Case Of Primary Carcinoid Tumor Research Articles

Primary carcinoid tumor of the kidney with estrogen and progesterone receptor expression.

Primary carcinoid tumors are uncommon neoplasms in the kidney. The current study presents a case of primary carcinoid tumor of the kidney in a 49-year-old female who suffered from painless gross hematuria for half a month. Left hydronephrosis, a horseshoe kidney and a space-occupying lesion of the left ureter were found by abdominal computed tomography scans and ultrasonic testing. Surgery was performed and an oval tumor was found under the left ureter; the tumor and left kidney were excised completely. The neoplasm was composed of solid nests of cells, trabeculae, adenoid structures and anastomosing cords in a loose and myxoid background. The tumor cells, which were consistent in volume, exhibited centrally oval nuclei with inconspicuous nucleoli, and eosinophilic finely granular cytoplasm. Upon immunohistochemical staining, the neoplastic cells were positive for AE1/AE3, vimentin, synaptophysin, chromogranin A, estrogen receptor and progesterone receptor, while being negative for epithelial membrane antigen, inhibin A, cluster of differentiation (CD)99, S-100 and CD10. Based on the histological characteristics, a diagnosis of primary carcinoid tumor of the left kidney was formed. The patient did not receive further treatment. The total follow-up period was 18 months after the surgery and repeated imaging examinations every 6 months revealed no recurrence.

Primary testicular carcinoid

Carcinoid tumors of testis are very rare and account for <1% of all testicular neoplasms. Clinically, they can be diagnosed only when there is a metastatic spread or presence of carcinoid syndrome. Mostly, they are diagnosed on histopathology. We report a case of primary carcinoid tumor of testis in a 34-year-old male without associated carcinoid syndrome. Patient underwent radical orchidectomy and is doing well on follow-up. Testicular carcinoid tumors, though rare, should be considered in differential diagnosis when evaluating a testicular tumor. They carry a good prognosis; however, long-term follow-up is necessitated due to potential for delayed metastasis.

A Primary Insular Type Carcinoid Tumor Arising in a Mature Cystic Teratoma of the Ovary: A Case Report

Background: Carcinoid tumors are rare neoplasms of the diffuse peripheral neuroendocrine system which produce biological amines and various peptides. Carcinoid tumors most commonly occur in the gastrointestinal tract. Primary ovarian carcinoids are rarely seen; they consist less than 0.1% of all ovarian cancers and 0.3% of all carcinoid tumors. Case: Here, we present a rare case of primary carcinoid tumor, insular type, arising in a mature cystic teratoma of the ovary. Conclusion: Surgical excision of the tumor is usually sufficient treatment for most of the patients.

Primary carcinoid tumor of the urinary bladder with prominent subnuclear eosinophilic granules

Primary carcinoid tumor of the urinary bladder is a very rare neoplasm. We report here a case of primary carcinoid tumor of the urinary bladder with an unusual cytological feature in a 72-year-old Japanese man. A bladder polypoid mass was incidentally found by ultrasonography during the follow-up of a benign prostate hyperplasia. Histological examination of the transurethrally resected tissue revealed that the upper part of the mass was a tumor showing tubuloglandular anastomosing structures. Most of the tumor cells had peculiar subnuclear eosinophilic granules. The features of the granules were reminiscent of those observed in neuroendocrine cells of the intestine. The tumor cells were immunohistochemically positive for chromogranin A and synaptophysin. The tumor was diagnosed as carcinoid tumor of pure form of the urinary bladder. The lower part of the mass showed the findings of glandular cystitis, as its coexistence with carcinoid tumors of the bladder has often been described in previous reports.

Two Cases of Primary Carcinoid Tumor of the Pancreas Associated With Marked Stenosis of the Main Pancreatic Duct

Hamada, Yoshihiro MD1; Nakayama, Yoshifuku MD1; Maeshiro, Kensei MD2; Ikeda, Takeaki MD1; Hayashi, Hiroaki MD1; Iwasaki, Hiroshi MD1 Author Information

Primary carcinoid tumour of nasal septum

We present the first reported case of primary carcinoid tumour of the nasal septum. Case report of our experience of a carcinoid tumour of the nasal septum. We discuss our clinical, radiological and pathological findings. An 83-year-old woman presented with a history of left-sided nasal blockage. Clinical examination showed a unilateral, left-sided nasal polyp. Further imaging and histological analysis confirmed this to be a carcinoid tumour. Carcinoid tumours outside the gastrointestinal tract are rare. There have been reports of carcinoid tumours in the head and neck region, but no published cases occurring in the nasal septum. Our management involved wide surgical resection with regular follow up to monitor for recurrence and for the development of carcinoid syndrome. Four years from initial presentation, the patient remained free of the primary tumour and had displayed no signs or symptoms suggestive of carcinoid syndrome. To the authors' best knowledge, and after searching the world literature, the presented case represents the first report of primary carcinoid tumour of the nasal septum. Despite its rarity, this tumour should be considered as part of the differential diagnosis, as timely recognition and intervention are critical for successful treatment.

Analysis of 32 cases of primary carcinoid tumors in bile duct and literature review

目的 探讨肝外胆管类癌的临床特征和临床诊治.方法 报告2例胆总管类癌并结合文献报道30例;对32例肝外胆管类癌进行分析.结果 肝外胆管类癌临床少见,32例中女性23例,男性9例,发病年龄平均为49岁(19～79)岁.临床表现梗阻黄疸最为常见,占55%.肿瘤局限于胆管内为71%,诊断时己有远处转移的为29%,其肿瘤局限于胆管内病例3年存活率为100%.结论 肝外胆管类癌与胆管腺癌不同,其发病年龄年轻(平均为49岁),并好发于女性.肿瘤的局部浸润为主,很少发生远处转移,根治切除后可获长期生存,对胆管类癌应行积极的根治切除。

Atypical primary carcinoid tumour of the skin

We present a new case of a primary carcinoid tumour of the skin. The mitotic index (4/10 HPF) warrants classification of this case as atypical. The patient was a 58-year-old woman with a 1-year history of a mass on the scalp. Literature review showed this to be only the seventh case of primary carcinoid tumour of the skin. Importantly, the evolution has been favourable in all seven tumours, with a mean follow-up of 2.5 years for the previous six cases. Although the number of cases is too small to draw definitive conclusions, information to date suggests that this type of tumour can be expected to have a benign behaviour, despite the presence in some cases of criteria suggestive of uncertainty, such as the presence of mitosis.

Primary Renal Carcinoid Tumor

Primary renal carcinoid tumor, first documented in the literature in 1966 by Resnick, is an exceedingly rare neoplasm. A primary renal cell carcinoid tumor is reported in this article. Fewer than 50 cases have been reported in the English literature. There is no gender predilection. The age of presentation ranges from 13 to 79 years. Some cases of primary carcinoid tumor of the kidney have been associated with other renal lesions such as horseshoe kidney, teratoma of the kidney, dysplastic kidney, other renal neoplasms, and autosomal dominant polycystic kidney disease. The clinical course of the disease and ultimate outcome remain difficult to predict due to the paucity of cases available for drawing statistically meaningful conclusions.

Mature Cystic Teratoma in the Anterior Mediastinum Containing a Carcinoid

Mature teratomas are common neoplasms in the anterior mediastinum. However, a primary carcinoid tumor occurring in a mature teratoma is extremely rare. To our knowledge, there are only 2 published articles in the literature to date reporting a mature cystic teratoma of the mediastinum containing a carcinoid. We herein report another case of primary carcinoid tumor arising from a mature cystic teratoma in the anterior mediastinum.

Primary Carcinoid Tumor in a Horseshoe Kidney

We report on a rare case of primary carcinoid tumor in a horseshoe kidney. A 56-year-old male was referred at our clinic with a history of urinary tract stones. A CT scan revealed a horseshoe kidney with a large mass in the lower pole of the right kidney. The patient was submitted to a partial right nephrectomy with resection of the lower half of the right kidney and isthmectomy The histological and immunohistochemical findings were compatible with a diagnosis of primary carcinoid tumor. After 24 months the patient is still alive without evidence of recurrence or progression.

Primary Carcinoid Tumor of the Testis: Case Report

Primary testicular carcinoid tumors are extremely rare and account for less than 1% of all testicular tumors. We recently experienced a case of primary carcinoid tumor of the testis in a 50-year-old man who presented with scrotal swelling. The ultrasonographic findings were evaluated and compared with those of previous reports.

乳腺カルチノイドの１例

乳腺カルチノイドの１例

Horseshoe Kidney is Associated With an Increased Relative Risk of Primary Renal Carcinoid Tumor

Purpose Carcinoid tumor is a rare neoplasm of the kidney with an unknown histogenesis. Of only 31 cases previously reported in the literature 4 arose within horseshoe kidneys. We report a case of primary carcinoid tumor arising within a horseshoe kidney and discuss the unique insight it provided into the pathogenesis of this tumor. Materials and Methods We reviewed in detail all 31 reported cases of renal carcinoid tumor and, using reported incidence rates of horseshoe kidney, we calculated the relative risk of renal carcinoid tumor arising within a horseshoe kidney. Immunohistochemical staining for neuroendocrine related markers was performed on tissue sections from the present carcinoid tumor, the adjacent kidney and 5 control samples of normal renal parenchyma. Results Of the reported tumors 15.6% occurred in horseshoe kidneys, yielding a calculated relative risk of 62. The present tumor was multifocal, arising from the wall of a cystic lesion and possibly representing a dilated calix within the isthmus. Intestinal epithelium lining the cyst cavity exhibited multifocal neuroendocrine cell hyperplasia with an immunohistochemical profile identical to that of the carcinoid tumor cells. Conclusions The relative risk of renal carcinoid tumor developing in a horseshoe kidney is markedly greater than that for Wilms tumor or transitional cell carcinoma. The clinical course of renal carcinoid tumor arising within a horseshoe kidney appears to be more benign than that of the nonhorseshoe variant. Our observations support the hypothesis that renal carcinoid tumors may arise from neuroendocrine cells within foci of metaplastic or teratomatous epithelium within the kidney.

AN AUTOPSY CASE OF PRIMARY DOUBLE TUMORS OF THE LIVER

A case of primary carcinoid tumor of the liver associated with hepatocellular carcinoma is reported. A 75-year-old male was treated for hepatic cirrhosis and hepatocellular carcinoma. He died of hepatic failure. The autopsy revealed a carcinoid tumor of the liver and hepatocellular carcinoma (Edmondson type II). The carcinoid tumor was positive for immunostaining with chromogranin and NSE, and neuroendocrine secretory granules were seen at the ultrastructural level. Neither tumor showed any mixed areas nor was primary carcinoid tumor found elsewhere. Primary carcinoid of the liver is very rare, and this case is the first report, to our knowledge, of primary carcinoid tumor of the liver associated with hepatocellular carcinoma.

Primary Hepatic Carcinoid Tumor: An Electron Microscopic and Immunohistochemical Study

A case of primary carcinoid tumor of the liver with striking morphologic and electron microscopic features is reported. Conventional histologic examination showed a prominent paranuclear clear zone in numerous tumor cells. By electron microscopic examination, this clear zone corresponded to a paranuclear mass of intermediate filaments admixed with neurosecretory granules and other cytoplasmic organelles.

頚胸椎へ転移をともなった睾丸カルチノイド腫瘍の1例

A case of primary carcinoid tumor of the right testis with metastases to the cervical and thoracic vertebrae and epidural is reported. A 53-year-old man was first recognized as being with dysthesia of the left arm and shoulder in April 1986. In June, 1987, he was admitted to the Neurology service, complaining of sudden occurrence of abasia. Myelography and computerized tomography demonstrated an epidural mass and several high density areas in the vertebral bodies of Th1 and Th2. The patient underwent laminectomy from C7 to Th2. At operation, the neurosurgeons noticed a tumor mass in the right scrotum and requested our consultation. Thus right high orchiectomy was performed. Pathological examination including Grimerius' and Fontana-Masson's stain revealed carcinoid tumor of the right testis associated with metastases to the spinal column. Postoperatively, tumor maker studies revealed elevation of blood 5-hydroxytryptophan and marked increase of urinary 5-hydroxy-indoleacetic acid excretion. They showed remarkable decreases after a course of PVB chemotherapy. The patient has been under our observation as an out-patient for the past 27 months with metastases. This is the first case of primary carcinoid tumor of the testis with metastases so far reported in the domestic literature.

後腹膜奇形腫を合併した原発性肝カルチノイドの１例

後腹膜奇形腫を合併した原発性肝カルチノイドの１例

Primary carcinoid tumor of the liver: A case report

A very rare case of primary carcinoid tumor of the liver that underwent hepatic artery embolization is reported. Computed tomography showed a low-density tumor with little contrast medium enhancement, whereas angiography revealed a slightly hypervasculor mass in the liver. The computed tomography findings after hepatic artery embolization showed a marked decrease in attenuation and gas formation.

Primary carcinoid tumor of the testis. Case report, ultrastructure and review of the literature

A case of primary pure carcinoid tumor of the testis which occurred in a 71-year-old male is reported. The patient was treated by radical orchiectomy and remains well and symptom free 10 months after operation. Histologically as well as ultrastructurally the tumor showed typical appearances of carcinoid tumor of midgut derivation. 23 cases of carcinoid tumors of the testis were discovered in the literature. Of these 17 were primary testicular carcinoids, and 6 were metastatic to the testis. Of the 17 cases of primary carcinoid tumors, 14 were pure carcinoids and only 3 were associated with teratoma. None of the primary testicular carcinoids were associated with metastases and the prognosis after orchiectomy was excellent, thus indicating that no further therapy is necessary. The prognosis of patients with carcinoid metastatic to the testis is poor. In view of this it is very important to determine whether the tumor is primary or metastatic.