Cases In Moderate Group Research Articles

Analysis on the MRI and BAEP Results of Neonatal Brain With Different Levels of Bilirubin.

BackgroundTo explore whether there is abnormality of neonatal brains' MRI and BAEP with different bilirubin levels, and to provide an objective basis for early diagnosis on the bilirubin induced subclinical damage on brains.MethodsTo retrospectively analyze the clinical data of 103 neonatal patients, to conduct routine brain MRI examination and BAEP testing, and to analyze BAEP and MRI image results of the neonatal patients, who were divided into three groups based on the levels of total serum bilirubin concentration (TSB): 16 cases in mild group (TSB: 0.0–229.0 ěmol/L), 49 cases in moderate group (TSB: 229.0–342.0 ěmol/L), and 38 cases in severe group (TSB ≥ 342.0 ěmol/L).ResultsWe found the following: A. Comparison of the bilirubin value of the different group: The bilirubin value of the mild group is 171.99 ± 33.50 ěmol/L, the moderate group is 293.98 ± 32.09 ěmol/L, and the severe group is 375.59 ± 34.25 ěmol/L. The comparison of bilirubin values of the three groups of neonates (p < 0.01) indicates the difference is statistically significant (p < 0.01). B. The weight value of the <2,500 g group is 2.04 ± 0.21 and the ≥2,500 g group is 3.39 ± 0.46; the weight comparison of the two groups indicates that the difference is statistically significant (p < 0.01). C. Comparison of the abnormal MRI of the different groups: The brain MRI result's abnormal ratio of the mild group is 31.25%, the moderate group is 16.33%, and the severe group is 21.05%, but the comparison of brain MRI results of the three neonates groups indicates that the difference is not statistically significant (p > 0.05). D. Comparison of abnormal MRI signal values of globus pallidus on T1WI in different groups: 1. The comparison of normal group signal values with that of mild group (p < 0.05), with that of moderate group, and with that of severe group (p < 0.01) indicates that the difference is statistically significant.ConclusionAt low level of bilirubin, central nervous system damage may also occur and can be detected as abnormality by MRI and BAEP. Meanwhile, MRI and BAEP can also provide early abnormal information for the judgment of central nervous system damage of the children with NHB who have no acute bilirubin encephalopathy (ABE) clinical features, and provide clues for early treatment and early intervention.

The expressions of miR-26a and TLR in peripheral blood mononuclear cells of patients with psoriasis vulgaris and their relationships with disease activity

Objective To investigate the expressions of micro RNA-26a (miR-26a) and toll-like receptor (TLR) in peripheral blood mononuclear cells (PBMCs) of patients with psoriasis vulgaris (PV), and to analyze their relationships with disease activity. Methods Total 200 PV patients treated in our hospital from June 2016 to June 2018 were selected as the study group. According to Psoriasis Area and Severity Index (PASI) score, the PV patients were divided into 71 cases in mild group, 84 cases in moderate group, 45 cases in severe group, at the same time, 100 healthy people in the physical examination center were selected as the control group. The mRNA levels of TLR2 and TLR4 in PBMCs were detected by fluorescence quantitative polymerase chain reaction (PCR); serum C-reactive protein (CRP) level was detected by immunoturbidimetry; Pearson correlation was used to analyze the relationships between the expressions of miR-26a, TLR2 and TLR4 with the activity of PV (PASI score and CRP level). Results There was no significant difference in sex, age, body mass index (BMI) and course of disease among PV patients of different grades in the study group (P>0.05); the mRNA expression levels of miR-26a, TLR2 and TLR4 in PBMCs of the study group were significantly higher than those of the control group (P<0.05); the PASI score, serum CRP level, miR-26a, TLR2 and TLR4 mRNA expression levels in severe PV group were significantly higher than those in mild group and moderate group (P<0.05), and the above indexe in the moderate group were significantly higher than those in mild group (P<0.05); the PASI score and serum CRP level of PV patients were positively correlated with miR-26a, TLR2 and TLR4 mRNA expression levels (P<0.01). Conclusions The mRNA expression levels of miR-26a, TLR2 and TLR4 in PBMCs of PV patients are increased and positively correlated with PASI score and CRP level, which can reflect the activity of PV disease. Key words: Psoriasis; Peripheral blood mononuclear cells; miR-26a; Toll-like receptors

Clinical outcomes of 241 cases with fetal ventriculomegaly

Objective To evaluate the pregnancy outcomes and prognosis of fetuses with different levels of ventriculomegaly. Methods Fetuses with ventriculomegaly subjected to the multidisciplinary consultation in the Obstetrics and Gynecology Hospital of Fudan University between January 2004 and December 2013 were included in this study. The fetuses were divided into three groups according to the width of the lateral ventricles on ultrasound examination as follows: mild ventriculomegaly (Mild Group, ≥10 - <12 mm, 151 cases), moderate ventriculomegaly (Moderate Group, ≥12 - <15 mm, 56 cases) and severe ventriculomegaly (Severe Group, ≥15 mm, 34 cases). All cases were followed up with additional ultrasound scans during pregnancy and follow-up was continued until the children were almost nine years old. Chi-square test, Fisher's exact test and Bonferroni method were used to analyze the data. Results Two hundred and forty one fetuses were followed up. Ninety-one cases were terminated, and 150 were born (105 cases in Mild Group, 30 cases in Moderate Group, and 15 cases in Severe Group). During ultrasound follow-up of the 150 cases, the lateral ventricle width regressed in 42 cases (28.0%) and remained stable in 108 cases (72.0%). In the regressed group, the ventricle width in 31 cases in the Mild Group regressed to normal and a hearing abnormality was noted in one case after birth. In the Moderate Group, the lateral ventricle width in nine cases regressed to normal, one case had mild ventriculomegaly, and none of these cases showed abnormalities after birth. One case in the Severe Group showed no abnormalities, while the width of the lateral ventricles decreased to 14.0 and 16.0 mm. With regard to the outcomes of lateral ventricle width with or without regression, one of 42 cases in the regressed group had a significant abnormality, while 19 of 108 cases in the stable group [eleven cases (14.9%, 11/74) in Mild Group, two (10.9%, 2/20) in Moderate Group, and six (6/14) in Severe Group] showed significant abnormalities. Statistically significant differences were found between the two groups [2.4%(1/42) vs 17.6%(19/108), χ2=4.940, P=0.026]. When the outcomes of the three groups were compared, 12 of 105 cases in the Mild Group (11.4%), two of 30 cases in the Moderate Group (6.7%), and 6 of 15 cases in the Severe Group (6/15) had significant abnormalities. Statistically significant differences were found between the three groups (χ2=6.908, P=0.032). Statistical significance was observed in the Moderate Group and Severe Group (χ2=4.929, P=0.026), while the Mild Group had a more favorable prognosis than the Severe Group (χ2=5.266, P=0.022). Chromosomal examinations were carried out in 57 cases and the incidence of chromosomal abnormalities was 8.8%(5/57) [7.0% (3/43), 1/8 and 1/6 in the three groups, respectively]. Infection screening was performed in 29 cases and one case was found to be positive for rubella virus-IgM, two cases were positive for cytomegalovirus-IgM, and one case was positive for toxoplasma gondii-IgM. Conclusions Pregnancy outcomes and the prognosis of fetal ventriculomegaly are associated with the degree and progression of ventricular dilatation. Key words: Ultrasonography, prenatal; Hydrocephalus; Pregnancy outcome; Follow-up studies

SAT0404 Efficacy and Safety of Hydrodissection of Median Nerve as a Treatment of Idiopathic Carpal Tunnel Syndrome

BackgroundCarpal tunnel syndrome (CTS) is the most common entrapment neuropathy. Ultrasound guided hydrodissection (UGH) of median nerve is a new method of treatment of CTS1. Ultrasonography (US) has the ability...

Tei index for right ventricular function monitoring in pregnant women complicated with cardiac disease and pulmonary hypertension

To investigate clinical value of Tei index used for monitoring right ventricular (RV) function in pregnant women complicating cardiac disease accompanying pulmonary hypertension (PH) and the influence on left ventricular (LV) function due to overload pressure of RV. Fifty-eight pregnant women complicating cardiac disease (including 32 cases with congenital heart disease, 14 cases with rheumatic heart disease and 8 cases with arrhythmia) were enrolled in this study, among 26 cases coexisted with pulmonary hypertension. According to the pressure of PH, those patients were divided into three groups: 11 cases in mild group [30 - 49 mm Hg (1 mm Hg = 0.133 kPa)], 9 cases in moderate group (50 - 79 mm Hg) and 6 cases in severe group (>or= 80 mm Hg). In the mean time, 15 healthy pregnant women were matched as control. Tei index were measured for LV and RV respectively. (1) The isovolumetric relaxation time [IRT, (93 +/- 52) ms] and isovolumetric contraction time [ICT, (66 +/- 41) ms] of RV in PH group were significantly higher than normal controls [(39 +/- 19) ms in IRT and (38 +/- 20) ms in ICT] and the other patients without PH group [(59 +/- 12) ms in IRT and (43 +/- 19) ms in ICT, P < 0.01, P < 0.05; P < 0.05, P < 0.05]; however, ejection time (ET) was (239 +/- 46) ms significantly shortened in PH group (P < 0.05, P < 0.01) when compared with (250 +/- 41) ms in patients without PH and (299 +/- 38) ms in normal controls. Tei index in PH group were 0.72 +/- 0.49, which were significantly higher than 0.38 +/- 0.12 in normal controls and 0.43 +/- 0.16 in patients without PH (P < 0.01, P < 0.05). (2) The IRT [(99 +/- 27) ms] and ICT [(71 +/- 40) ms] of LV in PH group were significantly higher than in normal controls [(88 +/- 20) ms, (50 +/- 24) ms] (P < 0.01, P < 0.01). ET of LV in PH group [(202 +/- 26) ms] were significantly shortened that (290 +/- 21) ms in normal controls and (220 +/- 36) ms in patients without PH (P < 0.01, P < 0.05). Tei index of LV in PH group were significantly higher than 0.43 +/- 0.15 in normal controls and 0.58 +/- 0.21 in patients without PH (P < 0.01, P < 0.05). (3) Positive correlation between Tei index of RV and pressure of pulmonary artery were observed (r = 0.84, P < 0.01). (4) Tei index of RV in severe PH were significantly higher than mild PH (0.75 +/- 0.43 vs. 0.68 +/- 0.35, P < 0.01) and moderate PH (0.75 +/- 0.43 vs. 0.71 +/- 0.14, P < 0.05). (1) The Tei index is a novel efficient Doppler index in assessing RV function of pregnant women complicating cardiac disease accompanying PH. And the fluctuation of Tei index might reflect seriousness of the disease. (2) The overload pressure of RV pressure due to PH has significant influence on LV function.