Case Of Multiple Glomus Tumors Research Articles

From diagnosis to recovery – a detailed case report on a nail bed glomus tumor

Introduction and aim. Glomus tumors represent benign neoplastic proliferations of the glomus body, an integral thermoregulatory component within the cutaneous microvasculature. Although they can manifest at various anatomical sites, they are predominantly observed in the subungual region. The tumors present as painful, firm, purplish, solitary nodules of the extremities, especially in the nail bed. They may be solitary or multiple; solitary lesions are encapsulated and most commonly subungual, while multiple tumors are unencapsulated and rarely subungual. Description of the case. Here, we present a case of multiple glomus tumors of the right hand in an 18-year-old female who presented with complaints of painful bluish discoloration of the right little finger for six years and progressive asymptomatic nodules on the right index finger for six months. A clinical examination revealed acute tenderness in both fingers. Love’s pin test and Hildreth’s test were positive. Excision of all lesions was done and sent for histopathology, which confirmed the diagnosis. The patient was symptom-free immediately following surgery. No nail deformities were noticed, and there was no recurrence of symptoms after one year of follow-up. Conclusion. The transungual approach is a safe and effective minimally invasive surgical technique for the treatment of symptomatic nail bed glomus tumors. It offers high success rates, promising cosmetic outcomes, and minimal complications. However, careful patient selection and meticulous surgical technique are essential to avoid potential nail deformities.

Gastric Glomus Tumor

Purpose: Gastric glomus tumors are rare neoplasms originating from modified smooth muscle cells of glomus bodies. Glomus bodies are temperature sensitive neuromyoarterial receptors that help regulate arterial blood flow. We describe a rare occurrence of a patient with a gastric glomus tumor. Case: A 62 year old white man presented with a one month history of lower abdominal pain radiating to the back, exacerbated by bending or stooping. He complained of decreased appetite, nausea and vomiting, but denied weight loss, fever or chills. On physical exam he was afebrile and vital signs were normal. He was in obvious discomfort. Bowel sounds were normoactive. His abdomen was soft, tender over the RUQ. There was no obvious organomegaly or discrete mass. Labs revealed a WBC count 8.3 k/uL, Hgb 12.9 g/dL and platelets 361 k/uL. Amylase, lipase and complete metabolic panel were unremarkable except for albumin 2.8 g/dL and globulin 4.1 g/dL. CT abdomen without contrast showed a 2.8 cm mucosal mass near the anterior gastric body. Esophagogastroduodenoscopy (EGD) revealed a 3 cm submucosal mass with two small centrally located ulcers in the distal gastric body. Biopsies revealed atypical lymphoid infiltrate suspicious for a lymphoproliferative disorder. Repeat EGD with biopsies was unremarkable for flow cytometry; histology revealed gastric glomus tumor and chronic active H. pylori gastritis. Endoscopic ultrasound revealed an oval intramural (subepithelial) heterogeneous lesion originating from the muscularis propria (Layer 4) with well defined outer borders and an intact interface between the mass and adjacent structures, suggesting lack of invasion. Transgastric fine needle aspiration revealed a lesion infiltrated by round, uniform cells with moderate amounts of cytoplasm amid numerous large vessels. Immunostains were positive for muscle specific actin and vimentin and negative for leukocyte common antigen and chromagranin. Cytopathology and flow cytometry were unremarkable. A diagnosis of gastric glomus tumor and chronic active H. pylori gastritis was made. Laparoscopic excision of the 2.5 × 2.3 × 1.9 cm tumor was performed with free margins, three (0/3) negative perigastric lymph nodes and no evidence of vascular invasion. Pathology interpreted as glomus tumor of the stomach. Discussion: Although they may be located anywhere in the body, glomus tumors are most commonly found in the distal peripheral soft tissues of the fingers and toes. Gastric glomus tumors are rare, and generally considered benign solitary neoplasms. However, cases of multiple glomus tumors of the stomach and gastric glomus tumor with liver metastasis have been described and therefore, surgical resection is generally recommended. Methods: N/A Results: N/A Conclusion: N/A

Multiple Glomus Tumors of the Urinary Bladder in a Cow Associated with Bovine Papillomavirus Type 2 (BPV-2) Infection

We report a case of multiple glomus tumors associated with bovine papillomavirus type 2 (BPV-2) infection in the urinary bladder of a 13-year-old cow suffering from severe chronic enzootic hematuria. Macroscopically, multiple submucosal reddish nodules were seen swelling the vesical mucosa. Histologically, neoplastic proliferation was characterized by the presence of numerous blood vessels. These were lined by normal endothelial cells surrounded by round epithelioid cells with central nuclei, prominent nucleoli, acidophilic cytoplasm, and well-defined cytoplasmic borders. Tumor cells were distributed around open vascular lumina and in perivascular spaces. They were immunohistochemically positive for actin and vimentin and negative for cytokeratins, desmin, and factor VIII-related antigen. On the basis of these findings, this tumor was diagnosed as glomus tumor, a neoplasm not previously reported in cattle and exceedingly rare in animals. BPV-2 DNA was amplified from the formalin-fixed, paraffin-processed tissue specimens obtained by laser capture microdissection. This report widens the spectrum of mesenchymal tumors of the bovine urinary bladder. Finally, the microscopic pattern of tumor described here shares striking morphologic and immunohistochemical similarities with the angiomatous form of glomus tumor known to occur in man.

MRI of multiple glomus tumors of the finger

A case of multiple glomus tumors of the finger is presented, in which MRI was valuable in the diagnosis and preoperative tumor localization.

Multiple glomus tumors of the face and eyelid

• The glomus tumor is a benign, vascular, hamartomatous derivative of the glomus body, a normal intradermal arteriovenous anastomosis. Most glomus tumors are solitary, tender lesions of the nail bed and are found only rarely on the eyelid. Occasionally, glomus tumors assume a multiple form, wherein they are nontender. I report a unique case of multiple glomus tumors involving the face, palate, eyelid, and anterior orbit.

Multiple Glomus Tumors of the Face and Eyelid

The glomus tumor is a benign, vascular, hamartomatous derivative of the glomus body, a normal intradermal arteriovenous anastomosis. Most glomus tumors are solitary, tender lesions of the nail bed and are found only rarely on the eyelid. Occasionally, glomus tumors assume a multiple form, wherein they are nontender. I report a unique case of multiple glomus tumors involving the face, palate, eyelid, and anterior orbit.

Multiple glomus tumors of the skin

Glomus tumors are divided into two types: (1) the classical, painful, solitary type; and (2) multiple painless hemangiomas. Forty-three cases of multiple glomus tumors have been reported; in three instances a familial pattern was recorded. This paper presents a family in which the occurrence of multiple glomus tumors is common.

Multiple Glomus Tumors of the Skin

Glomus tumors are divided into two types: (1) the classical, painful, solitary type; and (2) multiple painless hemangiomas. Forty-three cases of multiple glomus tumors have been reported; in three instances a familial pattern was recorded. This paper presents a family in which the occurrence of multiple glomus tumors is common.

Multiple glomus tumors. A clinical and electron microscopic study.

A case of multiple glomus tumors has been studied with angiography, thermography, plethysmography, and light and electron microscopy. No vascular abnormalities were found. Light microscopic studies revealed typical histopathology of glomus tumors of the multiple type. Electron microscopic studies confirmed that the glomus cells have the features of smooth muscle cells.

HEMANGIOPERICYTOMA

SUMMARYTwo cases of hemangiopericytoma are described, one lodging in the mediastinum and the other in the subcutaneous layer. Another case of multiple glomus tumors, earlier recorded by Bergstrand (5), is quoted. Among the latter re‐examination disclosed a tumor presenting the picture of hemangiopericytoma.

Multiple glomus tumors.

REPORTS of glomus tumors have appeared in the literature with increasing frequency since this entity was described by Masson1in 1924. The vast majority of these cases reported have been concerned with small solitary tumors situated on an extremity which were characteristically extremely sensitive to slightest pressure. Even with increased awareness of this entity, it is still relatively rare. Love2in 1935 described the first glomus tumor recognized at the Mayo Clinic. He recently reported 13 more such tumors and stated that other tumors not included in his series had been diagnosed in the Clinic.3In the Section on Dermatology at the Clinic a histological and clinical diagnosis of glomus tumor has been made in nine additional cases, only one of which presented multiple glomus tumors. A survey of the literature revealed only 18 cases of multiple glomus tumors previously reported.4In one case reported