Cases Of Neonatal Hypoxic-ischemic Encephalopathy Research Articles

The clinical role of meridian massage in neonatal hypoxic-ischemic encephalopathy

Objective The explore the effect of meridian massage on neonatal hypoxic-ischemic encephalopathy.Methods A total of 80 cases of neonatal hypoxic-ischemic encephalopathy were randomly divided into two groups.The experimental group adopted meridian masssage and the control group adopted traditional massage,2 times a day,15 min each time.Results The scores of the intake of milk,weight,length,recovery time of birth weight,meconium drained time and neurobehavioral in the experimental group were better than those in the control group,the difference were statistically significant (P ＜ 0.05).Conclusions Meridians massage has a good role in promoting growth and development on neonatal hypoxic-ischemic encephalopathy. Key words: Neonatal hypoxic-ischemic encephalopathy; Massage; Meridian; Growth and development

Neonatal hypoxic-ischemic encephalopathy in apparently low risk pregnancies: Retrospective analysis of the last five years at the University of Bologna

Objective. To provide recent figures on the occurrence of neonatal hypoxic-ischemic encephalopathy (NHIE) from a Teaching Hospital.Study Design. A retrospective case–control study was conducted in a tertiary level university hospital with more than 3000 deliveries annually. Twenty-four cases of NHIE that occurred in apparently low-risk pregnancies were analysed and compared to a group of controls for the most common labor variables. Odds ratios (OR) and 95% confidence intervals (CI) were calculated.Results. Of 15,371 apparently low-risk deliveries, 24 cases of NHIE were observed (0.16%), with perinatal death or cerebral palsy occurring in nine of these cases (0.06%). The following intra-partum variables were significantly more common in cases than in controls: stained amniotic fluid (OR: 7.50; 95% CI:1.77–31.79), maternal fever (none in the control group), abnormal CTG (OR: 253.0; 95% CI: 26.70–2397), persistent occiput posterior (OR: 15.67; 95% CI: 2.25–104.53) and operative delivery (OR: 3.98; 95% CI: 1.39–11.33).Conclusion. The incidence of NHIE is considerably low in a Tertiary care Centre.

Neuroprotective Interventions: Is It Too Late?

In most cases of neonatal hypoxic-ischemic encephalopathy, the exact timing of the hypoxic-ischemic event is unknown, and we have few reliable biomarkers to precisely identify the phase of injury or recovery in an individual patient. However, it is becoming increasingly clear that for neuroprotection in neonates to succeed, an understanding of the phase of injury is important to ascertain. In addition, in utero antecedents of chronic hypoxia, hypoxic preconditioning, intrauterine infection, and fetal gender may change the expected time course of injury. Neuroprotective interventions, such as hypothermia and N-acetylcysteine, currently have efficacy in human and animal studies only if instituted early in the inflammatory cascade. Although these cascades are currently being investigated, molecular mechanisms of recovery have received little attention and may ultimately reveal a window for therapeutic intervention that is much longer than current paradigms.