Case Of Primary Renal Lymphoma Research Articles

A Rare Primary Renal Lymphoma with Liver and Adrenal Gland Metastasis: A Case Report

Extra-nodal lymphomas include about 25%–35% of non-Hodgkin lymphomas (NHL), with the most frequent sites being the skin, small intestine, and stomach. Renal involvement by a lymphomatous tumor is rare, the majority of these tumors are nonHodgkin lymphomas and in more than 90% of cases this renal location is secondary. This neoplasm is frequently misdiagnosed initially as renal cell carcinoma. In this article we report a very unusual case of primary renal lymphoma (PRL) with hepatic and adrenal gland metastases in a 65-year-old woman.

Pediatric primary renal lymphoma presenting with multiple masses: A challenging case report and narrative review.

Only 20 cases of pediatric primary renal non-Hodgkin's lymphoma have been reported since 1995, rare cases and a variety of imaging manifestations have led to difficulties in its diagnosis and treatment. Herein, we share in detail a case of primary renal lymphoma (PRL) in a child and summarize the common clinical manifestations, imaging features, and prognostic factors of pediatric PRL by retrospectively analyzing cases reported in the literature. A 2-year-old boy presented to the clinic with a large mass on the right side of his abdomen along with loss of appetite. Imaging revealed a large right renal mass, nearly replacing the entire renal tissue, along with numerous small nodules in the left kidney. Given no local adenopathy and metastases, the diagnosis was unclear. A percutaneous renal puncture was performed, which proved the diagnosis of Burkitt's lymphoma. Since no bone marrow involvement, this child was diagnosed with pediatric PRL. This PRL boy was treated with the NHL-BFM95 protocol and supportive care. Unfortunately, this boy died of multiple organ failure in the fifth month of treatment. As per literature review, the presentation of pediatric PRL is fatigue, loss of appetite, weight loss, abdominal swelling, or other nonspecific symptoms. Although in 81% of cases it often infiltrates the bilateral kidneys, urine abnormalities caused by pediatric PRL are uncommon. 76.2% of pediatric PRL were boys and 2/3 of all cases presented as diffuse renal enlargement. Those PRL presented as masses could easily be misdiagnosed as WT or other malignancies. Absent of local enlarged lymph node, no necrosis or calcification suggest atypical presentation of renal masses and a percutaneous biopsy is needed in timely establishing the accurate diagnosis for appropriate treatment. Based on our experience, percutaneous renal puncture core biopsy is a safe procedure.

Perirenal Mass: An Unusual Presentation of Primary Renal Lymphoma

Primary renal lymphoma (PRL) is a rare type of Non-Hodgkin's Lymphoma (NHL), with B cell lymphoma being the most common subtype, to date; no more than 100 cases of PRL have been described and less commonly, when the involvement of perirenal space is isolated, without any renal parenchymal infiltration or contiguous abdominal adenopathy. In this article, we report a case of non-Hodgkin’s lymphoma (NHL) in 65-year-old man, presented initially for flank pain, fever and unintentional weight loss associated with dysuria and pollakiuria. Abdominal ultrasound revealed a hyperechoic masse of the left perinephric space without focal lesions in the kidneys. The CT scan confirmed the solid character of the perirenal abnormality. No intra or retroperitoneal lymphadenopathy was noted. Biopsy of the left perirenal mass using local anesthesia was performed under ultrasound guidance. The histopathological report was compatible with non-Hodgkin’s lymphoma and FDG PET-SCAN confirmed the primary localization of renal lymphoma in the left perinephric space. The aim of this work is to report a new case of primary renal lymphoma, as one of neoplasic causes of perirenal masses, describe the spectrum of imaging findings of these entities and discuss how to differentiate it from other causes of perirenal masses.

A case of primary renal lymphoma that was difficult to differentiate from invasive urothelial carcinoma, lymphoma-like/plasmacytoid variant

背景：今回われわれは術前尿細胞診にてリンパ腫様型/形質細胞腫型尿路上皮癌（PUC）と誤診した腎門部発生のびまん性大細胞型悪性リンパ腫（DLBCL）を経験したので，細胞所見を中心に報告する．

A Rare Case of Primary Renal Lymphoma: Case report

The kidney is one of the most common sites for extranodal lymphoma. Most often renal lymphoma is seen as a part of the disseminated lymphomatous disease. Primary renal lymphoma is a rare entity. Usually, patients are asymptomatic and are identified incidentally. This leads to the late presentation of the case. We present a case of 55 years male, who was evaluated for right upper quadrant pain. Radiologically, the case was diagnosed as renal cell carcinoma with hepatic metastases. Subsequent tests and biopsy were performed. Histopathology and immunohistochemistry revealed diffuse large B cell lymphoma with positivity for CD20, CD45, PAX5 and Bcl2 and negativity for CD3, CD5, CD10, CD23, CD30, Bcl6, CyclD1, and MUM1. The patient could be treated with chemotherapy but we lost to follow up.

Imaging features of primary renal lymphoma.

Background Cases of primary renal lymphoma (PRL) are quite rare and are often mistaken for renal cell carcinoma. Purpose To determine the multislice computed tomography (MSCT) and magnetic resonance imaging (MRI) characteristics of PRL. Materials and Methods Twenty-three patients with PRL were identified by CT and MRI, and their tumor characteristics were assessed. Results Tumors exhibited single or multifocal nodules (n = 19) and diffuse renal enlargement (n = 4). Twenty-two tumors exhibited an infiltrative appearance. There was no evidence of calcification in any of the cases. Twenty-one tumors displaced or wrapped around abdominal vessels rather than encasing them. Enlarged retroperitoneal nodes were observed in three cases. Neither extension into the venous system nor distant metastasis was found. Tumor enhancement was of low attenuation compared with that of normal renal cortex and medulla ( P < 0.05). PRL was isointense on T1-weighted imaging, slightly hypointense on T2-weighted imaging and hyperintense on diffusion-weighted imaging. Twenty-two patients exhibited biopsy-confirmed PRN. There were four, 12, and seven cases of low-grade, intermediate-grade, and high-grade tumors, respectively. Patient were followed up over 16 to 166 months. Six patients died within three years and five patients died within five years. Conclusion Infiltrative appearance and tumor displacement or extension around abdominal vessels rather than vessel encasement are common findings on CT or MRI imaging and may suggest a diagnosis of PRL.

Primary renal MALToma: A rare differential diagnosis for a recurrent renal mass after primary ablative therapy

We report a case of primary renal lymphoma of mucosa-associated lymphoid tissue in an 82-year-old woman. She presented with a history of renal mass previously treated with kidney percutaneous cryoablation at another centre.

A Case of Primary Renal Lymphoma

A Case of Primary Renal Lymphoma

A possible case of primary renal lymphoma: a case report

IntroductionThe entity primary renal lymphoma is controversial and rare.Case presentationWe report a case in a 60-year-old man. Computed tomography revealed a large, homogeneous, retroperitoneal mass with 14.8 × 11.5 cm size arising from the right kidney. An ultrasound guided percutaneous biopsy was performed and the tumour was diagnosed histopathological as non-Hodgkin lymphoma. The patient was treated by systemic chemotherapy and thereafter a nephrectomy was performed.ConclusionPrimary renal lymphoma is a controversial and infrequent disease. However, there is growing evidence that it does exist.

Linfoma renal primario

ObjectiveTo describe a case of primary renal lymphoma. Material and methodsWe presents a patient with a right renal mass which histological analysis revealed a non-Hodgkin Lymphoma. ResultsA 78-year-old male patient with right flank pain mass was referred to our Service. He was diagnosed of renal mass by imaging studies. Inmunohistochemical investigations revealed a B-cell-type lymphoma. He received combination chemotherapy with CHOP. ConclusionsPrimary renal lymphoma is a rare disease whose existence has been questioned, because the kidney does not normally contain lymphoid tissue. Its clinical presentation is like any other renal tumor and its definitive diagnosis is by histology. Elective treatment is chemotherapy (CHOP).

The Many Faces of Renal Lymphoma

Four clinicopathologic types of renal lymphoma (RL) are recognized: secondary RL, primary RL, renal intravascular lymphomatosis, and renal transplant lymphoma. Secondary RL is a lymphoma involving the kidney during the course of systemic lymphoma. Primary RL, defined as a lymphoma presenting with signs and symptoms related to the kidney, is first diagnosed from tissue taken from the kidney. It should be emphasized that in many cases of primary RL, a staging workup reveals simultaneous or subsequent lymphoma of other sites. Acute renal failure is a frequent initial presentation of primary RL. Lymphoma rarely involves the renal transplant as a manifestation of posttransplant lymphoproliferative disorder. Intravascular lymphomatosis is a rare variant of lymphoma in which the lymphoma cells are large and limited to vascular lumens, with minor perivascular expansion only in the terminal phases of the disease. The kidney is involved almost uniformly in intravascular lymphomatosis. Four cases of RL that encompass the morphologic spectrum of RL are reported, followed by a concise but comprehensive review of the different RL types. Familiarity with the many faces of RL promotes an intelligent diagnostic approach for this common condition and offers some insights into the fascinating biology of lymphoma.

Malignant lymphoma of the kidney

Background Primary renal lymphoma (PRL) is a rare disease, making information including etiologic factors for PRL extremely limited. Methods Clinical and pathologic findings of PRL in Japan are presented and compared with those from Western countries. The presence of Epstein-Barr virus (EBV) genomes in the tumor was also evaluated. Eight cases of PRL were collected from a review of the “Annual of the Pathological Autopsy Cases in Japan (1976–1992)”. These cases fullfilled the following criteria: (1) presence of renal mass without extrarenal lymphomatous involvement at admission and (2) absence of a leukemic blood picture. For histologic and immunohistochemical studies, 10% formalin-fixed and paraffin-embedded histologic specimens were used. Presence of Epstein-Barr virus (EBV) genome was examined by polymerase chain reaction (PRC) and in situ hybridization (ISH). Results There were five males and three females; age at admission ranged from 15 to 79 years (median 57 yr). Abdominal and/or flank pain were the most common presenting symptoms. No particular past history was present in any of the patients. Histologically, tumor cells in all cases showed a diffuse pattern of proliferation: large cell type in six cases, mixed cell type and small lymphocytic type in 1 each. Immunohistochemistry revealed B-cell nature of lymphoma cells in all cases. Neither PCR nor ISH showed the presence of EBV genome in any cases. Conclusions PRL is non-Hodgkin's lymphoma of predominantly large cell type with a B-cell immunophenotype. EBV etiology is unlikely in PRL. J. Surg. Oncol. 64:207–211, 1997 © 1997 Wiley-Liss, Inc.

Primary renal lymphoma

Lymphoma arising in the kidney is rare. Although 31 cases have been reported in the literature, it is likely that most of these neoplasms do not arise in the kidney. This report describes two cases of primary renal lymphoma and compares their clinical presentation, diagnostic modalities, treatment, and survival with the previously reported patients who satisfied our criteria for the diagnosis of primary renal lymphoma.

A Young Man with Left Renal Mass – A Case of Primary Renal Lymphoma

Renal involvement in lymphoma is not very uncommon but primary renal lymphoma is very rare and prognosis is poor. A 20 years male presented with localized, dull, constant pain and progressive swelling in left upper abdomen. He also gave history of significant weight loss. Examination findings revealed that he was anaemic, left kidney was hugely enlarged and hepatomegaly. Initially it seemed to be a case of renal cell carcinoma. But after doing invasive investigations it was proved to be a case of lymphoma, which considering all clinical and laboratory findings was diagnosed as a case of primary renal lymphoma. Keywords: Young man, Primary, Renal mass, Lymphoma DOI: http://dx.doi.org/10.3329/jom.v12i2.8424 JOM 2011; 12(2): 174-176