Cardiac Myeloid Sarcoma Research Articles

A CASE OF CARDIAC MYELOID SARCOMA POST-ALLOGENEIC TRANSPLANTATION

TYPE: Late Breaking Abstract TOPIC: Cardiovascular Disease INTRODUCTION: Extramedullary relapse of acute myelogenous leukemia (AML) has been reported in a small percentage of patients who received hematopoietic stem cell transplantation. Among the sites of involvement, cardiac myeloid sarcoma or cardiac chloroma is an exceedingly rare presentation. We present a case of a right atrial chloroma without medullary involvement in a patient with AML in remission. CASE PRESENTATION: A 53-year-old woman with a background of AML with myelodysplasia-related features status post-induction chemotherapy followed by an allogeneic hematopoietic stem cell transplant came to the emergency department with chest pain and shortness of breath. The patient was noted to have pericarditis and treatment was initiated. Transthoracic echocardiogram showed a right atrial mass extending into the pericardium, which was confirmed by cardiac magnetic resonance imaging (MRI). Initial right heart catheterization with tissue biopsy was indeterminate and a second one showed atypical cells with immunohistochemical stains consistent with myeloid sarcoma. Bone marrow biopsy did not show evidence of AML and treatment with Azacitidine and Venetoclax was indicated. DISCUSSION: The five-year survival rate for AML is 29.5% and the majority of patients die from infection or hemorrhage. The presence of cardio-respiratory symptoms in our patient led to an early diagnosis of cardiac myeloid sarcoma. It is a rare presentation that is usually diagnosed at autopsy with an incidence <1%. CONCLUSIONS: A high index of suspicion is a cornerstone in the early diagnosis and timely management of cardiac myeloid sarcoma. DISCLOSURE: No significant relationships. KEYWORD: chloroma

Cardiac Myeloid Sarcoma: A 1-kg Heart

A 53-year-old man with a background of acute myelomonocytic leukemia in remission presented with pleurisy. Repeat transthoracic echocardiography over several weeks revealed thickening left ventricular walls and decreasing systolic function. He died of decompensated heart failure due to cardiac myeloid sarcoma, with autopsy revealing an enlarged heart weighing >1 kg. (Level of Difficulty: Intermediate.)

Cardiac Myeloid Sarcoma: Multimodal Imaging and Histopathologic Findings.

Supplemental material is available for this article.

A journey across the Oceans with a heart full of hopes – A case report of cardiac myeloid sarcoma

A journey across the Oceans with a heart full of hopes – A case report of cardiac myeloid sarcoma

A journey across the oceans with a heart full of hopes – a case report of cardiac myeloid sarcoma

A journey across the oceans with a heart full of hopes – a case report of cardiac myeloid sarcoma

Tongue with cardiac myeloid sarcoma: a case report and literature review

报道1例发生于舌部及心脏的髓系肉瘤(MS)患者，对MS的治疗及预后进行文献复习。显示发生于舌部及心脏的MS很罕见，联合化疗应为首选治疗，预后不佳，心脏MS预后极差，多因心包填塞、心力衰竭猝死。

Cardiac Myeloid Sarcoma: Review of Literature.

Granulocytic Sarcomas (GS) also called as Myeloid Sarcomas (MS) or chloromas are the representatives of extramedullary infiltrates of immature myeloid cells including myeloblasts, promyelocytes and myelocytes. Primary cardiac malignancies per se are rare and infiltration of cardiac muscles by secondary malignant cells is also an uncommon finding. Out of these cardiac tumors, contribution of Cardiac Myeloid Sarcoma (CMS) is even more smaller thereby limiting our knowledge about this rare entity. Because of its very lower incidence, an exact guideline for diagnosis and management is still missing and usually haematologists around the world are treating CMS based on their clinical acumen. Aim of this review is to briefly discuss the presenting clinical feature, differential diagnosis, diagnostic workup and management based on published articles related to CMS till date.

Cardiac Myeloid Sarcoma: Multimodality Radiologic Imaging Features and Pathologic Correlation

Cardiac Myeloid Sarcoma: Multimodality Radiologic Imaging Features and Pathologic Correlation

Donor Cell Cardiac Myeloid Sarcoma Following Umbilical Cord Transplantation

Donor Cell Cardiac Myeloid Sarcoma Following Umbilical Cord Transplantation

Cardiac Myeloid Sarcoma

Myeloid sarcomas are rare extramedullary tumors composed of immature myeloid cells. Most cases are seen in childhood acute myelogenous leukemia (AML). They can develop at many sites, but cardiac involvement is a rare finding. We report the case of a 24-year-old woman who, after being in remission from AML for 10 years, developed an isolated cardiac myeloid sarcoma.

Therapy-related myelodysplastic syndrome presenting as fulminant heart failure secondary to myeloid sarcoma

Rapidly progressive heart failure is commonly caused by an extensive myocardial infarction, a mechanical complication of infarction, myocarditis, or acute valvular insufficiency. We present an unusual case that was caused by a diffuse infiltration of the myocardium with leukemic cells (myeloid sarcoma). The patient presented with episodic shortness of breath, he was anemic and thrombocytopenic, and his bone marrow biopsy revealed myelodysplastic syndrome from treatment for oligodendroglioma. His clinical course was characterized by a chronic leak of cardiac enzymes, a new right bundle branch block, and a large pericardial effusion causing tamponade and death from fulminant heart failure and ventricular arrhythmias within 2weeks. At autopsy, the heart was massively infiltrated with myeloblasts and other immature myeloid cells. There was no evidence of acute leukemia in the bone marrow or peripheral blood. Cardiac infiltration in a patient with myelodysplastic syndrome is extremely rare, especially in the absence of bone marrow involvement by blasts. The recognition of this entity is becoming increasingly important as the incidence of cardiac myeloid sarcoma may be on the rise as the number of patients receiving chemotherapy increases.

Atypical presentation of acute myeloid leukemia: cardiac myeloid sarcoma

We present the case of a 52-year-old man with a 2-month history of dyspnea, bilateral pleural effusion and cardiomegaly of rapid onset. A cardiac ultrasound showed pericardial effusion with infiltration of the infero-lateral cardiac wall, right auricle and aortic arch by a mass of unknown origin. Despite 1% blast cells in the peripheral blood, 2 bone marrow biopsies were negative for malignancy. Flow cytometry analysis of the blood and immunohistochemistry study of the pleural liquid showed a blast population of CD34+, CD33+, CD13+ and HLA-DR+ cells; a percutaneous cardiac biopsy showed CD34+ cells in the pericardium which led to the diagnosis of extramedullary acute myeloid leukemia (AML). The patient was treated with induction chemotherapy allowing remission, but unfortunately died of septic shock of fungal origin. This case illustrates a rare presentation of cardiac extramedullary AML.