To study the application effect of PDCA cycle combined with PBL teaching method in the teaching of cardiovascular internal medicine trainees. Sixty intern trainee doctors were selected as the research subjects, and were divided into the observation group and the control group using the random number table method, with 30 in each group. The observation group implemented the PDCA cycle combined with the PBL method of teaching, and the control group implemented the traditional method of teaching, observing and comparing the teaching effect of the two groups of doctors. The observation group was better than the control group in all assessment scores, teaching satisfaction and teaching effect indicators after teaching (P<0.05). Therefore, the PDCA cycle combined with the PBL teaching mode is conducive to improving the trainee doctors' learning initiative, cultivating clinical thinking ability, and improving the quality of teaching.