ZIF-67, a photocatalytic metal organic framework (MOF) was incorporated into a Na-Alginate/Bentonite matrix to develop novel ZIF-AB mixed matrix catalyst (MMC) bead for visible light driven peroxymonosulfate (PMS) activation and Tetracycline (TC) degradation in aqueous medium. Within 1h of visible light irradiation (intensity: 50 W), 0.5 g/L ZIF-AB with 2.5 wt% ZIF-67 (ZIF-AB(2.5)) and 1.5 g/L PMS degraded 99.8% of 25 mg/L TC in aqueous solution. All coexisting ions except Fe3+ and CO32− have negligible influence on the catalytic activity. The ZIF-AB(2.5)/PMS system effectively degraded TC from real-water sources, with minor residual TC concentrations (0.01–0.023 μg/L), lower than the permitted limit (0.04 μg/L) in discharge water. The Co2+/Co3+|surf. redox played pivotal role towards PMS activation and generation of various radicals, i.e., SO4•−, O•H, O2•−, etc. ZIF-AB(2.5) demonstrated good reusability and structural integrity towards multiple reuse and should be applicable towards industrial processes for continuous removal of emerging contaminants in water.