Case Of Conjunctival Lymphoma Research Articles

Epidemiological analysis of conjunctival lymphoma: a population‐based study, 2000–2016

PurposeTo study epidemiological trends of conjunctival lymphoma.MethodsA retrospective, population‐based analysis of patient data extracted from the Surveillance, Epidemiology, and End Results Registry US database was conducted from 2000 to 2016. Incidence (IR) was calculated in number of cases/million/year. Disease‐specific survival (DSS) was calculated using the Kaplan‐Meier method.Results978 cases of conjunctival lymphoma (CL) were identified, of whom 52% were females and 65% were white. The most common histological subtypes were mucosa‐associated lymphoid tissue (MALT; 70.9%) and follicular lymphoma (11.7%). Diffuse large B‐cell lymphoma constituted only 3.4% of cases. Overall IR of CL was 0.7. Annual percent change showed a significant decline (−1.4) in IR of CL during 2000–2016 (p = 0.02). There was no difference in IR between sexes (p = 0.34). IR in Asian/Pacific Islander patients (0.9) was significantly higher than that in white (0.6) and black (0.5) [p < 0.01] patients. Mean diagnostic age in years was 59.3 [Standard Deviation = 17.9]. IR in patients older than 65 years old (y/o) [2.36] was significantly higher than that in those 22–64 y/o (0.63; p < 0.01) and those younger than 21 y/o (0.06, p < 0.01). IR of unilateral cases (0.6) was significantly higher than that of bilateral ones (0.1) [p < 0.01] and there was no significant difference between left and right laterality (p = 0.72). 5‐year DSS during 2000–2012 was 97.4%. Race and sex did not affect survival. DSS was similar during 2010–2012 (98.5%) and 2000‐02 (94.1%) [p = 0.099].ConclusionsConjunctival lymphoma incidence is highest in the elderly and Asian/Pacific Islander populations and is not affected by sex. Incidence is decreasing over the timeframe 2000‐2016. Most common histology for CL is MALT. Overall 5‐year DSS for CL is 97.4%, and it is not affected by sex or race.BibliographySurveillance Research Program, National Cancer Institute SEER*Stat software (seer.cancer.gov/seerstat) version 8.3.6.

Lymphoma under disguise of conjunctivitis (clinical observations)

We present two clinical cases of conjunctival lymphoma, the disease which is classified as a malignant tumor of the eye. Conjunctival lymphoma has systemic involvement. Patients presented in our monitoring study received a conservative treatment for chronic conjunctivitis over a long period of time. The article considers the diagnostics and treatment plan of lymphoproliferative eye disease, which allows an increased effectiveness of treating.

Conjunctival extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in the fornix: do not overlook conjunctival lymphomas

BackgroundHere we report three cases of conjunctival lymphoma that were initially unnotified or misdiagnosed as other ocular diseases because of the small tumor size, peripheral tumor location (the tumor was hidden in the fornix), and nonspecific symptoms.MethodsThree patients diagnosed with conjunctivitis or nasolacrimal duct obstruction were referred to our clinic because they were unresponsive to standard medical treatments. Routine anterior segment examination did not reveal any lesions, but further careful examination with a strong eyelid draw revealed minimally elevated tumors in the peripheral fornix under the lid. Excisional biopsies were performed.ResultsHistopathologic and immunohistologic examinations indicated the presence of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). All patients underwent additional radiation therapy. There was no evidence of recurrence in any patient during the follow-up period.ConclusionDetection of conjunctival lymphoma can be challenging. If no apparent lesion is present and the patient has nonspecific symptoms, the inner surface of the eyelid should be carefully examined. Elaborate eyelid eversion, with eyeball movement, should be performed to avoid misdiagnosing or overlooking peripheral conjunctival lymphomas.

Unicentric extranodal lymphoma of the upper eyelid conjunctiva in a dog

A case of conjunctival lymphoma in a 4-year-old Siberian husky is reported. A large red mass protruding from the conjunctiva of the upper eyelid of the right eye was present. Irritation, blepharospasm and epiphora were revealed on initial ophthalmic examination. After anti-inflammatory treatment, surgery was performed. Histologically, the mass consisted of large polygonal cells with a high nucleus to cytoplasm ratio, moderate amounts of slightly eosinophilic cytoplasm, pleomorphic nuclei with vesicular chromatin and prominent multiple nucleoli. Mitotic figures were frequent. Approximately 70% of the neoplastic cells were CD3 positive and CD79alpha negative. On the basis of histologic and immunohistochemical findings, a diagnosis of intermediate-grade, diffuse large-cell lymphoma with T-cell immunophenotype was made. The surgical area healed uneventfully and, although chemotherapy was not received, after 12 months the dog exhibited no recurrence. To the authors' knowledge, this is the first report of unicentric extranodal conjunctival lymphoma in a dog.