ABSTRACT Collaboration skills are essential in the 21st century. As technology becomes increasingly integrated into teamwork, many studies have found that technology plays an important role in the development of collaboration skills. However, it is difficult to determine the effect of technology-based intervention in this respect. To explore the relationship between technology-based intervention and collaboration skills, we conducted a meta-analysis of 39 studies of this topic reported in 34 articles. The results show that technology-based intervention has a positive correlation with collaboration skills. Moreover, multiple factors, including technology category, learning space, learning stage, discipline, and collaboration skills dimension, significantly moderate the relationship. These findings suggest that collaboration skills are closely related to technology and its application methods. Overall, this study not only comprehensively reveals the complex effect of technology-based intervention on collaboration skills, but the findings also have important implications for research on technology-based intervention in promoting such skills.