Case Of Primary Malignant Mesothelioma Research Articles

Report of a Rare Case of Primary Malignant Mesothelioma of the Perineum Presenting as a Scrotal Abscess

A 57-year-old man presented with erythema and pain in the scrotum for 1 week, with pus exuding from the ruptured scrotum for 1 day. Physical examination showed an enlarged left scrotum, with a small area of ruptured skin, and yellowish-white discharge from the rupture was visible in the lower posterior part of the testes near the perineum, with slightly high local skin temperature, tenderness, and fluctuating sensation. The initial reproductive system ultrasound and pelvic CT were suggestive of inflammatory infection, which was confirmed by histology following two surgeries. The patient's condition did not show improvement for a long period of time, and repeat pelvic CT suggested multiple enlarged inguinal lymph nodes. Fine needle aspiration cytology suggested metastatic cancer. Histopathological examination and immunohistochemistry of the perineal scrotal area showed malignant mesothelioma, and whole-body PETCT suggested pulmonary metastases and invasion into the surrounding tissues, such as the organs of the reproductive system. The patient received chemotherapy and immunotherapy, but the disease progressed rapidly, and he ultimately died of respiratory failure.

Primary malignant mesothelioma of the diaphragm with liver invasion

Rationale:Malignant mesothelioma is a malignant tumor with poor prognosis, which usually originates in the pleura, peritoneum, and pericardial cavity. Mesotheliomas that originate from the diaphragm are very rare. Here, we report a case of primary malignant mesothelioma of the diaphragm with liver invasion.Patient concerns:A 66-year-old woman was admitted to our hospital because of a “liver space-occupying lesion,” without any special clinical symptoms. Imaging examinations suggested a cystic-solid mixed lesion in the right lobe of the liver.Diagnosis:The tumor was diagnosed as epithelioid mesothelioma of the diaphragm with liver invasion.Intervention:The patient underwent abdominal surgery in our hospital to remove the diaphragmatic mass, liver mass, and part of the diaphragm.Outcomes:The postoperative course was uneventful.Lessons:Primary diaphragmatic malignant mesothelioma is very rare and may involve liver or lung tissue and be mistaken for liver or lung tumor. Accurate diagnosis depends on careful pathological examination. Immunohistochemical staining is very useful to distinguish this tumor from other liver or diaphragmatic tumors.

A Case of Primary Malignant Mesothelioma of the Greater Omentum

症例は67歳，女性．既往歴は37歳時に卵巣嚢腫で開腹手術を受けた．下腹部痛を主訴に当院を受診した．腹部造影CTで大網の著明な肥厚を認め，特発性大網脂肪織炎と診断された．抗菌薬・ステロイドで改善せず，当科で診断的手術を行った．大網は腫瘍性に肥厚しており，術中迅速病理検査では悪性の診断であった．小腸間膜に多数の播種病変を認め，大網腫瘍の可及的な減量手術のみを行った．永久病理検査において，大網由来の上皮型悪性中皮腫と診断された．術後経過は良好であり第13病日に退院したが，急激に病状が悪化し手術から73日目に死亡した．中皮腫は漿膜腔を覆う中皮細胞由来の比較的稀な悪性腫瘍であり，胸膜，腹膜，心膜に発生する．腹膜原発は全中皮腫の10～30％とされ，その原発部位が同定されないことが多く，診断に難渋する．今回，われわれは大網原発の悪性中皮腫の1例を経験したので，文献的考察を加えて報告する．

総説 原発性心膜悪性中皮腫の1例と本邦集計例(118例)の検討

総説 原発性心膜悪性中皮腫の1例と本邦集計例(118例)の検討

Primary Malignant Mesothelioma of the Appendix

We report a case of primary malignant mesothelioma of the appendix. A 35-year-old man without any history of asbestos exposure was admitted to our hospital for further examination following the discovery of multiple liver tumors, an ileocecal tumor, and abdominal lymph node swelling. An ultrasound-guided liver tumor biopsy revealed malignant mesothelioma. Despite receiving systemic chemotherapy, he died 3 months after the initial diagnosis. At autopsy, a diagnosis of multiple organ metastases from a malignant biphasic mesothelioma of the appendix was made. To our knowledge, this is only the second reported case of primary malignant mesothelioma of the appendix.

Malignant mesothelioma of the greater omentum mimicking omental infarction: A case report

Mesothelioma develops most commonly in the pleura, and less frequently in the peritoneum. Usually, it manifests as diffuse peritoneal thickening and multiple nodules, and rarely as a solitary mass. We report a rare case of primary malignant mesothelioma of the greater omentum, which mimicked omental infarct. A 54-year-old Korean man was admitted because of severe abdominal pain of sudden onset. A tender mass with indistinct margins was palpated in the upper abdomen. Abdominal ultrasound and computed tomography showed an ill-defined mass in the greater omentum and little ascites in the peri-hepatic space, and neutrophil-dominant exudates were documented on paracentesis. Intravenous antibiotics and analgesics were given for omental infarction with superimposed infection, which resulted in symptomatic improvement. The imaging studies after a week revealed a growing mass and ascites. Laparoscopic surgery was performed and an 8 cm x 3.3 cm greater omental mass was found, with multiple small nodules on the peritoneum, diaphragm, and pelvic cavity wall. Histological examination showed proliferating malignant epithelioid cells that stained strongly for calretinin, which was compatible with malignant mesothelioma. We recommend that primary omental mesothelioma should be included in the differential diagnosis of patients with omental infarction, despite its rarity.

Mesotelioma peritoneal: una presentación clínica inusual en un paciente sin exposición al asbesto

Malignant mesothelioma is an insidious neoplasm arising from the mesotelial surfaces, of the pleural and peritoneal cavities, the tunica vaginalis, or the pericardium. The predominant cause is inhalation exposure to asbestos. We present a rare case of primary malignant mesothelioma of the peritoneum in a 64 year old man without history of inhalation exposure to asbestos. The initial symptoms were constitutional syndrome and right pleural effusion. Positron emission tomography combined with computed tomography (PET/TC) was useful for a supporting diagnosis and to determine the extension. The patient received treatment with systemic palliative chemotherapy, cisplatin-pemetrexed. After three cycles, partial response was observed, but the evolution was fatal due to secondary toxicity of chemotherapy.

A case of malignant mesothelioma of the uterus

Malignant mesothelioma of the uterus is a rare mesenchymal neoplasm originating from the mesothelial surface cell lining of the uterus. It is known to have very poor prognosis with median survival period of 4-18 months. We report a rare case of primary malignant mesothelioma of the uterus showing no evidence of recurrence for 2 years, after management with operation and adjuvant chemotherapy.

Primary malignant mesothelioma of the penis: case report and review of the literature

We present an unusual case of primary malignant mesothelioma of the penis in an adult male. The clinical features and microscopic, immunohistochemical, and ultrastructural characteristics that help to identify this entity are described. A discussion of the behavior of malignant mesothelioma follows, as well as a possible explanation for its origin in the penis. To date, no cases of primary malignant mesothelioma of the penis have been reported.

Primary malignant mesothelioma of the tunica vaginalis of the testis. Immunohistochemistry and electron microscopy

A case of primary malignant mesothelioma of the tunica vaginalis of the testis in a 75 year old man is here presented. Anamnesis for asbestos exposure was negative. Recurrent left hydrocele was the main symptom. Echography revealed a nodular mass in the caudal aspect of the epididymis and papillary projection on the surface of the tunica vaginalis of the testis. An inguinal left orchiectomy was performed. The tumor both in the solid area and in the papillary projections was identified as a malignant mesothelioma of epithelial type. The role of immunohistochemistry and ultrastructure for a correct definition of the tumor is underlined.