Cases Of Schistosomiasis Mansoni Research Articles

The cost of a disease targeted for elimination in Brazil: the case of schistosomiasis mansoni.

BACKGROUND Schistosomiasis mansoni is a poverty-related parasitic infection that has a variety of clinical manifestations. We consider the disability and deaths caused by schistosomiasis unacceptable for a tool-ready disease. Its condition in Brazil warrants an analysis that will enable better understanding of the local health losses and contribute to the complex decision-making process.OBJECTIVE This study estimates the cost of schistosomiasis in Brazil in 2015.METHODS We conducted a cost of illness study of schistosomiasis mansoni in Brazil in 2015 based on a prevalence approach and from a societal perspective. The study included 26,499 schistosomiasis carriers, 397 hepatosplenic cases, 48 cases with the neurological form, 284 hospitalisations, and 11,368.26 years of life lost (YLL) of which 5,187 years are attributable to economically active age groups.RESULTS The total cost of schistosomiasis mansoni in Brazil was estimated to be US$ 41,7million in 2015 with 94.61% of this being indirect costs.CONCLUSIONS The economic burden of schistosomiasis mansoni in Brazil is high and results in the loss of productivity. Its persistence in Brazil is a challenge to public health and requires inter-sectorial interventions in areas such as indoor water supply, basic sanitation, and education.

A possível cura espontânea da Esquistossomose mansoni humana: "follow-up" de três pacientes treze anos após as manifestações da forma aguda, toxémica. Nota prévia

Os aa. estudaram três casos da forma aguda, toxêmica, não tratados especificamente e que evoluíram, tanto quanto puderam averiguar, para a cura espontânea. Como se trata de uma nota prévia, não se aprofundaram em considerações de ordem teórica.

Observations on cases of Schistosomiasis mansoni in a nonendemic area (Aruba, N.W.L).

Summary (1) 100 cases of schistosomiasis mansoni were found among a group of West Indians who had immigrated to Aruba which is a non-endemic area. (2) The routine use of a skin sensitivity test with a cercarial antigen and biopsy of the rectal mucosa are the most dependable ways of establishing the diagnosis of the disease. (3) It is important to consider schistosomiasis in the differential diagnosis of patients originating in areas known to be endemic for Schistosoma mansoni who present signs and symptoms pointing to a disturbance of the intestinal tract, especially with dysentery and splenic enlargement. (4) Although the period of observation (3 years) only permits a provisional opinion, it seems likely that schistosomiasis in patients not subjected to reinfestation, and living under favorable conditions is a non-progressive relatively mild condition, interfering little with the patients' general condition and working capability. Longer observation is needed to confirm this impression.

Fuadin Therapy in 150 Cases of Schistosomiasis Mansoni with a Follow-up Study of 70 Cases 1

Summary and Conclusion 1. Fuadin was employed in the treatment of 150 Puerto Rican soldiers harboring Schistosoma mansoni ova in their stools. The patients studied were considered to have mild or moderately severe chronic infections. 2. No cases of schistosomiasis mansoni were encountered in North American troops stationed in Puerto Rico. 3. Fifty-five or 37 per cent of the individuals treated were asymptomatic prior to treatment. In 60 cases, or 40 per cent, the finding of schistosome ova in the stools was incidental to the condition for which the patient was hospitalized. 4. The frequency of various signs and symptoms encountered in ninety-five cases are presented. 5. The drug was given in courses of 45 cc. each, comprising a total of 10 intramuscular injections. The first 3 injections of 1.5, 3.5, and 5 cc. each, were given on successive days and the remaining 7 injections on alternate days. One hundred and fifty cases received 1 course of fuadin; twenty-one cases were given a second course (90 cc.) of therapy and fifteen others received 3 to 6 courses (135 to 270 cc.). 6. Toxic reactions of a mild degree occurred in 30 or 20 per cent of the cases. Two patients developed constitutional reactions. 7. The immediate effect of therapy was as follows: 114 cases or 76 per cent had negative stools after 1 course, and an additional 10 per cent following a second course. 8. Follow-up observations for a period of 1 to 24 months after treatment in 70 unselected cases revealed 39 individuals (56 per cent) with positive stools for schistosome ova and 31 (44 per cent) with no ova in the stools. 9. Fuadin, when given in 1 or 2 courses (45 or 90 cc.), is not a very efficient drug in the treatment of mild, asymptomatic, or moderately severe chronic infections with Schistosoma mansoni, as determined by the presence of ova in the stools.