from the retrospective and the current study were assessed by 3 investigators for the severity of upper facial wrinkles, based on the Skin Aging Atlas reference scale. Volume 1, Caucasian Type. Paris: EditionsMed'Com.Results. In a retrospective analysis, a result close to statistical significance with a negative Spearman's coefficient was obtained for the relationship – reduced number of the teeth in the lateral segments and CF (wrinkles around the eyes). In a current study statistical significance was obtained for correlations: Kłp ( right side eye wrinkles), KŁl (left side eye wrinkles), UEW (left side suborbital wrinkles).Conclusions. There is a need to treat even single missing teeth in the lateral segments in order to preserve the young appearance of the face.