Central nervous system (CNS) lymphoma is rare, representing 2% of all brain tumors. The commonest subtype is diffuse large B-cell lymphoma (DLBCL), with primary T-cell lymphomas (PCNSTL) accounting for ~2%. To determine the frequency and describe the key features of CNS lymphoma over a 10-year period in an Irish population. This retrospective review was carried out using the neuropathology database in Beaumont hospital, the largest of two national neurosurgical centers, to identify all cases of CNS lymphoma from 2007to2017. Clinical, radiological, morphological, immunophenotype, and molecular information was recorded where available. We identified 149 cases of CNS lymphoma from 2007to2017, which equated to a cumulative incidence rate of 0.4/100,000 persons. Median age at diagnosis was 66 years, and 46% were male. 86% were classified as DLBCL (n=128), 10% immunodeficiency-associated CNS lymphoma (n=15), 3% PCNSTL (n=4), and 1% (n=2) cases of intravascular large B-cell lymphoma. Location in declining frequency was as follows: supratentorial (n=125), infratentorial (n=22), spinal (n=1), and orbital (n=1). This is the first study in an Irish population to determine a cumulative incidence rate of CNS lymphoma, which is in line with larger international population-based registries. No significant trends in incidence rate have been observed from 2007 to 2017. DLBCL is the commonest subtype encountered. Rare variants including PCNSTL can pose a significant diagnostic challenge, and in this setting, molecular studies can be useful to confirm diagnoses.