Cardiorespiratory Fitness Test Research Articles

Association between iron and vitamin intake and cardiorespiratory fitness in adolescents of both sexes

Abstract Cardiovascular parameters and cardiorespiratory fitness in adolescents may be influenced by eating habits. The aim was to evaluate the association between the levels of some nutrients and micronutrients with blood pressure and VO2max in adolescents. A total of 60 adolescents (15.77 ± 0.96 years old) participated in the study, of whom 35 were girls and 25 were boys. Eating habits were assessed frequency questionnaire (FFQ). Before and after a cardiorespiratory fitness test (YOYO TEST), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were collected. A backward elimination method of multiple regression was performed to analyse the data. A positive association was found between VO2max and the intake of iron (), vitamin D (), vitamin B6 () and vitamin B12 () for girls. Additionally, no significant associations were found between sugar, fibre and fat intake and VO2max. There was a positive association between SBP and sugar intake () for girls and negative association between DBP after exertion and fibre intake () and body mass index () for boys. There is a positive association between the intake of iron, vitamins and VO2max in girls and intake of sugar with SBP for girls and negative association between fibres and DBP after exertion for boys.

Age-Related Differences and Reliability of a Field-Based Fitness Test Battery in Young Trained Footballers: The Role of Biological Age

Background: the purpose of this study was to analyze the reliability of a field-based fitness test battery in young trained football players, according to biological age. Methods: 197 young trained football players (12–19 years old) participated in the study. We measured anthropometric measurements (i.e., height, sitting height, length leg, and body mass), a bilateral vertical jumping test (CMJ), a progressive loading test of squats and hip thrust, acceleration and speed tests (10 m and 30 m sprint tests), a change-of-direction ability test (V–cut test), and a cardiorespiratory fitness test (30–15 intermittent fitness test). Statistical data are shown as the mean ± standard deviation by PHV group in tests and retests. Test reliability was assessed through the intraclass correlation coefficient (ICC), with an ICC above 0.9 being considered high. To evaluate accuracy and repeatability, standard error of measurement, coefficient of variation, and minimum detectable change at 90% were determined and Bland–Altman diagrams were used, establishing a statistical significance of p < 0.05. Results: All of the tests showed non-significant differences between the test and retest in the pooled sample (p > 0.05). Furthermore, all of them presented a trivial effect size (<0.2) and high intraclass correlation coefficients (>0.9), which indicates the high reproducibility of the tests, despite some of them presenting a significant difference between trials (i.e., the CMJ, 10 m sprint, V–cut, and squat tests). Low measurement errors were found for all tests (coefficient of variation [CV] = 4.39–9.39), except for the CMJ and the progressive loading test for squat and hip thrust exercises (CV = 12.2–21.11). Similar results were found irrespective of biological age group. Conclusions: All tests were reliable for the pooled sample as well as for the biological age groups.

Effects of Cardiopulmonary Rehabilitation on Cardiorespiratory Fitness and Clinical Symptom Burden in Long COVID: Results from the COVID-Rehab Randomized Controlled Trial.

To investigate the effectiveness of an eight-week cardiopulmonary rehabilitation program on cardiorespiratory fitness (VO2peak) and key cardiopulmonary exercise test measures, quality of life, and symptom burden in individuals with Long COVID. Forty individuals with Long COVID (mean age 53 ± 11 years), were randomized into 2 groups: 1/ Rehabilitation group: centre-based individualized clinical rehabilitation program (8 weeks, 3 sessions per week of aerobic and resistance exercises, and daily inspiratory muscle training) and 2/ Control group: individuals maintained their daily habits during an eight-week period. There was a significant difference between groups in mean VO2peak improvement (p = 0.003). VO2peak improved significantly in the rehab group (+2.7 mL.kg.min 95%IC:+1.6 to +3.8 p < 0.001) compared to the control group (+0.3 mL.kg.min 95%IC:-0.8 to +1.3 p = 0.596), along withVE/VCO2 slope (p = 0.032) (-2.4 95%IC:-4.8 to +0.01 p = 0.049 and + 1.3 95%IC:-1.0 to +3.6 p = 0.272 respectively) and VO2 at first ventilatory threshold (p = 0.045). Furthermore, all symptom impact scales improved significantly in the rehabilitation group compared to the control group (p < 0.05). An individualized and supervised cardiopulmonary rehabilitation program was effective in improving cardiorespiratory fitness, ventilatory efficiency, and symptom burden in individuals with Long COVID. Careful monitoring of symptoms is important to appropriately tailor and adjust rehabilitation sessions.

The Different Body Mass Index Does Not Impact Physical Health in Older Adults without Sedentary Behavior: A Cross-Sectional Study.

This study aimed to compare and determine the correlation of BMI on physical health, including muscle strength, balance, and cardiorespiratory fitness in older adults without sedentary behavior. A total of 65 older adults without sedentary behavior were recruited and divided into 3 groups on the basis of body mass index (BMI): normal weight (n= 22/group), overweight (n= 22/- group), and obese (n= 21/group). All the older adults were evaluated for upper limb muscle strength using the handgrip strength test, lower limb muscle strength using the sit-to-stand (STS10) test, balance ability using the time up and go (TUG) test, and cardiorespiratory fitness using the 6-minute walk test (6MWT). The handgrip strength test, STS10 test, and distance of 6MWT showed no difference among the groups (p> 0.05). However, overweight group had a significantly longer duration for the TUG test when compared to normal weight, while obese group had a significantly longer duration for the TUG test when compared with overweight and normal weight groups (p< 0.01). In addition, BMI was positively correlated with the duration of the TUG test. Whereas, the handgrip strength test, STS10 test, and distance of 6MWT were not correlated with BMI. The BMI does not impact upper and lower limb muscle strength or the cardiorespiratory fitness test, except for the ability to balance in older adults without sedentary behavior.

The Leisure Time Physical Activity Questionnaire for People with Disabilities: Validity and Reliability

There is an urgent need for valid and reliable measures of physical activity (PA) participation for use among people with physical and/or sensory disabilities. This study involved adapting the Leisure Time PA Questionnaire for People with Spinal Cord Injury for use in individuals with disabilities (i.e., the LTPAQ-D) and performing a preliminary evaluation of its content validity, construct validity, and same-day test–retest reliability in people with disabilities. User interviews assessed the content validity (n = 5). A cross-sectional study assessed the construct validity and same-day test–retest reliability (n = 27, 45 ± 21 years). Participants completed the LTPAQ-D, other self-report measures of aerobic and strength training PA, as well as tests of cardiorespiratory fitness (i.e., peak oxygen consumption (V˙O2peak)) and muscular strength. LTPAQ-D measures of min/week of aerobic LTPA, aerobic moderate-to-vigorous PA (MVPA), and strength training shared medium-to-large correlations with other self-report measures of aerobic and strength training PA (r = 0.458–0.942, ps &lt; 0.01). After controlling for age, aerobic LTPA and MVPA shared moderate partial correlations with V˙O2peak (r = 0.341 and 0.356, respectively). Min/week of strength training, measured by the LTPAQ-D, was associated with predicted maximal strength on the chest press (r = 0.621, p = 0.009). All LTPAQ-D measures demonstrated good-to-excellent test–retest reliability (intraclass correlations = 0.709–0.948, ps &lt; 0.01). This study provides preliminary evidence of the validity and reliability of the LTPAQ-D as a measure of LTPA among people with disabilities.

Association between change in cardiorespiratory fitness and prostate cancer incidence and mortality in 57 652 Swedish men

ObjectivesTo examine the associations between changes in cardiorespiratory fitness (CRF) in adulthood and prostate cancer incidence and mortality.MethodsIn this prospective study, men who completed an occupational health profile assessment including...

Do changes in mood and anxiety mediate exercise-induced reductions in alcohol cravings? An exploratory study.

Exercise is increasingly used as adjunct treatment for alcohol use disorder (AUD). Evidence suggests that moderate-to-high-intensity exercise can ameliorate cravings. We explored the potential mediating effects of changes in mood states in the relationship between exercise intensity and alcohol cravings. Secondary analyses of a nested single-arm trial within a randomized controlled trial (FitForChange). In total, 117 sedentary adults (68.4% female, M = 52 ± 12 years) with clinician diagnosed (Diagnostic and Statistical Manual of Mental Disorders, fifth edition) AUD and indications of craving (Desire for Alcohol Questionnaire) completed a 12-min submaximal cardiorespiratory fitness test on a cycle ergometer. Assessments of craving, mood states (POMS), and state anxiety (STAI-Y1) were taken immediately before, after, and 30 min after exercise. Ratings of perceived exertion (RPE) were included as indirect measures of exercise intensity. The med4way command in Stata was used to explore mediating and interaction effects of improvements in total mood disturbance (TMD) and state anxiety. Improvements in mood and anxiety did not mediate the effect of higher exercise intensity on reductions in alcohol craving. A significant reference interaction was found between "hard" (or greater) exertion and anxiety improvements (β = -1.06, 95% CI [-1.50, -0.61]). Participants whose anxiety reduced during exercise had two times higher odds of reduced cravings when exercising at a higher intensity than participants whose anxiety worsened (OR = 2.04, 95% CI [1.12, 3.72]). Reductions in anxiety may partly explain the positive effect of higher exercise intensity on alcohol cravings. The findings are preliminary and require replication in future studies. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

The Cardiorespiratory Fitness of Children and the Anthropometric Determinants During Late Childhood Within South East Wales: Potential Implications for Future Health.

Objective. This study investigated cardiorespiratory fitness (CRF) levels and the relationship with field-based measures of anthropometry in children aged 10 to 11 years. Methods. A total of 288 boys and 257 girls participated in the study. CRF (20 m shuttle run) and several field-based measures of anthropometry were assessed. Multiple regression was utilized for all data analysis. Results. Boys performed significantly better than girls on the CRF test (P < .001) and achieved higher classifications of CRF based on centile norms compared to girls. All measures of anthropometry were significant predictors of CRF, (P < .001), and each measure was significant in predicting a negative trajectory of CRF performance when they increased in value (P < .05). Conclusion. The study findings add to the international reporting of CRF and the use of simple field-based measures of anthropometry alongside the use of BMI to predict CRF for health with Welsh school children (UK).

PHYSICAL CAPACITY AS MARKER FOR RATE OF AGING IN MID LIFE

Abstract Biological age captures the heterogeneity of aging by providing an estimation for rate of aging. As an alternative to the widely investigated laboratory biomarkers of aging, behavioral functional markers of physical capacity may offer a feasible alternative for identifying individuals at risk for negative aging trajectory. We aimed to examine the associations of different functional tests both together and as a composite score of physical capacity with rate of aging. We conducted a cross-sectional study, with midlife adults (age ~45) reporting being able to perform leisure physical exercise. Biological age was estimated using the Klemera-Doubal method and a set of physiological biomarkers; rate of aging, ∆Age, was defined as the difference between age and estimated biological age. Physical capacity was measured using a testing battery of 15 functional tests linked with six physical capacity domains. 116 participants completed the testing battery. For women, better results in terms of strength, flexibility, cardiorespiratory fitness, and balance tests were negatively correlated with ∆Age (r=0.38-0.29, p&amp;lt;0.05); for men, beyond these tests, agility was also negatively correlated with ∆Age (r=0.27-0.59, p&amp;lt;0.05). A sex-standardized composite score of physical capacity was negatively associated with ∆Age after controlling for chronological age, smoking, and education (r=-0.437, p=0.007; r=-0.491, p&amp;lt;0.001 for women and men respectively). The suggested physical capacity battery offers a functional assessment for ∆Age. Higher physical capacity metrics correlate with smaller ∆Age, corresponding with younger biological age. Measuring physical capacity may help to assess aging trajectory and offer a suitable behavioral intervention goal.

Subpopulations of regulatory T cells are associated with subclinical atherosclerotic plaques, levels of LDL, and cardiorespiratory fitness in the elderly

BackgroundAtherosclerosis forms the pathological basis for the development of cardiovascular disease. Since pathological processes initially develop without clinically relevant symptoms, the identification of early markers in the subclinical stage plays an important role for initiating early interventions. There is evidence that regulatory T cells (Tregs) are involved in the development of atherosclerosis. Therefore, the present study aimed to identify and investigate associations with Tregs and their subsets in a cohort of healthy elderly individuals with and without subclinical atherosclerotic plaques (SAP). In addition, various lifestyle and risk factors, such as cardiorespiratory fitness, were investigated as associated signatures. MethodsA cross-sectional study was performed in 79 participants (male: n = 50; age = 63.6 ± 3.7 years; body mass index = 24.9 ± 3.1 kg/m²; mean ± SD) who had no previous diagnosis of chronic disease and were not taking medication. Ultrasound of the carotids to identify SAP, cardiovascular function measurement for vascular assessment and a cardiorespiratory fitness test to determine peak oxygen uptake were performed. Additionally, tests were conducted to assess blood lipids and determine glucose levels. Immunophenotyping of Tregs and their subtypes (resting (rTregs) and effector/memory (mTregs)) was performed by 8-chanel flow cytometry. Participants were categorized according to atherosclerotic plaque status. Linear and logistic regression models were used to analyze associations between parameters. ResultsSAP was detected in a total of 29 participants. The participants with plaque were older (64.8 ± 3.6 years vs. 62.9 ± 3.5 years) and had higher peripheral systolic blood pressure (133.8 ± 14.7 mmHg vs. 125.8 ± 10.9 mmHg). The participants with SAP were characterized by a lower percentage of rTregs (28.8% ± 10.7% vs. 34.6% ± 10.7%) and a higher percentage of mTregs (40.3% ± 14.7% vs. 30.0% ± 11.9%). Multiple logistic regression identified age (odds ratio (OR) = 1.20 (95% confidence interval (95%CI): 1.01–1.42)) and mTregs (OR = 1.05 (95%CI: 1.02–1.10)) as independent risk factors for SAP. Stepwise linear regression could reveal an association of peak oxygen uptake (β = 0.441), low-density lipoprotein (LDL) (β = –0.096), and SAP (β = 6.733) with mTregs and LDL (β = 0.104) with rTregs. ConclusionWhile at an early stage of SAP, the total proportion of Tregs gives no indication of vascular changes, this is indicated by a shift in the Treg subgroups. Factors such as serum LDL or cardiopulmonary fitness may be associated with this shift and may also be additional diagnostic indicators. This could be used to initiate lifestyle-based preventive measures at an early stage, which may have a protective effect against disease progression.

5 Large-Scale Network Connectivity and Cognitive Function after Exercise Training in Older Adults

Objective:Despite growing evidence regarding the association between exercise training (ET) and functional brain connectivity, little is known about the effects of ET on within- and between-network functional connectivity (FC) of core brain networks. We investigated the effects of ET on within- and between-network functional connectivity of the default mode network (DMN), frontoparietal network (FPN), and salience network (SAL) in older adults with intact cognition (CN) and older adults diagnosed with mild cognitive impairment (MCI). We further examined whether the ET-induced changes in FC were associated with changes in cognitive performance.Participants and Methods:33 older adults (78.0±7.0 years; 16 MCI and 17 CN) participated in the present study. Before and after a 12-week walking ET intervention, participants underwent cardiorespiratory fitness tests, the Controlled Oral Word Association Test (COWAT), the Rey Auditory Verbal Learning test (RAVLT), a narrative memory test (logical memory; LM), and a resting-state fMRI scan. We examined the within- and between-network connectivity of the DMN, FPN, and SAL before and after ET. We also used linear regression to examine associations between ET-related changes in the within- and between-network connectivity and cognitive function.Results:There were significant improvements in VO2peak, COWAT, RAVLT, and LM after ET across participants. Significant increases in within-network connectivity of the DMN and SAL were observed in response to ET across participants. FC between the DMN-FPN, DMN-SAL, and FPN-SAL were also increased after ET. Moreover, greater SAL within connectivity and FPN-SAL between connectivity were associated with enhanced LM immediate recall performance after ET. There were no significant interactions between Time (before vs after ET) and Group (CN vs MCI) for network connectivity or cognitive function.Conclusions:Our findings suggest that increased within- and between-network connectivity following 12-weeks of walking exercise may subserve improvements in memory performance in older individuals with intact cognition and in those diagnosed with MCI.

Data-driven MRI analysis reveals fitness-related functional change in default mode network and cognition following an exercise intervention.

Previous research has indicated that cardiorespiratory fitness (CRF) is structurally and functionally neuroprotective in older adults. However, questions remain regarding the mechanistic role of CRF on cognitive and brain health. The purposes of this study were to investigate if higher pre-intervention CRF was associated with greater change in functional brain connectivity during an exercise intervention and to determine if the magnitude of change in connectivity was related to better post-intervention cognitive performance. The sample included low-active older adults (n = 139) who completed a 6-month exercise intervention and underwent neuropsychological testing, functional neuroimaging, and CRF testing before and after the intervention. A data-driven multi-voxel pattern analysis was performed on resting-state MRI scans to determine changes in whole-brain patterns of connectivity from pre- to post-intervention as a function of pre-intervention CRF. Results revealed a positive correlation between pre-intervention CRF and changes in functional connectivity in the precentral gyrus. Using the precentral gyrus as a seed, analyses indicated that CRF-related connectivity changes within the precentral gyrus were derived from increased correlation strength within clusters located in the Dorsal Attention Network (DAN) and increased anti-correlation strength within clusters located in the Default Mode Network (DMN). Exploratory analysis demonstrated that connectivity change between the precentral gyrus seed and DMN clusters were associated with improved post-intervention performance on perceptual speed tasks. These findings suggest that in a sample of low-active and mostly lower-fit older adults, even subtle individual differences in CRF may influence the relationship between functional connectivity and aspects of cognition following a 6-month exercise intervention.

Poor cardiorespiratory fitness in first year medical students at a South African University

ABSTRACT The personal health behaviours, including physical activity, of healthcare professionals influence their counselling practices as they relate to non-communicable diseases (NCDs). However, despite the importance of producing healthy, physically active graduates, there are limited data on the physical fitness of future healthcare professionals. This cross-sectional observational study determined the prevalence of below-average fitness in the four components of fitness in first-year university medical students. 152 participants (46 male, 106 female, 20.16 ± 2.69 years) completed cardiorespiratory fitness tests (submaximal step test), flexibility (sit-and-reach test), muscle strength (handgrip), and muscle endurance tests (sit-ups, push-ups). Sex differences were reported using one-way ANOVA or Chi square test and significance was set at p < 0.05. The prevalence (%) of below-average fitness was 69.54% for cardiorespiratory, 25.66% for handgrip strength, 65.79% for sit-ups, 23.03% for push-ups and 7.24% for flexibility. Physical fitness parameters (mean±standard deviation (SD)) were compared between sexes, where it was found that females were more flexible than males (40.61 ± 8.40 cm vs 36.70 ± 9.31 cm, p = 0.012). Males had better handgrip strength (88.96 ± 12.04 kg vs 59.34 ± 10.36 kg, p < 0.001), muscle endurance sit-ups (33.46 ± 9.04 vs 24.48 ± 12.18, p < 0.001) and push-ups (30.28 ± 13.95 vs 24.27 ± 12.35, p = 0.009). First-year medical students have poor physical fitness, notably cardiorespiratory fitness and muscle strength, which are important markers for NCD risk assessment. Tertiary institutions training healthcare professionals should consider developing interventions to improve students’ physical fitness thereby influencing their health, wellbeing, academic performance and future counselling practices.

Comparison of Several Anthropometric Indices Related to Body Fat in Predicting Cardiorespiratory Fitness in School-Aged Children-A Single-Center Cross-Sectional Study.

Body fat (BF) and cardiorespiratory fitness (CRF) are important health markers that ought to be considered in screening exams. The aim of this study was to assess the value of six indicators, i.e., tri-ponderal mass index (TMI), relative fat mass (RFM), waist-BMI ratio, waist-to-height ratio (WHtR), waist-to-hip ratio (WHR) and body mass index (BMI) in predicting CRF in school-aged children. The analysis was based on the data coming from the examination of 190 children participating in school physical education (PE) classes. Their body weight (BW) and height (BH), waist and hip circumference (WC; HC) and percentage of body fat (%BF) were measured; the CRF test was performed with the use of the 20 m shuttle run test (20 mSRT); peak heart rate (HRpeak) was measured; TMI, relative fat mass pediatric (RFMp), waist-BMI ratio, WHtR, BMI and WHR were calculated. Statistical analysis was mainly conducted using regression models. The developed regression models, with respect to the sex and age of the children, revealed RFMp as the strongest CRF indicator (R2 = 51.1%) and WHR as well as waist-BMI ratio as the weakest ones (R2 = 39.2% and R2 = 40.5%, respectively). In predicting CRF in school-aged children, RFMp turned out to be comparable to body fat percentage obtained by means of the bioimpedance analysis (BIA) (R2 = 50.3%), and as such it can be used as a simple screening measure in prophylactic exams of school children. All of these models were statistically significant (p < 0.001).

Effects of short-term supervised exercise training on liver fat in adolescents with obesity: a randomized controlled trial.

The objective of this study was to quantify the effects of a 4-week, supervised, high-intensity interval training (HIIT) on intrahepatic triglyceride content (IHTG, percentage), cardiorespiratory fitness (CRF), and cardiometabolic markers in adolescents with obesity. A total of 40 adolescents (age 13-18 y, BMI 36.7 ± 5.8 kg/m2 ) at risk for metabolic dysfunction-associated steatotic liver disease (MASLD) based on obesity and elevated Fibroscan measured controlled attenuation parameter (CAP) scores were randomized to HIIT three times a week for 4 weeks (n = 34) or observation (control; n = 6). Liver magnetic resonance imaging proton-density fat-fraction (MRI-PDFF), CAP, oral glucose tolerance test, serum alanine aminotransferase, dual-energy x-ray absorptiometry, and CRF tests were performed before and after intervention. Within- and between-group differences were compared. A total of 13 (38%) and 4 (66%) children had MASLD by MRI-PDFF (IHTG ≥ 5%) in the HIIT and control groups, respectively. The implemented HIIT protocol had no impact on CRF or IHTG (baseline 5.26%, Δ = -0.31 percentage points, 95% CI: -0.77 to 0.15; p = 0.179), but it decreased the 2-h glucose concentration (baseline 116 mg/dL, Δ = -11 mg/dL; 95% CI: -17.6 to -5.5; p < 0.001). When limiting the analysis to participants with MASLD (n = 17), HIIT decreased IHTG (baseline 8.81%, Δ = -1.05 percentage points, 95% CI: -2.08 to -0.01; p = 0.048). Between-group comparisons were not different. The implemented exercise protocol did not reduce IHTG, but it led to modest improvement in markers of cardiometabolic health.

Effects of cardiorespiratory fitness and body mass index on cardiometabolic risk factors in schoolchildren

IntroductionHigh levels of physical fitness established during childhood and adolescence have been associated with positive effects on cardiometabolic risk factors (CMRF), which persist into adulthood. Conversely, a sedentary lifestyle, overweight, and obesity during this period are considered public health problems. These conditions tend to worsen in adulthood, increasing the incidence of chronic diseases, deteriorating CMRF, and consequently leading to higher comorbidity and mortality rates.ObjectiveTo investigate the effect of cardiorespiratory fitness (CRF) and body mass index (BMI) on CMRF in children and adolescents.MethodsThe sample consisted of 49 schoolchildren of both sexes aged 10–17 years. Anthropometric assessments, CRF test, muscle strength test, and blood pressure (BP) measurement were conducted. Participants were allocated into groups based on BMI (eutrophic, overweight, obese), and CRF levels (low-fit, normal-fit, and high-fit).ResultsObese individuals had lower CRF values compared to the eutrophic and overweight groups. The cardiometabolic risk profile (CMRP) was significantly higher in the obese group compared to the eutrophic group but showed no significant difference compared to the overweight group. The hight-fit group had lower CMRP values compared to the low-fit group.ConclusionsHigher BMI and CRF values had negative and positive effects on CMRF and CMRP in schoolchildren, respectively. Overweight or obese schoolchildren with low levels of CRF constitute an unfavourable cardiometabolic risk profile.

CORRELATION BETWEEN THE CARDIORESPIRATORY FITNESS LEVEL AND HABITUAL PHYSICAL ACTIVITY IN BRAZILIAN AIR FORCE RECRUITS

Cardiorespiratory fitness is the ability to maintain moderate or high-intensity efforts for long periods of time and is highly related to physical activity habits and fitness levels. Analyzing habitual physical activity in military personnel and its relationship with cardiorespiratory fitness is consequently fundamental. Thus, the objective of this study was to verify the correlation between the cardiorespiratory fitness level and habitual physical activity in Brazilian Air Force recruits. The sample consisted of 86 recruits in the final phase of the soldier training course. Data was collected using the 12-minute cardiorespiratory fitness test and the Baecke questionnaire validated for the Portuguese language to assess the practice of habitual physical activity. Descriptive statistics were used for sample characterization and exploratory analysis. The distribution of data normality was analyzed using the Shapiro-Wilk test, followed by Pearson’s correlation test and the Mann-Whitney U test to compare the groups with lower and higher cardiorespiratory fitness. The significance level of p ≤ 0.05 was adopted. According to the results, 63.9% of the sample had satisfactory cardiorespiratory fitness levels (good and excellent). No significant correlations were observed between cardiorespiratory fitness and habitual physical activity indices, except for the physical exercise/sports index (p= 0.05). It was found that only the Body Mass Index showed a difference (p= 0.017, Effect Size= 0.637) between the cardiorespiratory fitness groups. It is concluded that most military recruits have adequate cardiorespiratory fitness levels, but these are not influenced by the habitual practice of physical activity.&lt;p&gt; &lt;/p&gt;&lt;p&gt;&lt;strong&gt; Article visualizations:&lt;/strong&gt;&lt;/p&gt;&lt;p&gt;&lt;img src="/-counters-/soc/0036/a.php" alt="Hit counter" /&gt;&lt;/p&gt;

Cardiorespiratory fitness is associated with hippocampal resting state connectivity in women newly diagnosed with breast cancer.

Breast cancer and its treatment are associated with aberrant patterns of resting state functional connectivity (rsFC) between the hippocampus and several areas of the brain, which may account for poorer cognitive outcomes in patients. Higher cardiorespiratory fitness (CRF) has been associated with enhanced rsFC and cognitive performance; however, these associations have not been well studied in breast cancer. We examined the relationship between CRF, rsFC of the hippocampus, and cognitive performance among women newly diagnosed with breast cancer. Thirty-four postmenopausal women newly diagnosed with Stage 0-IIIa breast cancer (Mage = 63.59 ± 5.73) were enrolled in a 6-month randomized controlled trial of aerobic exercise vs. usual care. During baseline assessments, participants completed functional brain imaging, a submaximal CRF test, and cognitive testing. Whole-brain, seed-based analyses were used to examine the relationship between CRF and hippocampal rsFC, with age, years of education, and framewise displacement included as covariates. Cognition was measured with a battery of validated neurocognitive measures, reduced to seven composite factors. Higher CRF was positively associated with greater rsFC of the hippocampus to a cluster within the dorsomedial and dorsolateral frontal cortex (z-max = 4.37, p = 0.003, cluster extent = 1,020 voxels). Connectivity within cluster peaks was not significantly related to cognitive factors (all ps > 0.05). CRF was positively associated with hippocampal rsFC to frontal cortex structures, comprising a network of regions commonly suppressed in breast cancer. Future longitudinal research is needed to explore whether baseline rsFC predicts long-term cognitive resilience in breast cancer.

Preserved hemodynamics in breast cancer survivors not a function of cancer, but fitness

Introduction: One in eight U.S. women will develop breast cancer (BC), and cardiovascular disease is the second leading cause of death among survivors. Improving cardiorespiratory fitness (CRF) and increasing physical activity (PA) reduces risk of adverse cardiovascular events among the general population without BC. Specifically, improved heart rate recovery (HRR) and hemodynamic modulation established through greater PA are traditional methods of risk assessment for cardiovascular disease that may be beneficial for BC survivors. Purpose: The purpose of this study was to examine HRR and hemodynamic adjustments following a maximal test of CRF among active and inactive BC survivors compared to women without a BC diagnosis. Methods: Twenty-two BC survivors were separated into active (n=11, 48±9 yrs, 24.8±3 kg/m2, 373±172 min/wk) and inactive (n=11, 51±9 yrs, 26.1±3 kg/m2, 52±68 min/wk) groups and compared to 18 active women without BC (48±9 yrs, 25.3±5 kg/m2, 327±178 min/wk) based on the Paffenberger PA Questionnaire. Mean arterial pressure (MAP), cardiac output (CO), total peripheral resistance (TPR), and stroke volume (SV) were measured before and 5 minutes after after a cycle ergometry test of CRF (expressed as VO2peak) using an oscillometric device. Continuous heart rate was assessed using a three-lead ECG throughout and following the test to calculate the slow phase (Peak exercise [VO2peak] to 2-min post) of HRR. Results: Active BC survivors demonstrated similar HRR from peak exercise (-52±15 bpm) compared to active individuals without BC (-46±12 bpm), both of which were greater than the HRR observed in non-active BC survivors (-38±12 bpm; p for interaction=0.05). We found a significant relationship between CRF and HRR for the three groups (VO2peak, active BC survivors: 32.6±4 mL/kg·min-1; inactive BC survivors: 20.9±3 mL/kg·min-1; active controls: 29.5±6 mL/kg·min-1; r=0.38, p=0.01). Likewise, inactive BC survivors experienced a blunted change in SV following a maximal CRF test, compared to active BC survivors and control counterparts (%ΔSV [mL/min], active BC survivors: 32.7%; inactive BC survivors: 23.5%; active controls: 39.3%; p for interaction≤0.001). Active BC survivors (before: 1.32±0.1 mmHg/L·min-1, after: 1.13±0.2 mmHg/L·min-1) experienced a greater reduction in TPR following the maximal CRF test compared to their inactive BC survivors (before: 1.23±0.2 mmHg/L·min-1, after: 1.18±0.14 mmHg/L·min-1) and active individuals without BC (before: 1.20±0.2 mmHg/L·min-1, after: 1.16±0.12 mmHg/L·min-1; p for interaction=0.03). MAP was not different between the 3 groups ( p for interaction≥0.05). Conclusion: Physically active BC survivors exhibit preserved cardiac autonomic and hemodynamic control following maximal exercise, similar to active individuals without BC. This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Validity of the two-minute step test for healthy older adults

BackgroundIn healthy older adults, the two-minute step test (2MST) does not have its concurrent validity tested against the six-minute walk test (6MWT), which is a valid cardiorespiratory fitness test frequently applied in geriatric samples. ObjectiveTo derive an equation to predict 6MWT from 2MST and to observe the agreement between observed and estimated 6MWT distances. Methods6MWT and 2MST were measured in 51 older adults (72.9±4.6 years) from community multicomponent exercise programs. Multiple linear regression derives the predictive equation of 6MWT walked distance (dependent outcome) from steps obtained in 2MST, age, sex, and body mass index (independent outcomes). ResultsCorrelation between 6MWT and 2MST was strong (r=0.696, p<0.001). The regression equation showed good agreement with measured values, when 6MWT was below 600 m. ConclusionThe equation stands as a novel approach to obtaining a valid 6MWT estimation from the 2MST. 2MST is easier and faster, representing an alternative approach when time and space are limited.