Case Of Laryngeal Amyloidosis Research Articles

A Case of Laryngeal Amyloidosis with Dyspnea Triggered by Infection

Laryngeal amyloidosis is a relatively rare disease, and usually carries a good prognosis. However, if a patient with laryngeal amyloidosis develops inflammation of the larynx, airway narrowing and dyspnea may occur. In this article, we report the case of a patient with laryngeal amyloidosis who had a long clinical course and required two tracheostomies and microlaryngeal surgeries.The patient was a woman in her 30s at the time of her initial visit, who visited our hospital with the complaint of hoarseness. Laryngoscopy revealed a yellow lesion around the vocal cords. A tracheostomy and microlaryngeal surgery were performed for biopsy and reduction of the lesion. Histopathological examination of the resected lesion revealed the diagnosis of laryngeal amyloidosis, and after closure of the tracheotomy, the patient was followed up as an outpatient. Nineteen years later, the patient visited our hospital again with the chief complaint of dyspnea, and was hospitalized. She was diagnosed as having airway narrowing caused by recurrent laryngeal amyloidosis and laryngeal edema, and treated with antimicrobial agents. The laryngeal inflammation and edema subsided, however, the dyspnea due to airway narrowing caused by laryngeal amyloidosis failed to improve, so that a second tracheostomy and microlaryngeal surgery were performed.Although laryngeal amyloidosis is said to carry a good prognosis, dyspnea caused by edema of the larynx and recurrence of amyloidosis could be fatal, as in this case. Unlike in the case of other types of localized amyloidosis, otolaryngologists/head and neck surgeons should be aware that early amyloidosis reduction surgery under local anesthesia or microlaryngeal surgery is important for patients presenting with even mild clinical symptoms, such as hoarseness, to prevent the risk of development of airway obstruction due to infection.

Amiloidosis laríngea, un reto clínico. Reporte de serie de casos en el Hospital Universitario San Ignacio. Bogotá, Colombia

Laryngeal amyloidosis in an infrequent disorder, with nonspecific symptoms that difficult the diagnosis and without a consensus for its treatment. Through the description, analysis and comparison of three cases of laryngeal amyloidosis at the Hospital Universitario San Ignacio Bogota, we seek to expand the knowledge in this pathology and compare it with what is described in the literature. We made a retrospective research of patients with a diagnosis of laryngeal amyloidosis in the last five years in our institution, obtaining a final sample of 3 cases that met the inclusion criteria. The most frequent symptom was dysphonia, the most frequent presentation was systemic, contrary to what was reported in the literature. Airway remodeling was performed using laryngeal microsurgery with carbon dioxide laser, obtaining good clinical results. We consider important to carry out more studies on the subject in our country.

A Case of Recurrent Localized Laryngeal Amyloidosis

Herein, we report a case of recurrent localized laryngeal amyloidosis in a patient who had been followed up for 15 years after the first treatment. A 63-year-old male was referred to our department with the chief complaints of hoarseness and dyspnea. Several examinations showed submucosal swelling of the subglottic area bilaterally. A biopsy specimen obtained by laryngomicrosurgery showed submucosal deposition of amyloid. Debulking surgery was performed via an opening of the trachea. However, 9 months after the first surgery, the patient presented to us again complaining of dyspnea. We performed revision surgery for a repeat debulking of the lesion via a laryngofissure. His postoperative course was good and his dyspnea improved. However, 13 years after the revision surgery, the patient presented yet again with dyspnea. Therefore, we performed a third surgery using the same procedure as in the previous operation. Despite the repeated recurrences, we performed debulking of the lesion, and not total resection. Since amyloidosis is a benign disorder, and the larynx has important functions, organ-preserving surgery is recommended in cases of laryngeal amyloidosis.

Laryngeal Amyloidosis

Objectives: Amyloidosis constitutes less than 1% of benign laryngeal tumors and may occasionally be associated with systemic disease. It commonly presents with long-standing hoarseness or dyspnea. Diagnosis is established with histological features of acellular, amorphous, eosinophilic deposits which react positively with Congo red. We present 2 such cases of laryngeal amyloidosis, one localized and one with systemic involvement. Literature review, diagnostic work-up, and treatment options are discussed. Methods: Case 1: A 63 year old non-smoking male presented with hoarse voice for 2 months. Flexible laryngoscopy showed diffuse fullness on left hemilarynx. Microlaryngoscopy revealed submucosal lesion in anterior left vocal cord, which on deep biopsy confirmed AL type amyloid. Detailed work-up by a hematologist ruled out systemic disease. Case 2: A 74 year old moderate smoker presented with 6 months of hoarse voice and burning sensation in the tongue. He had a mucosa-covered growth in the right false vocal cord, which on biopsy confirmed amyloidosis (AL type). Further work-up revealed systemic disease with elevated serum free light chains, IgG Kappa paraprotein, and positive abdominal fat biopsy. Results: Patient 1 is under follow-up with no clinical recurrence. Patient two had treatment with CDT chemotherapy and is under hematologist surveillance. Past history includes carpal-tunnel decompression. Localized laryngeal amyloidosis is best treated with cold steel resection or CO2 laser excision and may require repeated removal in some patients. Systemic amyloidosis is caused by plasma-cell dyscrasia and treated with chemotherapy and or radiotherapy. Conclusions: Endolaryngeal treatment is sufficient with localized disease. Systemic disease needs more extensive treatment, and those with associated myeloma have poor prognosis.

A Case of Laryngeal Amyloidosis Treated by Endoscopic Surgery through Tracheostoma

A Case of Laryngeal Amyloidosis Treated by Endoscopic Surgery through Tracheostoma

Laryngeal Amyloidosis Mimicking Glottic Cancer: A Case Report

Amyloidosis is a slowly progressive, benign disease that is characterized by the extracellular deposition of fibrillar proteins in many different tissues and organs throughout the body. Primary amyloidosis can be subdivided into the systemic and localized forms. The localized form is less common than the systemic form and the larynx is the most frequently affected site. The importance of laryngeal amyloidosis lies in its possible confusion with glottic cancer because of the clinical feature. We report here on a case of laryngeal amyloidosis in a 47-year-old man who suffered from progressive dyspnea.

上皮性腫瘍を疑った喉頭アミロイドーシスの 1 例

上皮性腫瘍を疑った喉頭アミロイドーシスの 1 例

A Case of Laryngeal Amyloidosis

Amyloidosis is not a single entity but rather a group of diseases characterized by the presence of extracelluar deposition of insoluble, fibrillar, proteinaceous material with a well-defined, β-pleated sheet ultrastructure, mainly in tissues derived from the mesoderm. Approximately 9% to 15% of amyloid tumors are localized. The larynx is the most usually involved site in the head and neck. It is estimated that less than 1% of the benign tumors is found in the larynx. We report a case of laryngeal amyloidosis with a review of its clinical patterns, diagnostic tools, pathologic findings and treatments. Korean J Otorhinolaryngol-Head Neck Surg 2009;52:620-2 Key WordsZZLarynx·Amyloidosis.

내시경 절제로 치료한 후두에 국한된 아밀로이드증 치험 1예

내시경 절제로 치료한 후두에 국한된 아밀로이드증 치험 1예

Amyloid Tumor of the Larynx associated with Plasma Cell Infiltration: Differential Diagnosis

Localized amyloidosis of the larynx is uncommon, accounting for fewer than 1% of all benign laryngeal tumors. We report 2 cases of laryngeal amyloidosis in which dense plasma cell infiltrates were found in the vicinity of the amyloid deposits; in view of this finding, we suspected a hematologic disease--plasmacytoma in particular: However, molecular genetic analysis did not demonstrate any light-chain restriction, indicating that the plasma cells were of polyclonal origin and therefore consistent with chronic inflammation. We also discuss the available literature with respect to diagnostic and therapeutic procedures in patients with amyloidosis of the upper airway.

Laser in treatment of laryngeal amyloidosis.

Amayloidosis is the extracellular deposition of the fibrinous protein amyloid in one or more body sites. Amyloidosis may broadly be classifed as either primary or secondary. Primary amyloidosis is idiopathic (56 %), whereas the secondary form is associated with a chronic inflammatory or infectious process (5%). Amyloidosis is also related to multiple myeloma (26%), senescence (5%) and where tumor like deposits occur in isolated organ without systemic involvement (8%). Laryngeal amyloidosis is a rare disease. Surgery has been the mainstay of treatment either endoscopicalfy or by an external neck approach. One case of laryngeal amyloidosis, treated with endolaryngeal microsurgery and carbon dioxide laser is presented with a follow up of 8 years.

Laser in treatment of laryngeal amyloidosis: A case report.

Amyloidosis is the extracellular deposition of the fibrinous protein amyloid in one or more body sites. Amyloidosis may broadly be classified as either primary or secondary. Primary amyloidosis is idiopathic (56%), whereas the secondary form is associated with a chronic inflammatory or infectious process (5%), Amyloidosis is also related to multiple myeloma (26%). senescence (5%) and where tumor like deposits occur in isolated organs without systemic involvement (8%).Laryngeal amyloidosis is a rare discase. Surgery has been the mainstay of treatment either endoscopically or by an external neck approach. One case of laryngeal amyloidosis, treated with endolaryngeal microsurgery and carbon dioxide laser is presented with a follow up of 8 years.

Amylose laryngée : une cause rare de dysphonie

Introduction. – The larynx is a rare site of deposition for amyloidosis. Diagnosis may be delayed and evoked in patients with prolonged hoarseness. We have reported two cases of laryngeal amyloidosis. Exegesis. – One man and one woman suffered from hoarseness during one and three years, respectively. Laryngoscopic examination showed diffuse infiltration of the larynx. Amyloidosis was confirmed by the characteristic Congo-red staining of laryngeal biopsies. The search for other localizations of amyloidosis was negative. No monoclonal plasma cell proliferation was detected. Both patients received endoscopic CO 2 laser excision. In one case, chemotherapy was initially associated due to dystrophic plasma cells in bone marrow aspiration and then withdrawn because of clinical failure. With a 6-month follow-up, hoarseness remained stable. Conclusion. – Laryngeal amyloidosis is an essentially localized disease revealed by hoarseness. Treatment is endoscopic by laser excision. In nearly half of the cases in the literature, it had to be repeated due to localized recurrent lesions. Long-term prognosis of localized laryngeal amyloidosis is better than systemic AL amyloidosis.

Laryngeal Amyloidosis in a Child

A 14-year-old girl developed progressive hoarseness and breathing difficulty due to a mass in the subglottic larynx. A biopsy specimen obtained at direct laryngoscopy showed localized aggregates of amyloid. The lesion was excised completely with a carbon dioxide laser. This is the second case of laryngeal amyloidosis in a child reported in the English-language literature.

Laryngeal amyloidosis

Laryngeal amyloidosis is a rare disease. Surgery has been the mainstay of treatment either endoscopically or by an external neck approach. In more recent years, surgery with the carbon dioxide laser has been advocated for this condition. Four cases of laryngeal amyloidosis are presented. The application and the advantages of the carbon dioxide laser for the treatment of laryngeal amyloidosis are discussed.

Laryngeal amyloidosis.

Localized laryngeal amyloidosis is a benign, rare tumor of the larynx. Six cases of laryngeal amyloidosis were evaluated and treated from 1967 through 1984. One case is that of an 8-year-old female: the youngest reported case. Therapy is directed towards surgical resection. The cases in this report had significant laryngeal involvement necessitating extensive surgery.