Catecholamine Excretion In Patients Research Articles

50 Years Ago in TheJournalofPediatrics: Measurement of Urinary Catecholamine Excretion in Patients with Neuroblastoma

50 Years Ago in TheJournalofPediatrics: Measurement of Urinary Catecholamine Excretion in Patients with Neuroblastoma

Catecholamine excretion in patients with eating disorders

To compare clinical features of eating disorders and parameters of monoamine metabolism. Authors examined 21 patients with eating disorders during 2008-2011 using clinical/psychopathological method. To evaluate the status of monoamine neuromediator system, urine levels of dopamine, noradrenalin and adrenaline excretion were measured using high-yield liquid chromatography with electrochemical detection. The reference group included 26 sex- and age-matched volunteers. The common patterns of the pathogenesis of compulsive urges of different origin were identified. The results indicate not only nonspecific changes in catecholamine systems of patients with eating disorders associated with different stress disorders but also demonstrate the pathogenetic correlations between dopaminergic activity and clinical symptoms of addiction.

Effect of Hospitalization on Urinary Catecholamine Excretion in Patients with Hand‐Arm Vibration Syndrome

Effect of Hospitalization on Urinary Catecholamine Excretion in Patients with Hand‐Arm Vibration Syndrome: Mieko Iwamoto, et al. Department of Hygiene, Yamaguchi University School of Medicine—The purpose of this study was to investigate the effect of hospitalization for five weeks on the autonomic nervous activity of patients with hand‐arm vibration syndrome (HAVS). Urine samples were collected from ten patients with HAVS before, during, and after hospitalization. Amounts of urinary free catecholamines (norepinephrine, epinephrine and dopamine) were measured. Urinary excretion of norepinephrine and dopamine during hospitalization was significantly lower than that before hospitalization. The effect of hospitalization continued for 10 days after hospitalization. The results of this study suggest that hospitalization is useful for the treatment of patients with HAVS to reduce the sympathetic hyperactivity.

A Preliminary Study of the Effects of Venlafaxine on 24‐Hour Urinary Catecholamine Excretion Profile

Objective: To investigate the effects of venlafaxine on the 24‐hour urinary catecholamine excretion profile in patients treated with this drug for depression.Method: Patients to be treated with venlafaxine for the management of a depressive illness were requested to provide a 24‐hour urine sample immediately before the commencement of therapy. The urinary concentrations of adrenaline and noradrenaline were determined, and the 24‐hour urinary catecholamine excretion profile was calculated. This procedure was repeated after treatment with venlafaxine for 14 days.Results: Eight patients were enrolled in the study, but three patients did not complete the protocol because of adverse drug reactions. The effects of venlafaxine treatment on the profile of urinary catecholamine excretion were assessable in five patients. The mean 24‐hour excretion of noradrenaline appeared to be decreased after venlafaxine treatment, but this decrease failed to attain statistical significance. The 24‐hour urinary excretion of adrenaline was unchanged after venlafaxine, but the ratio of noradrenaline:adrenaline urinary excretion decreased significantly after treatment.Conclusions: This small prospective study demonstrates an altered profile of urinary catecholamine excretion in patients treated with venlafaxine for depression for two weeks. Further research is needed to determine whether there is a correlation between the effects of venlafaxine on urinary noradrenaline excretion and the therapeutic and/or adverse effects of this antidepressant.Aust J Hosp Pharm 1997; 27: 232–3.

Silent myocardial ischaemia in untreated essential hypertensives.

In hypertension, hypertrophy of the left ventricle might enhance the risk of ischaemia because of an augmented oxygen demand and an insufficient oxygen supply. The aims of the study were to estimate the prevalence of silent ischaemia in a group of untreated hypertensives with Holter monitoring and 3 different stress tests, and to look for a possible association between the presence of ischaemia and the blood pressure level as well as the left ventricular mass. The prevalence of silent ischaemia was tested in a group of 34 untreated hypertensives by Holter monitoring and by bicycle ergometer test, hyperventilation and captopril tests. 68% of the patients exhibited silent ischaemic periods during Holter monitoring. There was a trend towards a higher 24-hour SBP and DBP level in patients with ischaemia (p < 0.05), in addition to a tendency towards a higher catecholamine excretion in patients with ischaemia (p < 0.05), and a higher left ventricular mass (NS). Silent ischaemic episodes during ergometer exercise test were found in 27%. Only 3% had ischaemia during hyperventilation and captopril tests. In conclusion, the prevalence of ischaemia during the various stress tests was low, whereas Holter monitoring revealed signs of silent ischaemia in a substantial proportion of the patients. Patients with ischaemia tended to present more severe degrees of hypertension.

Urinary catecholamine excretion in patients with secondary adrenocortical insufficiency.

To evaluate the relationship between the secretion of cortisol and the activity of adrenal medulla in the secondary adrenocortical insufficiency, the excretion of epinephrine and norepinephrine was documented in 8 patients suffering from panhypopituitarism. Plasma levels and urinary excretion of cortisol were very low in baseline conditions, and the increase in these parameters of cortisol secretion occurring upon ACTH infusion was significantly reduced with respect to the response to ACTH documented in normal subjects. The mean value of urinary epinephrine excretion was at the lower limit of normal values, and a highly significant positive correlation was found between cortisolemia or cortisoluria and urinary epinephrine excretion in these patients. Despite a significant increase in cortisolemia and cortisoluria upon ACTH administration, this acute increase in adrenocortical activity was without any stimulatory effect on epinephrine or norepinephrine excretion. But, as in baseline conditions, a significant correlation was documented for the degree of adrenocortical activity and epinephrine excretion on the day of ACTH administration. It appears, therefore, that in severe secondary adrenocortical insufficiency the excretion of epinephrine is reduced proportionally to the decrease in adrenocortical activity.

Urinary catecholamine excretion in myocardial infarction.

The catecholamine excretion rates in urine were studied in three groups of patients with acute myocardial infarction. Group I patients had no complications. Group II patients had minor complications. In groups I and II urine was obtained during the first night of the patient's admission. Group III patients had major complications, and urine was collected during one episode of complications. Catecholamines were measured by spectrophotofluorometric assay using the trihydroxyindole method. A lack of elevation in basal catecholamine excretion in patients without complications and an elevated catecholamine excretion in those with complications suggest that myocardial necrosis or ischemia per se is not responsible for increased catecholamine excretion and that the increase in catecholamine excretion may reflect the presence of complicating factors. Recurrent or persisting chest pain, pulmonary congestion or edema, and ventricular arrhythmias were almost always associated with elevated catecholamine excretion. Although in some cases a causal relationship of these complications with observed increase in catecholamine excretion is suggested, further study is required for a definitive conclusion.

CATECHOLAMINE EXCRETION IN PATIENTS WITH RHEUMATOID ARTHRITIS.

Arthritis & RheumatismVolume 7, Issue 6 p. 687-692 Brief ReportFree to Read Catecholamine excretion in patients with rheumatoid arthritis Charley J. Smyth, Charley J. SmythSearch for more papers by this authorAlfred Staub, Alfred StaubSearch for more papers by this author Charley J. Smyth, Charley J. SmythSearch for more papers by this authorAlfred Staub, Alfred StaubSearch for more papers by this author First published: December 1964 https://doi.org/10.1002/art.1780070609Citations: 6AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume7, Issue6December 1964Pages 687-692 RelatedInformation