Case Reports In Medical Literature Research Articles

Rapid Vision Loss Due to Multifocal Glioma: A Diagnostic Challenge.

This is a unique case report in medical literature for its detailing of diagnostics of an uncommon presentation of a rapid unexplained bilateral vision loss of a 73-year-old male diabetic patient. This report highlights the crucial role of advanced molecular diagnostics in difficult neurological cases and also elucidates the difficulties involved in diagnosing optic nerve glioblastoma, an exceptionally rare and aggressive tumour. Slow and progressive loss of vision over 2 months, ultimately developing almost complete visual impairment in both eyes and a defect of right eye field of vision conclusively highlighted that the likely etiology was neuro-ophthalmic. Initially, the conditions were suspected to be an extended spectrum of diabetic eye disease complications but further deterioration was a hint towards something more substantive. This entailed in-depth diagnosis processes that included an MRI and the analysis of cerebrospinal fluid. The important discovery was through stereotactic biopsies of the optic nerve revealing a high-grade glial neoplasm. Next generation sequencing confirmed the pathology as IDH-wildtype glioblastoma. Despite management, his vision continued to deteriorate. Hence, an aggressive clinical course was followed. This case highlights the important learning need in considering glioblastoma of the optic chiasm as part of the differential diagnosis of rapid vision loss, which may present as multifocal brain lesions, especially in casesof rapid loss of vision where initial workup is negative. Quite a useful lesson that can be drawn from this case relates to the diagnostic process with advanced molecular profiling, more attention given to clinical suspicion and cutting-edge diagnostic tools applied in atypical presentation of neurological conditions.

Synovial Lipomatosis with Chondroblastoma in an 8-year-old Female: A Previously Unreported Entity.

Introduction:Synovial lipomatosis is a rare disease entity and a very small number of cases have been reported so far. It is characterized by villous proliferation of the synovium with expansion by mature adipose tissue. The etiology is unclear, thought cases can be seen secondary to injury, inflammation, chronic degenerative changes and neoplasms. Etiopathogenesis is still unclear, however is seen secondary to injury, inflammation, chronic degenerative conditions and neoplasms.Case Report:An 8-year-old female child presented with pain and swelling in the left knee. Radiological examination suggested of a lytic lesion in upper tibia along with reactive synovial thickening. The lytic lesion was excised and an incisional biopsy was taken from the hyperplastic synovium. Histopathological examination of the synovial tissue showed villi-like structures with mature adipose tissue expanding the synovial lining along with the presence of mild chronic inflammatory cell infiltrate. The lytic lesion showed a cartilaginous tumor comprising mineralized chicken wire matrix surrounding the chondroblasts. A final diagnosis of synovial lipomatosis with chondroblastoma was made on histopathological examination.Conclusion:This may be the first case report in medical literature of synovial lipomatosis coexisting with chondroblastoma in an adolescent girl. It also highlights the need for its increased awareness among young radiologists and pathologists so that an early diagnosis directs correct management and prevents further joint morbidity.

'Atypical Localized Not Well-Specified Cases' a case study of a rare type of Localized Lichen Myxedematosus

Lichen Myxedematosus (LM) is an uncommon and distinct disease entity characterized by cutaneous mucin deposition in dermis. It is classified in several subtypes depending on many factors including the monoclonal gammapathy, pattern of skin involvement and systemic involvement. We now present a case of LM which is localized in respect of skin involvement but according to recent classification it falls into a diagnosis of 'atypical localized not well- specified cases'. This is a very rare case and to the best of our knowledge, it is the first case report in medical literature until now. We treated the case with a short course of oral Prednisolone and got excellent result. Patient has been followed up in every 6 month for last 13 yrs and observed no progression to scleromyxedema.Medicine Today 2018 Vol.30(1): 44-46

Importancia de los reportes de casos. Guía para su diseño y elaboración

Case reports are an invaluable tool in the professional development of health workers and inseparable of the residents and fellow’s training. Their aim is to improve patient-centered care (customized medicine) during daily clinical practice, to stimulate the most upto-date search for medical information (clinical research-evidencebased medicine), to promote knowledge of diseases and their most advanced treatments —thus increasing medical information, and they are the first step in developing writing and scientific publication skills, which are a requirement and an obligation in current contemporary medicine. The present article has the purpose of presenting, in general, the importance of case reports in medical literature and also to establish a guide for its elaboration and design that could be useful for residents and fellows in the health area.

Dorsal penile frenulum: A rare developmental abnormality

Introduction: Dorsal penile frenulum is a very rare abnormality in literature. case report: this abnormality was present with normal external urethral meatus in a young adult male. there was no associated penile torsion. conclusion: this is the second case report in medical literature. A brief description of preputial anatomy and frenar band band is described. Various hypotheses have been discussed for development of dorsal penile frenulum.

Emergency Department Visits Involving Misuse and Abuse of the Antipsychotic Quetiapine: Results from the Drug Abuse Warning Network (DAWN).

Case reports in medical literature suggest that the atypical antipsychotic quetiapine, a medication not previously considered to have abuse potential, is now being subject to misuse and abuse (MUA; ie, taken when not prescribed for them or used in a way other than instructed by their health professional). Here we present systematic, nationally representative data from the 2005 to 2011 Drug Abuse Warning Network (DAWN) for prevalence of emergency department (ED) visits among the U.S. general population involving quetiapine and related to MUA, suicide attempts, and adverse reactions. Nationally, quetiapine-related ED visits increased 90% between 2005 and 2011, from 35,581 ED visits to 67,497. DAWN data indicate that when used without medical supervision for recreational/self-medication purposes, quetiapine poses health risks for its users, especially among polydrug users and women. These findings suggest that the medical and public health communities should increase vigilance concerning this drug and its potential for MUA.

Importance of Case Reports in Medical Literature

Importance of Case Reports in Medical Literature

Importance of Case Reports in Medical Literature

In a world of evidence-based medicine, where randomized trials are considered the gold standard of evidence, case reports and case series are at the bottom of this hierarchy. Whereas randomized control trials assess the level of uncertainty about a benefit or harm, case reports have a different fundamental function. Case reports typically highlight extremely unusual and novel findings. Case reports can rarely prove causation but generate a new hypothesis and stimulate further research. Only once a hypothesis is generated (a function of case reports), randomized trials will do final evaluation of therapies or tests. Case reports or case series are the only way to bring a new disease to the attention of the medical community. AIDS is a good example in the recent history, when astute physicians noticed immunodeficiency related diseases in a patient who had no reason to be immunodeficient [1]. New side effects of drugs are also usually reported in case reports or case series. The first case reports that suggested a link between the use of appetite suppressants and valvular heart disease were published in 1997

Xanthogranulomatous cystitis: A rare clinical entity

Xanthogranulomatous cystitis (XC) is a rare benign disease of unknown etiology. A case of XC in a 30-year-old male is presented due to sparcity of such case report in medical literature. Patient evaluation included clinical, biochemical and radiological studies before treatment. Histological study revealed the rare diagnosis. Patient was asymptomatic at eight weeks follow-up after treatment.

Prognosis of inner ear function in pneumolabyrinth: case report and literature review

Pneumolabyrinth, the presence of air within the labyrinth, is a rare radiologic finding associated with a well-known perilymphatic fistula (PLF). As there are only 24 published case reports in medical literature, multiple treatment options for the pneumolabyrinth are available. We report a case of a 20-year-old man with a pneumolabyrinth secondary to tympanic membrane and ossicular trauma. Despite conservative treatment, sensorineural hearing loss (SNHL) had progressed rapidly, and his profound deafness had not recovered after surgical exploration with closure of the PLF. Functional prognostic factors of SNHL are revised and compared with this case.

Role of case reports in medical literature: bathwater has not been shown to cleanse babies.

©2002The Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies