Case Of Squamous Odontogenic Tumor Research Articles

Fostering a faster post-operative wound healing process with hyperbaric oxygen therapy in a rare case of squamous odontogenic tumor.

IntroductionThe surgical removal of an intraoral tumor and preventing intraoral wound dehiscence are constant challenges faced by surgeons today. Hyperbaric oxygen therapy (HBOT), the inhalation of 100% oxygen at a greater atmospheric pressure, is often used in cases of wounds to induce a faster wound healing process, alongside other treatment modalities. We report a rare case of squamous odontogenic tumor (SOT) treated with HBOT after being surgically removed to foster an accelerated wound recovery.Case presentationA 39-year-old Asian male presented with an intraoral 3 × 4 cm tumor, accompanied by acute pain on the maxillary region. Biopsy results showed a solid, brown parenchyma with islands of mature squamous epithelial cells, confirming the diagnosis of an SOT. An intraoral surgical approach was performed to remove the tumor. The patient was then treated with prophylactic antibiotics and 5 consecutive, daily sessions of HBOT at 2.0 ATA as an adjuvant therapy. No further complaints and no abnormalities were found at the 2-week follow-up evaluation.DiscussionIn our case of SOT, HBOT plays a role to inhibiting the bacterial growth which could lead to post-operative wound infections. A number of studies have incorporated HBOT as an adjuvant therapy for post-operative intra oral wounds which has resulted in minimal wound complications.ConclusionThe use of HBOT as an adjunctive therapy in managing possible wound complications after the resection of an intraoral tumor enables a faster angiogenesis process, reduces tissue hypoxia and minimizes the risk of post-operative wound infections; hence fostering the wound healing process.

Squamous odontogenic tumor–an exceptionally rare neoplasm

The squamous odontogenic tumor (SOT) is exceptionally rare, benign, locally infiltrative neoplasm of the jaws originating from the rests of Malassez, gingival surface epithelium or from remnants of the dental lamina which is asymptomatic in nature, may present with symptoms of pain and tooth mobility. Radiographic appearance shows a triangular-shaped unilocular radiolucency associated with the roots of erupted, vital teeth. Common site of this tumor is anterior maxilla and the posterior mandible. Histologically, the formation of variable sized nests and cords of uniform, benign-appearing, squamous epithelium with occasional characterize the tumor Vacuolization and keratinization. Here we will present a case of squamous odontogenic tumor (SOT) occurring in a12 years-old female in the left side of upper jaw.
 Update Dent. Coll. j: 2019; 9 (2): 43-45

Squamous odontogenic tumor: A rare tumor of premolar region of mandible: a case report

Background: The squamous odontogenic tumor is characterized as an extremely uncommon amiable neoplasm, beginning from the rests of Malassez, gingival surface epithelium or from remainders of the dental lamina. The squamous odontogenic tumor was first described by Pullon et al. (1975), since that time only 50 cases in the English-language literature in which the microscopic characteristics are frequently very well demonstrated. The characteristic radiographic appearance is that of a triangular shaped unilocular radiolucency associated with the roots of erupted teeth and has a predilection for the anterior maxilla and the posterior mandible.Methods: We reported a case of squamous odontogenic tumor occurring in a 40-year-old female in the premolar are of mandible with common localization and appearance. The tumor underwent surgical excision for histopathological examination and confirming diagnosis, followed by total resection of the tumor and using demineralized freeze-dried bone allograft and collagen membrane to fill defect.Results: Histological examination revealed a proliferation of mature stratified squamous epithelial islands in a dense fibrous connective stroma and the diagnosis of squamous odontogenic tumor was confirmed.Conclusions: Although squamous odontogenic tumor is a rare tuomr which arise from the rest of Malassez, but it should be listed as a differential diagnosis and confirmed with histopathological examination, it should be treated first conservatively, but upon recurrence a more aggressive line of treatment is to be followed.

Squamous odontogenic tumor of the maxilla: a case report and review of the literature

Squamous odontogenic tumors are rare neoplasms of the jaw that are benign and locally infiltrative. The tumor originates in the gingival rests of Malassez, remnants of dental lamina or gingival surface epithelium. This type of tumor was first described by Pullon et al. (Oral Surg Oral Med Oral Pathol 40:616–630, 1975). The clinical presentation is mostly asymptomatic, though pain and tooth mobility may also occur. Radiographically, the tumor presents as a triangular radiolucent lesion found mostly in the maxilla and present between the roots of the teeth. Histologically, it may appear similar to acanthomatous and desmoplastic ameloblastoma; hence, it can present problems in differential diagnosis. Here, we describe a case of squamous odontogenic tumor of the anterior maxilla in a middle-aged Indian man.

Squamous odontogenic tumor: A case report

Squamous odontogenic tumor is a rare benign locally infiltrative odontogenic tumor of epithelial origin and only a few cases, less than 50, have been reported in literature. The challenge is in diagnosing the tumor is due to its close resemblance to acanthomatous ameloblastoma and well differentiated squamous cell carcinoma. Herein we report, not previously reported, characteristic case of squamous odontogenic tumor in the anterior maxilla in a teenager female. The diagnosis is predicated on recognition of the histopathologic features of squamous odontogenic tumor to obviate possible misdiagnosis of malignancy or ameloblastoma. The symptoms are modest. Squamous odontogenic tumor has a characteristic pathologic picture, which differs from ameloblastoma.

Squamous odontogenic tumor: A case report and review of literature

The squamous odontogenic tumor (SOT) is a rare, benign, locally infiltrative neoplasm of the jaws that appears to originate from the rests of Malassez, gingival surface epithelium or from remnants of the dental lamina. SOT was first described by Pullon et al. (1975). Since then there has been paucity in the number of reported cases, especially in the Indian subcontinent. The tumor is often asymptomatic, although it can present with symptoms of pain and tooth mobility. The characteristic radiographic appearance is that of a triangular-shaped unilocular radiolucency associated with the roots of erupted, vital teeth and has a predilection for the anterior maxilla and the posterior mandible. Histologically, the tumor is characterized by the formation of variably sized nests and cords of uniform, benign-appearing, squamous epithelium with occasional vacuolization and keratinization. We report a case of SOT occurring in a 58-year-old male in the anterior mandible with unusual localization and appearance.

Peri-Implant Squamous Odontogenic Tumor

Squamous odontogenic tumor (SOT) is a benign, locally infiltrative intraosseous tumor composed of well-differentiated squamous epithelium in a fibrous stroma. It seems to derive from the epithelial rests of Malassez in the periodontal ligament space. It presents an odontogenic origin, involving both the upper and lower maxillary bone, mainly areas without teeth or connective tissue of the odontogenic cysts. Clinically, SOT could be asymptomatic (3 cases), notwithstanding it is mainly characterized by pain, swelling, and tooth/teeth mobility. The most typical presentation of SOT is a slowly growing endobony lesion arising within a single periodontal location. Frequent misdiagnosis concerns either ameloblastoma and squamous cell carcinoma and fibroma. Since its first description in 1975, less than 50 cases have been identified. In light of the few reported cases, there are no consistently recorded clinical and radiographic features of SOT, and there is no predictable sex or site predilection. Diagnosis is predicated on recognition of the histopathologic features of SOT to obviate possible misdiagnosis of malignancy or ameloblastoma.We report the first case of SOT that arose in the vicinity of an implant. Through a meticulous review of literature, we discuss current etiology, pathogenesis, and treatment.

Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and delta1

BackgroundSquamous odontogenic tumor (SOT) is a rare benign odontogenic epithelial neoplasm. A slow-growing painless expansive swelling is the common presenting symptom. Histopathologically, SOT can be easily misdiagnosed as an acanthomatous ameloblastoma. Although Notch receptors and ligands have been shown to play a role in cell fate decisions in ameloblastomas, the role of these cell signaling molecules in SOT is unknown.Case reportThis paper describes a case of SOT affecting the anterior mandible of a 10-year-old Indian female. The patient was treated by local surgical excision and there has been no follow-up clinical record of recurrence 5 years after primary treatment. Histopathological examination revealed a solid, locally-infiltrative neoplasm composed of bland-looking squamatoid islands scattered in a mature fibrous connective tissue stroma and the diagnosis was SOT. Immunohistochemical evaluation showed positive reactivity of varying intensity in the neoplastic epithelial cells for Notch1, Notch3, Notch4, and their ligands Jagged1 and Delta1. Expression patterns showed considerable overlap. No immunoreactivity was detected for Notch2 and Jagged2.ConclusionsPresent findings suggest that Notch receptors and their ligands play differential roles in the cytodifferentiation of SOT.

多房性Ｘ線像を示した上顎骨歯原性へん平上皮腫の１例

Squamous odontogenic tumor (SOT) is a rare lesion apparently of odontogenic origin.Although 40 cases of this tumor have been reported outside of Japan, only 3 cases have been reported domestically. Only 4 cases of SOT with multilocular radiolucency have been described to our knowledge.We report a case of maxillary SOT in a 29-year-old woman. Radiography revealed an illdemarcated multilocular radiolucency between the left maxillary lateral incisor and the premolar. The lesion was diagnosed as SOT on examination of a biopsy specimen. Partial maxillectomy was performed. The removed specimen measured 25mm×25mm×20mm. There has been no evidence of recurrence as of 6 years 5 months after the operation.

下顎歯肉に発生したｓｑｕａｍｏｕｓ ｏｄｏｎｔｏｇｅｎｉｃ ｔｕｍｏｒの１例

We encountered and reported a case of squamous odontogenic tumor that developed in the gingiva of the lower third molar of a 51-ear old woman. This case may be the first of this kind of tumor ever reported in Japan. The chief complaints were gingival bleeding and painless swelling. The tumor was nodular, firm and located distal to the gingiva of the lower third molar. It was a tumor in size of the tip of the small finger, presenting the color of healthy gingiva. Radiographically, a horizontal type bone absorption was noted around the molar. As for the treatment, extraction of the molar and local excision of the tumor were performed. Histologically, numerous islands large and small consisting of well differentiated squamous epithelium were observed. The stroma was composed of mature fibrous collagenous connective tissue. The periphery of the islands was flattened or cuboidal but mostly flattened and showed no epithelial columnar cells. The presence of vacuolization and/or microcyst formation was observed in the islands and acidophilic substances were found in the microcyst formation. Prognostic observations were made for two years and six months during which no recurrence was noted. As to the development of this tumor, a theory that it is derived from Malassez epithelial remnant is widely accepted. However, we have presented a view againt this theory. In our view, it is possible that a weak dental lamina of the permanent teeth or the lateral enamel strand prior to formation of ameloblast remains in the jaw bone and/or paradentium and later developes into a tumor.

Squamous odontogenic tumor.

The twenty-fifth reported case of squamous odontogenic tumor is presented. The patient was a 39-year-old Chinese Malaysian male. The lesion was asymptomatic and did not recur after excision. It is important to distinguish this type of lesion from squamous odontogenic tumor-like proliferation. The rest of Malassez is thought to be responsible for the histogenesis of the lesion. Better understanding will only be achieved when more cases are reported and studied.

Squamous odontogenic tumor related to an unerupted lower canine

A new case of squamous odontogenic tumor (SOT) is presented. This is the seventeenth case of SOT to be reported and the first reported case related to a lower unerupted canine. A review of the literature reveals the extreme variability of the clinical and radiologic features of this tumor. Conversely, the microscopic characteristics of SOT are clearly defined: numerous islands of benign squamous epithelium scattered in an apparently mature connective tissue, absence of peripheral columnar cells with palisading nuclei, and absence of stellate reticulum. Keratin pearl formation, intraepithelial microcyst formation, and calcification are present to a variable extent. A circular arrangement of fibroblasts and fibrous condensation and/or hyalinization are observed around some epithelial islands, suggesting a reaction of the connective tissue to the epithelial proliferation. The observation of small epithelial islands near the apical surface of the retained tooth supports the theory that the tumor originates from Malassez's rests. The treatment of choice seems to be conservative, with thorough enucleation, but it should be borne in mind that multifocal cases have been described.