Lead Author's Financial Disclosures Nothing to disclose. Study Funding AstraZeneca Pharmaceutical Industry Company. Background/Synopsis Novel antihyperglycemic agents, including sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like-peptide-1 receptor agonists (GLP1-RA), demonstrate significant benefits in select patients with and without diabetes (T2DM). These benefits include improvements in cardiovascular, kidney and metabolic outcomes. Despite these benefits, these medications remain underutilized, attributed in part to a lack of provider knowledge across specialties. Our "Beyond-Diabetes" initiative is a health system-wide, multidisciplinary collaboration to raise awareness and prescriber utilization of these medications through a variety of informatics and educational modalities. Objective/Purpose The goal of this component of our initiative was to assess whether lecture based (grand rounds) and case-based conferences delivered via a virtual platform could improve understanding of SGLT2i and GLP1-RA among residents and fellows as part of their core curriculum. Methods We administered a 6-question electronic survey to assess knowledge of SGLT2i and GLP1-RA before and after a 1-hour, virtual case-based education that highlighted clinical uses, contraindications, dosing, adverse effects, and prescribing barriers. The housestaff were previously offered a grand rounds on the topic. The lectures and pre/post surveys were provided to internal medicine residents, as well as cardiology, nephrology, and endocrinology fellows. Efficacy was measured by analyzing the percent correct between pre/post-test questionnaires by a paired, two-sided t-test. Results After evaluating the pre-test and post-test results of the trainees, we found that among all disciplines (n = 119 pre/63 post), the average increase was 15% correct between pre-test and post-test (p-value <0.01) using random pre-test sampling. Limitations of this data include a low response rate with 28% of trainees completing the pre-test (119/418) and 53% completing the post-test (63/119). Cardiology fellows showed the greatest improvement in their overall scores with a 17% change. Endocrinology fellows had the least improvement, with a difference of 6%, likely attributable to having the highest baseline pre-test questionnaire scores. Analysis of each question showed that there was an increase in the percentage answered correctly, with the exception of one question, which had no change after education. Conclusions Our intervention demonstrates that a 1-hour virtual lecture can improve the knowledge of trainees across four disciplines regarding novel antihyperglycemic medications. This data supports the use of virtual lecture and case-based didactics to enhance provider knowledge regarding SGLT2i and GLP1-RA medications. However, further research into the most effective educational initiatives is warranted. This knowledge is essential to increase the utilization of these effective medications, which have been demonstrated to improve clinical outcomes and reduce healthcare expenditures. Nothing to disclose.