Cases Of Dermatitis Research Articles

A review of allergic contact dermatitis for dental professionals

INTRODUCTION Contact dermatitis is an inflammatory skin disorder that can present as an acute, subacute or chronic condition. This review highlights the burden of allergic contact dermatitis for dental professionals as well as discussing its cellular mechanism, clinical features, common causative agents in dentistry and treatment options. FINDINGS There are two main types of contact dermatitis. Allergic contact dermatitis accounts for 20% of reported contact dermatitis cases while the remainder are due to irritant contact dermatitis. Allergic contact dermatitis is a type IV hypersensitivity reaction that affects 22-43% of dental professionals globally. There is limited literature on the impact of this condition on dental healthcare professionals. Moreover, with the increased and prolonged use of personal protective equipment (PPE) to prevent occupational transmission of SARS-CoV-2, more healthcare professionals are presenting with allergic contact dermatitis against their PPE. CONCLUSIONS Allergic contact dermatitis is a prevalent occupational skin condition that can affect all members of the dental team, especially with the increased use of PPE due to the COVID-19 pandemic. Dental professionals with signs and symptoms should seek relevant advice and reduce exposure to known allergens.

Comparison of Malassezia Colonization of 'Maskne' Patients with Seborrheic Dermatitis Cases and Healthy Individuals.

With the Covid-19 pandemic, the use of masks has increased the frequency of 'maskne' cases. Local physiological changes due to the use of mask have caused changes in the presence of yeasts in the environment, such as acne and seborrheic dermatitis. The aim is to compare the differences of Malassezia species in the maskne region. A total of 408 subjects wearing masks at least 4 h a day for 6 weeks or longer, compromised of 212 acne patients, 72 seborrheic dermatitis sufferers, and 124 healthy volunteers were included in this study. Swab samples were taken for Malassezia cultures from nasolabial area and their control retro auricular region. The Statistical Package for Social Sciences (SPSS) version 22 was used for the statistical analysis. Malassezia species was most frequently found in the nasolabial region of the seborrheic dermatitis group. Malassezia species were more commonly isolated from the nasolabial region of acne and seborrheic dermatitis patients, compared to the retroauricular region of each patient, than the healthy subjects. The rate of M. globosa isolated from the nasolabial region was high in all groups, the isolation rate of M. restricta was low (P < 0.05). As Malassezia species are more commonly isolated from the nasolabial region of acne and seborrheic dermatitis patients, the increasing numbers of Malassezia species will trigger inflammation with an antibody reaction against these yeasts. Treatment of resistant acne and seborrheic dermatitis will be facilitated with the knowledge of this inflammation.

Skin lesions associated with personal protective equipment in medical workers during the COVID-19 pandemic

Aim. Analysis of the incidence of personal protective equipment (PPE)-associated dermatoses among medical workers during the COVID-19 pandemic.Materials and Methods. Screening of the papers indexed by PubMed, EMBASE, Google Scholar, eLibrary, and UpToDate databases, written in English and published from January 1, 2020 to October, 2021. The search keywords were: "medical workers", "skin", "dermatoses", "professional", and "personal protective equipment" in combination with "COVID-19" and "SARS-CoV-2".Results. Occupational contact dermatitis is responsible for 20% of all cases of contact dermatitis which accounts for 90% of all skin disease cases. During the COVID-19 pandemic, from 42.8% to 97.0% of medical workers reported about skin lesions provoked by prolonged wearing of PPE in combination with regular disinfection. About 61.7% of them noted the deterioration of a pre-existing skin disease, and 90.5% reported the appearance of new skin lesion symptoms associated with the PPE usage. The most common symptoms of skin lesions among medical workers were dryness, itching, burning, soreness, and skin rash. Irritant and allergic contact dermatitis, acne, rosacea, and seborrheic dermatitis were the most prevalent skin disorders among the interviewed medical workers. Risk factors for the development of PPE-associated dermatoses were the type and material of PPE, the duration of PPE wearing, and past medical history of skin diseases. Due to the increased incidence of PPE-associated dermatoses among the medical staff, some countries have developed recommendations on the prevention and treatment of undesirable PPE-associated skin reactions in medical professionals. Current research are focused on developing special tools and devices that would serve as a protective barrier between the skin and PPE, ameliorating the damaging effect of the latter.Conclusion. PPE-associated dermatoses are currently widespread among the medical workers, highlighting the need in novel materials for PPE manufacturing to minimise the risk of developing PPE-associated skin lesions.

Para-Phenylenediamine (PPD) in commercially available Henna preparations in Bangladesh

In Bangladesh Henna is one of the most popular cosmetic products. The leaves of Henna are dried to make powder on which oil or water is mixed to get a paste to stain the body or hair. Although the occurance of contact allergic dermatitis in natural Henna is not so common, but this risk is increased by adding para-Phenylenediamine (PPD), which is used to make the Henna color dark to deep black. According to Scientific Committee on Consumer Products (SCCP), para-Phenylenediamine (PPD) is treated as an allergen and is considered as a very strong potential skin sensitizer. The presence of PPD in the commercially used tube Henna increases the risk of allergic contact dermatitis and several cases have already been reported worldwide. For this study, about 10 Henna samples were randomly collected from 10 selected areas of Dhaka city. The presence of PPD in Henna samples was determined by using High Performance Liquid Chromatography (HPLC). The result showed the presence of PPD in all of the Henna samples at substantial concentrations, ranging between 79.12-204.77 mg/kg where the average range is 142.36 mg/kg, which is much higher than the permissible levels (&lt;2% or 0.1 mg/m3). The finding suggests that there should be a regulation and monitoring condition for the production and distribution of these adulterated Henna products in Bangladesh. Bioresearch Commu. 8(1): 1088-1092, 2022 (January)

Alopecia and Dermatitis Caused by Lepoarcarus gibbus in a New Zealand White Rabbit (Oryctolagus cuniculus) – Clinical and Parasitological Diagnosis and Treatment

Aim: Ectoparasites associated dermatological disorders are frequently encountered in laboratory and pet rabbit medicine practice, however, L. gibbus is the only ectoparasite rarely reported in either pet and laboratory rabbits or hares as L. gibbus are usually asymptomatic. The aim of the present report is to describe a case of alopecia and dermatitis associated with Lepoarcarus gibbis in a rabbit from India. Presentation of Case: A 1.5 year old female New Zealand White rabbit was presented to the Dermatology Unit with erythema and poorly demarcated alopecia on the dorsal neck and face. A skin scraping and coat brushings were performed. On microscopic evaluation of hair samples, L. gibbus infestation was confirmed. Treatment with ivermectin (0.3 mg/kg) biweekly once for 3 doses proved effective.&#x0D; Discussion and Conclusion: L.gibbus may be presented with severe hairfall in the absence of other mites and treatment with ivermectin is effective.&#x0D; Based on the literature research this may be the first case report on alopecia and dermatitis due to L.gibbus in rabbit from India. Further studies should be planned on the prevalence of the mite as it is reported to have zoonotic potential.

Determination of Methylisothiazolinone and Methylchloroisothiazolinone in personal care products by HPLC-DAD

Preservatives are often utilized to prevent growth of bacteria and extend shell-life of personal care products (PCPs). This causes an increase in the number of cases of allergic contact dermatitis to preservatives. This study focused on the determination of two isothiazolinones (MI and MCI) in PCPs by HPLC-DAD. Different pretreatment methods were examined for different sample matrices. Recoveries were over 80% with %RSD < 6% in three studied sample matrices (wet tissue, shampoo and cream) at three different spiked levels. The method was applied to determine MI and MCI in 84 PCPs (shampoo, shower gel, cream, etc.) purchased in Ho Chi Minh City, Vietnam from March to July in 2021. MI and MCI were detected in some PCPs.

Simultaneous determination of three allergic proteins in rice and products by high performance liquid chromatography-tandem mass spectrometry combined with stable isotope-labeled peptides

基于稳定同位素标记特征肽段和液相色谱-质谱联用仪建立稻米及制品中3种过敏蛋白质的同时定量方法。稻米及制品样品经盐溶液提取,赖氨酰基内切酶(Lys-C)和胰蛋白酶依次水解,C18-SD柱净化后,采用纳升高效液相色谱-线性离子阱-静电场轨道阱(NanoLC-LTQ-Orbitrap)采集和Protein Discovery软件鉴定,NCBI和Uniprot数据库的基本局部搜索比对工具(BLAST)筛选验证,最终获得表征稻米及制品中α-淀粉酶/胰蛋白酶抑制剂类蛋白质(seed allergenic protein RAG2, RAG2)、乙二醛酶Ⅰ活性蛋白(glyoxalase Ⅰ)和α-球蛋白(19 kDa globulin)3种过敏蛋白质的特异性肽段。3个特异性肽段经液相色谱梯度洗脱,在Poroshell色谱柱上实现完全分离,由三重四极杆质谱仪分析。实验通过优化多反应监测(MRM)质谱参数,比较不同溶剂体系、水解酶种类和酶量等酶解条件,结合内标法定量,实现对稻米及制品中3种蛋白质的绝对定量。实验结果表明,当酶解溶剂中含1 g/L十二烷基硫酸钠,采用Lys-C和胰蛋白酶组合消化策略,可有效提高3种蛋白质的酶切效率至65.7%~97.3%。该方法在1~200 nmol/L范围内线性关系良好,相关系数均大于0.9972, 3种蛋白质的检出限和定量限分别为3 mg/kg和10 mg/kg。3种蛋白质在空白稻米制品基质中3个水平下的加标回收率为80.6%~103.7%,日间和日内精密度均小于11.5%。该方法稳定性好,检测灵敏度高,操作简便,在分析各类稻米及制品中3种过敏蛋白质含量具有广泛的应用前景。

Pilot study of dogs with suppurative and non-suppurative Malassezia otitis: A case series

BackgroundRarely, Malassezia otitis presents as a painful, erosive otitis with an otic discharge containing Malassezia and neutrophils on cytology. There are no published reports of this type of suppurative Malassezia otitis (SMO). The role of Malassezia hypersensitivity in otitis is still unknown, and no association has been demonstrated with SMO. We compared Malassezia IgE levels, intradermal test and histology changes in SMO dogs with the more conventional Malassezia otitis (MO) presentation.ResultsThree dogs (case 1, case 2 and case 3) were diagnosed with SMO, one dog (case 4) was diagnosed with unilateral MO and unilateral SMO, and one dog (case 5) was diagnosed with MO. Only one case (case 4) with SMO/MO had a positive Intradermal Allergy Test (IDAT) and elevated IgE levels for Malassezia. Histopathology findings from SMO revealed: interface dermatitis (case 1 and 3), lymphocytic dermatitis (case 2) and chronic hyperplastic eosinophilic and lymphoplasmacytic dermatitis (case 4). Histopathology findings from MO showed perivascular dermatitis (case 4 and 5). All the cases were treated successfully.ConclusionsSMO presents with a distinct clinical phenotype in comparison with conventional MO. No consistent aetiology could be isolated. In these clinical cases it is possible that previous treatments could have influenced the results. More research is needed to understand the possible aetiologies and the pathogenesis of SMO.

Allergic contact dermatitis caused by dipropylene glycol diacrylate in the Omnipod® insulin pump.

Cases of allergic contact dermatitis (ACD) caused by isobornyl acrylate (IBOA) in the Omnipod® insulin pump have previously been reported. To present three cases of patients with ACD caused by a new allergen in the pump, and results from chemical analyses. Omnipod pumps from different batches were analysed by gas chromatography-mass spectrometry. Aimed testing, with the department's medical device (MD) series and substances identified in the pump including dipropylene glycol diacrylate (DPGDA) at 0·01% and 0·1% in petrolatum (pet.), was performed. Patch testing also included extracts from the device, the adhesive patch as is, and allergens from baseline series. All patients tested positive to 0·1% DPGDA in pet., and two patients additionally to a 0·01% concentration. DPGDA was found in extracts of the Omnipod pumps brought by the patients. An Omnipod pump from an earlier batch contained tripropylene glycol diacrylate, IBOA, N,N-dimethylacrylamide, di(ethylene glycol)ethyl ether acrylate (DEGEA) but no DPGDA. One of the patients reacted positively to all of these allergens except DEGEA, which was not tested. When suspecting ACD to MDs, DPGDA at 0·1% in pet. should be tested. The contents of Omnipod have changed over time. Patch testing with updated test series and relevance assessment of positive reactions is a delicate task. Children, with lifelong use of MDs, risk contracting many allergies with potential cross-allergies. A question should be raised as to whether these low molecular weight acrylates should be used at all in devices constantly worn on the skin.

M302 CHALLENGING DIAGNOSIS OF CONTACT DERMATITIS TO PERIPHERAL IV AND PHLEBOTOMY IN PREGNANCY

Evaluation of contact dermatitis (CD) to peripheral IV catheters and phlebotomy lack standardization. We present a case of recurrent dermatitis in pregnancy for whom patch testing (PT) post-partum gave borderline results.

M312 CRISABOROLE FOR THE TREATMENT OF SEVERE CONTACT DERMATITIS UNRESPONSIVE TO CORTICOSTEROIDS

Contact dermatitis is a type IV hypersensitivity reaction. Treatment for contact dermatitis includes corticosteroids and the removal of the causal agent. Crisaborole is a phosphodiesterase-4 (PDE-4) inhibitor that is currently approved for mild-to-moderate eczema for 3 months of age and older. We present a case of contact dermatitis that was treated with crisaborole after being unresponsive to corticosteroids.

Comparison of 2-octyl cyanoacrylate skin adhesive and interrupted polypropylene sutures for wound closure in total ankle arthroplasty

BackgroundAdhesive skin materials have increasingly been used in orthopedic surgery. We aimed to compare the efficacy and safety of skin adhesive (2-octyl cyanoacrylate and polymer mesh, Dermabond Prineo) and interrupted polypropylene sutures for wound closure in patients undergoing total ankle arthroplasty (TAA).MethodsWe prospectively enrolled 107 consecutive patients (108 ankles) undergoing TAA and divided them into two groups: skin adhesive group (36 ankles) and suture group (72 ankles). The primary outcome assessment included wound complications and patient satisfaction for wound cosmesis. The secondary outcome assessment included duration of surgery, length of hospital stay, and the Ankle Osteoarthritis Scale (AOS) pain and disability score.ResultsThere was one case of allergic contact dermatitis, three cases of wound dehiscence, and one case of superficial surgical site infection in the skin adhesive group. Among them, one case each with allergic contact dermatitis and wound dehiscence finally progressed to deep surgical site infection. Three cases of wound dehiscence were also reported in the suture group; however, there was no case of surgical site infection. Patient satisfaction for wound cosmesis was significantly higher in the skin adhesive group than in the suture group (p = 0.001). There was no statistically significant difference between the groups in terms of secondary outcomes (p > 0.05).ConclusionsAlthough the use of Dermabond Prineo showed better patient satisfaction for wound cosmesis, it showed significantly high wound complication rates and no other clinical benefits compared to interrupted polypropylene suture in TAA. Our results suggest that awareness of the possibility of wound complications is necessary when Dermabond Prineo is used in TAA.

A Double Histochemical/Immunohistochemical Staining for the Identification of Canine Mast Cells in Light Microscopy.

Immunohistochemistry (IHC) is a widely used technique in diagnostic pathology, but the simultaneous analysis of more than one antibody at a time with different chromogens is rather complex, time-consuming, and quite expensive. In order to facilitate the identification of mast cells (MCs) during immunohistochemical analysis of membrane and/or nuclear markers, we propose a new staining method that includes the association of IHC and toluidine blue as a counterstain. To achieve this goal, we tested c-kit, Ki67, and cannabinoid receptor 2 on several cases of cutaneous canine mast cell tumors (MCTs), cutaneous mastocytosis, and atopic dermatitis. The results obtained show how this double staining technique, although limited to non-cytoplasmic markers and of little use in poorly differentiated MCTs in which MC metachromasia is hard to see, can be used during the evaluation of nuclear and/or membranous immunohistochemical markers in all canine cutaneous disorders, especially if characterized by the presence of a low number of MCs. It can help to evaluate those MCTs in which neoplastic MCs must be clearly distinguished from inflammatory cells that can infiltrate the tumor itself, in facilitating the calculation of the Ki67 index. Moreover, it can be used to study the expression of new markers in both animal and human tissues containing MCs and in MC disorders.

The direct and indirect costs of adult atopic dermatitis.

BACKGROUND: Atopic dermatitis is considered a childhood illness, and the direct and indirect health care burden of atopic dermatitis in adults is not fully understood. OBJECTIVE: To measure the direct and indirect costs of atopic dermatitis among adults in 2018. METHODS: This retrospective cohort study compared commercial and Medicare-insured adults with atopic dermatitis in 2018 with directly matched (1:3) adults without atopic dermatitis. Atopic dermatitis prevalence was reported. Health care utilization, direct health care costs, and work loss data were compared between cohorts. This analysis was repeated for adults with atopic dermatitis in 2016 and 2017. RESULTS: 31,164 adults with atopic dermatitis in 2018 were identified and directly matched (1:3) to controls. Adults with atopic dermatitis had greater utilization of outpatient services, outpatient pharmacy services, and short-term disability benefits than controls. Unadjusted annual health care costs in 2018 were $4,979 higher for adults with atopic dermatitis ($14,603) than for the matched controls ($9,624), driven by outpatient services and pharmacy. Findings were supported by analyses of adults from 2016 and 2017 and multivariable analyses. One limitation of this study was that patients with mild cases of atopic dermatitis may not seek medical treatment and may be underrepresented in the study cohort. CONCLUSIONS: The direct health care and indirect (short-term disability) health care costs of atopic dermatitis present a significant health care burden among the adult population. DISCLOSURES: This study was funded by Eli Lilly and Company. Employees of Eli Lilly were involved in the planning, execution, and interpretation of the study. Pierce is employed by Eli Lilly and Company. Boytsov and Goldblum were employed by Eli Lilly and Company Health at the time this research was conducted. Manjelievskaia and Brouillette are employed by IBM Watson Health, which received funding from Eli Lilly and Company to conduct this study. Bonafede and Onyekwere were employed at IBM Watson Health at the time this research was conducted.

S2982 A Case of Eosinophilic Gastroenteritis and Eosinophilic Dermatitis in a Patient: Two Sides of the Same Coin?

S2982 A Case of Eosinophilic Gastroenteritis and Eosinophilic Dermatitis in a Patient: Two Sides of the Same Coin?

Dermatite fúngica por Scopulariopsis brevicaulis em Porquinho da Índia (Cavia porcellus)

Fungal dermatitis is classified into superficial, cutaneous and subcutaneous mycoses. However, the incidence of fungal dermatitis in small mammals is relatively low. Among rodents guinea pig the most affected specie, however it usually has an asymptomatic pattern. The present text reports an unusual case of fungal dermatitis in Caviaporcelluscaused by Scopulariopsis brevicaulis. The animal was received with complaint of alteration of coat around the neck, as well as report of incorrect feeding management. During the physical examination the presence of a dry and crusty dermatitis, negative on fluorescence test of wood. Samples of blood, skin, scabs and hair were collected for parasitic and mycological analysis. The hematological evaluation showed only a discrete eosinophilia; no ectoparasites were observed, but it was noticed the presence of Scopulariopsis brevicaulis. The animal underwent terbinafine and griseofulvin protocol, with total regression of the lesions after 30 days. S. brevicaulis is an unusual geophilic fungus causing animal mycosis, presenting more pathological reports in human mycoses, thus, representing a zoonotic potential. According to the clinical findings and results obtained from mycology assay, it was diagnosed dermatitis by Scopulariopsis brevicaulis, secondary to nutritional deficiency. The combined use of topical terbinafine with systemic griseofulvin was efficient in the treatment. Finally, it was recommended a dietary correction.

Patch testing results in skin of color: A retrospective review from the Massachusetts General Hospital contact dermatitis clinic

Patch testing results in skin of color: A retrospective review from the Massachusetts General Hospital contact dermatitis clinic

Dermatite de contact aux crevettes

Protein contact dermatitis is a cutaneous allergic reaction induced primarily by high molecular weight proteins of animal or plant origin. Clinically, it is characterized by chronic and recurrent dermatitis with erythema, scaling and fissuring with acute exacerbations occurring within minutes of contact with the offending allergen. We report a case of bullous shrimp contact dermatitis in a woman who had never handled shrimp with her hands.

The History of Surfactants and Review of Their Allergic and Irritant Properties.

Surfactants, many of which are used as detergents, can be found in many common household items, such as shampoos, conditioners, soaps, and cosmetics. One should recognize the multitude of surfactants that are used in today's products to identify any potential allergic contact dermatitis (ACD) or irritant contact dermatitis (ICD). Given their abundance in everyday products, it is understandable that many cases of occupational contact dermatitis that arise can be attributed to surfactants. The products most connected with ACD are cocamidopropyl betaine, oleamidopropyl dimethylamine, decyl glucoside, 3-dimethylaminopropylamine, amidoamine, and cocamide diethanolamine. Similarly, the most common surfactant-related causes of ICD are sodium lauryl sulfate and benzalkonium chloride. It is important for dermatologists to identify the causes and differentiate between the two, to adjust treatments and products accordingly. Here, the most frequently used surfactants, as well as their correlation between ACD and ICD, will be reviewed.

A Case of Acral Lick Dermatitis in a Dog with Multiple Lesions

A Case of Acral Lick Dermatitis in a Dog with Multiple Lesions