Case Of Nodular Fasciitis Research Articles

A Case of Nodular Fasciitis in the Alveolar Mucosa of the Upper Primary Incisors of an Infant

A Case of Nodular Fasciitis in the Alveolar Mucosa of the Upper Primary Incisors of an Infant

Left Posterior Chest Wall Reconstruction Using Prolene Mesh Following Excision Of Nodular Fasciitis A Case Report

Nodular Fasciitis (NF) is a benign, self-limiting condition that is characterized by myofibroblast / fibroblast proliferation. It is commonly found in the trunk, upper limbs (volar aspect of the forearm), and the back. Patient who are diagnosed with this condition typically presents with a history of rapidly enlarging subcutaneous mass over several weeks or months [1]. NF often mimicks a malignant process due to its rapid growth clinically, its high mitotic activity and cellularity and nonspecific cytomorphologic findings which makes it diagnosis pretty challenging. We describe a case of NF of the left posterior chest wall that presented to us and underwent wide local excision followed by chest wall reconstruction using a prolene mesh.

PPP6R3-USP6 amplification: Novel oncogenic mechanism in malignant nodular fasciitis.

Nodular fasciitis (NF) is a clonal self-limited neoplastic proliferation characterized by rearrangements of the USP6 locus in most examples. To our knowledge well-documented malignant behavior has never been previously observed in NF. In this report we present an unusual case of NF with classical histologic features that showed a protracted clinical course characterized by multiple recurrences and eventual metastatic behavior over a period of 10 years. Molecular analyses revealed the presence and amplification of the novel PPPR6-USP6 gene fusion, which resulted in USP6 mRNA transcriptional upregulation. These findings further support the oncogenic role of the USP6 protease in mesenchymal neoplasia and expand the biologic potential of NF. © 2016 Wiley Periodicals, Inc.

Infantile nodular fasciitis of the hand: A case report and literature review

Pediatric nodular fasciitis is uncommon and has a preference for the head and neck region. Occurrence in other anatomic locations is uncommon. We describe here a case of nodular fasciitis that arose in the hand of a newborn infant who presented with a rapidly growing mass. On MRI, it was heterogeneous isointense on T1-weighted and hyperintense on T2-weighted images. Histological examination showed short intersecting fascicles of uniform spindled myofibroblasts embedded in a myxoid to collagenous stroma, consistent with a nodular fasciitis. However, the lesion was initially diagnosed as an infantile fibrosarcoma due to the rapid growth, brisk mitotic activity and focally infiltrative architecture. This study illustrates that unusual presentation of nodular fasciitis may cause diagnostic confusion.

Nodular fasciitis on temple area resulting in surgical trauma.

Nodular fasciitis (NF) is a pseudosarcomatous reactive proliferative lesion that commonly occurs as a solitary, well-circumscribed, painful, rapidly growing soft tissue mass. It appears at any age, but incidence peaks in the third decade, with a slight predilection for women. It is most commonly located on the extremities, followed by the chest and trunk. Although a common site in the pediatric population, NF is found on the head and neck only in 7% to 20% in the adult population and includes the cheek, parotid region, zygoma, periorbital area, eyelid, forehead, and intraoral sites. The cause of NF is unknown, but an association with trauma may be present. A case of NF over the temple area in a 28-year-old man who has no trauma history but has surgical incisional biopsy history and tenderness on palpation is reported.

A Case of Nodular Fasciitis Causing Compressive Optic Neuropathy

A 16-year-old girl with worsening vision, new OD visual field deficits, and tumor in right orbital apex underwent biopsy and surgical excision. Orbital imaging revealed an apical tumor causing bony erosion. Histopathology confirmed the diagnosis of nodular fasciitis. This is a rare diagnosis, and one that can mimic a neoplastic process. To the authors' knowledge, this is the first case of nodular fasciitis in the deep orbit and the first case of nodular fasciitis causing an optic neuropathy.

胸腔鏡手術後のドレーン挿入部に発生した結節性筋膜炎の一例

患者は64歳の女性．大腸癌肺転移切除術後の経過観察中に，左胸壁腫瘤を認めた．次第に増大し，悪性腫瘍も否定できないために，胸腔鏡併用胸壁腫瘍摘出術を施行した．前回手術時の胸腔ドレーン挿入部に一致する肋間筋とともに，壁側胸膜を被った半球状の腫瘤を摘出．病理診断にて，紡錘形細胞の束状の増殖を認め，紡錘形細胞は，免疫染色にてSMAとVimentinに陽性であった．結節性筋膜炎の診断を得た．結節性筋膜炎は，四肢，特に前腕に多く発生する良性の線維芽細胞の反応性増殖性病変であるが，急激に増大する経過から，悪性腫瘍との鑑別が難しいことがある．胸腔鏡手術創や胸腔ドレーン挿入部から，結節性筋膜炎が発生したとの報告はなく，稀な症例と思われた．

Periorbital nodular fasciitis arising during pregnancy

Nodular fasciitis (NF) is a benign proliferation of fibroblasts and myofibroblasts that rarely occurs in the periorbital region. We report what we believe to be the first case of periorbital NF associated with pregnancy. A case of intravascular fasciitis, a NF variant, has been reported during pregnancy, but it was not located in the periorbital region. A weak presence of estrogen receptors has been reported in NF. This may make it more susceptible to the hormone-related changes during pregnancy and contribute to the development of the lesion by stimulating fibroblasts and smooth muscle cell types. Although rare, NF should be considered in the differential diagnosis of periorbital soft-tissue masses arising during pregnancy.

Nodular fasciitis of the breast mimicking breast cancer.

Nodular fasciitis is a benign proliferative lesion that is usually found in the soft tissue of the upper extremity and trunk in young to middle-aged persons. It has rarely been described in the breast. A 35-year-old woman had noticed a mass in her left breast. It was elastic-hard, 13 mm in size, and located mainly in the upper inner quadrant of the left breast. Mammography did not detect the mass. Ultrasonography revealed a hypoechoic lesion with an irregular margin. Neither fine-needle aspiration cytology nor core needle biopsy established a definitive diagnosis. Excisional biopsy was therefore performed. Histologically, the excised tumor tissue results were consistent with a diagnosis of nodular fasciitis of the breast. We report a case of nodular fasciitis of the breast, a rare histological type of breast tumor.

Cervical nodular fasciitis in a 10-year-old girl

Nodular fasciitis (NF) is a benign fibroblastic proliferation that usually involves superficial fascia in the subcutaneous tissue or muscle. The rapid growth, high cellularity and mitotic activity can simulate sarcoma. Thus, as clinical and morphologic characteristics are similar to those of malignant tumours, this entity is often misdiagnosed, with a few cases described in the literature. We present a case of nodular fasciitis involving the retropharynx and hypopharynx of a 10-year-old girl and discuss the importance of considering this rare diagnosis in different soft tissue masses. Keywords : excisional biopsy, histology, nodular fasciitis

Rapidly Growing Intraparotid Mass in a Young Child

Nodular fasciitis (NF) is a pseudosarcomatous lesion typically involving the subcutaneous tissue and fascia; rarely, it has been observed within a parotid gland. We report a case of NF in an 8-year-old boy who presented with a rapidly growing nodule in the right parotid gland. A preoperative fine-needle aspiration suggested a diagnosis of nodular (pseudosarcomatous) fasciitis. After fine-needle aspiration, the surgical excision of nodule with a conservative approach was made. Intraparotid NF was diagnosed by histopathologic examination confirming the former cytologic diagnosis. This case demonstrates that NF, although rarely may occur in unusual site as parotid gland, in cases of rapidly growing tumor masses in the parotid, a correct cytologic diagnosis in the fine-needle aspirate might spare unnecessary aggressive surgical treatment.

Nodular fasciitis over the anterior wall of the maxillary sinus: a case report and review of the literature

Nodular fasciitis (NF) is a benign tumor that grows extending from the muscular fascia to the subcutaneous tissue and, less frequently, into the underlying muscle. The cause of such proliferation is unknown, although trauma is believed to be important because of the location of these lesions over bony prominences. NF can often be confused with myofibromatosis or a sarcoma owing to its rapid rate of growth, rich cellularity, and mitotic activity. It is important, therefore, to distinguish the lesion from a more aggressive condition. NF that occurs in otherwise healthy individuals usually presents with a history of rapid growth, and is commonly found in the upper extremities and on the chest and trunk. We present a case of NF in a 39-year-old female patient occurring over the anterior wall of the maxillary sinus, along with a review of the literature.

Unusual presentation of nodular fasciitis as a rapidly growing haemorrhagic temporal mass

Nodular fasciitis (NF), also called proliferative or infiltrative fasciitis is considered to be a benign reactive process of the soft tissues (subcutaneous tissue, muscle or fascia) rather than a true neoplasm. Although the extremities are the most common sites, it may arise anywhere in the body. Local excision presents the main treatment. This study presents a case of NF with a unique clinical presentation, an acute subcutaneous temporal hemorrhagic growth. Because temporal NF is more often dermally situated than NF involving other anatomic sites, it may present with superficial ulceration or bleeding and appear clinically unusual. Nodular fasciitis should be considered in the differential diagnosis of other benign or malignant tissue masses involving the temporal area.

Nodular Fasciitis in the Forehead

Histologically, nodular fasciitis is observed as similar to sarcoma in soft tissues, and it is referred to as pseudosarcomatous fasciitis. Its histologic findings can be summarized as spindle-shaped fibroblasts, intercellular space between fibroblasts, red blood cells released to the extravascular area, and deposition of mucus within the interstitium. The lesion looks similar to sarcoma histologically and shows the characteristic of rapid growth, which in result is readily misdiagnosed as malignancy. It occurs preferentially in the upper extremities, whereas rarely occurring in the head and neck region. When we encounter subcutaneous nodules of the head and neck region, it is important to keep nodular fasciitis in mind as a differential diagnosis to avoid unnecessary wide resection. In this article, we report a rare case of nodular fasciitis on the forehead and some reviews of the literature.

RETRACTED ARTICLE: A case of nodular fasciitis in the upper eyelid

Purpose: To report a rare case of nodular fasciitis in the upper eyelid. Case summary: A 42-year-old woman presented with rapid enlarging mass, 15x12 mm in size at left upper eyelid. Orbit CT disclosed an enhanced, well-circumscribed preseptal lid mass. The histopathologic and immunohistochemical analyses after excisional biopsy were consistent with nodular fasciitis. There was no recurrence of the tumor after excision. Conclusions: For rapidly enlarging lid mass, nodular fasciitis should be considered as a differential diagnosis of sarcoma.

Nodular Fasciitis of the Zygoma: A Case Report

Nodular fasciitis (NF), a benign proliferation of fibroblasts, commonly presents as a solitary, well-circumscribed, rapidly growing soft tissue mass. It is most commonly located in the upper extremities, particularly on the volar aspect of the elbow, and on the chest and trunk. In adults, NF is rarely found in the head and neck region. Although benign, it can often be confused with a more malignant process and therefore must be properly diagnosed histologically. The cause of NF is unknown but an association with trauma may be present. Treatment is most commonly by local surgical excision, and recurrence is rare. A case of NF over the zygoma in a 60-year-old man not associated with trauma is presented.

Nodular fasciitis in the submandibular gland

Nodular fasciitis (NF) is a benign, proliferative lesion of myofibroblasts. The most common site of the lesion is in the upper extremities or trunk. NF in the head and neck is next in frequency and is the most common site in infants and children. In adults, NF in the submandibular region is very rare. We report a case of a 53-year-old man with a submandibular mass, rapidly growing for 10 days. Cytologic findings revealed a few sheets or clusters of small, uniform spindle cells. The uniform spindle cells had centrally located round to ovoid nucleus, but there were no nuclear atypia and atypical mitosis. There were focally loose stroma but we could not find chondroid or myxoid components. A partial parotidectomy was performed. We describe a case of NF in the submandibular region, adjacent to the parotid gland and review the clinical, cytologic, histologic, and immunohistochemical features of NF.

Intra-articular nodular fasciitis in the elbow joint, with an emphasis on MR imaging findings

Nodular fasciitis is a benign, usually self-limiting proliferation of myofibroblasts, arising from the fascia. In this article, a case of nodular fasciitis in the elbow joint of a 29-year-old man is presented. The nodular lesion developed from the synovial joint capsule in the elbow and histological and immunohistochemical studies revealed myofibroblastic proliferation. Only 13 cases of intra-articular nodular fasciitis have been reported in English literature. The present report describes the first case in which intra-articular nodular fasciitis occurs in the elbow joint of a patient. Additionally, magnetic resonance imaging findings of intra-articular nodular fasciitis are discussed along with a review of previous articles.

Nodular Fasciitis of the Face: Aesthetic Considerations

Nodular fasciitis is an uncommon tumor-like fibroblastic proliferation that occurs rarely in the head and neck region. A new case of nodular fasciitis occurring in the cheek of a 56-year-old woman is reported. The case was characterized by dental trauma preceding the appearance of the lesion (extraction of tooth 35). Histologically, the lesion consisted of proliferating fibroblasts and myofibroblasts presenting clinically as a rapidly growing subcutaneous nodule. A conservative surgical excision with curettage is the treatment of choice, and the lesion usually does not exhibit a tendency to recur. The clinical relevance of this condition relies on the fact that both the disorder and its surgical treatment may cause tissue distortion resulting in aesthetic compromise. Furthermore, it needs to be differentiated from malignancy due to its very rapid growth, its rich cellularity, and its high mitotic activity. Both of these aspects, i.e. aesthetic implications and differential diagnosis, have been discussed.

A Case of Nodular Fasciitis in the Upper Eyelid

Purpose: To report a rare case of nodular fasciitis in the upper eyelid. Case summary: A 42-year-old woman presented with rapid enlarging mass, 15x12 mm in size at left upper eyelid. Orbit CT disclosed an enhanced, well-circumscribed preseptal lid mass. The histopathologic and immunohistochemical analyses after excisional biopsy were consistent with nodular fasciitis. There was no recurrence of the tumor after excision. Conclusions: For rapidly enlarging lid mass, nodular fasciitis should be considered as a differential diagnosis of sarcoma.