Cardiac Neurosis Research Articles

Treatment of functional neurological disorders by example of a patient with cardiac neurosis, tension headache, musculoskeletal pain and insomnia

Treatment of functional neurological disorders by example of a patient with cardiac neurosis, tension headache, musculoskeletal pain and insomnia

Treatment of Cardiac Neurosis based on the "Harmonizing and Regulating the Pivot" Approach

The incidence of cardiac neurosis is increasing year by year, and there is a trend of rejuvenation. The etiology and pathological mechanism of Western medicine are complex, and it is believed that it may be related to the environment, personality and psycho-neurological factors, etc. Clinical treatments are based on sedation, anti-anxiety and symptomatic treatments, and the efficacy of the treatments is not good. This paper is based on the theory of "Harmonizing and Regulating the Pivot" elaborates on the correlation between cardiac neurosis and the cardiac mechanism, analyses the mechanism and treatment of cardiac neurosis in Chinese medicine, and concludes that the mechanism of this disease is the pivotal folding of the pivotal depression, the evil guest pivotal micro-organisms, the qi and blood deficiency stagnation, the imbalance of yin and yang; the treatment principle is to regulate the pivot to reach the pivot depression, to dispel the evils and the pivot, the external transfer of the internal and the harmonization and regulating the qi and blood, and to harmonise yin and yang and pivot the holding of the cold and heat. It further improves the pathogenesis and treatment of cardiac neurosis and provides reference for clinical treatment.

Electrocardiogram in different types of dizziness

We have studied the influence of neurological loadings on heart rate (HR) in patients with dizziness and correlations between types of dizziness and changes in the electrocardiography (ECG) parameters. Two hundred and twenty-one patients aged 44.82 ± 14.15 years were examined. ECG and HR have been recorded before and after neurological loadings: calculation, Takahashi, tracking, lowering the bed and diadochokinesis. All the tests resulted in HR changes. The data obtained have been discussed from the point of view of somatomorphic disorders, cardiac neurosis (F45.3 according to ICD-10) and the possibility of their detection in patients with cardiac complaints in whom ECG studies did not reveal any abnormalities. Correlations between certain types of dizziness and ECG interval indicators are discussed.

Brief Discussion on Zhigancao Decoction Combined with Psychotherapy for Cardiac Neurosis with Deficiency of Both Qi and Yin

Brief Discussion on Zhigancao Decoction Combined with Psychotherapy for Cardiac Neurosis with Deficiency of Both Qi and Yin

Specific Information about Cardiac Neurosis and Treatment and Prevention

Heart disease has plagued mankind since the earliest times. There are some common heart conditions like coronary heart disease, congenital heart disease, hypertensive heart disease and so on. These heart sicknesses afflict people of all ages. There is a people around who have heart disease, but don't hear about it often compared to others. She thought it was just a faster heartbeat until she was diagnosed, and then a variety of symptoms occurred that were more severe before she was diagnosed with cardiac neurosis. This disease can also occur at different ages, many behaviors and different other sicknesses have an impact on it as well. How do we recognize these symptoms as indicative of cardiac neurosis, and what can we do to prevent and treat the disease once it has been diagnosed? With these questions I want to learn more about this disease and let more people know this disease.

Clinical application of Chaihu Jia Longgu Muli Decoction based on modern pathophysiology mechanism

Chaihu Jia Longgu Muli Decoction was firstly recorded in Treatise on Cold Damage(ZHANG Zhong-jing, Eastern Han dynasty). According to this medical classic, it is originally used in the treatment of the Shaoyang and Yangming syndrome. Based on the modern pathophysiological mechanism, this study interpreted the classic provisions of Chaihu Jia Longgu Muli Decoction. Original records of "chest fullness" "annoyance" "shock" "difficult urination" "delirium" "heavy body and failing to turn over" all have profound pathophysiological basis, involving disorders in cardiovascular, respiratory, nervous, and mental systems. This formula is widely used, which can be applied to treat epilepsy, cerebral arteriosclerosis, cerebral infarction, and other cerebrovascular diseases, hypertension, arrhythmia, and other cardiovascular diseases, insomnia, constipation, anxiety, depression, cardiac neurosis and other acute and chronic diseases as well as diseases in psychosomatic medicine. The clinical indications include Bupleuri Radix-targeted syndrome such as fullness and discomfort in chest and hypochondrium, bitter taste mouth, dry throat, and dizziness, the insomnia, anxiety, depression, susceptibility to fright, upset, dreamfulness and other psychiatric symptoms, red tongue, thick and yellow tongue coating, and wiry hard and powerful pulse. This formula was found to be used in combination with other formulas, such as Gualou Xiebai Decoction, Wendan Decoction, Zhizhu Pills, Juzhijiang Decoction, Suanzaoren Decoction, and Banxia Baizhu Tianma Decoction.

Meta-Analysis on the Efficacy of Traditional Chinese Medicine Decoction in the Treatment of Cardiac Neurosis Complicated with Depression and Anxiety

Objective. To analyze and evaluate the effectiveness of traditional Chinese medicine decoction (TCMD) in the treatment of cardiac neurosis (CN) complicated with depression and anxiety. Methods. Relevant literature on TCMD in the treatment of CN complicated with depression and anxiety was retrieved from Chinese and English databases, and the retrieved literature was included and excluded. The quality of the retrieved literature was evaluated according to the Cochrane system, and the meta-analysis was undertaken with RevMan5.3 software. Results. A total of 10 papers were included, including 686 patients and 349 patients in the treatment group (131 males and 218 females), and there were 337 cases in the control group (131 males and 206 females). The results of the meta-analysis showed that compared with the control group, TCMD could significantly improve palpitation (MD = 0.78, 95% CI = 0.55–1.01, P < 0.00001 ), chest tightness/chest pain (MD = 0.53, 95% CI = 0.10–0.97, P < 0.05 ), shortness of breath (MD = 0.60, 95% CI = 0.26–0.93, P = 0.0005 ), and TCM syndrome score (MD = 5.91, 95% CI = 4.32–7.49, P < 0.00001 ), reduce resting heart rate (MD = 13.21, 95% CI = 9.01–17.40, P < 0.00001 ), and could reduce psychological scale scores, such as Zung’s self-rating Depression Scale (MD = 7.90, 95% CI = 4.98–10.83, P < 0.00001 ), Zung’s self-rating Anxiety Scale (MD = 6.55, 95% CI = 4.25–8.86, P < 0.00001 ), Hamilton Depression Scale (MD = 4.46, 95% CI = 3.00–5.92, P < 0.00001 ), and Hamilton Anxiety Scale (MD = 3.35, 95% CI = 1.85–4.85, P < 0.0001 ). The differences were statistically significant. Tonic drugs were commonly used; Angelica sinensis, Poria cocos, Polygala tenuifolia, Wild jujube kernel, and Bupleurum were the most frequently used traditional Chinese medicines. Conclusion. TCMD mainly composed of tonic and tranquilizing herbs could significantly improve the clinical symptoms of patients with CN and reduce heart rate, anxiety, and depression scores. However, the evidence grade of the clinical research was limited by the quality of the included literature, and more high-quality clinical trials are still needed for further verification. This trial was registered with PROSPERO: CRD42022312164

Study on the active components and mechanism of Suanzaoren decoction in improving cognitive impairment caused by sleep deprivation

Ethnopharmacological relevanceSuanzaoren Decoction (SZRD) is a traditional and classic prescription for the treatment of insomnia, with a history of more than 1,000 years. It replenishes blood components, calms the nerves, reduces fever and irritability. It is commonly used in the clinical treatment of chronic fatigue syndrome, cardiac neurosis, and menopausal syndromes. Modern pharmacological studies have shown that it improves cognitive impairment; however, its mechanism of action remains unclear. Aim of the studyThis study preliminarily investigated the potential bioactive components and mechanism of SZRD in improving cognitive impairment by exploring network pharmacology, molecular docking, and conducting in vivo experiments. Materials and methodsThe components of various Chinese herbs in SZRD and their disease-related targets were identified through network pharmacology and literature. Gene ontology (GO) function enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses of intersection targets were performed using the relevant database. Next, the “Components-Targets-Pathways” (C-T-P) and “Protein-Protein interaction” networks were constructed using the enrichment analysis results to further identify potential pathways, bioactive components, and hub genes. At the same time, molecular docking was used to further distinguish the key bioactive components and genes of SZRD responsible for improving cognitive impairment. Finally, the potential mechanism of action was further analysed and verified using in vivo experiments. ResultsA total of 117 potential active components and 138 intersection targets were identified by network pharmacology screening. The key bioactive components, including calycosin, 5-Prenylbutein, licochalcone G, glypallichalcone, and ZINC189892, were identified by analysing the networks and molecular docking results. Hub genes included ACHE, CYP19A1, EGFR, ESR1, and ESR2. The oestrogen signalling pathway was the most important in the enrichment analysis. In vivo experiments further proved that SZRD could improve cognitive impairment by affecting the oestrogen signalling pathway and the expression of ACHE and CYP19A1. ConclusionsNetwork pharmacology and in vivo experiments demonstrate that SZRD improves cognitive impairment caused by sleep disturbance through estrogen receptor pathway, which provides a basis for its clinical application.

Clinical Research Progress of Chaihu Longgu Oyster Decoction

Chaihu Longgu Oyster soup is a classic famous recipe, which has the functions of reconciling Shaoyang, clearing Yang and relieving heat, and calming the nerves. It is mainly used to treat the syndrome of evil invading Shaoyang, diffuse Sanjiao, diseases on the outside and inside, and mutual recognition of deficiency and reality. In recent years, the party has been widely applied in various clinical departments, and can be used to treat neurological diseases (insomnia, anxiety, depression, epilepsy), circulatory system (coronary heart disease, arrhythmia, hypertension, cardiac neurosis), digestive system (chronic gastritis, irritable bowel syndrome), endocrine system (diabetes, metabolic syndrome), urogenital system (premature ejaculation, impotence, seminal emission). Surgery (cervical spondylosis, compression fracture, osteoarthritis), obstetrics and gynecology (climacteric syndrome, amenorrhea), pediatrics (infantile tic, febrile convulsion), tinnitus, urticaria and other facial and dermatological diseases. In clinical application, we should grasp the key points of syndrome differentiation, add and subtract with symptoms, which can further expand the scope of application.

Clinical effect and safety of acupuncture in treatment of cardiac neurosis:a systematic review and meta-analysis

To systematically evaluate the clinical effect and safety of acupuncture in the treatment of cardiac neurosis. Chinese databases (including SinoMed, VIP, CNKI, and Wanfang Data) and English databases (including PubMed and The Cochrane Library) were searched for randomized controlled trials (RCTs) on acupuncture in the treatment of cardiac neurosis published up to March 2019. Two reviewers independently screened the literature, extracted data, and assessed the risk of bias of included studies, and then RevMan 5.3 was used to perform a meta-analysis. A total of 7 RCTs were included, with 491 patients with cardiac neurosis. The results of the meta-analysis showed that compared with the conventional western medicine group, the acupuncture group had a significantly higher total effective rate (risk ratio ［RR］=1.16, 95% CI［1.05,1.28］, P=0.005) and had significantly greater improvements in Hamilton Anxiety Scale score (mean difference ［MD］=-3.22, 95% CI［-6.05, -0.39］, P=0.03). There were no significant differences between the two groups in Hamilton Depression Scale score (MD=-1.92, 95% CI［-4.76, -0.91］, P=0.18)，traditional Chinese medicine symptom score (MD=-5.49, 95% CI［-11.55, 0.56］, P=0.08), somatization symptom score (MD=-0.91, 95% CI［-3.28, 1.46］, P=0.45), and adverse reactions (RR=0.67, 95% CI［0.26,1.78］, P=0.42). Acupuncture can alleviate the symptoms and is safe in the treatment of cardiac neurosis.

FUNCTIONAL STATE CHANGES OF THE VEGETATIVE NERVOUS SYSTEM IN PATIENTS WITH ACALCULOUS CHOLECYSTITIS DEPENDING ON THE TYPE OF SOMATOFORM VEGETATIVE DYSFUNCTION AND ESSENTIAL HYPERTENSION

Objective: to establish the features of the functional state changes of the autonomicnervous system in patients with chronic noncalculous cholecystitis, depending on the typeof concomitant somatoform autonomic dysfunction and hypertension stage II.Material and methods. 138 patients were examined: 98 of them with chronic acalculouscholecystitis in the exacerbation phase and concomitant somatoform autonomicdysfunction, 40 patients with chronic noncalculous cholecystitis in the phase ofexacerbation with accompanying essential hypertension stage II and 30 practicallyhealthy persons who made up the control group. To characterize the state of theautonomic nervous system we used A.M. Vein vegetative symptoms scale, Ashner-Danyini,Danielopulu (orthoclinostatic) tests.Results. Indices’ analysis of the carried out investigation of the general vegetativesymptoms have shown that the skin color changes during excitement, physical activity inpatients with somatoform autonomic dysfunction according to hypertensive type, cardiacneurosis and hypertension had a negative tendency, that is, the skin was pale, whatreflects an increase of the sympathetic nervous system tone and forms a decrease fromthe state of eutonia in scores by 1.7 times, 1.6 times and 2.0 times respectively (p<0.05).Pulse rate veritably increased (51.6%, 41.9% and 54.8% (p<0.05)) in patients of the 1st,3rd and 4th groups, in patients of the 2nd group it veritably decreased (29.0% (p <0.05))when conducting orthostatic test. During clino-orthostatic test, the pulse rate changed inthe diametrically opposite direction: in patients of the 1st, 3rd and 4th groups it sloweddown (21.9%, 28.1% and 31.3%, respectively (p< 0.05)), in patients of the 2nd groupit probably accelerated (21.9% (p <0.05)). During Ashner’s test in patients of the 1stand 3rd groups the pulse rate paradoxically tended to accelerate (20.0% and 26.7% (p<0.05)); in patients of the 4th group it veritably increased 30.0% (p <0.05), in patients ofthe 2nd group it veritably decreased (52.8%, p <0.05).Conclusions. Thus, an increase in the tone of the sympathetic part of the autonomicnervous system with frequent sympathoadrenal crises is observed in patients withchronic acalculous cholecystitis and concomitant somatoform vegetative dysfunction byhypertension type and cardiac neurosis as well as hypertension type II, and vagotonia witha predominance of the vago-insular crises is peculiar for the patients with concomitantsomatoform vegetative dysfunction according to hypotonic type.

Somatic symptoms and their association with anxiety and depression in Chinese patients with cardiac neurosis.

ObjectiveWe sought to investigate somatic symptoms detected by the Somatic Self-rating Scale and to evaluate whether they were associated with the psychological symptoms of anxiety and depression in patients with cardiac neurosis.MethodsA total of 180 patients with cardiac neurosis at the Third Xiangya Hospital, Changsha, China, were surveyed from January 2017 to July 2018. Participants completed a general information questionnaire, the Somatic Self-rating Scale, the Patient Health Questionnaire-9 and the Generalized Anxiety Disorder Scale-7.ResultsThe mean (±standard deviation) somatic symptom score in patients with cardiac neurosis was 40.83 ± 7.12. The most severe symptoms were cardiovascular symptoms, fatigue and muscle soreness. A total of 90 patients (46.4%) had anxiety and 80 (50.0%) had depression. Multiple stepwise regression analysis showed that somatic symptoms in patients with cardiac neurosis were associated with both anxiety and depression.ConclusionSomatic symptoms in patients with cardiac neurosis were associated with both anxiety and depression. Therefore, it is important to provide effective emotional interventions to promote patient rehabilitation.

Current Safety Data of the Complex Herbal Medicine with Sedative and Cardioprotective Actions

Background. The risk management plan is the one of main documents of pharmacovigilance system – a document focuses on the planning of pharmacovigilance activities and minimization of risks. As the use of herbal medicines has increased, so too have the reports of suspected toxicity and adverse events. As many herbal products on the market have not been thoroughly tested for their pharmacology and toxicology, pharmacovigilance has paramount importance in detecting unwanted reactions. One of the herbal preparations widely used to support the cardiovascular system under stress, neurocirculatory dystonia, cardiac neurosis, in the complex treatment of arterial hypertension, angina pectoris, arrhythmia is a complex medicinal product Carvelis, oral drops, solution. The active pharmaceutical ingredients of the drug are: extract from a mixture of hawthorn leaves, flowers and fruit (Сrataegi folii cum flore, fructus extractum); herb extract of canine nettle (Leonuri herbae extractum); melissae herbia extract Melissae herbae extractum); valerian root extract (Valerianae radix extractum). Objective. Сritical analysis of current scientific data on the benefit/risk ratio of a complex herbal medicine with sedative and cardioprotective effects. Results. Pathophysiological and epidemiological characteristic of following nosological forms have been analyzed: stress, neurocirculatory dystonia, cardiac neurosis, arterial hypertension, angina pectoris, arrhythmia. Current data on phytopreparation safety and estimation benefit/risk ratio have been generalized. Available clinical data were analyzed for individual phytocomponents or its combinations. Conclusions. The prevalence, seriousness and severity of the course of all manifestations of neurocirculatory dystonia, stress, nervous excitement, heart neurosis, especially with disproportionate approaches to the treatment of these diseases, is a serious medical and social problem. Given the proven efficacy of the use of Carvelis preparation components, and also that the risks are predictable, and their occurrence can be countered, and if they occur it can be effectively suppress with other drugs, the benefit of using the phytopreparation prevails above the risks.

Cause analysis of young patients with chest pain and negative results of coronary angiography

Objective To reduce the incidence of sudden cardiac death in young individuals with chest pain suspected to be acute coronary syndrome (ACS) and negative results of angiography, and so explored the causes of it. Methods A total of 134 young patients with suspected ACS admitted in PLA general hospital from January 2014 to December 2014 , were checked by coronary angiography. Comparisons of gender, professions, BMI, biochemical variables including glycohemoglobin (HBA1c), triglyceride (TG), C-reactive protein (CRP), troponin T (cTnT), high-density lipoprotein (HDL), brain natriuretic diuresis peptide (BNP)) and cardiac function including interventricular septum thickness, left ventricular posterior wall thickness, left ventricular end-diastolic volume and left ventricular systolic volume, stroke volume, ejection fraction and shortening fraction of left ventricle, E value, A value, E/A value among coronary angiography negative group (n=64), coronary angiography positive group (n=70) and healthy subjects group (n=77) . Quantitative variables were presented as means ± standard deviations, categorical data were presented as absolute values and percentages compared using t-test. One-way ANOVA was used to analyze variance between groups. Results The causes of negative group were found to be coronary atherosclerosis (90.6%), cardiac neurosis (4.7%), cardiomyopathy (1.6%), cardiac syndrome X (1.6%), and other 3.2%. There were 81.1% male and 58.9% officer of civil service management and business service personnel in negative group. The young patients in negative group had higher levels of BMI (P=0.000), total cholesterol (TC) (P=0.000), hypersensitive C-reactive protein (CRP) (P=0.003), cardiac troponin T (cTnT) (P=0.009) and lower high density lipoprotein (HDL) (P=0.000) compared with healthy subjects group. There was no significant difference in level of brain natriuretic peptide (BNP) between negative group and healthy subjects group (P=0.128). There were higher levels of left ventricular ejection fraction (LVEF) (P=0.000) and fractional shortening (FS) (P=0.000), and lower left ventricular end systolic volume (P=0.006) in negative group compared with positive group. Conclusions Coronary atherosclerosis is the major cause of young patients with chest pain suspected acute coronary syndrome (ACS) and with negative results of coronary angiography. Male, high stress occupation, a sedentary job, obesity, hyperglycemia and dyslipidemia are risk factors. Early diagnosis and prevention strategy are mandatory in these specific young individuals. Key words: Young people; Acute coronary syndrome; Sudden cardiac death; Chest pain; Causes; Coronary angiography negative; Biochemical indicators; Gender; Profession; Heart function

GW27-e0249 Comparative effects between Shuganjieyu capsules and Flupentixol and Melitracen tablets in the treatment of Cardiac Neurosis

GW27-e0249 Comparative effects between Shuganjieyu capsules and Flupentixol and Melitracen tablets in the treatment of Cardiac Neurosis

SYNERGETIC BIOPSYCHOSOCIOSPIRITUAL CONCEPTION OF MENTAL EPIDEMIC OF ISCHEMIC HEART DISEASE

Ischemic heart disease (IHD) is a burning mental epidemic of the contemporary world. At the maximum level of generalization, it can be considered as a stress-producing mentality trap of singular reality. IHD requires development of a multidisciplinary approach to etiopathogenesis and clinical findings, preventive-correctional and medical-rehabilitation aid. There has been proposed a synergetic conception of IHD including three prenosological fractals: predisposition - a cardiogenic family, latent - cardiogenic diathesis, initial - the neurocirculatory dystonia of the cardiac type (cardiac neurosis), and three nosological fractals: an onset, chronization and an outcome. There have been grounded mechanisms and pathogenesis of the trajectory of an IHD pandemy development on a four-dimensional model that allowed to measure and prognosticate resources of somato- and psycho-, socio- and animogenesis. There has been given a multidisciplinary program of aid.

Imaging features of thirteen cases of coronary-to-bronchial artery micro-fistula and the related clinical analyses

Objective To investigate imaging features and clinical characteristics of the small coronary - bronchial artery fistula (CBF). Methods By retrospective analysis of image data from May 2007 to November 2011 for coronary angiography in 30 284 patients without chronic lung or pulmonary vascular disease patients, 13 cases of small CBF (diameter of the end of fistula near coronary artery< 2 mm) were detected. Incidence of CBF was counted, its morphology was described, and its clinical features were preliminarily analyzed and summarized. Independent sample t test and χ2 test were used to compare diameters and incidences of CBF originatng from left and right coronary arteries. Results In this study primary CBF detection rate was 0.043%(13/30 284). The ends of CBFs near coronary arteries were slender and their diameter average was (1.57 ±0.75) mm. In this study all of the CBF were from the right coronary artery and left circumflex coronary artery, finding no cases starting from the left anterior descending coronary artery. There was no significant difference between incidence of CBFs originating from the right coronary artery and left circumflex coronary artery coronary and the diameters of CBFs. In 13 cases of CBF, 9 cases of myocardial ischemic symptoms were caused by coronary artery stenosis, which was proven by angiography; Four cases without myocardial ischemic symptoms or with very atypical symptoms were finally diagnosed as cardiac neurosis. After branching, the CBF diameters of these coronary arteries were seen no evindently reduced, which suggested that the coronary bypass had less blood flow, and therefore had no significant hemodynamic significance. Conclusions Congenital CBF can exist in populations without chronic lung or pulmonary vascular disease. The main image features are that their diametes were small and all originate from the right coronary artery and left circumflex coronary artery. The most fundamental clinical features are that there're no symptoms of myocardial ischemia due to coronary artery steal and no obviously hemodynamic significance. It is important to well recognize this type of CBF for enriching radiographic knowledge, identifying various anatomic variations, and carrying out clinical diagnosis and treatment. Key words: Arterio-arterial fistula; Coronary vessels; Bronchial arteries; Angiocardiography

Acupuncture at Nèiguān ( PC 6) in combination with respiratory reinforcing and reducing method for 38 cases of cardiac neurosis

ObjectiveTo observe the clinical effect of acupuncture at Nèiguān (▪ PC 6) in combination with respiratory reinforcing and reducing method for treatment of cardiac neurosis. MethodsThirty-eight patients with cardiac neurosis were selected for treatment through acupuncture at PC 6 in combination with respiratory reinforcing and reducing method. With twice per day, treated for 6 days per week, and 4 weeks as one course, the therapeutic effect was assessed after one course. ResultsTwenty-one cases were cured, 15 cases were remarkably improved, and 2 cases were failed. The total effective rate was 94.7%. ConclusionsAcupuncture at PC 6 in combination with respiratory reinforcing and reducing method is effective in treatment of cardiac neurosis.

Study on Diseases Scope of Prescriptions Related with the Palpitation in 『Shanghanlun』

*This article is a study on palpitation of which disease cause, disease mechanism and formulas were analyzed with reference to annotations on 『Shanghanlun』 and 『Jinkuiyaolue』. And the scope of modern diseases related with palpitation was drawn by research on clinical papers. The source books are 『Zhujieshanghanlun 』 and 『Jinkuiyaoluefanglun 』 and the clinical papers are searched in China Academic Journals(CAJ) of China National Knowledge Infrastructure(CNKI). 13 clauses in 『Shanghanlun』 and 9 clauses in 『Jinkuiyaolue』 and 12 formulas are related with palpitation. Disease mechanisms of palpitation were classified as yang deficiency, yin deficiency, qi deficiency, blood deficiency, retained fluid, cold, etc and these days, qi stagnation, phlegm turbidity, blood stasis and fire heat are also considered as disease mechanisms. Modern diseases related with palpitation are arrhythmia(extrasystole, atrial fibrillation, bradycardia, tachycardia, sick sinus syndrome, atrioventricular block), vascular diseases(arterial occlusion, phlebothrombosis, Buerger's disease, coronary artery disease, vasculitis), blood pressure disorder(hypertension, hypotension) and heart diseases such as heart failure, angina pectoris, myocardial infarction, myocarditis, cardiomyopathy, pericardial effusion. And diseases related with psychological change(cardiac neurosis, anxiety neurosis, neurosis, depression, hyperthyroidism, hypothyroidism), pyrexia, anemia, drug intoxication, etc are also related with palpitation. Zhen Wu Tang showing an efficacy in dilating blood vessels and strengthening cardiac function, Wuling Powder with diuretic effect and Fried Glycyrrhizae Decoction acting on the β receptor are applied to heart failure in different ways. Fried Glycyrrhizae Decoction(308 cases), Zhen Wu Tang(154), Wuling Powder(54), Xiao Chaihu Tang(34), Sini San(20) are reported to have been clinically applied to cardiovascular diseases and Zhen Wu Tang and Wuling Powder mainly applied to heart failure, Fried Glycyrrhizae Decoction, Lizhong Wan, Sini San and Zhen Wu Tang chiefly applied to arrhythmia related diseases. This study focuses on the general research and consideration on clinical applications and is a preliminary study to understand relations between Korean Medicine’s symptoms and categories of modern diseases.

Clinical observation on flupentixol and melitracen combined with metoprolol in the treatment of patients with cardiac neurosis

Objective To explore the clinical effect of flupentixol and melitracen combined with metoprolol in the treatment of patients with cardiac neurosis.Methods 57 patients with cardiac neurosis were divided into the control group and treatment group randomly.The control group received therapy of metoprolol and oryzanol ;The treatment group received additional therapy of flupentixol and melitracen based on treatment of the control group.Clinical effect,scores of HAMD and HAMA were observed and compared between the two groups.Results The total efficient rate of the treatment group was 96.67％,and significantly higher than that of the control group (85.19％) (x2 =21.814,P ＜0.05) ;HAMA and HAMD scores decreased significantly in all patients after treatment(all P ＜ 0.05),more significantly in the treatment group than those in the control group(all P ＜ 0.05).Conclusion Flupentixol and melitracen combined with metoprolol in the treatment of patients with cardiac neurosis has good effect,which is worthy of clinical application. Key words: Cardiac neurosis ; Metoprolol ; Flupentixol ; Melitracen