Cases Of Vascular Tumors Research Articles

Metastatic Hemangiosarcoma in a Cow

Background: Hemangiosarcoma is a malignant mesenchymal neoplasm of endothelial cells that mainly affects dogs and is less common in horses, cattle, goats, pigs, and sheep. In ruminants, however, few cases of hemangiosarcoma have been reported. Although this neoplasm may primarily occur in any tissue, it most often originates in the spleen, liver, heart, and skin. This study reports the clinical and pathological findings of a bovine hemangiosarcoma.Case: A 10-year-old lactating Girolando cow from the municipality of Vassouras/RJ was examinated because of uncontrolled cough and bilateral hemoptysis, loss of appetite, fever, weight loss, severe decline in milk production (a decrease of 28 L), and respiratory wheezing during chest auscultation. We performed a necropsy and collected fragments of various organs which were fixed using 10% buffered formalin and sent to the Pathology Anatomy Sector (SAP) of the Federal Rural University of Rio de Janeiro (UFRRJ) for routine histological assessment. Macroscopically, large hemorrhagic areas were observed in the lungs, mainly in the cranioventral portion of the pulmonary lobes, multifocal areas of hemorrhages in the liver, and a 10x8x5 cm soft red mass was observed in the spleen. Microscopically, was observed lung proliferation of endothelial cellsarranged in tapes, supported by a collagenous stroma associated with severe multifocal lobular hemorrhage with a large number of siderophages and diffuse and marked edema, and congestion. In the mediastinal lymph node, liver, and spleen, the proliferation of neoplastic endothelial cells equivalent to those described in the lungs was observed. The histologicalsections of liver and tumor spleen were subjected to immunohistochemical analysis for von Willebrand factor, in which marking was observed in neoplastic endothelial cells.Discussion: Previously, neoplasms in Brazilian cattle have been presented as case reports or, more recently, as scarce retrospective studies, signifying that hemangiosarcoma is a rare neoplasm in the bovine species. Among several studies, we highlight the one conducted in Rio Grande do Sul with neoplastic lesions found in bovine slaughterhouses, in which onlyone case of hemangiosarcoma was observed in 1.5% (1 of 65) cattle. In addition, similarities were also noted in a study of neoplastic lesions in bovine slaughterhouses in Canada, in which hemangiosarcoma was diagnosed in 0.3% (4 of 1370) cattle. In the present study, the positive immunostaining of neoplastic endothelial cells was easily identified from von Willebrand factor, also called factor VIII, and is similar to other studies described in the literature. In a serie of twelve cases of vascular tumors in domestic animals (dogs, horses and cattle), 100% were positive for von Willebrand factor and served to distinguish tumors of epithelial or histiocytic origin. Although the clinical signs observed in our case are non-specific, hemoptysis was the most intense signal and the only clinical manifestation that may indicate an important pulmonary lesionthat indicated possible pulmonary neoplasm. Among other diseases, the acute form of Pteridium aquilinum poisoning, thrombocytopenia, anticoagulant rodenticide toxicity and vena cava syndrome might cause hemoptysis, and therefore, should be incorporated in the list of differential diagnoses of neoplasm that occur with pulmonary metastasis. Further, neoplastic and or hemorrhagic diseases affecting cattle should be differentiated of hemangiosarcoma.Keywords: hemangiosarcoma, diseases of cattle, neoplasia.

Vascular tumors in Northern Nigeria: A 10-year retrospective review

Background: Vascular tumors range from benign hemangiomas to lesions that are locally aggressive but infrequently metastasize, to relatively rare, highly malignant angiosarcoma. Objectives: The objective of this study is to determine the relative frequency and histologic pattern of these tumors in this locality and discover if any, differences in frequency and histopathological pattern from other centers. Materials and Methods: This was a 10-year retrospective study of all cases of vascular tumors diagnosed in the Department of Pathology, in a Teaching Hospital. Results: A total of 305 cases of vascular tumors representing 16% of soft tissue tumors were analyzed. The benign cases constituted 68% and the remaining were malignant. Lobular capillary hemangioma (40%) was the predominant benign histologic subtype recorded while Kaposi sarcoma constitute the most frequent malignant entity (21.6%). Head and neck was the most common site of affectation. Conclusion: Hemangiomas and Kaposi sarcoma was the most common benign and malignant vascular tumors recorded in this locality, respectively.

Vascular tumors of the orbit

The author presents 536 cases of vascular tumors of the orbit. The most common orbital vascular lesions are cavernous hemangioma, capillary hemangioma, and lymphangioma. The hemangiopericytoma are less frequent than the three other types. The clinical and paraclinical characteristics of the most frequent tumors are analyzed and the various possibilities of treatment are discussed.

A Audiometric Study on Cerebellopontine Angle Lesions

An etiological consideration was made on hearing impairment of 22 patients with cerebellopontine angle lesions which were confirmed by surgery. Their audiometric examination results were analyzed, and the diagnostic value of the audiometric examinations was also discussed.1. The presumable causative factors of the hearing impairment. were described bellow.The first, direct involvement of the lesion to the acoustic nerve or central auditory pathway, the second, malcirculation in the labyrinth, the third, perilymphatic hypertension or affection on the central auditory pathway following elevated CSF pressure and affection on the perilymphatic fluid following the localized disturbance of CSF flow.2. In acoustic tumor cases, many patients generally showed 1) unilateral threshold elevation on pure tone audiometry, 2) Bekesy's type III and or IV unilateral hearing impairment (fixed frequency), but a few patients showed labyrinthine malfunction only.3. Patients with other tumors usually showed no remarkable difference between both ears on pure tone audiometry, and also showed Bekesy's type III and IV, but one case of meningioma developed around the orifice of the internal ear canal showed the similar results to that of acoustic tumor. Another case of vascular tumor showed an unexpected fluctuation of hearing.4. Cases of arachnitis were classified into 3 types as follows; Meniere's disease type, sudden deafness type with vertigo and no hearing impairment. and several various factors were presumed as the causative mechanism of hearing impairment as follows; 1) Inflammatory change of the VIII th cranial nerve. 2) Sudden elevation of pressure by the rapidly developed cyst on the VIII th cranial nerve and the labyrinthine artery. 3) Affection on the perilymphatic fluid.5. The results of audiometric examinations suggested us the possibility of evaluation of the forms and severity of the lesion, and it was very useful for differential diagnosis. Especially, Bekesy's type III and/or IV was very important to give us a clue of the differentiation of the lesions.6. The results of equilibrium function test of one case of acoustic tumor showing labyrinthine malfunction alone revealed the existence of severe, laterally localized brain stem lesion. It was noteworthy that the comparable consideration between hearing impairment, malequiribrium and neurological examinations would be necessary for the proper diagnosis.

The spontaneous involution of cutaneous vascular tumors

For the last five years several cases of vascular tumors (mainly infantile strawberry and cavernous hemangiomas) which had vanished without therapy were observed and the literature on the subject perused. It is difficult to form an exact idea of the percentage of such occurrences because of the prevailing opinion, especially among radiologists and surgeons, that it is unwise or dangerous to leave hemangiomas untreated. There is also parental unwillingness to wait for three or four years for spontaneous involution. Consequently, the great majority of such patients receive treatment in one form or another. To repeat Traub's words of nineteen years ago, “the obvious confusion existing in the minds of most physicians in regard to the proper disposition of vascular nevi” is still with us. I do not advocate expectant therapy for all cases; however, being convinced that a large majority do involute spontaneously, I am in favor of no therapy in selected cases in which the lesions are located in covered body areas or may be easily removed surgically at a later date in the event spontaneous involution does not materialize. Treatment usually is indicated in exposed parts if the hemangioma is small because there are easy, quick and safe methods, or if it is large because it may be “the exceptional one” which will not vanish and later therapy will be more difficult. As with the use of radium, I believe expectant therapy has its place and should be given due consideration.

Regional Medical Association of the ATSSR. Ear section. Meeting on March 23, 1933.

Fifteen people are present. Prof. Trutnev and Dr. Borschev K. G. report on a case of vascular tumor of the tympanic membrane observed in the Kazan ear clinic.

Case of Vascular Tumor on the Cheek — Error in Diagnosis — Removal

Case of Vascular Tumor on the Cheek — Error in Diagnosis — Removal