INTRODUCTION: Ascites is a major complication of cirrhosis with 50% mortality in 2 years. Spontaneous bacterial peritonitis (SBP) is an infection of ascitic fluid in the absence of an intra-abdominal surgically-treatable source. SBP is almost always monomicrobial and growth of more than 1 organism should raise suspicion for secondary bacterial peritonitis. We report a case of large intraabdominal abscess that was misdiagnosed and treated as SBP for several wks before the correct diagnosis was made. CASE DESCRIPTION/METHODS: A 56-year-old man with alcoholic cirrhosis presented with abdominal distention 6 months previously. Initial diagnostic tap yielded 36 PMNs/mm3 with negative culture. Ascites responded to medical management, but recurred 4 months later. Ascitic fluid on 2nd tap had 2648/mm3 PMNs with negative cultures. 11 days later, an ultrasound showed loculated ascites. A 3rd tap yielded fluid with 28,292 PMNs/mm3, cultures grew Klebsiella oxytoca and Streptococcus salivarius. IV cefotaxime was given for SBP. The 4th tap 3 days had >3 billion nucleated/mm3 (90% PMNs); cultures grew same organisms. He improved and was discharged on cefixime for 5 days, followed by trimethoprim/sulfamethoxazole for SBP prophylaxis. 2 weeks later, ascitic fluid on a fifth tap had nearly a million nucleated cells/mm3; cultures grew Streptococcus anginosus. Patient came to us 4 weeks later with abdominal distention and pain, had a mass-like firmness of the abdomen. Labs showed normal WBC count and liver enzymes. CT abdomen pelvis (Figure 1 A-B) showed intra-peritoneal fluid collection measuring 22 × 13 × 7.2 cm, with small ascites. Paracentesis yielded 5.6 L fluid growing Streptococcus anginosus and Lactobacillus fermentum. Patient underwent abdominal drain, was discharged on IV antibiotics. A repeat CT abdomen pelvis (Figure 2A–B) 4 weeks later showed near-complete resolution of abscess, was switched to oral amoxicillin for 3 weeks. He did well, with no recurrence of ascites. DISCUSSION: Ascitic fluid analysis can provide clues that differentiate SBP from secondary bacterial peritonitis. The cause of the abscess in this case is not clear, but the very high PMN counts and multiple organisms cultured from the ascites should have raised concern for secondary bacterial peritonitis. Because of failure to recognize these clues, definitive treatment was delayed. Not all cases of neutrophilic ascites in cirrhosis represent SBP.Figure 1.: A-B: CT abdomen pelvis cross sectional and coronal view showing a rim-enhancing fluid collection in the anterior peritoneal cavity measuring 22 × 13 × 7.2 cm, with small volume ascites and cirrhotic liver.Figure 2.: A-B: CT abdomen pelvis cross sectional and coronal view 4 weeks later showing near-complete resolution of the abscess with a small amount of air visible along the track of the drain catheter (solid white arrows).
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