Case Of Mucinous Cystadenocarcinoma Research Articles

Primary Mucinous Cystadenocarcinoma of the Testis: A Case Report and Literature Review

Primary mucinous cystadenocarcinoma (MCA) of the testis is extremely rare, only 10 cases having been reported to date. Metastases of mucinous adenocarcinomas that have originated in different sites can mimic primary MAC and must be included in the differential diagnosis. We report a case of primary MCA of the tunica vaginalis testis in a 28-year-old patient who presented with a painless mass on the left side of the scrotum. We present the clinical and pathological characteristics to contribute to the further understanding of these rare tumors.

Computed Tomography and Clinical Analysis of Ovarian Mucinous Tumors in Adolescent Patients

To investigate the clinical and computed tomography features of ovarian mucinous tumors in children and adolescents. A retrospective analysis of clinical and preoperative computed tomography (CT) data was performed in 59 patients who were 20 years or younger with ovarian mucinous tumors confirmed by histopathology. Patients' age, medical history, symptoms, tumor marker levels, and CT imaging findings were recorded. None. Identification of the clinical and CT features of ovarian mucinous tumors in pediatric and adolescent patients. There were 41 mucinous cystadenomas in 39 cases, 12 borderline mucinous cystadenomas in 11 cases, and 9 mucinous cystadenocarcinomas in 9 patients. A total of 55 tumors were multilocular (55/62, 88.7%), including fewer than 10 loculations in 23 tumors, 10-20 loculations in 17 tumors, and over 20 loculations in 15 tumors. Eleven borderline mucinous cystadenomas were multilocular (11/12, 91.7%), with over 10 loculations in 7 tumors (7/12, 58.3%). Twelve tumors appeared as multilocular cystic-solid (12/62, 19.4%), and a case of mucinous cystadenocarcinoma was predominantly solid (1/62, 1.6%). Seventeen tumors showed honeycomb sign and stained glass appearance. Six mural nodules, with sizes ranging from 1.1 to 3.5cm (average: 2.8cm), were found in borderline mucinous cystadenoma and mucinous cystadenocarcinoma. The CT findings of ovarian mucinous tumors in children are characteristic. The preoperative CT is helpful in making differential diagnoses.

A Case of Mucinous Cystadenocarcinoma in Labial Mucosa of Upper Lip

Mucinous cystadenocarcinoma (MCA) is a malignant tumor that mainly occurs in the breast or ovary, but MCA is internationally rarely reported in head and neck region. Especially MCA in minor salivary gland of oral cavity is even more rare. It is characterized by cystic spaces lining of epithelial cells containing intracytoplasmic mucin. We report a case of MCA in the labial mucosa of upper lip considered to develop from minor salivary gland with a review of literatures. Key Words: Cystadenocarcinoma, Mucinous, Head and neck cancer, Labial mucosa

Breast mucinous cystadenocarcinoma – case report

Introduction: Mucinous cystadenocarcinoma (MCC) is a rare primary breast tumor, first described in 1998. It was removed from the WHO classification in 2012, due to lack of consensus about its definition. To our knowledge, only 25 cases have been published in the literature. Objective: Case report and discussion of a case of breast MCC diagnosed in Centro de Doenças da Mama in Curitiba. Case report: Premenopausal 51 year-old patient, complaining of pain and nodule in the left breast. Physical examination showed a palpable nodule of approximately 2 cm, in the UOQ of the left breast. The ultrasound showed a 2.3 cm nodule, BI-RADS 5, submitted to core-needle biopsy with diagnosis of carcinoma with mucinous differentiation, positive for estrogen receptor (ER). The PET-Scan did not show extramammary site capture. Conserving surgery and sentinel lymph node were performed, with breast reconstruction using the geometric compensation technique. Macroscopy showed a cystic and solid mass, of mucinous content, measuring 4.0x3.5 cm. The histological status was suggestive of MCC, with 2 negative sentinel lymph nodes. The IQ showed mammaglobin expression, CK7 and ER, negative expression of c-erbB-2, CK20 and CK5/6. The patient was submitted to radiotherapy and hormone therapy. Discussion: The primary breast MCC needs to be distinguished from ovarian and pancreatic metastasis. The IQ for CK7 and CK20 can be useful, considering that the pancreatic and ovarian MCC have concomitant expression of CK7 and CK20; the breast MCC expresses only CK7. In the 26 cases described in the literature, including this study, mean age was 62 years (41‒96), and the tumor size was variable (0.8–19 cm). Only 4 cases presented positive lymph nodes. Most described cases did not express ER. The reported cases were associated with good prognosis. Conclusion: A consensus on the histological nomenclature and longer follow-up time are necessary to better understand this variant.

Multiple Mucinous Cystadenocarcinoma Indicative of an Abdominal Tumor with Ascites in the Male Chinese Patient: A Case Report

Mucinous cystadenocarcinoma in men is very rare; we reported 1 case of mucinous cystadenocarcinoma in the pancreatic disease institute of Wuhan union hospital in China. The aim of the study was to focus our attention on the gender of this patient. The mucinous cystadenocarcinoma is a pathology frequently seen among women. The clinical presentation of this patient is a characteristic which deserves to be described.

A Study on Expression of P53 in Surface Epithelial Ovarian Tumours

Aims and Objectives: (1) To perform and interpret p53 immunostaining on the diagnosed malignant surface epithelial ovarian tumours. (2) To correlate expression of p53 with histological type of malignancy. Materials and Methods: A 2-year prospective study was done i.e., from October 2011 to September 2013 on ‘A study on expression of p53 in surface epithelial ovarian tumours’ in MGM Hospital, Warangal. All the ovarian surface epithelial tumour specimens, received in the pathology department during this period were considered. Results: A total of 121 cases were studied, out of which benign tumours were the most common (64.4%), followed by malignancy (25.6%) and 12 cases(10%) of borderline malignancy. Most of the benign tumours were unilateral; the cases that showed bilateral involvement were mostly malignant. The maximum number of cases in the present study was seen in the age group of 31–60 year. The youngest patient was 16 year old and the oldest was 68 year old. Serous cyst adenoma was the most common neoplasm found and accounted for 53 cases (43.8%), followed by mucinous cystadenoma, which accounted for 21 cases (17.3%).Nine cases of serous cystadenofibroma (7.43%), 3 borderline serous tumours (2.47%) and 11 serous cystadenocarcinoma (9%) were found in the present study. Out of the 44 mucinous tumours, 21 were benign (17.3%), 3 were of borderline malignancy (2.47%) and 20 were malignant (16.5%). One case of mucinous cystadenocarcinoma was found to be associated with adenocarcinoma of ascending colon. One case of benign Brenner tumour was also found in the present study. The rate of p53 abnormalities varies with histological type, grade and stage of the tumour. P53 expression was more in malignant serous tumours as compared to the malignant mucinous tumours.

虫垂切除術46年後に手術創に生じた粘液嚢胞腺癌の1例

虫垂切除術46年後に手術創に生じた粘液嚢胞腺癌の1例

遺残虫垂より発生し腹腔内膿瘍の様相を呈した粘液嚢胞腺癌の1例

症例は80歳，女性．60年前に虫垂切除，その30年後に遺残膿瘍の手術を受けていた．3年前より時々右下腹部痛を認め，最近になり発熱と腹痛の増悪，右下腹部腫瘤を触知するようになったため来院した．腹部CT上，回盲部に接し後腹膜に及ぶ膿瘍を認めたため経皮的にドレーンを挿入し入院となった．大腸内視鏡では腫瘍性病変は認めないものの盲腸粘膜の浮腫，発赤と盲腸憩室を認めた．当初は盲腸憩室後腹膜穿通による膿瘍と診断していたが，腫瘍マーカーの上昇もあり腫瘍性病変の可能性も考え手術を行った．開腹すると膿瘍と考えられていた部分は約10cmの巨大な腫瘤であり，回盲部切除およびドレーン刺入部の瘻孔切除を行った．病理組織学的に腫瘤内には遺残虫垂組織を認め多量の粘液・壊死組織が充満，腫瘤壁には高分化腺癌の浸潤を認めた．以上より遺残虫垂より発生した粘液嚢胞腺癌と考えられた．

Mucinous cystadenocarcinoma of the breast with a basal‐like immunophenotype

Mucinous cystadenocarcinoma (MCA) of the breast is extremely rare and was only recently described as a distinct variant of invasive ductal carcinoma of the breast. A case of MCA is reported in a 41-year-old woman. Mammographic and ultrasonographic examinations showed an irregularly shaped 10.0 × 8.0 × 5.5 cm lesion with patching calcification in the upper outer quadrant of the left breast. The gross examination revealed that the tumor has a well-circumscribed edge with a gelatinous cut surface and hemorrhage and necrosis were also noticed in the mass. Microscopically, the mass resembled mucinous cystic neoplasm of the ovary and pancreas closely, with cystic areas lined by columnar mucinous cells and associated with abundant extracellular and intracellular mucin, which is distinctively different from mucinous carcinoma with typically nests of low grade neoplastic cells floating in the mucin pool. The tumor cells were positive for CK7, CK20 and CDX2 were negative and displayed a typical immunophenotype of basal-like breast cancer (ER, PR, HER2 were negative, CK5/6 and EGFR were positive). Metastatic carcinoma was identified in three of 14 axillary lymph nodes. We describe here a very unusual case of breast MCA with basal-like immunophenotype.

A Rare Renal Epithelial Tumor: Mucinous Cystadenocarcinoma Case Report and Review of the Literature

Primary renal mucinous cystadenocarcinoma is a very rare lesion of kidney which originates from the metaplasia of the renal pelvic uroepithelium. Only one case with primary mucinous cystadenocarcinoma has been reported in the English literature. We report second case of mucinous cystadenocarcinoma which was radiologically classified as type-IIF Bosniak cyst in peripheral localization. We aimed to present this extreme and unusual entity with its radiological, surgical, and pathologic aspects under the light of literature.

Expression and Mutational Analysis of c-kit in Ovarian Surface Epithelial Tumors

Coexpression of Kit ligand and c-kit has been reported in some gynecologic tumors. To determine whether imatinib mesylate is useful in ovarian epithelial tumors, we performed immunohistochemical and mutational analysis. The cases consisted of 33 cases, which included 13 serous cystadenocarcinomas, 1 borderline serous tumor, 8 mucinous cystadenocarcinomas, 6 borderline mucinous tumors and 5 clear cell carcinomas. Five cases of serous cystadenoma and 5 cases of mucinous cystadenoma were also included. In the immunohistochemical study, 3 cases (3/6, 50%) of borderline mucinous cystic tumor and two cases (2/8, 25%) of mucinous cystadenocarcinoma show positive staining for KIT protein. Only one case (1/13, 7.7%) of serous cystadenocarcinoma had positive staining. On mutational analysis, no mutation was identified at exon 11. However, two cases of borderline mucinous tumors and one case of mucinous cystadenocarcinoma had mutations at exon 17. In these cases, the immunohistochemistry also shows focal positive staining at epithelial component. Although, KIT protein expression showed higher incidence in mucinous tumors than serous tumors, they lack KIT-activating mutations in exon 11. Thus, ovarian surface epithelial tumors are unlikely to respond to imatinib mesylate.

術前に施行したCTガイド下生検にて腹壁再発をきたした虫垂粘液嚢胞腺癌の1例

術前に施行したCTガイド下生検にて腹壁再発をきたした虫垂粘液嚢胞腺癌の1例

肺に発生したｍｕｃｉｎｏｕｓ ｃｙｓｔａｄｅｎｏｃａｒｃｉｎｏｍａの１例

肺に発生したｍｕｃｉｎｏｕｓ ｃｙｓｔａｄｅｎｏｃａｒｃｉｎｏｍａの１例

直腸癌との鑑別が困難であった虫垂癌直腸穿通の１例

症例は89歳の女性で,血便を主訴として近医を受診し当科を紹介された.注腸造影検査および大腸内視鏡検査により直腸Rs領域に40mm大の2型腫瘤影を認め,生検の結果,高分化腺癌と診断された.このため直腸癌の診断にて手術を施行した.腫瘍は盲腸,右尿管・卵管に癒着しており,直腸低位前方切除術に加え,回盲部切除,右尿管部分切除,右卵巣卵管切除を行った.切除標本で,腫瘍は虫垂から直腸を貫くように発育していた.病理組織検査では粘液嚢胞腺癌で,これに接する直腸壁は正常であった。以上の所見より,原発性虫垂癌の直腸穿通と診断した.自験例は特異な発育進展形態のため,直腸癌と術前診断したが,術後の検索で原発性虫垂癌の直腸穿通と診断されたまれな症例である.

A case of mucinous cystadenocarcinoma with a fistula between cyst and stomach

A case of mucinous cystadenocarcinoma with a fistula between cyst and stomach

腹腔鏡下胆嚢摘出術後に再発切除した胆嚢粘液嚢胞腺癌の１例

症例は49歳のボリビア人女性で, 1997年10月27日, 他医にて腹腔鏡下胆嚢摘出術を受けた. 慢性胆嚢炎の病理組織診断であった. 1998年12月より右悸肋部痛を認め, 肝膿瘍として保存的に加療された (別の他医). その後右悸肋部痛が続き, 腹壁腫瘤を認め, 1999年7月26日当科入院となった. 腹部CT検査にて腫瘤は肝床部から肝実質へおよぶ径約8cmの充実性部分を伴う多嚢胞病変とそれらとは独立した嚢胞病変を皮下および腹腔内に複数個認め, 8月11日手術を施行した. 肝床を中心とした腫瘤は十二指腸球部, 横行結腸に浸潤していた. また, 前回術創の皮下から腹腔内, 大網に嚢胞性病変を計4個認め, 肝床切除, 胃, 十二指腸, 横行結腸合併切除, 腹壁腫瘤摘出を施行した. 術後の病理組織診断では腫瘤はすべて粘液嚢胞腺癌であった. 初回手術時の切除胆嚢を再検したところ, 一部に同様な粘液嚢胞腺癌を認め, 最終的に腹腔鏡下胆嚢摘出術後に肝床, 皮下, 腹腔内に再発した胆嚢粘液嚢胞腺癌と診断した.

Detection of human papillomavirus DNA in malignant lesions from Chinese women with carcinomas of the upper genital tract.

The aim of this study was to determine the prevalence of high-risk oncogenic human papillomaviruses (HPVs) in malignant lesions from Hong Kong Chinese women with carcinomas of the upper genital tract. The presence of high-risk HPVs in 55 cases of endometrial adenocarcinomas and 60 cases of primary epithelial ovarian cancers was detected by polymerase chain reaction (PCR) using consensus primers complementary to late 1 (L1) gene of the genital HPVs. Amplified PCR products were verified and typed by Southern blot analysis using (32)P-labeled DNA probes prepared from cloned HPV-16 and -18 plasmids. To confirm the presence of high-risk HPV types in the tumor tissues, PCR amplification using HPV type 16- and 18-specific primers for part of the E6 gene were also carried out. While HPV-18 was not detected, HPV-16 DNA sequences were identified in 5 (9.1%) of the 55 studied endometrial carcinoma samples. Of the 5 HPV-16-positive cases, there were 4 stage I, and 1 stage II endometrial cancer. In addition, 6 (10%) of the 60 epithelial ovarian carcinomas were positive for high-risk HPVs, which included 5 cases with HPV-16 and 1 case with HPV-18. Clinical staging revealed that 5 of the 6 HPV-positive cases were stage I and the remaining case was stage III ovarian cancer. Histology of the 6 HPV-positive cases showed that there were 1 case of clear-cell adenocarcinoma, 1 case of mucinous cystadenocarcinoma, and 4 cases of mucinous tumor of borderline malignancy. No other HPV types were detected. High-risk HPV was detected in approximately 10% of the tumor samples from women with upper genital tract carcinomas. As compared to the high positive rate of HPV infections in cervical cancer, it appears that HPV infection plays a relatively minor role in the pathogenesis of endometrial and ovarian carcinomas.

A Case of Mucinous Cystadenocarcinoma Arising from a Mature Cystic Teratoma in the Right Ovary

A Case of Mucinous Cystadenocarcinoma Arising from a Mature Cystic Teratoma in the Right Ovary

Mucinous Cystadenocarcinoma of the Appendix. A Rare Tumour of the Right Iliac Fossa

A case of mucinous cystadenocarcinoma of the appendix is presented.The clinical feature is a painful syndrome of the right iliac fossa.In our observation, the diagnosis was not allowed by preoperative imaging. Appendectomy was initially performed and completed by right hemicolectomy and lymphadenectomy after histological diagnosis of the appendicular malignant tumour was forwarded.The prognosis of this tumour is generally excellent providing early diagnosis and wide enough surgery.

A case of mucinous cystadenocarcinoma which developed from the edge after appendectomy

A case of mucinous cystadenocarcinoma which developed from the edge after appendectomy