A case of pleurisy and pericarditis in a hypersensitive individual is described in which the significant features were the onset with cardiac arrhythmia, pneumonitis followed by pleurisy with effusion, and pericarditis with effusion, 80 per cent eosinophiles in the cell count of the pleural fluid, failure of reaction to the antibiotics, absence of proof of viral etiology, and recovery associated with the administration of Pyribenzamine. It is not known whether the recovery was spontaneous or resulted from the use of this antihistamine drug. To our knowledge this is the first report in which an attempt was made, with apparent success, to utilize the antihistamine drugs in therapy in such a case. These features, with the other clinical data discussed, even without positive pathological findings or the reproduction of the clinical picture by a specific agent, seem sufficient to add this case to the accumulating literature illustrating a hyperergic etiology of cardiovascular disease. In the absence of death with postmortem studies or in cases of localized arteritis involving organs not readily accessible for biopsy, histological proof is impossible and reliance must be placed on clinical evaluation.
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