Cattle In Great Britain Research Articles

Bovine TB infection status in cattle in Great Britain in 2022.

Bovine TB infection status in cattle in Great Britain in 2022.

Bovine TB infection status in cattle in Great Britain in 2021.

Bovine TB infection status in cattle in Great Britain in 2021.

Bovine TB infection status in cattle in Great Britain in 2020.

Bovine TB infection status in cattle in Great Britain in 2020.

Determining the prevalence of antibodies to Salmonella Dublin in dairy herds in Great Britain by quarterly bulk tank testing

Salmonella enterica subspecies enterica serovar Dublin has been the most common Salmonella serovar isolated from cattle in Great Britain for the previous 22 years. It can cause a wide variety of clinical presentations and result in significant welfare and productivity concerns in infected herds. Bulk tank antibody testing undertaken every three or four months forms the basis of eradication and monitoring programmes in Denmark and the Netherlands and has been shown to be a sensitive, specific and cost-effective way of establishing seroprevalence and monitoring infection at a herd level. A prevalence estimate based on quarterly bulk tank testing has not been previously carried out in Great Britain. This study recruited 410 herds across Great Britain, who submitted milk samples on a quarterly basis for screening by an ELISA for Salmonella Dublin antibody. Classifying herds according to the Danish eradication scheme classification gave an apparent prevalence of 38% (95% confidence intervals 34–43%) and an estimated true prevalence of 40% (95% confidence intervals 35–45%), taking into account the test sensitivity and specificity. Of the 401 herds which completed the quarterly bulk tank testing, 45% had one or more positive bulk tank results.

Mannheimia haemolytica serovars associated with respiratory disease in cattle in Great Britain

BackgroundMannheimia haemolytica is commonly associated with respiratory disease in cattle worldwide as a cause of fibrinous pneumonia, bronchopneumonia and pleuritis. M. haemolytica is further subdivided into 12 serovars, however not all are considered to be pathogenic in cattle. The study aim was to determine the most common serovars of M. haemolytica associated with respiratory disease in cattle in Great Britain, which is currently unknown and could be useful information for clinicians when considering preventative strategies.ResultsOne hundred four M. haemolytica isolates isolated from bovine clinical pathology and post-mortem samples from pneumonia cases between 2016 and 2018 were tested using a multiplex PCR assay to identify M. haemolytica serovars A1, A2 and A6. 46 isolates (44.2%) typed as M. haemolytica serovar A1, 31 (29.8%) as M. haemolytica serovar A2 and 18 isolates (17.3%) as M. haemolytica serovar A6. Nine isolates (8.7%) were not A1, A2 or A6 so were considered to belong to other serovars or were not typable.ConclusionThis study highlights the importance of M. haemolytica serovars other than A1 which may be responsible for respiratory disease in cattle and could help guide the veterinarian when making choices on preventative vaccination programmes.

Spatial and temporal variation in proximity networks of commercial dairy cattle in Great Britain

The nature of contacts between hosts can be important in facilitating or impeding the spread of pathogens within a population. Networks constructed from contacts between hosts allow examination of how individual variation might influence the spread of infections. Studying the contact networks of livestock species managed under different conditions can additionally provide insight into their influence on these contact structures.We collected high-resolution proximity and GPS location data from nine groups of domestic cattle (mean group size = 85) in seven dairy herds employing a range of grazing and housing regimes. Networks were constructed from cattle contacts (defined by proximity) aggregated by different temporal windows (2 h, 24 h, and approximately 1 week) and by location within the farm.Networks of contacts aggregated over the whole study were highly saturated but dividing contacts by space and time revealed substantial variation in cattle interactions. Cows showed statistically significant variation in the frequency of their contacts and in the number of cows with which they were in contact. When cows were in buildings, compared to being on pasture, contact durations were longer and cows contacted more other cows. A small number of cows showed evidence of consistent relationships but the majority of cattle did not. In one group where management allowed free access to all farm areas, cows showed asynchronous space use and, while at pasture, contacted fewer other cows and showed substantially greater between-individual variation in contacts than other groups.We highlight the degree to which variations in management (e.g. grazing access, milking routine) substantially alter cattle contact patterns, with potentially major implications for infection transmission and social interactions. In particular, where individual cows have free choice of their environment, the resulting contact networks may have a less-risky structure that could reduce the likelihood of direct transmission of infections.

Bovine TB infection status in cattle in Great Britain in 2019.

Bovine TB infection status in cattle in Great Britain in 2019.

Commercial practice of out-wintering dairy heifers in Great Britain

The majority of dairy cattle in Great Britain (GB) are housed during winter but replacement heifers are out-wintered on some farms, a practice that may reduce the need for high capital-cost housing and facilitate herd expansion. Dairy farmers that were out-wintering replacement heifers in GB in 2012 were surveyed to determine current practice and attitudes. A typical system involved heifers strip grazing pasture or a crop, with baled grass silage as supplementary feed; strongly resembling outdoor wintering systems in New Zealand. Many used more than one grazed forage; predominantly, pasture on 68%, kale on 53% and fodder beet on 33% of farms. Supplementary feed was 44% of the diet in younger, and 35% in older heifers. Although farms were approximately three times larger than the national average and 60% were expanding, expanding herd size was not the primary reason for out-wintering, with the main reasons being to reduce cost and improve animal health and welfare. Farmers that out-wintered heifers typically reported good animal average dairy gain of 0.6 kg/d and high body condition, however, this contrasts with some measured performance in GB. Farmers may benefit from accurate feed allocation and monitoring heifer live weight during winter to ensure high performance.

Use of the rSpaA415 antigen indicates low rates of Erysipelothrix rhusiopathiae infection in farmed cattle from the United States of America and Great Britain

BackgroundClinical cases of Erysipelothrix rhusiopathiae, a zoonotic gram-positive bacterium, have been reported in many ruminant species, including in cattle, deer, moose and muskoxen. Fatal cases have been repeatedly reported in cattle over the years but to date there is only one Japanese study investigating the seroprevalence of this bacterium in cattle using the growth agglutination test (GAT). This technique is subjective, time-consuming, expensive and hazardous compared to modern serological tests such as enzyme-linked immunosorbent assays (ELISA) or the newly developed fluorescent microbead-based immunoassays (FMIA).ResultsThe FMIA based on the surface protein SpaA (rSpaA415) antigen of E. rhusiopathiae developed in this study had an almost perfect agreement with the GAT (k = 0.83) and showed a sensitivity of 89.7% and a specificity of 92.9% when compared to the GAT. Overall, detection rates of E. rhusiopathiae antibody positive samples were 13.8% (51/370) in British herds and 6% (12/200) in US herds. Positive cattle were present in 34.3% (24/70) of the investigated British farms and in 34.7% (8/23) of the US farms with an on-farm prevalence of 7.1 to 100% for the British farms and 8.3–30% for the US farms.ConclusionsFMIA is a fast, safe and economic alternative to the GAT for the diagnosis of E. rhusiopathiae in cattle. This work is the first seroprevalence study of E. rhusiopathiae in healthy farmed cattle in Great Britain and the US and revealed that infection occurs at a low level. Further investigations to evaluate risks of zoonotic transmission when handling cattle are needed.

Detection of extended-spectrum β-lactam, AmpC and carbapenem resistance in Enterobacteriaceae in beef cattle in Great Britain in 2015.

This study investigated the occurrence and genetic diversity of Enterobacteriaceae with extended-spectrum β-lactamase (ESBL)-, AmpC- and carbapenemase-mediated resistance in British beef cattle, and related risk factors. Faecal samples (n=776) were obtained from farms in England and Wales (n=20) and Scotland (n=20) in 2015. Isolates from selective agars were identified by MALDI ToF mass spectrometry. Selected isolates were characterized by multiplex PCR (blaCTX -M, blaOXA , blaSHV and blaTEM genes), whole-genome sequencing (WGS), minimum inhibitory concentrations and pulsed-field gel electrophoresis. None of the faecal samples yielded carbapenem-resistant Escherichia coli. Ten (25%) of the farms tested positive for ESBL-producing CTX-M Enterobacteriaceae, 15 (37·5%) of the farms were positive for AmpC phenotype E.coli and none were positive for carbapenem-resistant E.coli. WGS showed a total of 30 different resistance genes associated with E.coli, Citrobacter and Serratia from ESBL agars, and colocation of resistance genes with blaCTX -M1 . Buying bulls and bringing in fattening cattle from another farm were identified as significant risk factors for positive samples harbouring CTX-M Enterobacteriaceae or AmpC phenotype E.coli respectively. Beef cattle on a proportion of farms in GB carry ESBL-producing Enterobacteriaceae. Factors, such as operating as a closed herd, may have an important role in reducing introduction and transmission of resistant Enterobacteriaceae. The results indicate management factors may play an important role in impacting ESBL prevalence. In particular, further study would be valuable to understand the impact of maintaining a closed herd on reducing the introduction of resistant Enterobacteriaceae. This is the first study showing the presence of ESBL-producing Enterobacteriaceae in British beef cattle.

Risk-based inspection as a cost-effective strategy to reduce human exposure to cysticerci of Taenia saginata in low-prevalence settings

BackgroundTaenia saginata cysticercus is the larval stage of the zoonotic parasite Taenia saginata, with a life-cycle involving both cattle and humans. The public health impact is considered low. The current surveillance system, based on post-mortem inspection of carcasses has low sensitivity and leads to considerable economic burden. Therefore, in the interests of public health and food production efficiency, this study aims to explore the potential of risk-based and cost-effective meat inspection activities for the detection and control of T. saginata cysticercus in low prevalence settings.MethodsBuilding on the findings of a study on risk factors for T. saginata cysticercus infection in cattle in Great Britain, we simulated scenarios using a stochastic scenario tree model, where animals are allocated to different risk categories based on their age, sex and movement history. These animals underwent different types of meat inspection (alternative or current) depending on their risk category. Expert elicitation was conducted to assess feasibility of scenarios and provide data for economic analysis. The cost-effectiveness of these scenarios was calculated as an incremental cost-effectiveness ratio, using the number of infected carcasses detected as the technical outcome.ResultsTargeting the high-risk population with more incisions into the heart while abandoning incisions into the masseter muscles was found to reduce the total number of inspections and cost, while simultaneously increasing the number of infected carcasses found.ConclusionsThe results suggest that, under reasonable assumptions regarding potential improvements to current inspection methods, a more efficient and sensitive meat inspection system could be used on animals categorised according to their risk of harbouring T. saginata cysticercus at slaughter. Such a system could reduce associated cost to the beef industry and lower microbial contamination of beef products, improving public health outcomes.

The political economy of bovine tuberculosis in Great Britain.

A brief history of bovine tuberculosis (bTB) and its control in Great Britain (GB) is presented. Numerous diverse policies to control the disease in humans, cattle and wildlife have been pursued over the last 100 years and many millions of pounds have been spent. After notable success in reducing the incidence and prevalence of bTB in cattle in GB from the 1950s to the mid-1980s, the geographical spread of the disease and the number of cattle slaughtered have increased continually since that time, with a high point of bTB incidence in 2008. This increase appeared to coincide with changing policy regarding the control of the disease in badgers, with a more humane approach adopted and with strengthened protection for badgers through legislation. Indeed, there has been much controversy in the debate on the role of badgers in disease transmission to cattle and the need for their control as vectors of the disease. The issue has attracted the attention of the media and there have been various commissioned research projects, trials and public consultations. The findings of two social science investigations presented as examples showed that citizens generally believed that bTB in cattle is an important issue that needs to be tackled, but objected to badgers being killed, whilst cattle farmers were willing to pay around £17/animal/year for a bTB cattle vaccine. It is noted that successes regarding the control of bTB in other countries have combined both cattle and wildlife controls and involved industry working in close partnership with government.

Responses to diagnostic tests for bovine tuberculosis in dairy and non-dairy cattle naturally exposed to Mycobacterium bovis in Great Britain

Field surveillance of British cattle using the single intradermal comparative cervical tuberculin (SICCT) test shows a higher incidence rate of bovine tuberculosis (bTB) in dairy compared to beef herds, but a lower probability of post-mortem examination confirmed (PMC) Mycobacterium bovis infection in dairy herds. A cross-sectional study was conducted to compare animal level differences in bTB detection between dairy and non-dairy cattle in Great Britain. During the period from 2002 to 2005, 200 (41% dairy) reactors in the SICCT test (standard interpretation) were randomly selected, and 200 in-contact cattle (43% dairy) were purposively selected from bTB-infected herds. Interferon (IFN)-γ responses in blood to bovine and avian purified protein derivative (PPD), and early secretory antigen target 6 kDa and culture filtrate protein 10 (ESAT-6/CFP10), were measured. The post-mortem examination included gross pathological examination, mycobacterial culture and histopathology. The proportions of cattle positive to ESAT6/CFP10 were 26% (95% confidence interval, CI, 15–39%) in dairy reactors and 62% (95% CI 51–72%) in non-dairy reactors (P < 0.001). PMC risk was 34% (95% CI 24–45%) in dairy reactors and 69% (95% CI 60–78%) in non-dairy reactors (P < 0.001). The odds ratio for PMC risk in dairy reactors compared to non-dairy reactors, after controlling for bTB prevalence, herd size and SICCT test response, was 0.27 (95% CI 0.14–0.53; P < 0.001). In surveillance data, adjusted animal level PMC risks were lower for dairy reactors than for beef reactors aged >2 years (P < 0.001).

Regional and temporal characteristics of bovine tuberculosis of cattle in Great Britain

Bovine tuberculosis (TB) is a chronic disease in cattle that causes a serious food security challenge to the agricultural industry in terms of dairy and meat production. Spatio-temporal disease analysis in terms of time trends and geographic disparities of disease dynamics can provide useful insights into the overall efficiency of control efforts as well as the relative efficiency of different management measures towards eradication. In GB, Scotland has had a risk based surveillance testing policy under which high risk herds are tested frequently, and in September 2009 was officially declared as TB free. Wales have had an annual or more frequent testing policy for all cattle herds since January 2010, while in England several herds are still tested every 4 years except some high TB prevalence areas where annual testing is applied. Time series analysis using publicly available data for total tests on herds, total cattle slaughtered, new herd incidents, and herds not TB free, were analysed globally for GB and locally for the constituent regions of Wales, Scotland, West, North, and East England. After detecting trends over time, underlying regional differences were compared with the testing policies in the region. Total cattle slaughtered are decreasing in Wales, Scotland and West England, but increasing in the North and East English regions. New herd incidents, i.e., disease incidence, are decreasing in Wales, Scotland, West English region, but increasing in North and East English regions. Herds not TB free, i.e., disease prevalence, are increasing in West, North, and East English regions, while they are decreasing in Wales and Scotland. Total cattle slaughtered were positively correlated with total tests in the West, North, and East English regions, with high slopes of regression indicating that additional testing is likely to facilitate the eradication of the disease. There was no correlation between total cattle slaughtered and total tests on herds in Wales indicating that herds are tested frequent enough in order to detect all likely cases and so control TB. The main conclusion of the analysis conducted here is that more frequent testing is leading to lower TB infections in cattle both in terms of TB prevalence as well as TB incidence.

Fasciola hepatica from naturally infected sheep and cattle in Great Britain are diploid.

Diploid (2n = 2x = 20) and triploid (2n = 3x = 30) Fasciola hepatica have been reported in the UK, and in Asia diploid, triploid and mixoploid (2x/3x) Fasciola spp. exist but there is little information to indicate how common triploidy is, particularly in UK fluke. Here the ploidy of 565 adult F. hepatica from 66 naturally infected British sheep and 150 adult F. hepatica from 35 naturally infected British cattle was determined. All 715 of these parasites were diploid, based on observation of 10 bivalent chromosomes and sperm (n = 335) or, since triploids are aspermic, sperm alone (n = 380). This constitutes the first extensive analysis of the ploidy of F. hepatica field isolates from Great Britain and shows that most F. hepatica isolated from cattle and sheep are diploid and have the capacity to sexually reproduce. These data suggest that triploidy, and by extension parthenogenesis, is rare or non-existent in wild British F. hepatica populations. Given that F. hepatica is the only species of Fasciola present in Britain our results indicate that the parasite is predominantly diploid in areas where F. hepatica exists in isolation and suggests that triploidy may only originate in natural populations where co-infection of F. hepatica and its sister species Fasciola gigantica commonly occurs.

Bovine TB infection status in cattle in Great Britain in 2013

This report, provided by the APHA, summarises the infection status of bovine TB in cattle in Great Britain from January 1 to December 31, 2013 and describes some of the...

The feasibility of testing whether Fasciola hepatica is associated with increased risk of verocytotoxin producing Escherichia coli O157 from an existing study protocol

The parasite Fasciola hepatica is a major cause of economic loss to the agricultural community worldwide as a result of morbidity and mortality in livestock, including cattle. Cattle are the principle reservoir of verocytotoxigenic Escherichia coli O157 (VTEC O157), an important cause of disease in humans. To date there has been little empirical research on the interaction between F. hepatica and VTEC O157. It is hypothesised that F. hepatica, which is known to suppress type 1 immune responses and induce an anti-inflammatory or regulatory immune environment in the host, may promote colonisation of the bovine intestine with VTEC O157. Here we assess whether it is statistically feasible to augment a prospective study to quantify the prevalence of VTEC O157 in cattle in Great Britain with a pilot study to test this hypothesis. We simulate data under the framework of a mixed-effects logistic regression model in order to calculate the power to detect an association effect size (odds ratio) of 2. In order to reduce the resources required for such a study, we exploit the fact that the test results for VTEC O157 will be known in advance of testing for F. hepatica by restricting analysis to farms with a VTEC O157 sample prevalence of >0% and <100%.From a total of 270 farms (mean 27 cows per farm) that will be tested for VTEC O157, power of 87% can be achieved, whereby testing of F. hepatica would only be necessary for an expected 50 farms, thus considerably reducing costs. Pre-study sample size calculations are an important part of any study design. The framework developed here is applicable to the study of other co-infections.

Bovine TB infection status in cattle in Great Britain in 2012

This report, provided by the AHVLA, summarises the infection status of bovine tuberculosis (TB) in cattle in Great Britain from January 1 to December 31, 2012 and describes some of...

Feline tuberculosis caused by Mycobacterium bovis

NO-ONE connected with farming or veterinary science could fail to know that bovine TB caused by Mycobacterium bovis is a major problem in cattle in Great Britain, especially in the...

A restatement of the natural science evidence base relevant to the control of bovine tuberculosis in Great Britain †

Bovine tuberculosis (bTB) is a very important disease of cattle in Great Britain, where it has been increasing in incidence and geographical distribution. In addition to cattle, it infects other species of domestic and wild animals, in particular the European badger (Meles meles). Policy to control bTB is vigorously debated and contentious because of its implications for the livestock industry and because some policy options involve culling badgers, the most important wildlife reservoir. This paper describes a project to provide a succinct summary of the natural science evidence base relevant to the control of bTB, couched in terms that are as policy-neutral as possible. Each evidence statement is placed into one of four categories describing the nature of the underlying information. The evidence summary forms the appendix to this paper and an annotated bibliography is provided in the electronic supplementary material.