Case Of Primary Intracranial Melanoma Research Articles

Bilateral fetal lobulated kidney with unilateral twin renal artery

Primary intracranial malignant melanomas are rarely reported tumors of the central nervous system that are highly malignant with a poor prognosis, accounting for 0.1% of intracranial neoplasms. Given the location of the tumor, preoperative diagnosis by imaging study is difficult. Typically, mainstream therapy involves total excision of the tumor followed by radiation therapy. We present a case of primary intracranial melanoma arising from convexity of the left frontal lobe in a 49-year-old male who presented with headache and progressive mentality change for one month. After total tumor excision and whole brain radiation therapy, the patient has experienced tumor-free survival extending through 47 months of follow-up. Herein we have reported the patient's MRI findings, pathological examination, treatment and outcome.

Radiological assessment of patterns and thickness of bony roof of superior semicircular canal

Primary intracranial malignant melanomas are rarely reported tumors of the central nervous system that are highly malignant with a poor prognosis, accounting for 0.1% of intracranial neoplasms. Given the location of the tumor, preoperative diagnosis by imaging study is difficult. Typically, mainstream therapy involves total excision of the tumor followed by radiation therapy. We present a case of primary intracranial melanoma arising from convexity of the left frontal lobe in a 49-year-old male who presented with headache and progressive mentality change for one month. After total tumor excision and whole brain radiation therapy, the patient has experienced tumor-free survival extending through 47 months of follow-up. Herein we have reported the patient's MRI findings, pathological examination, treatment and outcome.

Neurocutaneous Melanosis: A Case of Primary Intracranial Melanoma with Metastasis

Neurocutaneous melanosis is a rare disorder characterized by the presence of large or multiple congenital melanocytic naevi and benign or malignant pigment cell tumours of the leptomeninges. Distant metastasis is unusual in primary leptomeningeal/intracranial melanomas. We present the case history of an adult male who had multiple primary intracranial melanomas associated with neurocutaneous melanosis (naevus of Ota) in the ophthalmic division of the left trigeminal nerve. Excision of the intracranial tumours was carried out in two stages, but the patient died 2 days after the second operation. Autopsy showed multiple metastatic deposits in the liver. Symptoms and signs of raised intracranial pressure, the presence of Ota's naevus, and a dural-based mass or masses should alert the treating physician to suspect a primary leptomeningeal/intracranial melanoma.

Neurocutaneous Melanosis: A Case of Primary Intracranial Melanoma with Metastasis

Neurocutaneous Melanosis: A Case of Primary Intracranial Melanoma with Metastasis

Primary solitary intracranial melanoma: Case report and review of the literature

Among CNS tumors, intracranial melanomas represent a subject of interest for neurooncologists and neurosurgeons because clinical and radiological patterns of these tumors can mimic the presence of meningiomas, and in spite of their malignant behavior they can be satisfactorily treated. In the present report we describe a new case of primary intracranial melanoma that displayed some radiological features of meningioma; we review the clinical features of 80 previously well-documented cases. The importance of neuroradiological and histochemical (S-100 protein, antimelanin antibodies, proliferating cell nuclear antigen staining) methods and of flow cytometry in helping with histopathological examination is stressed. Review of the clinical histories demonstrates that surgical excision is recommended in most cases, depending on tumor location, and that if total removal is performed, longterm disease-free periods can be attained.

Primary Intracranial Melanoma

We present a rare case of primary intracranial melanoma in the right occipital region of a 76-year-old male. Magnetic resonance imaging showed an isointensity mass with shorter T1 and T2 relaxation times than those of the opposite hemisphere. A well-defined, dark black tumor was totally removed and histologically diagnosed as malignant melanoma. Eight months postoperatively, however, the tumor recurred and was excised again. He was doing well 1 year after the second operation without additional treatment. In our case, 1) no systemic melanomas were found in close clinical examinations; 2) there was a single nodular tumor attached to the leptomeninges; and 3) a favorable outcome was obtained by surgical treatment alone. These results are consistent with the diagnosis of primary intracranial melanoma.

Primary malignant melanoma of the cerebellum.A case with metastases outside the nervous system

A case of primary intracranial melanoma in a 65-year-old female is described. A complete postmortem examination revealed multiple metastases in the liver, and eliminated the possibility of an extraneural primary melanoma. A review of the literature confirmed that such cases are highly exceptional, and that an exhaustive autopsy including particularly the eyes is indispensable to substantiate the diagnosis. When these conditions are fulfilled, there is no reason not to consider the eventuality of visceral deposits from a primary melanoma of the central nervous system.