Purpose: The purposes of this study were to examine the associations among caregiver burden, anxiety, spirituality, family relationship and depression and to determine predictors of depression among caregivers of hospitalized children.Methods: The participants were 128 caregivers of hospitalized children. Data were collected through self-report questionnaires and analyzed using descriptive statistics, independent t-test, one-way ANOVA, Pearson’s correlation coefficient and multiple regression analysis with SPSS ver. 27.Results: Depression was significantly positively associated with caregiver burden, anxiety and negatively associated with family relationships. Multiple regression analysis revealed that caregiver burden, anxiety, family relationship, and being 6 months or more post diagnosis were significant factors having an explanation power of approximately 56% of the variance in depression.Conclusion: Our study findings show that it is necessary to develop strategies to reinforce family relationship and reduce caregiver burden to prevent caregiver depression.