Case Of Lobular Capillary Hemangioma Research Articles

A Rare Case of Synchronous Lobular Capillary Hemangioma and Non-Lobular Capillary Hemangioma Arising From the Both Arytenoid Mimicking Laryngeal Granuloma

Laryngeal granuloma (LG) is a non-neoplastic lesion that mainly develops in the posterior vocal folds. It arises in response to inappropriate vocal use, and endotracheal intubation. Recently, it has been found that the coronavirus disease 2019 (COVID-19) also causes it. On the other hand, lobular capillary hemangioma (LCH) and non-LCH are two histopathological types of inflammatory hyperplasia lesions that are less common in the larynx. The LCH and non-LCH are usually caused by stimuli such as low-grade local irritation, traumatic injury. Despite the differences, as it is difficult to differentiate them from each other, surgical biopsy is necessary. It is rare to find either LCH or non-LCH in the larynx, and to our knowledge, bilateral LCH or non-LCH without endotracheal intubation history or smoking history have never been reported worldwide. Here, with a review of the literature, we report a rare case of bilateral LCH and non-LCH of arytenoid mimicking LG.

Nasal lobular capillary hemangioma: etiologic factors

<p class="abstract">Nasal lobular capillary hemangioma (LCH) is a rare and benign vascular tumor of unknown etiology, often associated with hormonal factors and a history of trauma. In this case series we present twelve cases of nasal LCH diagnosed on patients treated at the Hospital da Senhora da Oliveira from January 2010 and December 2019. Of the 12 patients, 66, 7% were males. The most common clinical presentation was epistaxis (75%) followed by nasal obstruction (50%). In 75% of patients the most commonly affected area was the nasal septum. Regarding proposed contributing factors, nasal trauma was the most prevalent (33%), followed by the use of oral contraceptives (25%) and pregnancy (8.3%). Endoscopic sinus surgery was performed in all patients, with complete excision of the lesion, and no post-operative complications were observed. Nasal LCH should be considered in the differential diagnosis of nasal vascular lesions associated with unilateral epistaxis and nasal obstruction. Complete surgical resection should be the treatment of choice, since it’s associated with lower risk of recurrence.</p>

Surgical excision of lobular capillary hemangioma with laser under N2O/O2 conscious inhalational sedation in an uncooperative pediatric patient, Frankl class 2: a case report

<p>Here, we report a case of lobular capillary hemangioma (LCH) associated deleterious oral habit on lateral border of the tongue in an anxious child excised under nitrous oxide (N<sub>2</sub>O) sedation using soft tissue diode laser. LCH are rapidly growing vascular lesions and are common occurrence over tongue, but to be associated with deleterious oral habit is an uncommon occurrence. A 9-year-old female child was brought to the dept by her parent due growth on the tongue. The child was quite anxious and displayed negativity towards examination and treatment. The child was classified as Frankl 2 on the behaviour rating scale. A pre-anaesthetic check-up was carried out on the child as it was envisaged to carry out the treatment under inhalational sedation. The anaesthesiologist along with crash cart were present throughout the procedure to cater to any adverse events. The excision was done with 980-nm soft tissue diode LASER to reduce intraoperative haemorrhage, enhance patient comfort and improve postoperative healing. A novel combination of inhalational sedation with soft tissue diode LASER with all necessary precautionary protocols as used in management of this child may be an useful approach for successful and uneventful management. To highlight the importance of proper use of pharmacologic methods in behaviour management as well as surgical techniques for better management of these vascular lesions in children.</p><p><strong> </strong></p>

Lobular capillary hemangioma of the conjunctiva.

We report a case of lobular capillary hemangioma of the conjunctiva in a 32‐year‐old man, who had no history of eye surgery or trauma, and did not respond to topical corticosteroid therapy. He was treated successfully by surgical excision. Excisional biopsy confirms the diagnosis and rules out any malignant lesion in medically uncontrolled cases.

A Case of Lobular Capillary Hemangioma at the False Vocal Cord With Intermittent Stridor

Lobular capillary hemangioma (LCH) is a type of benign vascular tumor. It arises from vascular endothelial cells and contains capillaries arranged in a lobular pattern. In the head and neck, the most common presenting location of LCH is the lips, and presentation in the larynx is very rare. LCH might not be distinct from granuloma in macroscopic views. We report a 71-year-old female with LCH of the larynx that was totally resected via laryngeal microsurgery with a CO<sub>2</sub> laser and briefly review the literature.

Maxillary Sinus Lobular Capillary Hemangioma in a 15-Year-Old Boy.

Lobular capillary hemangioma (LCH) is a benign capillary proliferation with a microscopically distinctive lobular architecture, composed of small to medium-sized vessels of capillary type. Rarely, it originates from the mucosa of the nasal cavity, most frequently from the anterior nasal septum, turbinates, and nasal vestibule. Etiology is unclear, but previous investigations suggest that this lesion is associated with injury, hormonal factors, some viral infections, and therapy with some drugs. We present a case of LCH arising from the medial wall of the maxillary sinus in a 15-year-old boy, which was completely excised by preoperative embolization and endoscopic sinus surgery. To our knowledge, this is the second reported case of an LCH originating from the maxillary antrum. Etiology, pathogenesis, diagnosis, and treatment modalities of LCH were also discussed.

A rare case of pediatric intranasal lobular capillary hemangioma

<p class="abstract">Pediatric nasal cavity vascular tumors express a wide variety of pathologies. Lobular capillary hemangioma (LCH) is an acquired benign vascular growth of skin and mucosa whose etiology remains unknown, though trauma and hormonal influences are implicated. Although well documented in the head and neck literature for children age five or less, it is a rarity within the nasal cavity and has yet to be documented in the mid-septum. We describe a unique case of intranasal LCH and review the current literature. A nine-year-old male presented with one week of profuse intermittent unilateral epistaxis and no history of nasal trauma. Rhinoscopy revealed a pink, pedunculated mass of the right mid-nasal septum at the bony-cartilaginous junction. CT and MRI imaging were consistent with an expansile vascular lesion receiving prominent bilateral sphenopalatine artery supply. Following embolization, en bloc endoscopic surgical excision of the lesion using cold dissection was performed with no bony or cartilaginous involvement noted. The epistaxis resolved following resection. Final histology confirmed the mass as a lobular capillary hemangioma. Paediatric intranasal LCH is a rare entity, yet warrants consideration in our differential diagnosis of pediatric vascular tumors. Our study indicates these lesions can develop in the mid-septum despite the absence of a vascular plexus. Preoperative embolization should be considered for pediatric nasal cavity tumors due to concern for hemorrhage. Endoscopic wide local excision is an appropriate and effective treatment. </p>

ANGIOGENESIS AND COX2 IN PYOGENIC GRANULOMAS: AN IMMUNOHISTOCHEMICAL STUDY

Oral pyogenic granuloma (PG) is a frequent reactive lesion. Angiogenesis and inflammation are involved in its development, however, its etiopathogenesis is still not fully understood. Objective: The immunoexpression of CD34 and COX2, markers used in the study of angiogenesis and inflammation, respectively, was evaluated. Study Design: Forty-nine PG cases were selected and divided into 25 cases of lobular capillary hemangioma (LCH) and 24 cases of non-LCH. For the analysis of CD34, 5 hot spot areas were chosen, from which 2 fields were selected, in which the positive cells were counted and a mean was taken from these values. The evaluation of COX immunoexpression was by means of a semi-quantitative analysis in 5 selected fields. For all evaluations, significant values were considered with P < .05. Results: Regarding the expression of CD34, the highest angiogenic indices were attributed to the histologic subtype of LCH in lesions with less inflammatory infiltrate. Regarding the expression of COX2, there was a higher frequency of scores 1 and 2 in the cases of LCH and non-LCH. There was no positive correlation between angiogenesis and inflammation (P < .004). Conclusion: It is suggested that these 2 processes participate in the pathogenesis of PG, but not necessarily synergistically. Oral pyogenic granuloma (PG) is a frequent reactive lesion. Angiogenesis and inflammation are involved in its development, however, its etiopathogenesis is still not fully understood. Objective: The immunoexpression of CD34 and COX2, markers used in the study of angiogenesis and inflammation, respectively, was evaluated. Study Design: Forty-nine PG cases were selected and divided into 25 cases of lobular capillary hemangioma (LCH) and 24 cases of non-LCH. For the analysis of CD34, 5 hot spot areas were chosen, from which 2 fields were selected, in which the positive cells were counted and a mean was taken from these values. The evaluation of COX immunoexpression was by means of a semi-quantitative analysis in 5 selected fields. For all evaluations, significant values were considered with P < .05. Results: Regarding the expression of CD34, the highest angiogenic indices were attributed to the histologic subtype of LCH in lesions with less inflammatory infiltrate. Regarding the expression of COX2, there was a higher frequency of scores 1 and 2 in the cases of LCH and non-LCH. There was no positive correlation between angiogenesis and inflammation (P < .004). Conclusion: It is suggested that these 2 processes participate in the pathogenesis of PG, but not necessarily synergistically.

Lobular Capillary hemangioma localized to the nasal vestibule: Rare presentation and review of literature

The lobular capillary hemangioma is lesion of vascular nature, benign, polypoid appearance, unique and of unknown origin. It usually occurs at any age, without predominance of sex. The clinical development of these lesions is slow, the most frequently observed symptoms are epistaxis and nasal obstruction. Histopathological examination is necessary to confirm the diagnosis. We report a case of lobular capillary hemangioma of the nasal vestibule in a 43-year-old male patient. Keywords: Lobular capillary hemangioma; Nasal vestibule; Vascular tumors

Participation of Intussusceptive Angiogenesis in the Morphogenesis of Lobular Capillary Hemangioma

In lobular capillary hemangioma (LCH), misnamed pyogenic granuloma, only sprouting angiogenesis (SA) has been considered. We assess the occurrence of intussusceptive angiogenesis (IA) in LCH and whether IA determines the specific and other focal patterns in the lesion. For this purpose, we study specimens of 120 cases of LCH, using semithin sections (in 10), immunohistochemistry, and confocal microscopy (in 20). In addition to SA, the results in LCH showed (1) intussusceptive phenomena, including pillars/folds and associated vessel loops, which encircled interstitial tissue structures (ITSs). (2) Two types of evolved loops depending on interendothelial contacts from opposite walls: (a) numerous interendothelial contacts, alternating with capillary-sized lumens (main capillary pattern of the lesion) and (b) few interendothelial contacts, wide open lumens, and intravascular transport of pillars/folds, which were arranged linearly, forming septa (focal sinusoidal-like pattern) or were irregularly grouped (focal intravascular papillary endothelial hyperplasia, IPEH-like pattern). In conclusion, we demonstrate that IA participates in synergistic interaction with SA in LCH development and that the prevalence of specific intussusceptive phenomena determines the predominant capillary pattern and associated sinusoidal hemangioma-like and IPEH-like patterns in the lesion, which suggest a role of IA as conditioner of vessel tumour/pseudo-tumour morphology.

Lobular Capillary Hemangioma: a Case Report

This article aims to report a case of lobular capillary hemangioma. A 23-year-old man complained of a lump in his mouth resulting from an auto accident approximately 7 months prior. On intraoral clinical examination, it was possible to verify, in the left mandibular region between teeth #31 to #34, the presence of a pediculated nodular lesion approximately 2 cm in diameter, with an ulcerated surface and reddish pink coloration, showing bleeding and soft consistency, suggestive of central giant cell granuloma. The patient underwent excisional biopsy, and as a result of A.P., lobular capillary hemangioma was diagnosed. The patient was followed-up, and no recurrence was observed.

A Case of Giant Lobular Capillary Hemangioma in Glottis Causing Airway Obstruction

The lobular capillary hemangioma (LCH) was previously known to pyogenic granuloma and is benign vascular lesion which grows rapidly on skin and mucosa. It arises from whole body, but oral and nasal cavities are most predilection sites in the head and neck area. The laryngeal LCH looks like a granulomatous lesion of posterior glottis and its common etiology are tracheal intubation and laryngopharyngeal reflux disease etc. The LCH in larynx can cause blood tinged sputum and lump sense. The lesions refractory to medical therapy or causing dyspnea may require surgical excision. A 74-year-old man who presented gradually aggravated dyspnea, lump sensation and hoarseness of one month came to our hospital. The stroboscopic examination revealed large well-margined glottic mass. It was excised with CO2 laser and finally diagnosed as LCH. We present a rare unique case of glottic LCH with a review of literatures.

Lobular capillary haemangioma of the gingiva: Clinical management and a review of the literature

Introduction: Lobular capillary hemangioma, otherwise called pyogenic granuloma represents an exuberant connective tissue proliferation to a known stimulus or injury. The aim of this paper is to present a case in our clinical practice, discuss the differential diagnosis and review the literature. Materials and Methods: A narrative review of the literature was performed to evaluate recent information as regards etiopathogenesis, clinical presentation as well as management of pyogenic granuloma. A search of the literature was performed on PubMed using the following keys terms: lobular capillary hemangioma, pyogenic granuloma, etiopathognenesis, clinical features and management. The search criteria were filtered to include articles on human studies, which were published in English Language. Results: We present a clinical case of pyogenic granuloma demonstrating positivity for estrogen receptor and a narrative review of the English Literature and management of a large case of lobular capillary hemangioma of the gingiva. Conclusion: The conventional deep scaling and polishing and root plaining, in addition to surgical excision of the lesion is still the acceptable treatment option of lobular capillary hemangioma of the gingiva. However, there is need to consider other less aggressive and less morbid methods of treatment such as cryosurgery and laser therapy.

A troublesome lesion of the larynx: Lobular capillary hemangioma

Lobular capillary hemangioma (LCH), which is also known as pyojenic granuloma, is a benign and vascular lesion of the skin and mucous membranes and mostly seen in females between 20-40 years of age. Although the etiology of the condition is still unknown, some conditions, such as trauma, poor oral hygiene, viral or fungal infections, and periodontal and gingival diseases are considered to be related to the formation of LCH. It mostly seems in cheek and oral cavity in head and neck region. Larynx localization of LCH is very rare. We present a case of LCH in a 47-year-old male and review the literature.

Pediatric Lobular Capillary Hemangioma Nasal Cavity

ABSTRACT A lobular capillary hemangioma (LCH) is a benign uncommon entity of unknown etiology among vascular lesions of the head and neck. Although it has no predilection for age, it is more common in the third decade and in females. Lobular capillary hemangioma usually involves the gingiva, lips, tongue and buccal mucosa. The nasal cavity is a rare location. The most common symptoms are nasal obstruction and epistaxis. The treatment is nasal endoscopic surgery. We review these vascular lesions and present the clinical features, radiological findings, treatment performed and histopathological results of two cases of LCH originating in the left inferior turbinate and septum. No recurrence was observed after complete endoscopic resection during 6 months follow-up. Lobular capillary hemangioma should be taken into consideration among the differential diagnosis of a painless hemorrhagic endonasal mass even though it is a rare entity. If complete resection is performed, prognosis is excellent and the recurrence rate is low. How to cite this article Varshney S, Malhotra M, Kaur N, Gairola P. Pediatric Lobular Capillary Hemangioma Nasal Cavity. Clin Rhinol An Int J 2015;8(2):76-80.

Lobular Capillary Hemangioma of the Ethmoid Sinus: A Report of Two Cases

Soft-tissue tumors are rare in the paranasal region. Lobular capillary hemangioma (LCH) is a distinctive vascular lesion most commonly seen on the skin and oral mucosa in the fourth and fifth decades of life. Forasmuch as the nasal cavity and paranasal sinuses are rare locations for LCH, it is not well known by many ENT surgeons. Here we present two cases of LCH of the ethmoid sinus. These cases are being reported owing to their scarcity as per the literature published global.

Torsion of lobular capillary hemangioma of greater omentum: A rare cause of acute abdomen

Metastatic tumors of the omentum are common. In contrast, the primary tumors of the omentum are very rare. Primary benign tumors of the omentum include lipomas, myxomas, and desmoid tumors. Primary malignant tumors include leiomyosarcoma, liposarcoma, etc. We report here a case of a 32-year-old female who presented to our emergency department with pain in lower abdomen of 1-day duration. The patient underwent laparotomy and was found to have an irregular mass with bosselated surface arising from the omentum that had caused torsion of the omentum. Histopathology confirmed it to be a lobular capillary hemangioma (LCH) of greater omentum. The postoperative course was uneventful, and she has followed up for last 6 months without any recurrence. There is not yet a single reported case of LCH of omentum.

Spindle Cell Hemangioma of the Nasal Cavity: A Rare Tumor with Unusual Presentation

ABSTRACT Vascular tumors as such are rare in the nasal cavity. Few cases of lobular capillary hemangioma, cavernous hemangioma and epitheloid hemangioendothelioma have been reported in the nasal cavity. But, there are no reports of spindle cell hemangioma occurring within the nasal cavity. They usually present as subcutaneous nodules in the extremities. A case of recurrent bleeding polypoid lesion in the left nasal cavity, arising from the middle turbinate which showed features of spindle cell hemangioma is reported for its rarity and unusual presentation. The tumor was excised by minimally invasive transnasal endoscopic approach. How to cite this article Suranagi V, Harugop AS, Bannur HB, Pilli GS, Mudhol RS. Spindle Cell Hemangioma of the Nasal Cavity: A Rare Tumor with Unusual Presentation. Clin Rhinol An Int J 2013;6(3):149-151.

Capillary Hemangioma of the Lateral Nasal Wall: An Unusual Location

ABSTRACT Capillary hemangioma also known as lobular capillary hemangioma (LCH) or pyogenic granuloma is a benign, vascular lesion of unknown origin, composed of blood vessels and are probably developmental rather than neoplastic in origin. They usually affect skin and mucous membranes of the oral cavity and rarely nasal mucosa. LCH bleeds on manipulations due to high vascularity. Microtraumas and hormonal imbalance are the major etiological factors in its development. Total excisional surgery is sufficient for treatment of the LCH. Capillary hemangioma arising from the nasal cavity is rarely encountered in our practice and rarely reported in the literature. We are reporting this case of LCH of lateral nasal wall because of its unusual location. How to cite this article Gupta DK, Somavanshi S, Agrawal A, Bharti R, Shree N. Capillary Hemangioma of the Lateral Nasal Wall: An Unusual Location. Clin Rhinol An Int J 2012;5(3): 127-129.

Pediatric Nasal Lobular Capillary Hemangioma

Background. LCH is a benign vascular growth of the skin and mucous membranes commonly affecting the head and neck. Since it was first described in the nineteenth century, this entity has been variously known as “human botryomycosis” and “pyogenic granuloma.” The shifting nomenclature reflects an evolving understanding of the underlying pathogenesis. We review the histopathology of and current epidemiological data pertaining to LCH which suggests that the development of these lesions may involve a hyperactive inflammatory response influenced by endocrine factors. We report two new cases of pediatric lobular capillary hemangioma (LCH) of the nasal cavity and review current theories regarding the etiology, diagnosis, and treatment of nasal LCH. Methods. Retrospective case series. Case Series. Two adolescent females presented with symptoms of recurrent epistaxis, nasal obstruction, and epiphora. Both patients underwent computed tomography imaging and biopsy of their intranasal mass. The tumors were excised using image-guided transnasal endoscopic technique. Seven other cases of nasal LCH have been reported to date in the pediatric population. Conclusion. Nasal LCH is a rare cause of an intranasal mass and is associated with unilateral epistaxis, nasal obstruction, and epiphora. We advocate for image-guided endoscopic excision of LCH in the adolescent population.