Case Of Primary Cutaneous Mucormycosis Research Articles

A RARE CASE OF PRIMARY MUCORMYCOSIS OF ABDOMINAL WALL IN AN YOUNG IMMUNOCOMPETENT PATIENT

Mucormycosis of the anterior abdominal wall is an uncommon disease and very rarely found in immunocompetent, nondiabetic patients. We herein report a case of primary cutaneous mucormycosis in an immunocompetent and nondiabetic individual. Our patient was a 31year old young male, bike mechanic. He was diagnosed to have cutaneous mucormycosis of the anterior abdominal wall, and managed with serial wound debridement and intravenous amphotericin B therapy. A total of 7300 mg of liposomal amphotericin B was administered for 21days and antibiotics as per culture reports. After complete healing of the wound, split skin grafting was done. We would like to emphasize the importance of high index of suspicion and early start of therapy in this condition which has high rate of mortality

Successful surgical management of primary abdominal wall mucormycosis in an immunocompetent patient

Primary abdominal wall mucormycosis rarely occur in immunocompetent, non-diabetic patients but may affectin patients with traumatic injury with contaminated wounds and patients underlying malignancies usually infiltrating into skin. Herein we are reporting a case of primary cutaneous mucormycosis in a 17-year-old male without immunodeficiency or any comorbidity. He was managed with multiple debridement of the wound and intravenous amphotericin B therapy with cumulative dose of 2000 mg of liposomal amphotericin B followed by split skin grafting. We would like to emphasize the importance of high index of suspicionof fungal sepsis and early start of antifungal therapy in this condition can reduce high rate of mortality and management of large wound with split skin grafting in same setting to avoid morbidity.

Suspect the Unsuspected: An Unusual Case of Primary Cutaneous Mucormycosis at a Peripheral Intravenous Catheter Insertion Site. A Case report and Literature review

Fungal Infections can have atypical presentation This makes the diagnosis of fungal infections very challenging and in many cases increases morbidity and in unfortunate cases causes rsquo mortality Mucormycosis is a rare fungus which can present with wide clinical spectrum and can mislead as other etiologies This fungus manifests itself mostly in immune compromised hosts High index of suspicion is needed for accurate diagnosis Prompt treatment includes combination of surgical debridement and antifungals Early diagnosis and initiation of appropriate management can significantly decrease morbidity and mortality Histological diagnosis is the only means of confirming mucormycosis infection Our case is a typical example of atypical presentation of mucormycosis in an immune compromised patient which resulted in limb amputation

Devastating posttraumatic primary cutaneous mucormycosis in a diabetic patient

Mucorales are saprophytic fungi causing mucormycosis, which is a life threatening infection manifested as rhinocerebral, pulmonary, gastrointestinal, cutaneous, and disseminated forms. The cutaneous form is further divided into primary and secondary forms. The major risk factors include uncontrolled diabetes mellitus with or without ketoacidosis, other forms of metabolic acidosis, and trauma. We report here a case of primary cutaneous mucormycosis caused by Rhizopus oryzae, in a diabetic after a road traffic accident.

Mucormycosis in the post renal transplant surgical scar

Cutaneous mucormycosis is a rare entity related to kidney transplantation, which usually presents with ecthyma-like lesions and black necrotic cellulitis. Cutaneous mucormycosis should be considered in the differential diagnosis when a kidney transplant recipient develops erythema nodosum-like lesions with panniculitis or discharging sinus.We report an unusual case of primary cutaneous mucormycosis in a post-renal transplant patient, presenting as pus discharging sinus from the surgical incision site.

A case of primary cutaneous mucormycosis caused by minor trauma

We present the case of a 66-year-old neutropenic man with mantle-cell lymphoma who presented for evaluation of a rapidly expanding necrotic eschar after a minor cutaneous injury. Histopathology revealed infection with Rhizopus indicating primary cutaneous mucormycosis. Our case reviews the presentation and management of this condition as well highlights the potential for minor cutaneous injuries in the hospital to lead to this dangerous infection.

Mucor irregularis Infection Around the Inner Canthus Cured by Amphotericin B: A Case Report and Review of Published Literatures

We report a case of primary cutaneous mucormycosis caused by Mucor irregularis. A 47-year-old farmer was presented to our clinic with the history of progressive red plaque around the inner canthus following dacryocystectomy about a year earlier. Linear, aseptate hyphae were seen by direct KOH examination and in biopsy. Fungal culture revealed light yellow filamentous colonies that were identified as Mucor irregularis by nucleotide sequencing of rRNA gene. Amphotericin B and dexamethasone were used in gradually increasing dosage. The treatment lasted 43 days, and the patient received 760 mg total amphotericin B. The patient was discharged after 2 months of treatment. The plaque became smooth, and fungal culture was negative. There was no recurrence for half a year through telephone follow-ups. A review of published studies revealed 23 cases of Mucor irregularis infection. Most cases resulted following injuries or surgical complications. Farmers and manual laborers were most at risk with males outnumbering females among patients. Amphotericin B and its liposomal preparations remain most effective treatment choices.

A case of primary cutaneous mucormycosis caused by Mucor irregularis in Henan province

A 50-year-old female farmer presented with nodules,plaques and ulcers on as well as erythematous swelling of the right upper limb for six years,plaques on the right buttock for two years and on the fight cheek for one year.She had been treated with terbinafine and itraconazole,but no obvious improvement was achieved.Broad,septated and right-angled branching hyphae were found by both routine pathological examination and periodic acid-Schiff (PAS) staining of the lesional tissue from the right upper limb and buttock.The fungus was identified as Mucor irregularis by culture and molecular biological approaches,and the patient was diagnosed with primary cutaneous mucormycosis and given intravenous amphotericin B with the total dose being 1 060 mg.Subsequently,the plaques on and swelling of the right cheek and buttock gradually regressed,and the plaques on,swelling and necrosis of the right dorsal hand subsided with shedding of black crusts and formation of scar.The repeated fungal culture of lesional tissue on the right limb was negative.The patient was followed for one year and no recurrence was observed. Key words: Mucor irregularis; Rhizomucor variabilis; Amphotericin B; Primary cutaneous mucormycosis

Rare case of primary cutaneous mucormycosis of the hand caused byRhizopus microsporusin an immunocompetent patient

Primary cutaneous mucormycosis is a very uncommon manifestation occurring most often in diabetics or following trauma. We herein present a case of primary cutaneous mucormycosis of the hand caused by Rhizopus microsporus in an immunocompetent patient. This is the second such reported case in the literature.

Heterothallic mating inMucor irregularisand first isolate of the species outside of Asia

This study reports on the discovery of heterothallic mating in Mucor irregularis (formerly Rhizomucor variabilis var. variabilis) and it extends the range of this species from Asia to the United States. We report on a case of primary cutaneous mucormycosis, involving the forearms of a cotton farmer from North Carolina, in which the infection was cured using amphotericin B therapy. Intraspecific crosses between the North Carolina strain DUMC 150.04 and M. irregularis CBS 103.93, the ex-type strain of R. variabilis var. variabilis from China, resulted in the formation of abundant fertile zygospores. By way of contrast, interspecific crosses between the North Carolina isolate and the ex-neotype strain of M. hiemalis NRRL 3624 resulted in the formation of putative azygospores by M. irregularis DUMC 150.04.

Primary mucormycosis of abdominal wall: A rare fungal infection in a immunocompetent patient

Mucormycosis of the anterior abdominal wall is an uncommon disease and it is very rare to find this disease in immunocompetent, non-diabetic patients which usually affects patients with trauma, with contaminated wounds, patients with underlying malignancies or patients with immunocompromised state, e.g., diabetics. We herein report a case of primary cutaneous mucormycosis in an immunocompetent and non-diabetic patient. Our patient was a 48-year-old female, executive by profession. She was diagnosed to have cutaneous mucormycosis of the anterior abdominal wall, and was managed with multiple debridements of the wound and intravenous amphotericin B therapy. She was administered a total of 1500 mg of liposomal amphotericin B and when fully healed, split skin grafting was done. We would like to emphasize the importance of high index of suspicion and early start of therapy in a condition with high rate of mortality.

Primary Gangrenous Cutaneous Mucormycosis of the Scalp in a Child

Primary cutaneous mucormycosis (MM) is a rare fungal infection of childhood and is most often encountered in immunocompromised patients. It is a potentially lethal opportunistic fungal infection with rapid progression and high mortality. A report of cutaneous MM involving the head region is very rare. We herein report a case of primary cutaneous MM in a malnourished patient. The infection progressed rapidly, and the infant died from infection. The diagnosis was made at postmortem examination. Early diagnosis and surgery should be undertaken to prevent fatal outcome, and complete study of the etiologic agent must be carried out in all cases.

Primary cutaneous mucormycosis in an immunocompetent host

Mucormycosis in immunocompetent hosts is rare, and is often related to trauma. We report a case of primary cutaneous mucormycosis in a 26 year old immunocompetent female due to Mucor species. A combination of Amphotericin B and surgical debridement completely eradicated the infection.

Primary cutaneous mucormycosis in a healthy young girl: Report of a case caused by Mucor hiemalis Wehmer

We report an unusual case of primary cutaneous mucormycosis caused by Mucor hiemalis Wehmer that occurred in a healthy young girl after an insect bite. The patient had a slowly extending, indurated, erythematous, and scaling eruption on the right cheek. Histologic examination revealed granulomatous dermatitis and characteristic broad, nonseptate, pale-staining hyphae. This is the first report of an infection in a human being caused by Mucor hiemalis Wehmer. The infection was cured with intravenous amphotericin B.

Cutaneous mucormycosis

We report two cases of primary cutaneous mucormycosis in immunocompromised patients. Although their clinical presentation showed nonspecific necrotic ulcers, the histopathologic features were diagnostic. In both cases, broad, branching, nonseptate hyphae were found in the dermis and subcutaneous tissue. In one case the hyphae could be observed in the epidermis. To our knowledge, this is the only reported case of primary cutaneous mucormycosis with hyphae detectable in the epidermis.