Case Of Primary Leiomyosarcoma Research Articles

Primary Leiomyosarcoma of Humerus Presenting with Pathological Fracture and Treated Initially with Inadvertent Plate Fixation: a Case Report with Literature Review

Leiomyosarcoma is a malignant tumor of smooth muscle origin and commonly diagnosed in the uterus, gastrointestinal tract, and mucous membranes or as metastasis to the skeletal system. Primary leiomyosarcoma of bone is an uncommon type of tumor. Patient with primary bone sarcoma may present with a pathological fracture following a trivial injury, resulting in pain, swelling, and deformity. The pathological fracture needs to be evaluated with a high index of suspicion and proper investigations must be performed prior to fracture fixation. We present a case of primary leiomyosarcoma of humerus, who presented as pathological fracture and underwent inadvertent plating at a peripheral hospital. We treated this patient with wide resection of the tumor and the reconstruction was performed with an implant (Kuntscher’s nail and extra-articular plate) with bone cement spacer. The use of this novel method allowed us to perform implant fixation with small distal humerus bone segment and preserve native elbow joint. In this case report, we aim to highlight the importance of thorough preoperative evaluation and keeping a high index of suspicion while dealing with suspected pathological fractures to differentiate between primary and metastatic disease.

Primary Leiomyosarcoma of the Penis: A Review and Update of the Literature

Less than 50 cases of Primary Leiomyosarcomas of the Penis (PLOP) have been reported despite this PLOPs are the second most common sarcomas of the penis. The usual site for the development of PLOP is the shaft or base of the penis but the malignancy can affect any site of the penis. PLOPs are likely to be superficially located above the tunica albuginea in comparison with deep seated PLOPs. Superficial PLOPs may be asymptomatic or they may present as lumps, ulcers or nodules on the penis. Deep PLOPs may manifest with dysuria and difficulty with micturition when they compress the urethra. Diagnosis of PLOP is based upon the pathology examination features of specimens of the penile lesion that show interlacing fascicles of spindled-cells that have abundant eosinophilic cytoplasm, focal juxta-nuclear vacuoles and blunt ended nuclei and moderate to severe nuclear atypia, rarely atypical multi-nucleated giant cells and focal necrosis tend to be seen. There may be evidence of many mitoses. Immunohistochemistry studies of PLOP tend to show tumor cells that exhibit positive staining for desmin, muscle specific-actin, and alpha smooth muscle actin. Most often superficial PLOPs tend to be treated by wide complete excision of the tumor with tumor free and clear surgical resection margins. Deep seated PLOPs have also been treated by complete excision in various forms depending upon the site and size of the tumor and some of these have included Wide excision, partial penectomy and total penectomy alone and sometimes with adjuvant chemotherapy/radiotherapy. Some cases of deep PLOPs tend to be associated with the development of recurrences and metastases as well as death of the patient and hence deep PLOPs are aggressive tumors. Some people are of the opinion that chemotherapy and radiotherapy are not effective for the adjuvant treatment of PLOP. For this reason it would appear that there is need for the development of new chemotherapy medicaments that would effectively destroy PLOP tumor cells. There is need to undertake a global multi-center treatment trial of immunotherapy, chemotherapy and radiotherapy in order to streamline the treatment of PLOPs especially deep PLOPs.

Leiomyosarcoma of infrarenal inferior vena cava: A single institution experience and review of literature

We report three cases of primary leiomyosarcoma (LMS) of inferior vena cava (IVC). Vascular LMSs are rare tumors, arising most frequently from IVC. These tumors have a female predominance. Their diagnosis is often challenging, as patients may present with nonspecific complaints such as dyspnea, malaise, weight loss, abdominal pain, or back pain, preceding the diagnosis by several years. LMS of the IVC most frequently occurs in the middle segment. The final diagnosis can be made by an ultrasound or computed tomography-guided biopsy. Due to limited experience with this disease, optimal management of IVC LMS is unknown. Curative surgical resection remains the current treatment of choice for primary LMS of IVC. Neoadjuvant therapy may be given to downsize the tumor and increase resectability rates. Nonetheless, there is no proven role for adjuvant therapy, and recurrence is common. We, hereby, report three cases of this rare entity with emphasis on management.

A Rare Case of Primary Leiomyosarcoma of the Ovary

A Rare Case of Primary Leiomyosarcoma of the Ovary

From Hernia Repair to Pancreatectomy: A Case of Primary Leiomyosarcoma of the Pancreas

From Hernia Repair to Pancreatectomy: A Case of Primary Leiomyosarcoma of the Pancreas

Leiomyosarcoma of inferior vena cava with intracardiac extension presenting as Budd-Chiari syndrome: Report of a rare case

Primary leiomyosarcoma of vascular origin is a rare malignant smooth muscle tumor. This report describes a case of primary leiomyosarcoma of the inferior vena cava (IVC) in a 52-year-old male who presented with complaints of abdominal pain, chest pain, and bilateral lower limb swelling for 4 months. Imaging of the chest and abdomen revealed a mass in the IVC extending into right atrium, heterogeneous enhancement of liver, hepatosplenomegaly, and ascites. Histopathological examination showed a malignant spindle cell tumor with cells arranged in fascicular and hemangiopericytomatous pattern. Immunohistochemistry for smooth muscle actin and desmin confirmed smooth muscle origin of the tumor. Recognition of this tumor in this rare location and Budd-Chiari syndrome-like presentation is imperative for proper management of the patient.

Primary leiomyosarcoma of the first metatarsal bone: A case report

INTRODUCTION: Primary leiomyosarcoma of bone is a rare entity which has never been reported in the foot. We report a case of primary leiomyosarcoma of metatarsal bone. CASE REPORT: A 60-year-old male presented with a history of pain, progressively increasing swelling and a non-healing ulcer over the dorsomedial aspect of his right foot. Plain radiograph showed an osteolytic, destructive lesion of the first metatarsal with involvement of surrounding soft tissue and bones. Magnetic resonance imaging showed a lesion that was hypointense on T1- and heterogeneous on T2-weighted images. Histology of the tumour with immunohistochemistry features aid in making the diagnosis of primary leiomyosarcoma of the first metatarsal bone, which was rare for this location. DISCUSSION: A brief review of the literature is done to determine the epidemiology, radiological and histological features and management of this tumour. CONCLUSION: Primary leiomyosarcoma of bone is a rare tumour and should be kept in the differential diagnosis of primary malignant osteolytic, destructive neoplasms especially in the older age group LEVEL OF EVIDENCE: therapeutic, IV

Léiomyosarcome du cou : à propos d’un cas

Leiomyosarcoma is malignant tumor of smooth muscle which accounts for only 4% of head and neck sarcomas. The tumor is characterized by a slow growing and metastatic potential. The physical appearance of these tumors can be deceptively benign and can be mistaken for non-malignant tumor. An early diagnosis and aggressive initial treatment remains the mainstay of therapy for a good prognosis. The primary modality of therapy of Leiomyosarcoma is surgery, which must be designed to be curative. Adjuvant radiotherapy or chemotherapy may be used for control of local recurrence in case of positive surgical margins, high-grade or large tumors. We are presenting one case of primary leiomyosarcoma of head and neck region with review of literature.

Leiomyosarcoma of the Broad Ligament - a Case Report

Primary leiomyosarcoma of the broad ligament (LBL) are extremely rare tumours with no defined risk factors. They are mostly reported in postmenopausal women with only 3 case reports of tumor developing before 40 years of age. Diagnosis is difficult as signs and symptoms are nonspecific. None of the reported cases so far have been diagnosed preoperatively. In view of very few documented cases, there are no guidelines for the management of this rare tumor. We report a case of primary leiomyosarcoma of broad ligament with its management.

A Rare Case of Primary Leiomyosarcoma of the Ovary in Association with Cellular Leiomyoma of the Broad Ligament and Uterus

Abstract Background: Primary ovarian leiomyosarcoma is an extremely rare tumor, contributing to <0.1% of all ovarian malignancies, and its association with cellular leiomyoma of the broad ligament and uterus is an even rarer presentation. There are very few reports of primary ovarian leiomyosarcoma in the literature. Case: This article reports on a case of a 55-year-old postmenopausal woman who presented with complaints of abdominal distention and pain of 5 months' duration, with dyspnea. On examination there was an intra-abdominal mass corresponding to 36 weeks of gestation. Abdominal ultrasonography (USG) revealed a huge abdominopelvic mass with solid and cystic areas. The patient's CA-125 level was 2.7 U/mL (normal 35 U/mL). Total abdominal hysterectomy, with left salpingo-oopherectomy and right ovariotomy, was performed. The broad-ligament fibroid was excised. Samples were sent for histology analysis. Results: On gross examination, the right ovary was found to be enlarged, with a broad ligament and in...

A case of primary leiomyosarcoma of the liver

A case of primary leiomyosarcoma of the liver

Primary leiomyosarcoma of the inferior vena cava: a case report

Primary leiomyosarcoma of the inferior vena cava (IVC) is a rare malignant tumor originating from the vein smooth muscle. We present one case of primary leiomyosarcoma of the IVC. The patient benefited of surgical exploration at seventh day after admission. Tumor located in the junction of the anterior wall of the IVC and the left and right renal vein. We carried out the tumor resection, vena cava artificial vascular patch prosthetics. The patient did not take anticoagulant drugs after surgery and was discharged at 12 days after surgery. Currently, the patient had survived for nearly six months, repeated abdominal computed tomography examinations showed no clear recurrence.

Combined Treatment Approach for Rare Occipito- Cervical Spinal Lesions: Leiomyosarcoma

Combined Treatment Approach for Rare Occipito-Cervical Spinal Lesions:Leiomyosarcoma Leiomyosarcoma, a rare malignant tumor arising from smooth muscle, has rarely been reported to occur in association with spinal involvement. The treatment approach depends on tumor characteristics, staging, and presenting symptoms, and may include surgery with or without adjuvant radiation and chemotherapy. We present a case of primary leiomyosarcoma at the craniocervical junction in a 65 year old female treated by suboccipital craniectomy for tumor debulking followed by proton radiotherapy.

Leiomyosarcoma of the Pancreas with Liver Metastases as a Paradigm of Multimodality Treatment: Case Report and Review of the Literature

Primary leiomyosarcoma is a rare malignant neoplasm, although it is the most common primary pancreatic sarcoma [1]. It accounts for 0.1 % of malignant pancreatic neoplasms [2], and it seems to arise from smooth muscle cells of ducts or blood vessels within the pancreas [3] Pancreatic leiomyosarcoma is a highly aggressive neoplasm in which widespread metastases occur frequently and the liver is typically affected [4], so the prognosis is generally bad [5]. Radical resection of the primary lesion seems to offer the best possibility for cure [6]. We report a case of primary leiomyosarcoma of the pancreas with synchronous hepatic metastases occurring in a 54-year-old female who was treated with repeated surgical excision together with different chemotherapeutic regimens.

Primary leiomyosarcoma of the seminal vesicle: Case report and review of the literature

BackgroundPrimary leiomyosarcoma of the seminal vesicle is exceedingly rare.Case PresentationWe report a case of a 59-year-old man with tumour detected by rectal symptoms and ultrasonography. Computed tomography and magnetic resonance imaging suggested an origin in the right seminal vesicle. Transperineal biopsy of the tumour revealed leiomyosarcoma. A radical vesiculo-prostactectomy with bilateral pelvic lymphadenectomy was performed. Pathological examination showed a grade 2 leiomyosarcoma of the seminal vesicle. The patient received adjuvant radiotherapy. He developed distant metastases 29 months after diagnosis, and received chemotherapy. Metastatic disease was controlled by second-line gemcitabine-docetaxel combination. Fifty-one months after diagnosis of the primary tumour, and 22 months after the first metastases, the patient is alive with excellent performance status, and multiple asymptomatic stable lung and liver lesions.ConclusionsWe report the eighth case of primary leiomyosarcoma of the seminal vesicle and the first one with a so long follow-up.

Primary breast leiomyosarcoma: case report and literature review

PURPOSE: Leiomyosarcoma of the breast is extremely rare. To date, the factors that are predictive of patient prognosis have not been identified. To clarify the nature of leiomyosarcoma of the breast, and also to establish the proper treatment strategy, we report this case We report this case while discussing The Clinical presentation, diagnosis, therapy and pathologic feature. INTRODUCION: Sarcomas comprise less than 1% of all primary breast neoplasms and only a minority of these are leiomyosarcomas. There were only 35 cases being reported in English literature. The mainstay of treatment is surgical excision with clear margins and longterm followup is essential. Its prognosis is better compared to other breast sarcoma. CASE PRESENTATION: We report a case of primary leiomyosarcoma of the breast occurring in young female patient which was successfully treated by surgery and radiotherapy. CONCLUSION: According to literature data, primary leiomyosarcoma is characterized by a better prognosis compared with other breast sarcomas, To date, the factors that are predictive of patient prognosis have not been identified. .The rarity and diagnostic difficulty imposed a multidisciplinary approach.

Primary leiomyosarcoma of the greater omentum

Leiomyosarcoma is a rare tumor that originates in the smooth muscle. The omentum has been rarely reported as a primary of occurrence with leiomyosarcoma. A 58-year-old woman presented with abdominal distension and palpable pelvic mass. Abdominal computed tomography scan showed 32×27×16 cm-sized heterogeneous enhancing mass in the pelvic and abdominal cavity. An exploratory laparotomy revealed a solid tumor in the greater omentum and total omentectomy and multiple biopsies were performed. The tumor was diagnosed as a leiomyosarcoma by histological and immunohistochemical examinations. We present here a case of primary leiomyosarcoma of the greater omentum with brief review of literature.

Leiomyosarcoma of the parotid gland: a case report

Primary leiomyosarcoma of the parotid gland is an extremely rare neoplasm. We here describe the case of a 78-year-old male patient presenting with such a tumor. Five years after surgical treatment, the patient is alive and recurrence-free. To our knowledge, our case represents just the sixth case of primary leiomyosarcoma of the parotid gland reported in the English literature. The clinical features of these cases are summarized.

Leiomyosarcoma of the oral cavity: Report of seven cases and review of literature

Leiomyosarcoma is a relatively uncommon tumor that exhibits smooth muscle differentiation. Occurrence of this neoplasm in the oral cavity is exceedingly rare. Presenting signs and symptoms of leiomyosarcoma in the oral region are generally non-specific. The tumour is commonly encountered as a slow growing, discreet firm, and non-ulcerated painless mass. The physical appearance of these tumors can be deceptively benign and can also be mistaken for non-malignant conditions. Due to its innocuous clinical presentation and similarity to certain benign lesions it is critical for the dental surgeon to be familiar with this unusual lesion, as early diagnosis and aggressive initial treatment remains the mainstay of therapy for a good prognosis. This article presents seven cases of primary leiomyosarcoma in the oral region and highlights the need for early prudent diagnosis and treatment, without which may lead to a very poor out come of ill-fated patients.

A case of primary leiomyosarcoma of the mesentery with hepatic metastasis

Primary tumors of the mesentery are uncommon, and primary leiomyosarcoma of the mesentery is especially rare, and thus an accurate preoperative diagnosis is difficult. We experienced a case of 32-year female with primary leiomyosarcoma of the mesentery. We report this case with a brief review of the literature.