In the present study, the zero- and first-order radiative correction to the Casimir energy for the massive and massless scalar field confined with mixed (Neumann-Dirichlet) boundary condition between two parallel lines in 2+1 dimensions for the self-interacting $\phi^4$ theory was computed. The main point in this study is the use of a special program to renormalize the bare parameters of the Lagrangian. The counterterm used in the renormalization program, which was obtained systematically position-dependent, is consistent with the boundary condition imposed on the quantum field. To regularize and remove infinities in the calculation process of the Casimir energy, the Box Subtraction Scheme as a regularization technique was used. In this scheme, two similar configurations are usually introduced, and the vacuum energies of these two configurations in proper limits are subtracted from each other. The final answer for the problem is finite and consistent with the expected physical basis. We also compared the new result of this paper to the previously reported results in the zero- and first-order radiative correction to the Casimir energy of scalar field in two spatial dimensions with Periodic, Dirichlet, and Neumann boundary conditions. Finally, all aspects of this comparison were discussed.