Objective To explore the application value of individualized guidance scheme based on stone component analysis in postoperative patients with calculi. Methods From January 2016 to January 2017, 300 cases of urinary calculi treated by endoscopic surgery in our hospital were studied. All patients were analyzed by automatic infrared spectroscopy for chemical composition of urinary calculi samples, and individualized prevention program was given based on the analysis of calculi components. In addition, 40 patients with urinary calculi who had not been analyzed by component analysis were selected as control group, and the recurrence rate of postoperative calculi was compared between the two groups. Results Most of the urinary calculi specimens were mixed component calculi.The proportion of mixed component calculi was 38.67%, that of mixed component calculi was 34.00%, and that of single component calculi was 27.33%.Calcium oxalate calculi accounted for the highest proportion of single component calculi, mixed component calculi and different calculi occurrence sites(upper urinary tract and lower urinary tract calculi), followed by uric acid calculi.After 3 months, there was no significant difference in recurrence rate between the two groups(P>0.05). The recurrence rate of stone in observation group was lower than that in control group half a year and one year after operation(P<0.05). Conclusions Infrared spectroscopy is a simple and fast way to obtain the information of the composition of calculus.The composition of calculus is complex, and most of them are calcium oxalate calculus and uric acid calculus.The analysis of calculus components is the basis of putting forward individualized prevention plan, which can effectively reduce the recurrence rate of postoperative calculus. Key words: Lithotripsy; Principal Component Analysis; Health Education