ObjectiveTo perform the translation and cross-cultural adaptation of the Quick Environmental Exposure and Sensitivity Inventory (QEESI) for the Spanish population. Patients and methodsSeventy-seven patients diagnosed with multiple chemical sensitivity (MCS) and 154 subjects without the syndrome, matched by sex and age, were included in this cross-sectional study. A translation, back-translation and a cross-cultural adaptation of the original questionnaire were performed. Subsequently, the Mann-Whitney test was used to compare the median score by scale between the subjects previously diagnosed and undiagnosed. Internal consistency by scale was analyzed (Cronbach's α). ResultsSignificant higher median score was found in subjects previously diagnosed on 4 out of 5 scales (P<.001). Good internal consistency was found in these 4 scales. Previously diagnosed subjects presented lower median scores on the Masking Index scale (P<.001). ConclusionsExcept for the Masking Index, the scales present strong potential for detecting cases of MCS among symptomatic subjects.