Cases Of Oral Lymphoma Research Articles

Differential diagnosis of hematopoietic malignancies of head and neck: Report of six cases

Background: Lymphoma and multiple myeloma account for a small but significant proportion of all oral malignancies. Oral manifestations of hematopoietic malignancies are sometimes diagnosed with delay as most of them mimic various other diseases like osteomyelitis and periodontal diseases. We present five unusual, challenging cases of head and neck lymphomas and one case of oral myeloma. Methods: In this article, we report six cases, five cases of oral lymphomas, and one oral multiple myeloma case. All cases were initially diagnosed by oral histopathologists and then referred to specialists for further treatment. Results: We report these cases to understand these lesions better, as we saw some worrisome delays in their diagnoses. We aim to raise awareness about these hematopathological diseases among general dentists. Conclusion: It is crucial for the multidisciplinary team members to thoroughly examine the oral cavity for any worrisome lesions like these, as they might be an initial sign of a systemic disease. Pathologists must also be aware of the pitfalls in the interpretation of immunohistochemical sections and the immune profile of a tumor.

Canine Oral Lymphoma: A Review and 3 Case Studies.

Canine oral lymphoma is an infrequently diagnosed malignancy in dogs and reports in the literature are lacking. Most cases are due to epitheliotropic lymphoma, in which lesions are often multifocal and involve the skin as well as the oral cavity. Epitheliotropic lymphoma is an uncommon form of lymphoma that is characterized by neoplastic T-lymphocyte tropism for epithelial tissues. However, not all cases of oral lymphoma are due to epitheliotropic lymphoma, and B-cell disease is also possible. This article describes very different cases of oral lymphoma in dogs including the history at presentation, examination and radiographic findings, treatments, and outcomes. The cases highlight the variability in signalment, examination findings, and clinical courses that are found with oral lymphoma.

Clinical manifestations of oral lymphomas – Retrospective study of 15 cases in a Taiwanese population and a review of 592 cases from the literature

Due to the rarity of oral lymphoma (OL), we aimed to evaluate the clinical features of OL and discuss these findings in light of the literature. English language literature (1980-2019) related to OL was searched in two electronic databases. Patients (2000-2019) diagnosed with OL were also selected from the database of the Oral Pathology Department in our institution. The clinical features, radiographic appearance, and histopathological diagnosis in these selected cases from publications and our institution were then analyzed. 607 cases of OL (15 in our institution and 592 from literature) in patients aged between 0 and 92 years (average, 51.8 years) with a male to female ratio of 1.6:1 were included. The most common diagnosis was diffuse large B-cell lymphoma (n=205), followed by Burkitt lymphoma (n=72) and T-cell lymphoma (n=37). The most frequent site was the gingiva, followed by palate, maxilla, mandible, tongue and buccal mucosa. The most frequent symptoms were swelling, ulceration, paresthesia, mobile tooth and pain. Radiographic findings included ill-defined osteolytic lesion, thickening of the periodontal ligament, loss of lamina dura and tooth displacement. Despite the rarity of extranodal lymphomas in oral cavity, their occurrence may be part of disseminated disease. Detailed history-taking, clinical and imaging examination and awareness of the patient's signs and symptoms are important for early diagnosis and an improved prognosis. The current data form a useful basis for clinical investigation and teaching regarding lymphoma occurring in the oral cavity.

Onset of oral extranodal large B-cell non-Hodgkin's lymphoma in a patient with polycythemia vera: a rare presentation

Polycythemia vera (PV) is a hematologic malignancy characterized by excessive proliferation of erythroid, myeloid and megakaryocytic elements in the bone marrow. Patients suffering from PV may subsequently be affected by other neoplasms of the haematopoietic system, but lymphomas are very rare and no cases of oral lymphoma have yet been reported. We report the case of a patient with PV in whom a primary non-Hodgkin's lymphoma (high grade malignancy on the Kiel scale) of the oral cavity subsequently developed. The case is unusual for its extranodal onset, its location in the oral cavity and the clinical presentation.

Oral lymphomas

Six cases of oral lymphoma are described, and their histories and features are given. The literature on this subject is reviewed, and an attempt is made to draw a clcarer clinical picture of these rare lesions.