Category Test Research Articles

The impact of rehabilitation on the recovery of executive functions in stroke patients with different location of the ischemic focus.

Cognitive dysfunction is part of the clinical picture of stroke. Most of the executive dysfunctions are diagnosed in the early stage of rehabilitation, a few weeks after the vascular incident. Coexistence of executive dysfunctions with other disorders in stroke patients may hinder patient's functions, slow down the rehabilitation process, and disrupt self-awareness, interpersonal communication, and professional activity in everyday life. Ninety patients after ischemic stroke were examined (right hemisphere stroke: N = 33, left hemisphere stroke: N = 57). The study group (N = 45) consisted of patients rehabilitated in the Department of Rehabilitation and Physical Medicine of the University Teaching Hospital of the Military Medical Academy in Lodz, Łódź, Poland, in whom a comprehensive neurorehabilitation program was implemented, consisting of motor and neuropsychological rehabilitation. The control group (N = 45) consisted of patients awaiting admission to the department, who were covered by comprehensive environmental rehabilitation including exercise therapy and neuropsychological therapy. Executive function was measured with 3 popular diagnostic tools: the Wisconsin Card Sorting Test (WCST), the Trail Making Test (TMT part A, TMT part B), and the letter test and category test with the Verbal Fluency Test (VFT). The tests were carried out twice: the first time before the start of rehabilitation and 5 weeks later after its completion. Although patients with right-hemispheric stroke showed better improvement in executive functions, stroke location did not prove to have significant impact on how effective the rehabilitation was. Right hemisphere stroke patients showed greater improvement in restoring executive functions after rehabilitation compared to left hemisphere stroke patients. The location of the stroke did not significantly correlate with the efficiency of the rehabilitation setting. Int J Occup Med Environ Health. 2024;37(4).

Investigating the relationship between cognitive impairment and brain white matter tracts using diffusion tensor imaging in patients with prolactinoma.

Cognitive impairment is known to occur in patients with prolactinoma, but the underlying mechanism is unclear. To evaluate cognitive function in patients with prolactinoma and to investigate the basis of possible cognitive impairment in brain white matter changes using diffusion tensor imaging (DTI). 37 consecutive patients with prolactinoma and 37 healthy controls of similar age, sex, and education were enrolled in the study. Hormone levels were determined in all participants, comprehensive neuropsychological testing was performed, and DTI was used to reconstruct and evaluate white matter tracts. In patients with prolactinoma, short- and long-term visual and verbal memory, attention, concentration, and executive and language functions were impaired compared to the healthy group. When comparing the DTI results, lower fractional anisotropy (FA) values were found in the patients' right uncinate fasciculus (R-UF), indicating neuronal damage. After applying the Bonferroni correction, the two groups had no significant difference in 42 tracts (p > 0.0012 for all). A positive correlation was found between poor FA scores on the R-UF and low scores on long-term memory, category and letter fluency tests. In addition, patients with hypoprolactinemia had the worst short-term memory scores, while normoprolactinemia had the best scores. Also, the poorer R-UF FA values were found in the patients with hypoprolactinemia and the highest in those with normoprolactinemia. This study is the first to investigate reasons for cognitive dysfunction in patients with prolactinoma by DTI. No significant structural changes were found in brain tracts of patients with prolactinoma. Still, there may be a link between potential damage in the R-UF and cognitive dysfunction, and further research is needed. In addition, the results showed that the development of hypoprolactinemia is associated with cognitive dysfunction and emphasized that overtreatment should be avoided.

Predicting Fractional Shrub Cover in Heterogeneous Mediterranean Landscapes Using Machine Learning and Sentinel-2 Imagery

Wildfires pose a growing threat to Mediterranean ecosystems. This study employs advanced classification techniques for shrub fractional cover mapping from satellite imagery in a fire-prone landscape in Quinta da França (QF), Portugal. The study area is characterized by fine-grained heterogeneous land cover and a Mediterranean climate. In this type of landscape, shrub encroachment after land abandonment and wildfires constitutes a threat to ecosystem resilience—in particular, by increasing the susceptibility to more frequent and large fires. High-resolution mapping of shrub cover is, therefore, an important contribution to landscape management for fire prevention. Here, a 20 cm resolution land cover map was used to label 10 m Sentinel-2 pixels according to their shrub cover percentage (three categories: 0%, >0%–50%, and >50%) for training and testing. Three distinct algorithms, namely Support Vector Machine (SVM), Artificial Neural Networks (ANNs), and Random Forest (RF), were tested for this purpose. RF excelled, achieving the highest precision (82%–88%), recall (77%–92%), and F1 score (83%–88%) across all categories (test and validation sets) compared to SVM and ANN, demonstrating its superior ability to accurately predict shrub fractional cover. Analysis of confusion matrices revealed RF’s superior ability to accurately predict shrub fractional cover (higher true positives) with fewer misclassifications (lower false positives and false negatives). McNemar’s test indicated statistically significant differences (p value < 0.05) between all models, consolidating RF’s dominance. The development of shrub fractional cover maps and derived map products is anticipated to leverage key information to support landscape management, such as for the assessment of fire hazard and the more effective planning of preventive actions.

Childhood Neighborhood Disadvantage and Cognitive Function among Veterans Recovering from Mild Traumatic Brain Injury

Abstract Objective Identifying risk factors and interventions for chronic symptoms following mild traumatic brain injury (TBI) is an important area of research for Veterans. Growing up in a disadvantaged neighborhood is associated with poorer health outcomes. We examined the relationship between childhood neighborhood disadvantage and cognitive outcomes among symptomatic Veterans with history of mild TBI. Method 58 Participants completed neuropsychological tests (CVLT-3, TMT A&B, COWA, Category Test), NSI, and PCL-5. The Neighborhood Atlas was used to derive disadvantage scores using childhood addresses. Global deficit scores were calculated as described by Heaton (2004). Results Neighborhood disadvantage was significantly correlated with CVLT-3 Total Learning (r = −0.26, p = 0.046), but not the overall global deficit or deficit performance across CVLT-3 Delayed Recall, TMT-A, TMT-B, COWA, and Category Test. There was a significant difference in neighborhood disadvantage between participants scoring in the deficit and normal ranges on CVLT-3 Total Learning (p = 0.046). There were no other differences in neighborhood disadvantage across other neuropsychological tests. There was a significant difference in PTSD symptoms between participants scoring within the deficit and normal ranges on the COWA (p = 0.002). There were no other significant group differences in neuropsychiatric symptoms or PTSD symptom severity. Conclusions Among Veterans in this sample, neighborhood disadvantage was not associated with cognitive function or cognitive deficits. Although neighborhood disadvantage is an important psychosocial risk factor for poor outcomes in the civilian literature, these results suggest that it may not be an important contributing factor in recovery from mild TBI for military Veterans.

Morbidity and Mortality of Hospital-Onset SARS-CoV-2 Infections Due to Omicron Versus Prior Variants : A Propensity-Matched Analysis.

Many hospitals have scaled back measures to prevent nosocomial SARS-CoV-2 infection given large decreases in the morbidity and mortality of SARS-CoV-2 infections for most people. Little is known, however, about the morbidity and mortality of nosocomial SARS-CoV-2 infections for hospitalized patients in the Omicron era. To estimate the effect of nosocomial SARS-CoV-2 infection on hospitalized patients' outcomes during the pre-Omicron and Omicron periods. Retrospective matched cohort study. 5 acute care hospitals in Massachusetts, December 2020 to April 2023. Adults testing positive for SARS-CoV-2 on or after hospital day 5, after negative SARS-CoV-2 test results on admission and on hospital day 3, were matched to control participants by hospital, service, time period, days since admission, and propensity scores that incorporated demographics, comorbid conditions, vaccination status, primary diagnosis category, vital signs, and laboratory test values. Primary outcomes were hospital mortality and time to discharge. Secondary outcomes were intensive care unit (ICU) admission, need for advanced oxygen support, discharge destination, hospital-free days, and 30-day readmissions. There were 274 cases of hospital-onset SARS-CoV-2 infection during the pre-Omicron period and 1037 cases during the Omicron period (0.17 vs. 0.49 cases per 100 admissions). Patients with hospital-onset SARS-CoV-2 infection were older and had more comorbid conditions than those without. During the pre-Omicron period, hospital-onset SARS-CoV-2 infection was associated with increased risk for ICU admission, increased need for high-flow oxygen, longer time to discharge (median difference, 4.7 days [95% CI, 2.9 to 6.6 days]), and higher mortality (risk ratio, 2.0 [CI, 1.1 to 3.8]) versus matched control participants. During the Omicron period, hospital-onset SARS-CoV-2 infection remained associated with increased risk for ICU admission and increased time to discharge (median difference, 4.2 days [CI, 3.6 to 5.0 days]). The association with increased hospital mortality was attenuated but still significant (risk ratio, 1.6 [CI, 1.2 to 2.3]). Residual confounding may be present. Hospital-onset SARS-CoV-2 infection during the Omicron period remains associated with increased morbidity and mortality. Harvard Medical School Department of Population Medicine.

Histoire de la description du « signe du miroir » dans les Annales Médico-Psychologiques (1927–1930). Aperçus sur sa postérité et sa valeur sémiologique

Described as an early sign of schizophrenia (or dementia praecox) between the years 1927 and 1930 by two French psychiatrists, Paul Abély and Achille Delmas, the “mirror sign” was subsequently the object of in-depth studies by eminent specialists outside of France who discussed its semiotic value and its early interpretations. In this regard, we will underscore the key role played by psychoanalytical ideas, specifically the concept of narcissism. We will also note the relative neglect of results of the mirror test for other categories of patients, particularly those with intellectual deficiencies due to aging (a now well-studied group).

Nutraceutical and dietary supplement use in the cancer population: The impact of evidence-based education.

10611 Background: The nutraceutical market is a multi-billion dollar industry. Studies show many cancer patients turn to vitamins and nutraceutical supplements, seeking health improvements post-diagnosis. Despite their popularity, the efficacy & safety of most substances remains unverified through clinical trials. Additionally, interaction with cancer treatments could potentially increase toxicities or diminish chemotherapy effects. In response, our Cancer Center initiated a comprehensive program aimed at enhancing informed decision-making. This involved conducting surveys to understand patient’s attitudes, knowledge, and perceptions about supplement use, alongside evaluating the impact of an educational intervention designed to encourage the discontinuation of self-prescribed vitamins and supplements during cancer treatment. Methods: We utilized a structured survey with open-closed-ended questions to assess dietary supplement use among cancer patients. The survey featured multiple-choice and 1-5 Likert scale questions covering supplement types (e.g., vitamins, minerals, herbs), reasons for use, duration, and timing of use, and beliefs about safety & efficacy. Clinicians also reviewed disclosed non-prescription supplements, advising on their continuation or cessation. Our goal was to understand patient perspectives on supplement use pre & post-educational intervention, among new patients undergoing oral or systemic cancer treatment. We analyzed changes in supplement use with McNemar’s Exact Tests for paired proportions. Results: Following the educational intervention with 144 cancer patients, the proportion not using any supplements rose from 44.4% to 50.0%, hinting at a trend towards discontinuing supplement use. Yet, McNemar’s tests for various supplement categories revealed no statistically significant changes (p>0.05). Of the 73 patients taking supplements and evaluated post-education by a physician, 53.4% were permitted to continue (primarily vitamins), 26% agreed to stop, and 20.5% reaffirmed they would not discontinue use. Of the resistant patients choosing to continue despite medical advice, 93.3% were taking high-dose vitamins, 20% minerals, and 13% herbs/botanical compounds. Conclusions: Supplements are heavily marketed as promoting various anticancer benefits. Our study shows the challenging nature of modifying cancer patients' perceptions. Despite a modest uptick in stopping, a significant portion persisted supplement use post-education, highlighting entrenched beliefs & attitudes. This emphasizes the importance of ongoing, tailored discussions within oncology care to reduce the risks associated with unsupervised supplement use. Our results advocate for incorporating longer-term educational strategies about supplements, underscoring the critical need for evidence-based guidance in managing their use among cancer patients.

Development of Learning Media Based on Video Tutorials on the Subjects of Software Applications and Building Interior Design at SMK Negeri 1 Sumatera Barat

This research was motivated by the problem encountered, namely the lack of use of media in the learning process of Software Applications and Building Interior Design. This research uses the type of research and development (R&D). This development model refers to the development model (DDD-E) with 4 stages, namely Decide, Design, Development, Evaluate. The subjects of this research were media experts, material experts and class XII Competency Design Skills Modeling and Building Information, SMK Negeri 1 Sumatera Barat, 30 students. This research instrument is in the form of a validation sheet to obtain product validation data, and a student respondent questionnaire to obtain product practicality test results. The research results show that the validity of the material is in the very valid category with an achievement level of 88.4%. Media validity with an achievement level of 90.65% in the very valid category and practicality test with an achievement level of 89.53% in the very practical category. The conclusion of this research is that the learning media developed is valid and practical for use in the learning process Software Application and Building Interior Design class XII Competency Design Skills Modeling and Building Information, SMK Negeri 1 Sumatera Barat.

Trajectories in depressive symptoms and midlife brain health

Depressive symptoms may either be a risk factor or prodromal to dementia. Investigating this association in midlife may help clarify the role of depression in cognitive aging. We aimed to identify trajectories in depressive symptoms in early to mid-life and related cognitive and brain outcomes in midlife. This study includes 3944 Black and White participants (ages 26−45 years at baseline) from the Coronary Artery Risk Development in Young Adults (CARDIA) study with 20 years of follow-up. Depressive symptoms were assessed using the Center for Epidemiological Studies Depression scale at five time points over 20 years. Growth mixture modeling (GMM) was used to identify depressive symptom trajectories. Participants completed a neuropsychological battery 20 years after baseline, including the Digit Symbol Substitution Test (DSST), Rey-Auditory Verbal Learning Test (RAVLT), Stroop Test, Montreal Cognitive Assessment (MoCA), and category and letter fluency tests. A sub-sample of participants (n = 662) underwent brain magnetic resonance imaging (MRI) to characterize gray matter volumes and white matter hyperintensities (WMHs). We identified four classes of depressive symptom trajectories: a “declining” class (n = 286, 7.3%) with initially high symptoms and subsequent decline, a class with consistently high symptoms (“steady high”; n = 264, 6.7%), a class with late increases in symptoms (“increasing”; n = 277, 7%), and a class with consistently low symptoms (“steady low”; n = 3117, 79.0%). The steady high and the increasing classes had poorer performance on all cognitive tests, while the declining class had poorer performance on the DSST, verbal fluency, and MoCA. Compared to the steady low symptom class, the steady high class had lower volumes in the entorhinal cortex (β: −180.80, 95% CI: −336.69 to −24.91) and the amygdala (β: −40.97, 95% CI: −74.09 to −7.85), the increasing class had more WMHs (β: 0.55, 95% CI: 0.22 to 0.89), and the declining class was not significantly different in any brain measures. Trajectories in depressive symptoms in young to mid-adulthood show distinct cognitive and brain phenotypes in midlife. Steady high depressive symptoms may represent a group that is at risk for dementia, whereas increasing symptoms in midlife may be associated with white matter damage.

Analysis of Smartphone Addiction With Anxiety in School-Aged Children

Introduction: Increasing smartphone overuse among children is an addictive behavior that not only creates physical difficulties, but also affects their mental health in ways such as mood changes, withdrawal, emotional discomfort, fear and worry regarding certain social situation. The study aimed at determining the analysis correlation between smartphone addiction with anxiety in Pawyatan Daha elementary school, Kediri, East Java. Methods: This study use a cross-sectional design. The sampling method was simple random sampling and 154 students from Pawyatan Daha elementary school, Kediri, East Java comprised the sample. Data collection was carried out in November to December 2022. In this study, the independent variable was smartphone addiction as measured by the smartphone addiction risk children questionnaire (SARCQ), and the dependent variable was anxiety as measured by the revised child anxiety and depression scale (RCADS). Data analysis was using the spearman rho test with α=0.05. Result: The study showed the majority 77.3% of respondents are addicted smartphone in the high category, anxiety majority 52.6% of respondents are general anxiety disorders category and statistical test result show a significant correlation with a p-value of 0.001 (p<0.005) and r = 0.330. Conclusions: Smartphone addiction has a correlation with anxiety in school-aged children, parents must supervise their children's smartphone use in order to help them develop character and avoid addicted behavior and nurse can act as counselors by providing regular counseling service visits to elementary school to reduce smartphone addiction.

Associations of Polycystic Ovary Syndrome With Indicators of Brain Health at Midlife in the CARDIA Cohort.

Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with an adverse cardiometabolic profile early in life. Increasing evidence links cardiovascular risk factors, such as diabetes and hypertension, to accelerated cognitive aging. However, less is known about PCOS and its relationship to brain health, particularly at midlife. Our goal was to investigate possible associations between PCOS and midlife cognitive function and brain MRI findings in an ongoing prospective study. We used data from the Coronary Artery Risk Development in Young Adults (CARDIA) study, a geographically diverse prospective cohort study of individuals who were 18-30 years at baseline (1985-1986) and followed for 30 years. We identified women with PCOS from an ancillary study (CARDIA Women's study (CWS); n = 1,163) as those with elevated androgen levels and/or hirsutism in conjunction with symptoms of oligomenorrhea. At year 30, participants completed cognitive testing, including the Montreal Cognitive Assessment, Rey Auditory Verbal Learning Test (RAVLT) (verbal learning and memory), Digit Symbol Substitution Test (processing speed and executive function), Stroop test (attention and cognitive control), and category and letter fluency tests (semantics and attention). A subset completed brain MRI to assess brain structure and white matter integrity. Multivariable linear regression models estimated the association between PCOS and outcomes, adjusting for age, race, education, and study center. Of the 1163 women in CWS, 907 completed cognitive testing, and of these, 66 (7.1%) met criteria for PCOS (age 54.7 years). Women with and without PCOS were similar for age, BMI, smoking/drinking status, and income. At year 30, participants with PCOS performed lower (mean z score; 95% CI) on Stroop (-0.323 (-0.69 to -7.37); p = 0.008), RAVLT (-0.254 (-0.473 to -0.034); p = 0.002), and category fluency (-0.267 (-0.480 to -0.040); p = 0.02) tests. Of the 291 participants with MRI, 25 (8.5%) met PCOS criteria and demonstrated lower total white matter fractional anisotropy, a measure of white matter integrity (coefficient (95% CI) -0.013 (-0.021 to -0.005); p = 0.002), though not abnormal white matter. Our results suggest that women with PCOS have lower cognitive performance and lower white matter integrity at midlife. Additional research is needed to confirm these findings and to determine potential mechanistic pathways including potential modifiable factors.

Results of evaluation of neurometabolic and rehabilitation therapy for vincristine polyneuropathy in children with acute lymphoblastic leukemia

Introduction. Vincristine-induced peripheral neuropathies (VIPN) is a current problem in the management of pediatric acute lymphoblastic leukemia (ALL). There are no effective therapeutic strategies for VIPN. The aim of the study to present the results of evaluation of neurometabolic therapy in the acute period of VIPN in children with ALL and the method of virtual rehabilitation in the recovery period. Materials and methods. The single-center prospective comparative pilot study involved 69 children with VIPN who were treated in the acute period with the following drugs: group 1 - pyridoxine, group 2 - thioktovic acid, group 3 - inosine + nicotinamide + riboflavin + succinic acid. Clinical and electrophysiological parameters before and after drug treatment were analyzed. Among 10 children with motor deficits in the lower extremities in the recovery period of VIPN, rehabilitation with immersive virtual reality was performed, and the clinical parameters before and after the course were compared. Results. A positive effect of the studied drugs on the clinical condition of patients by the 30th day of therapy was revealed. In groups 1 and 3 the total score on the NIS-LL scale correlated with mild polyneuropathy - 4 [2÷8] and 2 [2÷6] points, respectively. Neurologic impairment in each of these groups persisted for 19 [14÷25] and 19 [13÷30] days, which was less in contrast to the duration of symptoms in group 2 (p1-2 = 0.021 and p2-3 = 0.046). In the VIPN recovery period before and after virtual rehabilitation: muscle strength in the lower limbs increased (p = 0.025); the severity of polyneuropathy decreased according to the NIS-LL scale (p = 0.003); balance improved according to the Berg scale (p = 0.017); and patients’ mobility increased according to the Functional Walking Category test (p = 0.025) and walking speed according to the time-recorded walking test (p = 0.008). Discussion. Improvement of clinical parameters with neurometabolic therapy and virtual rehabilitation in children with VIPN has been shown. Conclusion. Preliminary results of the effectiveness of pyridoxine and inosine + nicotinamide + riboflavin + succinic acid in the acute period of VIPN in children with ALL and the method of virtual rehabilitation in the recovery period were obtained.

Trajectories in Depressive Symptoms and Midlife Brain Health

AbstractBackgroundEvidence in older adults suggests that depressive symptoms may be part of prodromal mood changes in dementia, rather than a risk factor. However, it is unclear whether variations in depressive symptoms in adulthood exhibit distinct characteristics in brain structure and cognitive function in midlife.MethodsFrom the Coronary Artery Risk Development in Young Adults study, we identified 662 Black and White participants (age 23‐36 at baseline) who completed the Center for Epidemiological Studies Depression scale (CES‐D) at six time points over 20 years. 20 years after baseline, the participants underwent magnetic resonance imaging to characterize gray matter (GM) structures (total GM, temporal cortex, hippocampus, and entorhinal cortex) and white matter hyperintensities (WMHs). Participants also completed neuropsychological tests including the Digit Symbol Substitution Test (DSST), Rey‐Auditory Verbal Learning Test (RAVLT), Stroop Test, Montreal Cognitive Assessment (MoCA), and category and letter fluency tests, analyzed as z‐scores.ResultsUsing growth mixture modeling, we identified four trajectories of depressive symptoms (Figure 1): consistently low scorers (“steady low”; n = 509, 76.9%), a class with an early peak and decline in symptoms (“declining”; n = 63, 9.5%), a class with late increases in symptoms (“increasing”; n = 49, 7.4%), and consistently high scorers (“steady high”; n = 41, 6.2%). Compared to the steady low class, the steady high class had lower entorhinal cortex volume (β: ‐180.80, 95% CI: ‐336.69 to ‐24.91). The increasing class, had more WMHs (β: 0.55, 95% CI: 0.22 to 0.89) and less total brain volume (β: ‐9269.25, 95% CI: ‐17104.67 to ‐1444.82). Both the steady high and the increasing classes had poorer performance on the Stroop task (β: ‐0.40, 95% CI: ‐0.70 to ‐0.10; β: ‐0.39, 95% CI: ‐0.64 to ‐0.14, respectively), however the steady high also had poorer DSST performance (β: ‐0.40, 95% CI: ‐0.67 to ‐0.13), while the increasing class had poorer performance on the MoCA (β: ‐1.20, 95% CI: ‐2.04 to ‐0.37). The declining group was not significantly different from the steady low group on any brain or cognitive measures.ConclusionsOur findings suggest that trajectories in depressive symptoms in young to mid‐adulthood show different cognitive and brain phenotypes in midlife.

Diaphragmatic breathing combined with abdominal drawing-in maneuver for walking function in post-stroke patients: a randomized controlled study protocol

BackgroundPatients with stroke frequently experience walking dysfunction. Core training can help improve balance and walking function in patients with stroke. However, core training movements in clinical practice are numerous and differently targeted. Therefore, this study will investigate the improvement of walking function in patients with combined diaphragmatic breathing maneuver (DBM) and draw-in breathing technique (ADIM) training.MethodsThis single-blind, randomized controlled preliminary will analyze the viability of DBM combined ADIM training versus routine rehabilitation therapy in patients with stroke with early to mid-stroke. Patients will be randomly assigned to either the DBM and ADIM training or the routine rehabilitation training. We will recruit 42 stroke inpatients from the Second Rehabilitation Hospital of Shanghai who meet the trial criteria and measure the balance and walking functions and improvement of that after 4 weeks of intervention. The primary outcome is the 10 m maximum walking test (10MWT). The secondary outcomes indices include the limits of stability test (LOS), Berg balance scale test (BBS), Functional Ambulation Categories test (FAC), Timed Up and Go test (TUG), trunk impairment scale test (TIS), ultrasound indicators of the diaphragm and transversus abdominis (UI), rhythmic weight shift test (RWS), walk across test (WA), Fugl-Meyer assessment of lower extremity (FMA-LE), and Barthel index of ADL test.DiscussionThe primary objective of this project was to investigate the effects of DBM combined with ADIM on balance capacity and walking function for patients with early to mid-stroke. The outcomes of this study will hold significant implications for future clinical applications in rehabilitation.Trial registrationChinese Clinical Trial Registry (ChiCTR), ID: ChiCTR2100054897. Registered on 28 December 2021.

B - 54 The Influence of Executive Functioning on Long-Term Memory.

The aim of the study is to measure how executive functioning predicts performance on a measure of delayed memory. Data was selected from a de-identified database of clinical adults. The sample chosen (N = 438) comprised of mixed psychiatric adults consisting of Caucasians (N = 193, M_edu =13,42% male & 58% female), African Americans (N = 88, M_edu = 12, 52.1% males & 47.8% females), Hispanics (N&#3f111, M_edu =13,53.5% male & 46.4% female), and Other (N = 47, M_edu =13,38.4% male & 61.6% female). All participants were administered the WMS-IV, Stroop, WCST, and Category. Multiple hierarchical regressions were run to test the influence executive functioning has on both immediate and long-term memory when controlling for age and education. In the final model for immediate memory, the following predictors were significant: Category test sr = 0.465, Stroop: Color/Word sr = 0.607, and WCST sr = -0.518. For delayed memory the following was significant, Category test sr = 0.430, Stroop: Color/Word sr = 0.491, and WCST sr = -0.461. Executive functions utilized on Stroop Color/Word, WCST, and Category directly influence memory skills. Pattern switching between trials on the WCST and Category requires remembering the patterns throughout each trial. Stroop Color/Word requires remembering the rule to read the color of the printed word rather than the printed word itself. These executive functioning measures also require a degree of memory skills which are directly linked to the memory performance on the WMS-IV. The study did not differentiate effects between immediate and delayed memory but demonstrated memory abilities in general. Strong executive functioning capacities are predictive of strong memory capabilities due to high-level cognition abilities.

A - 153 Differing Impacts of Divided Auditory and Visual Attention on Abstract Reasoning among Patients with Mild Traumatic Brain Injury.

Although not all mild traumatic brain injuries (mTBIs) lead to long-term effects, they can still have significant cognitive and emotional impacts. One of the common lasting symptoms of mTBI is attentional deficit, with divided attention being specifically negatively impacted by mTBIs. This study investigated the impacts of divided auditory attention and divided visual attention on executive functioning among patients with mTBI. Participants were 98 mTBI patients. Ethnicity was self-identified as 77.5% White, 6.3%, Asian, 2.7% Hispanic, and 13.5% Mixed/Other, gender was 68% women. Tests included the Neuropsychological Assessment Battery (NAB) Numbers & Letters Test to assess divided visual attention, Paced Auditory Serial Addition Task (PASAT) for divided auditory attention, and the Halstead Category Test (HCT) to assess the abstract reasoning domain of executive functioning as part of a full neuropsychological evaluation at a private outpatient clinic. Multiple linear regression was used to analyze the data. The overall model was statistically significant (F(3,94) = 3.23, p = 0.03, R2 = 0.09). Results indicated a significant positive relationship between abstract reasoning and auditory divided attention (β= 2.42, p = 0.03), but no significant relationship between abstract reasoning and visual divided attention (β= 1.5, p = 0.2). The findings of this study suggest that divided auditory and visual attention may impact the abstract reasoning and problem-solving domain of executive functioning differently among those who have sustained mild traumatic brain injury. Specifically, divided auditory attention may play a more significant role in abstract reasoning abilities than visual divided attention.

Association of Complex Repetitive Discharges With Chronicity and Clinical Symptoms in Radiculopathies.

Complex repetitive discharges (CRDs) are incompletely understood needle electromyography (EMG) waveforms seen in both myopathic and neurogenic disorders including radiculopathies. This study aimed to clarify the significance of CRDs in patients with radiculopathies. This case-control study randomly identified 100 patients with needle EMG evidence of radiculopathy demonstrating at least one CRD in the electrodiagnostically involved myotome between January 2017 and January 2022. These patients were compared with 100 randomly selected patients with EMG evidence of radiculopathy without CRDs controlled for sex, age at EMG testing, and affected nerve root segment. Patient clinical symptoms, neurologic examination, EMG features, and imaging were analyzed. A paired sample t-test for categorial data and χ2 test for nonparametric data were used for statistical analysis with significance defined as P < 0.05. Patients with radiculopathies with CRDs had longer disease duration averaging 59 months (range 1-480) compared with patients with radiculopathies without CRDs averaging 26 months (range 1-192, P < 0.01). Clinical symptoms of paresthesias and weakness were both significantly more common in patients with radiculopathies with CRDs than those without CRDs (P < 0.01 and 0.01, respectively). Needle EMG demonstrated a greater average number of muscles with neurogenic motor unit potentials per radiculopathy in patients with radiculopathies with CRDs compared with those without CRDs. Imaging studies of patients with radiculopathies with CRDs were more likely to reveal evidence of nerve root compression (P < 0.01). The presence of CRDs in patients with radiculopathies is consistent with clinically more symptomatic radiculopathies and a longer duration of nerve root compromise.

Entrepreneurial framing: How category dynamics shape the effectiveness of linguistic frames

AbstractResearch SummaryHow do new entrepreneurial ventures effectively deploy linguistic frames to attract customer demand? Drawing on framing and categories research, we develop and test theory about how category dynamics shape the effectiveness of two commonly observed frames—social impact framing and innovativeness framing—in the context of prosocial categories. We test our predictions by tracking entrepreneurial ventures in the market category for massive open online courses over the category's first 10 years of existence (2012–2021). Our fixed‐effects models show that higher levels of category salience increase the effectiveness of a social impact framing but decrease the effectiveness of an innovativeness framing; conversely, higher levels of category crowdedness decrease the effectiveness of a social impact framing but increase the effectiveness of an innovativeness framing.Managerial SummaryThis research explores how startups can strategically frame themselves to attract customers. We specifically compare the effectiveness of a “social impact framing” (emphasizing the startup's benefits to society) versus an “innovativeness framing” (emphasizing innovativeness) under different market conditions. Our longitudinal study finds that startups benefit most from a social impact framing when their market attracts a lot of attention or has low competition. While an innovativeness framing can backfire under such conditions, it effectively helps to attract customers in a market that receives little attention or exhibits fierce competition. Entrepreneurs and managers can leverage our insights to more effectively tailor their framing strategies to their market environment and ultimately gain more customer traction.

Sex Differences in the Association Between Cumulative Use of Cannabis and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults Study.

Background: Cannabis use may impair cognitive function (CF) differently in men and women, due to sex-specific differences in neurobiological mechanisms and environmental risk factors. Objective: Assess sex differences in the association between cumulative exposure to cannabis and cognitive performance in middle age. Methods: We studied participants from the Coronary Artery Risk Development in Young Adults (CARDIA) Study, including Black and White men and women 18-30 years old at baseline followed over 30 years. Our cross-sectional analysis of CF scores at year 30 was stratified by sex. We computed categories of cumulative exposure in "cannabis-years" (1 cannabis-year=365 days of use) from self-reported use every 2 to 5 years over 30 years. At years 25 and 30, we assessed CF with the Rey Auditory Verbal Learning Test (verbal memory), the Digit Symbol Substitution Test (processing speed), and the Stroop Interference Test (executive function). At year 30, additional measures included Category and Letter Fluency Test (verbal ability) and the Montreal Cognitive Assessment (global cognition). We computed standardized scores for each cognitive test and applied multivariable adjusted linear regression models for self-reported cumulative cannabis use, excluding participants who used cannabis within 24 h. In a secondary analysis, we examined the association between changes in current cannabis use and changes in CF between years 25 and 30. Results: By year 30, 1,352 men and 1,793 women had measures of CF; 87% (N=1,171) men and 84% (N=1,502) women reported ever cannabis use. Men had a mean cumulative use of 2.57 cannabis-years and women 1.29 cannabis-years. Self-reported cumulative cannabis use was associated with worse verbal memory in men (e.g., -0.49 standardized units [SU] for ≥5 cannabis-years of exposure; 95% CI=-0.76 to -0.23), but not in women (SU=0.02; 95% CI=-0.26 to 0.29). Other measures of CF were not associated with cannabis. Changes in current cannabis use between years 25 and 30 were not associated with CF in men or women. Conclusions: Self-reported cumulative cannabis exposure was associated with worse verbal memory in men but not in women. Researchers should consider stratified analyses by sex when testing the association between cannabis and cognition.

Letter and Category Fluency: Normative Data for Lebanese Older Adults.

Verbal fluency tasks are frequently used for neuropsychological assessment in clinical practice and research. It consists of two tasks namely category and letter fluency tests. To determine normative values in category (animals, vegetables, fruits) and letter fluency [Mim () "M", Alif () "A", Baa () "B"] tasks in Arabic language in 60 s. This study was a cross-sectional national survey and included 859 community-dwelling, cognitively intact Lebanese residents aged ≥55 years. Norms were presented according to age (55-64 years, 65-74 years, ≥75 years), sex and level of education (illiterate, no diploma, primary certificate, baccalaureate or higher). Level of education had the most significant positive effect on verbal fluency tasks performance amongst Lebanese older adults. The negative effect of older age was more prominent in the category fluency task compared to the letter fluency task. Women outperformed men in vegetables and fruits categories. This study provides clinicians with normative scores of category and letter fluency tests, which can be used for neuropsychological assessment of older Lebanese patients being evaluated for cognitive disorders.