Carcinoma Of Cheek Research Articles

Frequency Clinical Presentation and Risk Factors of Carcinoma of Cheek in Patients Presenting at JPMC Karachi

Objective: To assess the frequency, clinical presentation, and associated risk factors of carcinoma cheek in patients presenting at Ear, Nose, and Throat (ENT) department at Jinnah Postgraduate Medical Centre (JPMC), Karachi.Methods: A descriptive cross-sectional study was carried out at ENT outpatient department of JPMC, Karachi, Pakistan. Two years data of patients with complain of non-healing ulcer of buccal mucosa for more than 4 weeks duration irrespective of age and gender were retrieved from medical record. Biopsy confirmed cases of carcinoma of cheek were noted along with the treatment history of the positive patients. The detailed history of the patients regarding demographic characteristics, smoking habits, and chewable tobacco habits were noted.Results: Of 330 patients, the mean age of the patients was 44.36 ±7.32 years. There were 251 (76.1%) males and 79 (23.9%) females. Carcinoma of cheek was observed in 277 (83.9%) patients. A significant association of carcinoma of cheek was observed with age (p-value <0.001), occupation (p-value 0.004), residence (p-value <0.001), marital status (p-value 0.031), and addiction of chewable tobacco (p-value <0.001). The chances of cheek carcinoma were 9 times significantly higher among addicted chewable tobacco patients as compared to those patients' who did not addict of chewable tobacco (aOR 9.48, 95% CI 1.88 – 47.6).Conclusion: The study revealed that carcinoma of cheek was considerably higher among patients presented with non-healing ulcer of buccal mucosa for more than 4 weeks duration.

A clinicopathological study of cheek carcinoma and different types of reconstructive procedure for its treatment in a tertiary care centre in India

Background: The incidence of oral cancer varies globally and regionally and is closely linked with geographical, social, economical, biological, ethnic, dietary and environmental factors. In India, buccal mucosa (cheek) is the most common site for the lesion having 50% of all the oral cavity cancers and the incidence of oral cancers is about 10.6 % of all cancers. The aim of the study was to study the mucosal lesions with regard to mode of presentation, aetiopathology, histopathological aspects, various surgical modalities.Methods: The prospective observational and descriptive tertiary care institute based case study was undertaken at Medical College, Kolkata. A total of 30 patients were included in the study.Results: Maximum number of patients was in the 51-60 yr age group and the male: female sex ratio was 7:3. The maximum risk factors were found to be smoking and tobacco. 16.67% patients had premalignant lesions namely leucoplakia whereas 73.33% of the patients presented with oral ulcers as the chief complaint. Most of the patients presented in the late stage. Squamous cell carcinoma was the most common histological type. Out of 30 patients, 6 underwent wide local excision only and the rest underwent neck dissection. Mandibulectomy was done in 14 patients, Pectoralis major myocutaneous flap was the most common reconstructive procedure used (43.33%).Conclusions: Cancer of the oral cavity accounts for a high incidence in our country due to our social habits. In spite of easy accessibility to early lesion, the number of locally advanced lesion is very high. This can be prevented by creating health awareness.

A Prospective study on Principles and Outcomes of Reconstructive Flaps in Carcinoma of Cheek

A Prospective study on Principles and Outcomes of Reconstructive Flaps in Carcinoma of Cheek

Merkel cell carcinoma of cheek– response to radiation – a rare case scenario

Merkel cell carcinoma of cheek– response to radiation – a rare case scenario

Merkel Cell Carcinoma of Cheek: 2 Case Reports

Merkel cell carcinoma (MCC) is a rare aggressive skin cancer with the mortality rate of 33%. MCC was first described by Toker in 1972 as a trabecular cell carcinoma and is classified as a neuroendocrine tumor similar to small cell lung carcinoma and melanoma. The pathogenesis of MCC remains largely unknown. However, ultraviolet radiation and immunosuppression are likely to play a significant pathogenic role. The primary skin lesion is usually asymptomatic and it typically presents as a red or purple dome-shaped nodule. The management of MCC is controversial, however, local wide excision followed by radiotherapy is accepted as the primary treatment modality. The regional draining nodal basin is the most common site for recurrence. Therefore, sentinel lymph node biopsy is recommended in all cases, except for the clinically node-negative cases. We herein report two cases of MCC on the left cheek with different clinical manifestations. Key words: Cheek ㆍ Merkel cell carcinoma ㆍ Neoplasms

SYNCHRONOUS SQUAMOUS CELL CARCINOMA OF EXTERNAL ACOUSTIC MEATUS FOLLOWING PIGMENTED BASAL CELL CARCINOMA OF CHEEK -A RARE OCCURRENCE

Introduction: A synchronous second primary malignancy as squamous cell carcinoma of external acoustic meatus following basal cell carcinoma of cheek is reported with their management and review of literature.
 Case Report: Pigmented basal cell carcinoma of cheek was managed successfully by wide local excision followed by flap reconstruction and subsequently diagnosed squamous cell carcinoma of external acoustic meatus by concurrent chemoradiation after initial surgical debridement.
 Conclusion: Second primary malignancy as squamous cell carcinoma of external ear canal is rare after basal cell carcinoma of cheek though there is anatomical vicinity. Surgery in case of basal cell carcinoma and concurrent chemoradiotherapy in case of external ear canal squamous cell carcinoma is the mainstay of treatment.

Oral Squamous Cell Carcinoma Metastases to the Kidneys: Is It Common?

Metastases to the kidneys are rare and are frequently erroneously diagnosed as primary renal tumour. The kidney is unusual site of metastatic disease and is the fifth most common site of metastases in the body after lung, liver, bone and adrenals. A 42-year-old male known case of operated buccal carcinoma of cheek (squamous cell carcinoma) presented with complaints of upper abdominal discomfort. Patient was investigated with Computed Tomography (CT) scan outside for the same and was detected to have multiple space occupying lesions in lungs, liver and both kidneys [Table/Fig-1a-c]. For characterization of these lesions patient was referred to us. In our institute patient underwent contrast-enhanced Magnetic Resonance Imaging (CE-MRI). On T2-weighted and CE-MRI images, multiple lesions were detected in liver, bilateral kidneys and left adrenal. Lesions in kidneys were multicentric, appeared as ‘black holes’ on MRI and showed restriction on Diffusion-weighted images [Table/Fig-2,​,3].3]. The imaging was classical in keeping with metastases involving the liver, kidney and left adrenal gland. [Table/Fig-1a-c]: (a) Axial contrast-enhanced CT scan of neck showing fat graft (arrow) in a case of operated squamous cell carcinoma buccal mucosa (b) Lung window sections showing cavitating and solid lung metastases (arrows) (c) Coronal contrast-enhanced MRI image showing ... [Table/Fig-2a,b]: (a) Coronal MR-FIESTA sequence showing hypointense black hole lesions (arrows) in bilateral kidneys (b) Coronal contrast-enhanced MRI image hypo enhancing black hole lesions (arrows) better [Table/Fig-3a-f]: (a-c) Axial MR diffusion-weighted images showing bright lesions (arrows) in liver, left adrenal and bilateral kidneys (d-f) corresponding ADC maps MR image showing lesions appearing dark (arrows) suggestive of diffusion restriction

Study on application of ultrasound microbubbles in the diagnosis of buccal carcinoma and metastatic cervical lymph nodes in mice.

This project's aim was to explore the enhancing effect of contrast media on primary cancer and cervical metastatic lymph nodes of cheek carcinoma by local injection. Lymphatic metastasis cheek carcinoma mice models were established, then self-made contrast media was administered into the primary cheek carcinoma and harmonic mode imaging was performed to observe the enhancement of primary lesions and cervical metastatic lymph nodes. The echo intensity (EI) was compared. The detection rate of metastatic lymph nodes and inflammatory lymph nodes was 61% (17/28) and 50% (6/12) before contrast-enhanced ultrasound (CEUS) imaging and 82% (23/28) and 75% (9/12) after CEUS imaging. After CEUS imaging, the EI of primary cancer and cervical metastatic lymph nodes was significantly increased, (P<0.01). After injection of self-made contrast media via the primary lesion, it can enter the lymph duct and obviously enhance the effect of ultrasonography on cervical metastatic lymph nodes of cheek carcinoma.

Malignant peritoneal mesothelioma: a multicenter study on 81 cases

BackgroundMalignant peritoneal mesothelioma (MPM) is a rare disease characterized by a difficult diagnosis, different types of presentation, variable course and poor prognosis. Materials and methodsEighty-one patients with MPM observed in 14 Italian oncology institutions from 1982 to 2007 have been examined with the aim of delineating the history of MPM. ResultsPresentation symptoms were ascites, abdominal pain, asthenia, weight loss, anorexia, abdominal mass, fever, diarrhea and vomiting in various associations. Computed tomography scan and echotomography signs were ascites, abdominal mass and peritoneal thickening. Peritoneal fluid cytology (61 cases) was positive for mesothelioma in 31 and for malignancy, not mesothelioma, in 13. Laparoscopy was carried out in 40 cases and laparotomy in 36. Thrombocytosis was present in 59 cases. Associated tumors diagnosed during the lifetime were colorectal cancer in two cases and cheek carcinoma, thyroid carcinoma, tongue carcinoma, bladder carcinoma and testicular seminoma. Thirty patients were treated with surgery and 45 with chemotherapy. The median survival time from diagnosis is 13 months. Ascites, fever and vomiting were significative variables at presentation; only vomiting holds significance in a multivariate analysis. ConclusionsMPM is a disease with various types of presentation, frequently associated with thrombocytosis, sometimes with other tumors. Survival and diagnosis time can differ in various types of MPM. Prognosis is poor.

Choice of different flaps to repair defects of carcinoma of cheek

Background and Objectives: This study evaluated the survival rates and clinical results of three types of flap to repair defects of carcinoma of cheek: vertical platysma flap, forearm flap and free anterolateral thigh flaps. Modified radical, supraomohyoid or radical neck dissection were performed in all patients.

Sebaceous carcinoma of cheek arising in a lesion of solar keratosis

Cutaneous extraocular sebaceous carcinoma is a rare tumor that frequently occurs on face and scalp. Sebaceous carcinoma is not considered to be associated with ultra violet radiation exposure. We describe a case of sebaceous carcinoma of the right side of the cheek occurring in a lesion of solar keratosis in a 44-year-old female, who is a farmer by occupation. Actinic keratosis carries about 8-20% risk for malignant transformation into squamous cell carcinoma. Other malignant lesions that have been reported to occur in actinic keratosis include basal cell carcinoma, sebaceous carcinoma and trichilemmal carcinoma. To our knowledge, this is the third case to be reported in English language literature. Unlike the two cases reported previously, this has occurred in a younger patient and presented as an ulcerative, invasive lesion of 3cm size. The association of actinic keratosis and sebaceous carcinoma indicate that solar UVR is probably of importance in the pathogenesis of sebaceous carcinoma, as in the case of squamous cell carcinoma.

Usefulness of dynamic maneuvers in MR evaluation of oral malignancies

Abstract Objectives: The purpose of this study was to evaluate the usefulness of dynamic maneuvers like "distended cheek" and "tongue deviation" in MR evaluation of oral malignancies. Methods: Ninety nine patients of oral malignancies who reported to this institute for treatment were enrolled in this study. All the patients evaluated with conventional MR imaging and supplemented by additional MR imaging with dynamic maneuvers using T1Weighted and STIR sequences with reduced scan time. Distended cheek imaging was performed in 73 cases of carcinoma cheek, gingiva &amp; RMA (retromolar area) and tongue deviation in 24 cases of carcinoma tongue &amp; floor of mouth. Two cases of carcinoma of lower gingiva performed both maneuvers. In selected cases MR imaging with dynamic maneuvers was also performed following contrast administration. Results: Lesions appearing inseparable from two mucosal surfaces (buccal mucosa and gingiva) on routine MR images were well separated in the distended cheek images in all cases except for two cases who could not perform the maneuvers. Distended cheek images demonstrated involvement of buccogingival sulci in 30 patients of carcinoma of cheek, involvement of cheek in 8 cases of carcinoma gingiva &amp; involvement of gingiva in 6 cases of carcinoma cheek which were not appreciated on routine MR images. Similarly MR imaging with tongue deviation helped in better delineation of tongue lesions in 12 cases and showed involvement of glossogingival sulcus in 5 cases that were not appreciable on routine MR imaging. Conclusion: MR imaging with dynamic maneuvers provide additional information of clinical significance regarding origin and extent of disease in oral malignancies &amp; should supplement the conventional MR imaging in selected cases.

PD.135 Locally advanced cheek carcinoma; radical surgery and reconstruction of the through and through defects

PD.135 Locally advanced cheek carcinoma; radical surgery and reconstruction of the through and through defects

Keeping chewing tobacco in the cheek pouch overnight (night quid) increases risk of cheek carcinoma

Chewing Chewable Indian Tobacco (CIT) is a popular addiction in India. Some of the addicts keep the bolus of chewed tobacco tucked in the gingivo-labial sulcus (cheek pouch) overnight. This is known as the habit of the night quid. To assess the influence of night quid on the development of oral cancer we carried out this case control observational study in the Out Patient Department of Surgery, Sir Sunder Lai Hospital, Varanasi, India. A total of 105 consecutive oral cancer patients (epidermoid carcinoma) and 71 sex- and age-matched CIT addicts of the same duration of addiction were investigated for the habit of the night quid. The habit increased the risk of development of cheek carcinoma significantly at Odd's Ratio of 12.5. Simply giving up the habit of night quid could help in the reduction of oral cancer in CIT addicts.

The occurrence of leukemia in a patient with pulmonary asbestosis.

A 77-year-old man, who had been a subway construction worker, was admitted to our hospital for surgical treatment of left cheek carcinoma and an examination for pancytopenia on November 17, 1986. Bone marrow aspiration revealed that 10% of the nucleated cells were blasts with morphological atypism. Bone marrow biopsy showed hypocellular marrow and a diffuse increase of argyrophil fibers with the presence of asbestos fibers was observed by microscope. A chest X-ray showed the findings of old tuberculosis and pulmonary asbestosis, and asbestos fibers were demonstrated in the broncho-pulmonary lavage fluid. He was diagnosed to have pulmonary asbestosis complicated with hypoplastic low percentage leukemia.

Case 91 Large carcinoma of cheek

Case 91 Large carcinoma of cheek

Two Cases of Carcinoma of Cheek

Two Cases of Carcinoma of Cheek