Caucasian Canadians Research Articles

Common dihydropyrimidinase ( DPYS ) genetic variations do not predict fluoropyrimidine-related chemotherapy toxicity in a Canadian cohort.

Known genetic variations in dihydropyrimidine dehydrogenase (gene name DPYD ) do not fully predict patients at risk for severe fluoropyrimidine-associated chemotherapy toxicity. Dihydropyrimidinase (gene name DPYS ), the second catabolic enzyme in fluoropyrimidine metabolism, has been noted as a potential determinant of variation in fluoropyrimidine metabolism and response. In this study, we genotyped for DPYS c.-1T>C (rs2959023), c.265-58T>C (rs2669429) and c.541C>T (rs36027551) in a Canadian cohort of 248 patients who were wild type for Clinical Pharmacogenetics Implementation Consortium recommended DPYD variants and had received a standard dose of fluoropyrimidine chemotherapy. None of our patients were found to carry the DPYS c.541C>T variant, while the minor allele frequencies were 63% and 54% for c.-1T>C and c.265-58T>C, respectively. There was no association between DPYS c.-1T>C wild type and heterozygote [odds ratio (OR) (95% confidence interval, CI) = 1.10 (0.51-2.40)] or homozygote variant carriers [OR (95% CI) = 1.22 (0.55-2.70)], or between DPYS c.265-58T>C wild-type patients and heterozygote [OR (95% CI) = 0.93 (0.48-1.80)] or homozygote variant carriers [OR (95% CI) = 0.76 (0.37-1.55)] in terms of fluoropyrimidine-associated toxicity. Therefore, in our cohort of mostly Caucasian Canadians, genetic variations in DPYS do not appear to be a significant contributor to severe fluoropyrimidine-associated toxicity.

Exploring and bioinformatics analysis of differentially expressed genes in bronchial asthma

Objective: To screen core differentially expressed genes of bronchial asthma and conduct bioinformatics analysis. Methods: Macrophage microarray data GSE22528 from asthma patients were downloaded from gene expression database (GEO). The dataset included transcriptome information from 10 human alveolar lavage fluid samples, and five of them were from allergic asthmatic subjects and five from control subjects. Differential expression genes (DEGs) were screened by R 4.0.4 software. Gene ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed to select DEGs using DAVID 6.8 database. Protein interaction network (PPI) was constructed from DEGs encoded proteins using STRING online database. Cytoscape software was used to construct core modules and determine core DEGs. Results: Alveolar lavage fluid samples were all collected from Caucasian Canadians, with age range as (20, 37) and (18, 36) years, respectively, including 3 males for each group. In asthmatic patients, 449 genes were up-regulated and 47 down-regulated. GO analysis showed that the up-regulated genes in asthmatic patients were mainly involved in biological processes such as response to folded proteins, and the molecular function was focused on binding of folded proteins and growth factors. Down-regulated genes were mainly involved in biological processes such as histone deacetylation and ubiquitin-mediated protein degradation, and their molecular functions focused on histone deacetylation activity. KEGG pathway enrichment analysis showed that pathways were mainly enriched by up-regulation genes, involving Hippo signaling pathway, hypertrophic cardiomyopathy, estrogen signaling pathway, arrhythmogenic right ventricular cardiomyopathy, basal cell carcinoma, neuro-activated receptor ligand interaction, dilated cardiomyopathy and adhesion and connection signaling pathways. Two core modules were obtained by PPI analysis, and 14 core DEGs were screened out. They were pro-melanin concentrating hormone (PMCH), prepronociceptin (PNOC), Sphingosinol-1-phosphate receptor 2 (S1PR2), Sphingosinol-1-phosphate receptor 5 (S1PR5), CC-type chemokine ligand 21 (CCL21), Kelch-like protein 25 (KLHL25), ubiquitin binding enzyme E2V2 (UBE2V2), F-box protein 17 (FBXO17), taste receptor type 2 member 3 (TAS2R3), somatostatin receptor 2 (SSTR2), metabolic glutamate receptor 2 (GRM2), Lister E3 ubiquitin protein ligase 1 (LTN1), LIM domain specific protein 7 (LMO7) and ring finger protein 19A gene(RNF19A), in which LTN1 and UBE2V2 were down-regulated and the rest were up-regulated. Conclusion: DEGs was found in macrophages of asthmatic and control individuals. PMCH, PNOC, S1PR2, S1PR5 and CCL21 might be the core genes in the pathological process of asthma.

Demographic, psychosocial, and cultural predictors of entitlement in a multiethnic Canadian undergraduate sample

The current study sought to examine the demographic, psychosocial, and cultural predictors of psychological entitlement (PE) and academic entitlement (AE) and their impacts on psychological well-being in a sample of Asian and Caucasian young adults in Canada. This study found that on average, less than 80% of the participants endorsed items characteristic of entitlement. Based on multiple regression analyses, higher PE was predicted by unemployment, older age, more recent generation status, and a weaker tendency for social comparison. Higher AE, on the other hand, was predicted by younger age, more recent generation status, lower self-esteem, and lower self-efficacy. AE was found to be negatively associated with a number of psychological well-being indicators, while PE was not. The results suggest that entitlement in the form of AE may be more problematic as compared to PE. With respect to ethnic differences, PE and AE were higher among Asian Canadians than Caucasian Canadians. Implications for future research and practice are discussed.

Bag Across the Border

Prior research documents /æ/ raising and tensing when followed by /g/ in words like bag in the Pacific Northwest, particularly in Seattle. The present study compares /æg/ raising among speakers from Seattle, Washington, and Vancouver, British Columbia, and explores the social motivations for its use. The findings show that while the feature occurs in both cities, its social distribution is not identical. Different age and gender distributions and varying metalinguistic commentary raise questions about the trajectory of change in each city. Nonetheless, speakers’ realizations of raised bag are associated with similar sociocultural backgrounds and ideologies. In Seattle, bag raisers have multigenerational ties to the area, take strong ideological stances against changes in the area’s industries and economy, and oppose “gentrification.” Nonraisers have more international ties, show stronger interest in moving elsewhere, and embrace Seattle’s new industries. In Vancouver, BAG raisers describe growing up as Caucasian Canadians in majority Asian neighborhoods and emphasize the changing demographics and increased cost of living. In both cities, bag raisers are ideologically opposed to perceived encroachment and take conservative stances toward changes in their city. This highlights that the West and Canada participate in some of the same sound changes and show similar, locally contextualized motivations for their use.

Whole-body heat exchange in black-African and Caucasian men during exercise eliciting matched heat-loss requirements in dry heat.

What is the central question of this study? Black-African descendants are thought, by some, to possess genotypic adaptations conducive to survival in hot climates. We therefore assessed whether Canadian residents of black-African descent display enhanced whole-body total heat loss (evaporative plus dry heat exchange) in comparison to Caucasian Canadians during exercise eliciting matched heat-loss requirements in dry heat. What is the main finding and its importance? Neither whole-body total heat loss nor body heat storage differed significantly between groups, irrespective of the exercise intensity. Our findings indicate that genotypic adaptations associated with ethnicity do not appreciably modify whole-body heat exchange during exercise-heat stress. Ethnicity has long been thought to modulate thermoregulatory function; however, an evaluation of whole-body heat exchange in men of black-African descent and Caucasian men (white-European descendants), born and raised in the same climate, during exercise eliciting matched heat-loss requirements remained unavailable. We therefore used direct calorimetry to assess whole-body total heat loss (evaporative plus dry heat exchange) in young (18-30 years of age), second-generation (or higher) black-African (n=11) and Caucasian (n=11) men. Participants performed three 30min bouts of semi-recumbent cycling at fixed metabolic heat productions (and therefore matched heat-loss requirements between groups) of 200 (light), 250 (moderate) and 300Wm-2 (vigorous), each followed by 15min recovery, in dry heat (40°C, ∼13% relative humidity). Across all exercise bouts, dry (P=0.435) and evaporative (P=0.600) heat exchange did not differ significantly between groups. As such, total heat loss during light, moderate and vigorous exercise was similar between groups (P=0.777), averaging [mean (SD)] 177 (10), 217 (13) and 244 (20)Wm-2 in black-African men and 172 (13), 212 (17) and 244 (17)Wm-2 in Caucasian men. Accordingly, body heat storage across all exercise bouts (summation of metabolic heat production and total heat loss) was also similar between the black-African [568 (142) kJ] and Caucasian groups [623 (124) kJ; P=0.356]. We demonstrated that, when assessed in young, second-generation (or higher) black-African and Caucasian men during exercise eliciting matched heat-loss requirements in dry heat, ethnicity did not significantly modulate whole-body dry and evaporative heat exchange or the resulting changes in total heat loss and body heat storage.

Genetic Risk Score Predictive of the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation in a Mexican Population.

Our group built a genetic risk score (GRS) of the plasma triglyceride (TG) response to an omega-3 (n-3) fatty acid (FA) supplementation in Caucasian Canadians that explained 21.53% of the TG variance. The objective was to refine the GRS by fine mapping and to test its association with the TG response in young Mexican adults. A total of 191 participants underwent a 6-week n-3 FA supplementation providing 2.7g/day of docosahexaenoic and eicosapentaenoic acids. Using quantitative polymerase chain reaction (PCR), 103 single-nucleotide polymorphisms (SNPs) were genotyped. A stepwise regression adjusted for age, sex, and body mass index (BMI) was used to select the strongest SNPs to include in the genetic risk model. A GRS was calculated from the sum of at-risk alleles. The contribution of the GRS to the TG response was assessed by ANCOVA with age, sex, and BMI included in the model. Several differences in allele frequency were observed between Canadians and Mexicans. Five lead SNPs were included in the genetic risk model, in which the GRS accounted for 11.01% of the variance of the TG response (p < 0.0001). These findings highlight the important contribution of genetic factors to the heterogeneity of the TG response to an n-3 FA supplementation among Mexicans.

How Chinese and Caucasian Canadians Conceptualize Creativity: The Mediating Role of Uncertainty Avoidance

The current study examines cultural value mediators of the relationship between culture and the relative weight placed on novelty versus usefulness when conceptualizing creativity. With a sample of Chinese and Caucasian Canadian undergraduate students, we found that uncertainty avoidance, but not power distance or individualism/collectivism, mediated the relationship between culture and preferences toward the novel versus useful dimensions of creativity. We replicated the effect of uncertainty avoidance in a second study with Chinese Canadians’ bicultural identity integration predicting focus on novelty versus usefulness in the predicted direction. We advance prior research by isolating a cultural value mechanism driving cultural variation in the conceptualization of creativity when considering novelty versus usefulness. We discuss theoretical contributions and implications for future research addressing additional creativity domains, situated cognition, and norm salience.

Cultural Differences in Memory for Objects and Backgrounds in Pictures

The purpose of this study is to investigate cultural differences in memory for individual objects and backgrounds that have been studied together in one picture. Thirty-six Caucasian Canadians in Toronto and 36 Han Chinese in Beijing were tested with a picture recognition paradigm. At encoding, participants viewed 60 line drawing pictures, each containing an object and a background scene. Participants then recognized these objects and backgrounds in isolation, and were asked to report subjectively whether they allocated their attention toward the objects, backgrounds, or both during encoding. In general, we did not find any cultural difference in memory for the isolated objects. However, Canadian participants showed significantly better memory for backgrounds than Chinese participants. Our supplementary data suggested that this effect appeared primarily among participants who self-reported paying attention to both objects and backgrounds. We speculated that relative to Canadian participants, Chinese parti...

Is Multi-Ethnic Advertising a globally viable strategy for a Western luxury car brand? A mixed-method cross-cultural study

While Multi-Ethnic Advertising is increasingly used by non-luxury brands, global luxury brands still almost exclusively use Caucasian models in their global brand communication. We suggest that this is due to inconsistency in meaning and valence of Multi-Ethnic Advertising across and within countries. In qualitative interviews with 145 young consumers in Japan, China, Austria, and Canada (recent Japanese and Chinese immigrants, and Caucasian Canadians) we find that Multi-Ethnic Advertising stands for “brand globalness” in ethnically homogeneous markets, but for “brand inclusiveness” in ethnically diverse markets. In line with Optimal-Distinctiveness Theory, ethnic-majority consumers in Japan and China prefer All-Caucasian Advertising over Multi-Ethnic Advertising for a Western luxury car brand, while recent Japanese and Chinese immigrants to Canada show a relatively stronger appreciation for Multi-Ethnic Advertising. A quantitative study among 370 Chinese consumers in China and recent Chinese immigrants to Canada confirms these patterns and the mediating role of Need for Differentiation.

Age-related macular degeneration: is polypoidal choroidal vasculopathy recognized and treated?

ObjectiveTo assess how polypoidal choroidal vasculopathy (PCV) is recognized and treated, and to assess whether treatment outcomes are different between Chinese and Caucasian Canadian patients with age-related macular degeneration (AMD). DesignRetrospective chart review. Participants154 eyes from 135 Chinese patients and 2291 eyes from 1792 Caucasian patients who were newly diagnosed with either AMD or PCV and had more than 1 year of follow-up were included. MethodsAll newly diagnosed AMD patients presenting to the Retina Service of 3 Toronto University Hospitals, between March 25, 2008, to September 30, 2014, were reviewed. Results10/154 eyes (6.5%) in Chinese Canadians and 16/2291 eyes (0.7%) in Caucasian Canadians were diagnosed as having PCV. Indocyanine green angiography (ICGA) was used to diagnose PCV in 20% of Chinese Canadians and 8.8% of Caucasian Canadians. Clinical practices with a larger percentage of Chinese patients were more likely to diagnose PCV in both Chinese (p = 0.004) and Caucasian patients (p = 0.03), were more likely to use photodynamic therapy (PDT) (p < 0.01), and had significantly greater central retinal thickness decrease (p < 0.001). ConclusionOur study has shown that PCV is under-recognized in a Canadian population, and ICGA is underutilized. In clinical practices with a greater portion of Chinese patients, PCV is more often recognized and PDT is used more liberally.

Domestic tourism of Chinese in Canada: Distinct differences

Abstract Domestic tourism in Canada has seen a significant increase in recent years; however, surprisingly little attention has been paid to it. Immigrants are an important part of the Canadian population and bring both opportunities and challenges to its tourism industry. Yet they have seldom been studied in previous research, and their heterogeneity is usually neglected. Canadians of Chinese origin are the largest non-European ethnic group in Canada, and therefore represent an increasingly important segment. This study examines the tourist behaviors of three ethnic Chinese groups based on their birthplace: Canada, Hong Kong and Mainland China. The findings show that they do not represent a homogeneous segment in the Canadian domestic market, although the tourist behaviors of Caucasian Canadians are similar to Chinese born in the country, suggesting a certain assimilation by the second generation. This research enables destination management organizations to understand the differences between the three Chinese groups and provides insights into potential marketing approaches to better attract and satisfy these segments.

Living in Two Cultures: Chinese Canadians’ Perspectives on Health

Chinese people have distinctive perspectives on health and illness that are largely unrecognized in Western society. The purpose of this descriptive study was to develop a profile of Chinese immigrants' beliefs and practices related to diet, mental and social health, and sexual health. A quantitative survey with descriptive and correlational analyses was employed to examine 100 first-generation Chinese immigrants living in four urban centres across Canada (Vancouver, Toronto, Halifax, and St. Catharines). Although most Chinese immigrants preferred a Chinese diet, where they resided affected the groceries they bought and the meals they ate. Almost all participants reported their mental health was important to them and most felt comfortable discussing mental health issues with others. However, only a third would see a psychiatrist if they believed they had a mental health problem. Most participants believed social relationships were important for their health. Only a small number of participants, however, preferred making friends with mainstream Caucasian Canadians. More men than women believed sexuality contributed to health and were comfortable talking about sexual health. Chinese immigrants should be encouraged to be more engaged in the larger community in order to fully integrate themselves into Canadian society while still being encouraged to retain their healthy practices. These findings may help educators and practitioners enhance their understandings of Chinese immigrants' perspectives on health and develop culturally competent education and services in health care and health promotion.

CYP2E1*1D regulatory polymorphism: association with alcohol and nicotine dependence.

CYP2E1 bioactivates environmental protoxins and metabolizes alcohol. CYP2E1 is induced by alcohol and cigarette smoking and may contribute to metabolic tolerance in alcoholics. The CYP2E1*1D polymorphism has been associated with greater CYP2E1 inducibility. One objective was to determine the frequency of the variant allele in eight ethnic groups. Further, the Canadian Native Indian, South-east Asian Canadian and Caucasian Canadian groups were stratified by alcohol and nicotine dependence (as measured by DSM-IV criteria) to examine the potential association of CYP2E1*1D with drug dependence. We found a significantly greater frequency of the CYP2E1*1D allele among Indo-Asian Canadians (0.31), Chinese Canadians (0.19), Taiwanese (0.20), Japanese Canadians (0.18), African Americans (0.13), African Canadians (0.10) and Canadian Native Indians (0.09) compared to Caucasian Canadians (0.02). Although the power of the association study was low among some subgroups, the CYP2E1*1D genotype (subjects with at least one variant allele) was associated with alcohol as well as nicotine dependence. Specifically, Canadian Native Indians dependent on nicotine alone or alcohol alone exhibited significantly greater CYP2E1*1D frequencies compared to non-drug dependent controls, while the variant frequency among Southeast Asians dependent on nicotine was greater than their non-drug dependent counterparts. We also found that CYP2E1*1D genotype was associated with significantly greater 3-hydroxycotinine per cigarette in African Americans. The variable frequency of CYP2E1*1D among ethnic groups suggests a greater risk for diseases putatively related to CYP2E1 in some non-Caucasian ethnic groups. The association of CYP2E1*1D with alcohol and nicotine dependence suggests that CYP2E1 may contribute to the development of these dependencies.

Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations

ObjectivesVariants of the secreted glycoprotein, proprotein convertase subtilisin/kexin 9 (PCSK9), associate with both hypo- and hyper-cholesterolemic phenotypes. Herein, we carried out full exonic sequencing of PCSK9 documenting the frequency of single and multiple PCSK9 variations and their effects on serum lipoprotein and PCSK9 levels in Caucasian Canadians.MethodsThe 12 exons of PCSK9 were sequenced in 207 unrelated Caucasian Canadians. Minor allele frequencies of PCSK9 variants were compared amongst LDL cholesterol (LDLC) quintiles. Serum PCSK9 levels were measured by ELISA and lipoproteins by enzymatic methods. Comparisons were made with a Caucasian family cohort (n = 51) and first generation African Canadians (n = 31).ResultsIn Caucasians, but not African Canadians, the c.61_63insCTG (denoted L10Ins) and A53V PCSK9 variations were linked and their frequency was significantly higher among Caucasian Canadians with LDLC levels in the <25th percentile. In both the unrelated and family Caucasian cohorts those carrying the L10A53V PCSK9 variant had significantly lower LDLC without reduction in plasma PCSK9. The I474V PCSK9 variant associated with significantly lower serum PCSK9 and LDLC. A novel PCSK9 variant was identified; E206K. We found that the frequency of multiple PCSK9 variations was higher in first generation African Canadians.ConclusionsWe showed that the L10A53V and I474V PCSK9 variants were significantly associated with lower LDLC levels in Caucasian Canadians but differed in their effect on serum PCSK9 concentrations, illuminating differences in their mechanism of inaction and indicating that that PCSK9 measurement alone may not always be a good indicator of PCSK9 function.Full exonic sequencing of PCSK9 pointed to factors that may contribute to L10Ins PCSK9 variant loss of function in Canadians of Caucasian but not those of African descent. These included; (1) its tight linkage with the A53V variant in Caucasians and/or (2) for both the L10 and I474V, the combined (and negating) effect of multiple, differing phenotypic PCSK9 variants within individuals of African ancestry for which combinations of PCSK9 variations and their overall frequency was higher. No population studies, to our knowledge, have addressed or accessed the effect of multiple PCSK9 variants on cholesterol profiles. Our results indicate that this should be considered.

Cultural Influences on Stigmatization of Problem Gambling: East Asian and Caucasian Canadians

Cultural influences on problem gambling stigma were examined using a between subject vignette study design. Students of East Asian (n=64) and Caucasian (n=50) ancestry recruited from a Canadian University rated a vignette describing either an East Asian problem gambler or a Caucasian problem gambler on a measure of attitudinal social distance. In accordance with the hypothesis, a factorial ANOVA revealed that East Asian Canadians stigmatize problem gambling more than Caucasian Canadians. Moreover, East Asian participants stigmatized the East Asian individual described in the vignette more than they did the Caucasian individual. Individuals with gambling problems were generally not perceived as being dangerous. However, participants who perceived problem gambling as a dangerous condition wanted more social distance than those who did not perceive individuals with a gambling problem as dangerous.

The effect of age and gender on arterial stiffness in healthy Caucasian Canadians

We aimed to investigate age and gender differences in arterial stiffness, and whether this cardiovascular risk factor was detectable in healthy Caucasians before established disease was manifest. A growing number of risk factors including diabetes, obesity, hypertension, hyperlipidaemia, smoking and age have been linked to the adverse cardiovascular end-points of myocardial infarction, stroke and heart failure. These risk factors lead to an increase in arterial stiffness. Measuring this stiffness at an early age may identify candidates for primary preventative intervention strategies by nurses. Caucasian Canadians (n = 176) were recruited. Peripheral and central blood pressure, pulse pressure, augmentation pressure, arterial compliance (augmentation index and pulse wave velocity) and sub-endocardial viability ratio (SEVR), were assessed using applanation tonometry (SphygmoCor system). Blood was drawn for fasting lipid and glucose profiling. Women participants had significantly stiffer arteries than men (augmentation index: 28 SEM = 1% vs. 18 SEM = 2% respectively; p < 0.001). Pulse wave velocity, however, was not different (7.7 SEM = 0.2 m/s vs. 8.3 SEM = 0.1 m/s respectively; p < 0.001). Age was a strong predictor of arterial stiffening in both genders, but the effect was greater in women. Women having stiffer arteries than men, thus at greater cardiovascular risk, may require earlier screening. The effect might be postmenopausal, and mechanisms require further investigation. However, both middle-aged men and women considering themselves 'healthy' may benefit from more proactive primary prevention. Applanation tonometry, used extensively by nurses, provides early detection of central haemodynamic changes and vascular compliance at all ages. Knowledge of arterial stiffness could guide the management of primary prevention in the nursing cardiovascular risk reduction clinic.

CYP2E1*1D regulatory polymorphism

Objective CYP2E1 bioactivates environmental protoxins and metabolizes alcohol. CYP2E1 is induced by alcohol and cigarette smoking and may contribute to metabolic tolerance in alcoholics. The CYP2E1*1D polymorphism has been associated with greater CYP2E1 inducibility. One objective was to determine the frequency of the variant allele in eight ethnic groups. Further, the Canadian Native Indian, South-east Asian Canadian and Caucasian Canadian groups were stratified by alcohol and nicotine dependence (as measured by DSM-IV criteria) to examine the potential association of CYP2E1*1D with drug dependence. Results and conclusions We found a significantly greater frequency of the CYP2E1*1D allele among Indo-Asian Canadians (0.31), Chinese Canadians (0.19), Taiwanese (0.20), Japanese Canadians (0.18), African Americans (0.13), African Canadians (0.10) and Canadian Native Indians (0.09) compared to Caucasian Canadians (0.02). Although the power of the association study was low among some subgroups, the CYP2E1*1D genotype (subjects with at least one variant allele) was associated with alcohol as well as nicotine dependence. Specifically, Canadian Native Indians dependent on nicotine alone or alcohol alone exhibited significantly greater CYP2E1*1D frequencies compared to non-drug dependent controls, while the variant frequency among Southeast Asians dependent on nicotine was greater than their non-drug dependent counterparts. We also found that CYP2E1*1D genotype was associated with significantly greater 3-hydroxycotinine per cigarette in African Americans. The variable frequency of CYP2E1*1D among ethnic groups suggests a greater risk for diseases putatively related to CYP2E1 in some non-Caucasian ethnic groups. The association of CYP2E1*1D with alcohol and nicotine dependence suggests that CYP2E1 may contribute to the development of these dependencies.

Common mutations in the lipoprotein lipase gene (LPL): effects on HDL-cholesterol levels in a Chinese Canadian population

Background: favorable lipid profiles including low total serum cholesterol (TC), TC/HDL-cholesterol (HDL-C) ratio and elevated HDL-C levels have been previously reported in Chinese living in China. More recent data, however, suggests a changing trend toward decreased HDL-C and increased TC and LDL cholesterol (LDL-C) in Chinese populations. Environmental factors likely contribute, in part, to these findings. However, genetic factors contributing to lipoprotein metabolism may also play a role in determining the lipid/lipoprotein phenotype observed in Chinese populations. Lipoprotein lipase (LPL) mutations have been associated with altered HDL-C concentrations in Caucasians but have not yet been studied in a large population of Chinese descent. Methods: 1577 Chinese Canadians of Cantonese descent were recruited for a cardiovascular risk factor study. The frequency and effect of three LPL gene polymorphisms [Asp9Asn (D9N, n=374), Asn291Ser (N291S, n=321) and Ser447-Ter (S447X, n=403)] on serum HDL-C concentrations was assessed. All the three polymorphisms have been shown to alter HDL-C levels in different Caucasian populations. Results: lower TC, LDL-C, and TG and higher HDL-C were observed in both male and female Chinese Canadian subjects compared to other population samples. The D9N and N291S LPL polymorphisms were identified in 1/374 (0.3%) and 5/321 (1.6%) subjects, respectively. Carrier frequency of the S447X mutation was (102/403) 25.3%. This S447X polymorphism was observed with higher frequency in males with HDL-C levels in the highest tertile compared with those in the lowest HDL-C tertile (carrier frequencies 37.3 vs. 19.4%) ( P=0.046). Conclusion: in this cohort of Chinese Canadians, the serum lipid profiles were more favorable than what has been reported for Caucasian Canadians. A favorable spectrum of polymorphisms in the LPL gene may mitigate the adverse effects of western lifestyle on plasma lipoproteins in this cohort of Cantonese Canadians.

Anthropometric Anatomical and Morphological Nose Widths in Canadian Caucasian Adults

The ratio of morphological (bialar diameter [al-al]):anatomical (alar base width [ac-ac]) nose width defines the quality of the soft nose contours. Quantitative data on ac-ac and its relationship to al-al, and the relationship of both nose widths to face width (bizygomatic diameter) have not been available in the literature. To correct this, the anatomical and morphological widths of the nose were measured anthropometrically in an ethnically mixed group of 120 healthy, young adult, Caucasian Canadians, and the ratios of nose widths:face width (which greatly influences nasofacial harmony in the frontal view) calculated. In 80% of subjects, the morphological (classical) nose width was larger than the anatomical nose width, which has close contact with the underlying skeleton. Mean nose width was 24.9% (ac-ac) and 26.1% (al-al) of the face width. This study may help in the corrective surgery of disproportions between the two nose-width measurements in patients with cleft lip nose, and in the restoration of harmony between the nose and face widths.

Changing Media Consumption in a New Home: Acculturation Patterns among Hong Kong Immigrants to Canada

Abstract This study investigates (1) how immigrant consumers change their media consumption when they move across cultural boundaries and (2) whether media exposure relates to consumers' acculturation of the new social norms. A total of 938 respondents from four sample groups including Hong Kong residents, long-time and new Hong Kong immigrants to Canada and English-speaking Caucasian Canadians responded to a predesigned questionnaire. It was found that while the immigrant groups did not increase their total media consumption, their consumption across different media types followed both assimilation and ethnic affirmation models. This acculturation process seemed to be affected by immigrants' original media consumption behavior and language ability. Media exposure was found to relate significantly to immigrants' acculturation of the new social norms after influences due to personal characteristics were removed.