The central moments-based cascaded lattice Boltzmann method (CLBM) for then Newtonian and non-Newtonian Buongiorno’s model mixture nanofluids (CuO, ZnO, Al2O3-water) has been implemented and applied in a square chamber with a vertical heat radiator using accelerated graphics processing unit (GPU) computing through compute unified device architecture (CUDA) C/C++ platform. Due to the higher numerical stability, the CLBM is a superior numerical tool to the raw moments-based MRT-LBM (multiple-relaxation-time lattice Boltzmann method). Three different models for the viscosity and thermal conductivity of the nanofluids: (i) the Binkmann model for the constant viscosity and the Maxwell model for the constant thermal conductivity (ii) Binkmann and Maxwell model with temperature dependent Brownian motion and (iii) Corcione model with non-Newtonian fluid where the temperature and strain rate determine the nanofluid effective thermal conductivity and viscosity, have been used. The enclosure’s upper and bottom walls are thermally adiabatic, but the left and right walls are uniformly cold. A vertical heater is immersed in the middle position of the cavity. The benchmark results for non-Newtonian, Newtonian, and nanofluids for the various computational domains are used to validate the current code adequately. The Bingham number (Bn), the Rayleigh number (Ra), and The volume fraction of the nanoparticles (ϕ) are the three key parameters that are varied in this investigation to demonstrate the effects of natural convection on the isotherms, streamlines, isolines of nanoparticle volume fractionation, yielded and unyeilded zone, and average Nusselt number (Nu¯). The Brownian motion effects of the nanoparticles augmented the average rate of heat transfer and the use of the Bingham nanofluids reduced the heat transfer enhancement. For the CuO-water nanofluid, the augmentation of the rate of heat transfer is 15.42% from ϕ=0 to 4% while Ra=106 and the corresponding heat transfer enhancement for the ZnO-water nanofluid is 11.11%. For the Bingham fluid, the rate of heat transfer increases 7% from Ra=105 to Ra=106 while ϕ=2% and Bn=0.3. The findings can be applied to optimize automotive radiator systems, which are crucial for maintaining engine temperature.