Case Of Uterine Tumor Research Articles

EML4–NTRK3 Fusion Cervical Sarcoma: A Case Report and Literature Review

The concept of neurotrophic factor tyrosine kinase receptor (NTRK) fusion tumor has emerged in recent years. Moreover, NTRK fusion is unusual in common tumors but can often be identified in rare tumors. The NTRK fusion cervical or uterine tumors are mainly recognized through case reports due to their extremely low incidence. In this study, we reported a new case of EML4–NTRK3 fusion cervical sarcoma to enhance its recognition. To the best of our knowledge, this is the first case from a Chinese institution. We also conducted a literature review, in which a total of 19 cases of NTRK fusion cervical tumors and 4 cases of uterine tumors were retrieved. We summarized the clinicopathological features, treatment methods, and prognosis of these cases. Based on available information, we observed that surgery and complete excision, if possible, are still the primary modes of therapy. In addition, an increasing number of studies have shown that tropomyosin receptor kinases (TRK) inhibitors can improve the prognosis of cancer patients with NTRK gene fusion, which gives a silver lining for patients with metastatic lesions. We found that age and mitotic rate may be associated with recurrence or metastasis by univariate survival analysis. To draw more convincing conclusions, there is a need to establish an international database of rare cases and aggregate these sporadic cases.

Clinicopathological features of two cases of uterine tumors resembling ovarian sex-cord tumors (UTROSCTs) and a comprehensive review of literature

Clinicopathological features of two cases of uterine tumors resembling ovarian sex-cord tumors (UTROSCTs) and a comprehensive review of literature

Three-Dimensional (3D) Sonography in Gynecology

In Chang-Gung Memorial Hospital, Lin-Kou, three-dimensional (3D) sonography with power Doppler angiography had been applied in clinical evaluation since 2002. The technique can be utilized in many complicated conditions, and we had cumulative experiences in mainly three circumstances. The first one was to evaluate Mullerian duct anomaly such as HWW syndrome, uterine septum, and vaginal agenesis. The second was to assist differenciating benign from malignant tumors in uterus and ovaries. Finally, abnormal placentation such as placenta accreta was evaluated to predict the obstetric outcome. Currently, over five hundred cases of uterine anomaly and over one thousand cases of uterine tumor were collected. With all these experience, we summarized several diagnostic criterias for vessel characteristics in uterine and ovarian malignancy. Marked increased sensitivity and specificity were obtained in comparison with traditional two-dimensional sonography. Furthermore, we could provide precise and real-time images of congenital Mullerian duct anomaly and adjustable to fit individual angle of uterus with 3D sonography. MRI is also utilized for diagnosis of Mullerian duct anomaly. However, MRI has angle limitation that may affect the accurate diagnosis. It is also more expensive then 3D sonography. In our experiences, 3D sonography is a useful modality in diagnosis of Mullerian anomaly and can provide more details for treatment strategy.

Statistical Correlations of the Spontaneous Abortion with Trombophilia and Other Associated Pathologies.

15-20% of all known pregnancies progress with a miscarriage or an ectopic pregnancy. The recurrent miscarriage is a delicate clinical situation because with all the advances in genetic and immunologic research the incriminating factors haven't been discovered yet. The treatment is also subject to controversies, being perceived as either ineffective or aggressive. A number of 376 pregnant women with a gestational age smaller than 12 weeks have been selected, 226 of them with spontaneous abortion. In the study group of patients with previous spontaneous abortions we have found a series of associated pathology. From the cases with secondary non idiopathic recurrent miscarriage we have identified 4 cases of thrombophilia with antiphospholipid syndrome, 2 cases of thrombocytosis, one case of autoimmune thyroiditis, one case of uterine tumor, one case of MTHFR C homozygous thrombophilia and one case of FVL heterozygous thrombophilia. Knowing the correlations between the recurrent miscarriage and the hereditary thrombophilia as well as the options of treatment for increasing the chances of having a pregnancy with a normal evolution direct the doctors in testing the patients with recurrent miscarriage for hereditary thrombophilia.

Uterine Tumors with Neuroectodermal Differentiation. A Report of 4 Cases

We report four cases of uterine tumors with neuroectodermal differentiation. One tumor had neuroectodermal component only; in the three other tumors, the neuroectodermal component was admixed with another component, namely rhabdomyosarcoma (1 case), and endometrioid adenocarcinoma (2 cases). Histologically, the neuroectodermal component consisted of small to medium sized cells arranged in diffuse sheets. The tumor cells had round nuclei with stippled to coarsely granular chromatin, mostly with non-prominent nucleoli, and scant eosinophilic or amphophilic cytoplasm. Immunohistochemically, 4/4 tumors showed expression of vimentin, synaptophysin and CD56; 3/4 tumors were CD99 and NSE positive; 2/4 tumors showed focal expression of S-100 protein; and 1/4 tumors had focal dot-like cytoplasmic positivity for cytokeratin AE1/AE3. FLI-1 was negative in all cases. FISH examination was performed and none of the tumors showed rearrangement of EWSR1 gene. Uterine tumors with neuroectodermal differentiation are rare; to the best of our knowledge only 44 cases have been reported in the literature to date, referred to as Ewing sarcoma, peripheral PNET (pPNET), PNET (not otherwise specified) and uterine tumors with neuroendocrine differentiation.

Case of Uterine Tumor — Removed by Operation

Case of Uterine Tumor — Removed by Operation