AIDS Cases Research Articles

Analysis and prediction of infectious diseases based on spatial visualization and machine learning.

Infectious diseases are a global public health problem that poses a threat to human society. Since the 1970s, constantly mutated new infectious viruses have been quietly attacking humanity, and at least one new type of infectious disease is discovered every year. Therefore, early warning of infectious diseases will greatly reduce the socio-economic harm of infectious diseases. This study is based on the data of COVID-19 epidemic in China (except Macau and Taiwan Province) from 2020 to 2022. Firstly, we used ArcGIS software to analyze the spatial agglomeration pattern of the number of patients in various regions of China through global spatial autocorrelation analysis, local spatial autocorrelation analysis, center of gravity trajectory migration algorithm and other statistical tools; In addition, the areas with serious COVID-19 epidemic and requiring special attention were screened out. Then, autoregressive integrated moving average model (ARIMA), extreme learning machine (ELM), support vector regression (SVR), wavelet neural network (Wavelet), recurrent neural network (RNN) and long short-term memory (LSTM) were used to predict COVID-19 epidemic data in Guangdong Province, China; And the prediction performance of each model was compared through prediction accuracy indicators. Finally, a multi algorithm fusion learning model based on stacking technology is proposed to address the problem of poor generalization ability of single algorithm models in prediction; Furthermore, radial basis function network (RBF) was used as a two-level meta learner to fuse the above models, and particle swarm optimization (PSO) was used to optimize RBF parameters to reduce generalization error. The experimental results show that the performance of the integrated model is better than that of the single model in the COVID-19 dataset. In order to better apply the stacking model to the prediction of new infectious diseases, we applied the prediction model based on the COVID-19 dataset to the prediction of the number of AIDS and pulmonary tuberculosis (PTB) cases, and verified the wide applicability of our model in the prediction of infectious diseases.

Allir geta smitast af HIV en enginn ætti að fá alnæmi · Tvö tilfelli alnæmis hjá íslenskum konum ·

HIV can have various clinical manifestations and without treatment it can progress to AIDS and have severe complications. We have effective treatments against the infection and want to treat everyone with HIV before it progresses to AIDS. The premise for that is HIV testing. HIV infection should be on the differential when patients present with signs and symptoms not otherwise explained. We describe here two recent cases of AIDS in Icelandic women that did not have perceived risk factors resulting in a significant delay in HIV diagnosis leading to AIDS

Exploring Phytochemical Compounds: A Computational Study for HIV-1 Reverse Transcriptase Inhibition

Background: HIV-1 is the most virulent type, causing most AIDS cases worldwide. Therapeutics like NRTIs and NNRTIs terminate replication by terminating polymerization reactions. Natural-based therapeutics are increasingly being used to reduce side effects and combat disease. Method: The study focuses on identifying phytochemical compounds that effectively inhibit the HIV-1 reverse transcriptase process using molecular docking and molecular dynamic simulations. Result: Molecular docking results show anisomelolide has a significantly stronger binding affinity (-29.9992KJ/mol) compared to nevirapine (-13.34696 KJ/mol), forming more hydrogen bonds and hydrophilic interactions, indicating a more stable and specific binding. MD simulations further support these findings, with anisomelolide exhibiting lower RMSD and RMSF values, suggesting greater structural stability and lower flexibility. Interaction energy analysis reveals robust binding and stability for anisomelolide over time. Additionally, hydrogen bond analysis indicates more frequent and stronger interactions for anisomelolide. Conclusion: The phytochemical compound anisomelolide exhibits superior binding affinity, structural stability, and interaction dynamics, making it a promising candidate for drug development against HIV-1 RT.

Disparities in HIV incidence and mortality rates between Japanese nationals and international migrants before and during the COVID-19 pandemic: evidence from Japan’s national HIV surveillance data (2018–2021)

ABSTRACT Migrants often encounter heightened health risks during crises. We analysed the disparities in the burden of HIV between Japanese nationals and international migrants in Japan by comparing new HIV infections, AIDS cases, and HIV-related deaths between 2018–2019 (pre-COVID-19) and 2020–2021 (during the COVID-19 pandemic). Between 2018 and 2021, 4,705 new HIV infections were reported in Japan (2,813 Japanese nationals and 522 international migrants). Additionally, 1,370 AIDS cases (1,188 Japanese nationals, 182 international migrants) were recorded, representing 29.1% of the total. Comparative analysis of HIV incidence and mortality rates between Japanese nationals and international migrants indicates elevated disparities: During the COVID-19 pandemic, the HIV incidence rate among Japanese nationals decreased from 1.8 to 1.5 cases/100,000 people, while the rate among international migrants remained high at 12.8 cases/100,000 people. The AIDS incidence also increased for international migrants from 2.8 to 3.8 per 100,000 people, while Japanese nationals maintained a low at 0.5 per 100,000 people. International migrants living with HIV experienced a significantly younger age at death due to HIV-related illness (coefficient = −11.7, p < .01). The COVID-19 pandemic may have exacerbated the disparities with more international migrants living with HIV being diagnosed late and with less precise reporting. Investment in more equitable HIV care is warranted.

The Development and the Assessment of Sampling Methods for Hard-to-Reach Populations in HIV Surveillance.

Due to stigma or legal issues, populations with higher HIV risk are often hard to reach, which impedes accurate population estimation of HIV burden. To better sample hard-to-reach populations (HTRPs) for HIV surveillance, various sampling methods have been designed and/or used since HIV epidemic following the first reported AIDS cases in 1981. This paper describes the development and the assessment (i.e., validity and reproducibility) of approximately eight sampling methods (e.g., convenience sampling, snowball sampling, time location sampling, and respondent-driven sampling) for HTRPs in HIV surveillance, with a focus on respondent-driven sampling (RDS). Compared to other methods, RDS has been greatly assessed. However, current evidence is still inadequate for RDS to be considered the best option for sampling HTRPs. The field must continue to assess RDS and to develop new sampling approaches or modifications to existing approaches.

Human Immunodeficiency Virus / Acquired Immunodeficiency Syndrome Prevention Behavior among Men Who Have Sex with Men (MSM) in the Gender Sexuality Group Community

Between January-August 2019, Central Sulawesi Province recorded 235 HIV and 94 AIDS cases. Data from the Gender Sexuality Group indicates that their community houses 28 MSM, 18 of whom are living with HIV/AIDS. This research seeks to understand HIV/AIDS prevention behaviors among MSM at the Gender Sexuality Group Community in Palu City. A qualitative case study approach was employed, with data collection through triangulation techniques including in-depth interviews, observation, and documentation using interview guides. Results show that MSM within the Gender Sexuality Group community demonstrate good knowledge of HIV/AIDS prevention. However, four out of seven informants still engage in risky behaviors. To address this, community and healthcare workers need to provide better infrastructure for HIV/AIDS prevention and treatment, especially for MSM living with HIV. Collaborative support from healthcare workers and the community is crucial in strengthening and assisting MSM. It's recommended that the Gender Sexuality Group community continues to conduct Communication, Information, and Education (CIE) activities to enhance MSM knowledge, particularly about HIV transmission and prevention. All MSM should undergo HIV testing at least twice a year. The community could organize seminars featuring disguised MSM PLWHA (People Living with HIV/AIDS) from outside the city as resource persons to increase awareness about HIV/AIDS within the key community

HIV infections and AIDS cases in Poland in 2021 year.

Despite a temporary decrease in the number of newly HIV infections in Poland in 2020, a return to the growing number of new infections was observed in 2021 in the surveillance. The aim of the study was to assess the epidemiological situation of newly HIV infections and AIDS cases and death among AIDS cases in Poland in 2021 in comparison to the changes in preceding years. Analysis of the epidemiological situation was based on reports of newly detected HIV cases and AIDS cases received from doctors and laboratories and the results of the annual survey of HIV testing conducted by laboratories throughout the country. A dataset on clients from Voluntary Testing and Counselling, coordinated by the National AIDS Center, which anonymously collects epidemiological and behaviour data on tested people was used. In 2021 there were 1 367 HIV cases newly diagnosed in Poland (diagnosis rate 3.58 per 100,000), including 236 among non-Polish citizens. The number of HIV infections increased by 43.3% compared to the previous year and was higher by 3.8% compared to the median in 2015-2019 years. Similarly, among VCT clients, number of HIV increased by 45%, from 309 in 2020 to 448 in 2021 year. The total number of AIDS cases reported to surveillance was 62 (incidence 0.16 per 100,000). The HIV infection was most often detected in the age group 30-39 year (35.8%) and among men (82.1%). Among cases with known transmission route, 68.7% concerned among MSM. The percentage of AIDS cases diagnosed at the same time with HIV increased by more than 30 percent points (from 63.5% to 95.1% of all AIDS cases). In 2021 the number of newly detected HIV infections increased compared to the previous year, probably due to a reduction in restrictions related to the COVID-19 pandemic and increased in HIV testing rate.

Growing ill: Spanish childhood, HIV and the echoes of a pandemic

ABSTRACT This article focuses on the Spanish films La niña de tus sueños (Jesús R. Delgado, 1995), Cachorro (Miguel Albaladejo, 2004) and Estiu 1993 (Carla Simon, 2017), which revolve around characters with HIV/AIDS. In these films, innocence and youth are often highlighted through children and adolescents who live with and next to HIV. Such a move serves to legitimize these cases of HIV and AIDS, which are marked as exceptional cases through their innocence and thus escape the feedback loop of disease and impending death that categorizes popular thinking on the illness. By highlighting these representations of children and HIV/AIDS, this article argues that the coupling of guilt, innocence and illness allows audiences and a larger public in Spain to inhabit a sanitized version of history and ignore the messy complexities of living through and with the HIV/AIDS pandemic.

Rehabilitation of Drug Users in Makassar City

The spread and abuse of narcotics is a complex problem, which requires comprehensive mitigation efforts involving multidisciplinary, multisectoral cooperation and active community participation carried out continuously, consistently and consistently. Even though in medical science, most classes of narcotics are still useful for treatment, if they are misused or used not according to medical indications or treatment standards, especially if accompanied by illegal distribution, it will have very detrimental consequences for individuals and society at large. The cumulative number of AIDs cases in Indonesia in the second quarter of 2010 was 21,770 cases. The spread of HIV/AIDS among Injection Drug Use/IDUs has reached 8,795 cases. Methadone substitution therapy needs to be carried out with the aim of reducing adverse health, social and economic impacts, reducing the risk of contracting and transmitting HIV to other people, however therapy failure often occurs due to non-compliance or poor adherence. The research is observational with a cross sectional approach. Data were collected using questionnaires through interviews with informants following the therapy program. The results of the study showed good compliance in following therapy. Factors related to compliance in therapy are knowledge, attitudes, motivation, self-efficacy, family role, peer role, and health worker role. Multivariate analysis of multiple Logistic Regression, the most influential factors are motivation and the role of peers.

Effect of Combined HAART Plus ATT in Patients of Extrapulmonary Tuberculosis in HIV Patients and Effect on Quality of Life.

HIV is a disease which reduces human resistant to fight. When our immunity becomes so weak that we are not able to fight even the common commensals of our body, this leads to what is called as an opportunistic infection. Tuberculosis is one of those most common type of opportunistic infection and in this pulmonary tuberculosis is more common. Extrapulmonary tuberculosis with HIV is the area of lesser research. In this study we tried to prove the Prevalence of extrapulmonary tuberculosis in AIDS patients and also the effect of combined HAART and ATT on prevalence of extrapulmonary tuberculosis and also its effect on Quality of life of the patient. This is a retrospective study conducted in a tertiary centre in the Department of Otorhinolaryngology & head and neck surgery from January 2020 to December 2020. A total of 80 patients were studied for 1year. Confirmed cases of AIDS with extra pulmonary tuberculosis in head and neck region were studied, keeping all ethical issues in mind and after complete treatment of ATT along with HAART. After treatment, a significant number of patients got resolved with EPTB and gave positive response on their quality of life. Not only pulmonary tuberculosis, extrapulmonary tuberculosis with HIV is on the rise nowadays. Combined treatment of both can help in decreasing prevalence of extrapulmonary tuberculosis and improves quality of life.

Can ferritin be a surrogate marker for CD4 cells in human immunodeficiency virus patients? A cross-sectional study of association of serum ferritin levels with immunological staging of human immunodeficiency virus patients.

The human immunodeficiency virus (HIV)/AIDS in India came into public view in 1986 with the detection of the first case of HIV in Chennai, Tamil Nadu, and the first AIDS case in Mumbai, Maharashtra in 1987. In acute phase response, iron distribution occurs in the liver and mononuclear phagocytic system. A high prevalence of elevated serum ferritin levels is reported in HIV infection and serum ferritin levels increase with the clinical worsening of infection and with decreasing CD4 lymphocyte counts. This study is designed to find the role of acute phase reactant serum ferritin in the progression of the disease of HIV which is complicated by opportunistic infections, by finding the correlation of serum ferritin with immunological stages of HIV. This cross-sectional study was conducted on 75 patients admitted to various wards of the Department of Medicine or attending medicine outdoor or ART Centre, Maharana Bhupal Government Hospital, RNT Medical College Udaipur. Serum ferritin, total iron binding capacity, and total serum iron were analyzed in Cobas® analyzer. CD4 cells are measured using the flow cytometry technique. The results were tabulated and subjected to statistical analysis. There was a negative correlation among serum ferritin and CD4 cells with r = -0.195 which was statistically significant (P < 0.05). As the CD4 cell count decreased incidence of serum ferritin increased. Elevation of serum ferritin levels is associated with a low count of the CD4+ in HIV-diagnosed patients. In a patient diagnosed with HIV, elevated serum ferritin indicates underlying inflammatory pathology. Serum ferritin can be used as a guide to further evaluation of underlying disease in HIV patients.

Impact of HIV-1 genetic diversity on disease progression: a prospective cohort study in Guangxi.

The high proportion of AIDS cases and mortality rates in Guangxi underscores the urgency to investigate the influence of HIV-1 genetic diversity on disease progression in this region. Newly diagnosed HIV-1 patients were enrolled from January 2016 to December 2021, and the follow-up work and detection of CD4+T lymphocytes were carried out every six months until December 2022. Multivariate logistic regression was used to analyze the factors affecting pre-treatment CD4+T lymphocyte counts, while local weighted regression models (LOESS) and generalized estimating equation models (GEE) were conducted to assess factors influencing CD4+T Lymphocyte Recovery. Cox regression analysis was utilized to examine the impact of subtypes on survival risk. Additionally, HIV-1 env sequences were utilized for predicting CXCR4 and CCR5 receptors. The study encompassed 1867 individuals with pol sequences and 281 with env sequences. Our findings indicate that age over 30, divorced/widowed, peasant, heterosexual infection, CRF01_AE, long-term infection, and Pre-treatment Viral load >10000 copies/ml were factors associated with higher risk for pre-treatment CD4+T lymphocyte decline. Specifically, male gender, age over 30, heterosexual infection (HETs), long-term infection, CRF01_AE, and Pre-treatment CD4 T cell counts below 350/µL were identified as risk factors impeding CD4+T lymphocyte recovery. Pre-treatment CD4+T lymphocyte counts and recovery in individuals infected with CRF01_AE were lower compared to CRF07_BC and CRF55_01B. Additionally, CRF01_AE and CRF08_BC subtypes exhibited higher mortality rates than CRF07_BC, CRF55_01B, and other subtypes. Notably, CRF01_AE demonstrated the highest percentage of CXCR4 affinity ratios. This research unveils the intricate influence of HIV-1 gene diversity on CD4+T lymphocyte dynamics and clinical outcomes. It highlights the multifaceted nature of HIV infection in Guangxi, providing novel insights into subtype-specific disease progression among HIV-infected individuals in this region.

Evaluation of Quality of Prevention of Mother to Child Transmission of HIV Service Provision and Its Determinants: The Case of Health Facility Readiness and Mothers' Perspectives.

Prevention of Mother-To-Child Transmission of HIV (PMTCT) is a comprehensive intervention aimed at reducing vertical transmission. More than 90% of pediatric AIDS cases are caused by MTCT. However, the quality of care has lagged in terms of service integration, client satisfaction, and facility readiness, although improvements have been observed. Evidence on the quality of PMTCT services is required by clinicians, and policymakers. Therefore, this study aimed to evaluate the effectiveness of PMTCT services provided by public health facilities in Northwest Ethiopia. This cross-sectional study was conducted at nine public health facilities in Gondar city between June 1 and July 17, 2022. A total of 334 mothers were participated. The Structure-Process-Outcome components were used to evaluate service quality. About 135 counseling sessions were observed. The SPSS 26 software was used for statistical analyses. To identify mothers' satisfaction with the service, P-values < 0.25, and < 0.05 were considered in the binary and multiple logistic regression analyses to identify significant variables, respectively. The overall performance of the health facilities was 74.09% (72.19-76.01 CI 95%). In 88.89% of cases, the output quality was higher and rated as good. However, the quality of the input and process services was 60.40% and 72.97%, respectively. Women's satisfaction was 67.09%. Women aged 15-24 years (AOR= 0.31; 95% CI:0.06, 0.79), formally educated (AOR=0.59; 95% CI:0.35, 0.67), > one hour of arrival (AOR=0.71; 95% CI:0.55, 0.93), > 30 minutes waiting time (AOR=0.23; 95% CI:0.11, 0.37), sufficient time for counseling (AOR=2.83; 95% CI:1.72, 3.97), and opening hours (AOR=4.27; 95% CI:2.09, 6.67) were factors associated with satisfaction in women. The quality of PMTCT service provision and mothers' satisfaction were low. Reducing waiting time, punctuality of service providers, adequate counselling, and availability of basic resources can boost mothers' satisfaction.

Role of Ninik Mamak in the Prevention and Control of HIV/AIDS in Minangkabau

Background: West Sumatra is ranked 19th regarding the highest number of HIV cases with 541 HIV cases and 258 AIDS cases. Meanwhile in the city of Padang the HIV incidence rate in 2019 was 287 cases. Objective: Is there a relationship between the role of Ninik Mamak and HIV/AIDS risk behavior? Results: As many as 59.61% of respondents behaved at risk of HIV/AIDS and as many as 51.92% of respondents stated that Ninik Mamak played a role in controlling HIV/AIDS. There is a relationship between the role of Ninik Mamak and HIV/AIDS risk behavior (P-value = 0.002). Conclusion: There is a relationship between the role of Ninik Mamak and HIV/AIDS risk behavior.

Sex, Age, and Risk Group Variations among Individuals Infected with HIV, HTLV-1, and HTLV-2: Review of Data Records (1983–2017) from a Public Health Laboratory in São Paulo, Brazil

The inaugural AIDS Program in Brazil was established in São Paulo in 1983, with the Instituto Adolfo Lutz appointed for laboratory assistance. Subsequently, research on HIV infections and HIV/HTLV (HIV/HTLV-1 and HIV/HTLV-2) co-infections was conducted. This narrative review focuses on studies from the Immunology Department (1983–2017) that significantly influenced AIDS diagnosis or provided epidemiological data such as prevalence rates, sex, age, and risk factors. Twelve studies, encompassing over 8000 individuals, are discussed. During 1983–1985, nearly all AIDS cases were attributed to homosexual/bisexual men aged 31 years old. Subsequently, heterosexual men and women emerged as risk groups owing to intravenous drug use (IDU) and/or unprotected sexual intercourse with AIDS patients or multiple partners per year. From 1985 onwards, vertical transmission led to child infections. HIV/HTLV co-infection rates decreased over time, initially associated with male IDU, and in the 2010s with female IDU, and individuals aged &gt;40 years. Trends in HIV and HIV/HTLV co-infections among younger men and women (&lt;30 years of age) were observed from 2015 to 2017. The changing characteristics and risk groups for HIV and HIV/HTLV co-infections over the years underscore the necessity for ongoing public policies to prevent retrovirus transmission, particularly among adolescents and young adults.

A Study to assess the knowledge regarding HIV-AIDS among the students studying in the selected senior colleges in Gokhale Education Society, Nashik

Background: AIDS emerged as one of the most important public health issue of the late twentieth and early –first centuries and is now one of the leading cause of global morbidity and mortality. In India, 35% of all reported AIDS cases are among the age group of 15-24 years, indicating the vulnerability of the younger population to the epidemic. Many Adolescents around the world are sexually active and many sexual contacts among them are unprotected, they are at risk of contracting sexually transmitted diseases (STDs) including HIV/AIDS. Objectives: 1. To assess the knowledge of the senior college students regarding Meaning of HIV - AIDS, Incidence of HIV-AIDS, Ways of transmission of HIV –AIDS, Common signs of HIV –AIDS and Common investigations to detect HIV-AIDS 2. To assess the knowledge of the senior college students regarding control and preventive measures of HIV – AIDS (at the individual level, family level and community level) 3. To find out the relationship between the knowledge with the selected demographic variables. Material and Method: descriptive survey approach to assess the knowledge regarding HIV-AIDS among the student studied in the selected senior colleges in Gokhale Education Society, Nashik. Data were collected from 100 students, the structured questionnaire is used to collect data on 27th January 2017. Results: In the present study, 93% of the samples had knowledge about meaning of HIV. Near about 50% of the samples had knowledge about way of transmission, common signs and investigation of HIV-AIDS. More than 50%of the samples had knowledge about when the world AIDS day is celebrated. There was positive correlation found between source of information of the samples and average knowledge score of the samples

Abstract B130: Social determinants associated with HPV disparities among people with HIV infection in Puerto Rico

Abstract Background: People with HIV (PWH) have a higher risk of acquiring oral HPV infection when compared to people without HIV, which can lead to the high prevalence of oropharyngeal cancers in PWH. Puerto Rico (PR), a US jurisdiction, is on the top 10 in terms of HIV prevalence and cumulative AIDS cases among the US and have a significant burden and disparity of HPV-related malignancies. Additionally, PR has socio-economic disadvantages, which is a social determinant of oral health disparities, and can potentially affect oral HPV. The relationship of these social determinants with HPV have not been investigated in PWH in PR. Hence, in this study, we evaluated the relationship between socio-economic, behavioral, and oral health factors with oral HPV among PWH. Methods: We evaluated 117 sexually active PWH (102 males and 15 females) from a community clinic in San Juan, PR. Oral rinse samples were collected and analyzed for HPV infection and genotype using the DNA ELISA kit HPV SPF10 and RHA kit HPV SPF10-LiPA25. We collected sociodemographic characteristics (age, marital status, employment, income) as well as lifestyle variables (smoking habits, alcohol consumption, sexual practices) through an administered questionnaire. Participants also underwent a clinical full-mouth periodontal assessment following the CDC/AAP guidelines. Statistical analyses in relation to HPV were performed in R statistical software. Findings: There was a prevalence of oral HPV infection of 29.9% in PWH in PR, which 70% were high-risk genotypes, with HPV-18 being the most abundant genotype (27.5%). There were 33.3% of males who had oral HPV while only 20% of females had oral HPV. Also, oral HPV infection was significantly associated with periodontitis (p&amp;lt;0.05). In men, oral HPV positivity trended to be frequent with no HPV vaccination (p=0.08). No HPV vaccination was associated with lower income (p&amp;lt;0.05). There was no association between HPV status and sociodemographic and lifestyle variables. Interpretation: The prevalence in high-risk HPV genotypes among PWH was higher than what has previously been observed in PR. We also found a higher prevalence of HPV-18, which may explain clinical disparities concerning oropharyngeal cancer in PR’s population. Additionally, our findings highlight the importance of access to medical care in low-resource settings. Low income can be a surrogate of lack of access of care, which can impact early diagnosis, risk, and prevention of oral HPV. Therefore, targeting social determinants, may help lower the risk of infection and oral cancer in underserved populations. While our findings contribute to understanding the impact of social determinants in oral cancer, more studies are still needed that investigate the relationship between other sociodemographic factors that affect oral health in PWH. Citation Format: Carlos A. Solá-Morlá, Yabdiel Ramos-Valerio, Coral Martes-Villalobos, María M. Sánchez-Vázquez, Ramón F. Gonzalez-García, Ana P. Ortiz, Magaly Martinez-Ferrer, Josué Pérez-Santiago. Social determinants associated with HPV disparities among people with HIV infection in Puerto Rico [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr B130.

Knowledge and attitudes towards Behavior of HIV/AIDS Patients Management among dental students: Observational Study

In 1981, AIDS was first recognized in the United States. Every year, AIDS cases always increase. The incidence of cross-infection cases in dentists reaches 36% when managing HIV/AIDS patients. Having good knowledge and attitudes can lead to good behavior towards the management of HIV/AIDS patients. The formation of knowledge, attitudes, and good behavior will increase over time, along with the experience of a dentist. This research aims to determine the relationship between the knowledge and attitudes of dental students at RSGM UMY and the management behavior of HIV/AIDS patients. This research is an analytical observation with a cross-sectional approach that used a questionnaire instrument. The respondents of this research were 75 dental students. This research questionnaire includes knowledge, attitudes, and behavior about HIV/AIDS towards the management of HIV/AIDS patients. Data analysis used Chi-square analysis. The results of the descriptive analysis showed that 93.3% of dental students had high knowledge and positive attitudes, and 6.7% had moderate knowledge and were neutral towards HIV/AIDS patients. 77.3% of dental students fell into the good behavior category, 12% in the moderate behavior category, and 10.7% in the bad behavior category. The results of statistical tests using Chi-square obtained p value = 0.456 ( 0.05), indicating no significant relationship between research variables. Based on the results of the research, there was no significant relationship between the knowledge, behavior, and attitudes of dental students at RSGM UMY and the management behavior of HIV/AIDS patients.

Predictors of short-term mortality in HIV-infected patients admitted to Intensive Care Unit

Introduction: Historically, complications of HIV infection have been related to admissions to the Intensive Care Unit (ICU). Despite therapeutic advances, the results of the analysis of prognostic factors in patients with HIV/AIDS have varied, including late diagnosis and failure to adhere to antiretroviral treatment. Objective: To evaluate the predictors of short-term mortality in HIV-infected patients admitted to the ICU, as well as their sociodemographic and clinical characteristics. Methods: A retrospective cohort study including patients admitted to the ICU of a teaching hospital from 2003 through 2012. Data were collected from medical records after the Institutional Review Board approval. Results: 148 HIV-infected patients were identified and 131 were eligible. Among included patients, 42.75% were HIV new diagnoses and 5.34% had no information about the time of diagnosis. The main reasons for admission to the ICU were respiratory failure and sepsis while mortality was 70.23% between 2003 and 2012. Among the risk factors for mortality were low albumin, high APACHE, low CD4+ T lymphocyte count, and not using antiretroviral therapy. Conclusion: Despite the availability of diagnosis and treatment for HIV-infected individuals, the number of new cases of advanced Aids diagnosed in high-complexity services such as ICU is high, as well as the non-use of combination antiretroviral therapy. It is necessary to strengthen anti-HIV screening to detect and treat more cases in the early stages.

The Distribution and Associated Factors of HIV/AIDS Among Youths in Guangxi, China, From 2014 to 2021: Bayesian Spatiotemporal Analysis.

In recent years, the number of HIV/AIDS cases among youth has increased year by year around the world. A spatial and temporal analysis of these AIDS cases is necessary for the development of youth AIDS prevention and control policies. This study aimed to analyze the spatial and temporal distribution and associated factors of HIV/AIDS among youth in Guangxi as an example. The reported HIV/AIDS cases of youths aged 15-24 years in Guangxi from January 2014 to December 2021 were extracted from the Chinese Comprehensive Response Information Management System of HIV/AIDS. Data on population, economy, and health resources were obtained from the Guangxi Statistical Yearbook. The ArcGIS (version 10.8; ESRI Inc) software was used to describe the spatial distribution of AIDS incidence among youths in Guangxi. A Bayesian spatiotemporal model was used to analyze the distribution and associated factors of HIV/AIDS, such as gross domestic product per capita, population density, number of health technicians, and road mileage per unit area. From 2014 to 2021, a total of 4638 cases of HIV/AIDS infection among youths were reported in Guangxi. The reported incidence of HIV/AIDS cases among youths in Guangxi increased from 9.13/100,000 in 2014 to 11.15/100,000 in 2019 and then plummeted to a low of 8.37/100,000 in 2020, followed by a small increase to 9.66/100,000 in 2021. The districts (counties) with relatively high HIV/AIDS prevalence among youths were Xixiangtang, Xingning, Qingxiu, Chengzhong, and Diecai. The reported incidence of HIV/AIDS among youths was negatively significantly associated with road mileage per unit area (km) at a posterior mean of -0.510 (95% CI -0.818 to 0.209). It was positively associated with population density (100 persons) at a posterior mean of 0.025 (95% CI 0.012-0.038), with the number of health technicians (100 persons) having a posterior mean of 0.007 (95% CI 0.004-0.009). In Guangxi, current HIV and AIDS prevention and control among young people should focus on areas with a high risk of disease. It is suggested to strengthen the allocation of AIDS health resources and balance urban development and AIDS prevention. In addition, AIDS awareness, detection, and intervention among Guangxi youths need to be strengthened.