Carboxylate Groups Of Ligands Research Articles

A europium(III) metal-organic framework as effective fluorescence sensor for detection of ofloxacin antibiotic

Antibiotic overuse, a critical global concern, poses significant threats to both the eco-environment and human health. Thus, selective and sensitive detection of antibiotics is an extremely important issue. Herein, a europium(III) metal-organic framework Eu2(FA)3(H2O)4·2DMAC (1) (FA = fumaric acid, DMAC = dimethylacetamide) was synthesized by solvothermal strategy. Single-crystal structural analyses indicate that Eu3+ ions are double-bridged by carboxylate groups of fumarate ligands to create one-dimensional (1D) infinite chains, which further form a 3D pillared-layer framework. 1 exhibits superior fluorescence detection performance toward ofloxacin (OFLX) with a high quenching efficiency Ksv of 4.1 × 104 M−1 and low detection limit of 2.4 × 10−6 M, and demonstrates excellent anti-interference properties and durability. Furthermore, the mechanism of fluorescence quenching was mainly attributed to static quenching process and internal filtration effect.

Two new bismuth salts with succinic acid: synthesis, structural, spectroscopic and thermal characterization.

Two novel bismuth succinate hydrates, namely, poly[[diaqua(μ3-butane-1,4-dicarboxylato)hemi(μ-butane-1,4-dicarboxylato)bismuth] monohydrate], {[Bi(C4H4O4)1.5(H2O)2]·H2O}n (1), and poly[[μ-aqua-aqua(μ3-butane-1,4-dicarboxylato)(μ-butane-1,4-dicarboxylato)-μ-oxido-dibismuth] monohydrate], {[Bi2(C4H4O4)2O(H2O)2]·H2O}n (2), have been synthesized. Their crystal structures were determined by single-crystal X-ray diffraction and the compounds were characterized by IR and Raman spectroscopy, powder X-ray diffraction and thermal analysis. The crystal structure analysis revealed that the compounds are coordination polymers, with 1 having a two-dimensional layered structure and 2 displaying a three-dimensional (3D) framework. Fully deprotonated succinate anions (C4H4O42-) in two different conformations (trans and gauche) are included in their composition. The Bi3+ cations are surrounded by O atoms from the carboxylate groups of succinate anions and aqua ligands. BiO9 coordination polyhedra in 1 are connected in pairs by edges. These pairs are bound together by bridging succinate ligands to form layers. Bismuth coordination polyhedra of two different types (BiO9 and BiO7) in 2 are connected by edges to form infinite ribbons. Ribbons of polyhedra with bridging succinate ligands form a 3D polymeric structure.

A novel three-fold interpenetration 3D Cd-based coordination polymer for the sensing of glutamate in aqueous medium and calf serum

As a special biomarker for many nervous system diseases, Glutamate (Glu) plays an important role in clinical application. Therefore, it is of great significance to sense Glu sensitively in aqueous medium or serum. Here, a novel three-fold interpenetration 3D framework of {[Cd (HTCPB) (4,4′-bbib)]·2H2O}n (1) (H3TCPB ​= ​1,3,5-tris(4-carbonylphenyloxy)benzene, 4,4′-bbib ​= ​4,4′-bis(benzoimidazo-1-yl)biphenyl) (1) has been successfully synthesized and characterized by single-crystal X-Ray diffraction (SCXRD), X-ray powder diffraction analyses (PXRD), thermogravimetric (TG) and X-ray photoelectron spectroscopy (XPS). Stability experiments show that 1 has excellent water and thermal stability. And luminescence experiments demonstrated that 1 can selectively and sensitively sense Glu in aqueous solution with the limit of detection (LOD) being 1.15 ​× ​10-7 ​M. Meanwhile, the detection concentration of 1 towards Glu in serum is 4.31 ​× ​10-5 ​M, which is far lower than that of Glu (4 ​× ​10-4 ​M) in the blood of patients with glioma. In addition, the interaction between carboxylate groups (-COOH) of H3TCPB ligands in 1 and amino-groups (−NH2) of Glu is mainly responsible for the turn-on phenomenon of 1. These results provide a platform of 1 for sensing Glu in clinical application.

Water molecules bonded to the carboxylate groups at the inorganic-organic interface of an inorganic nanocrystal coated with alkanoate ligands.

High-quality colloidal nanocrystals are commonly synthesized in hydrocarbon solvents with alkanoates as the most common organic ligand. Water molecules with an approximately equal number of surface alkanoate ligands are identified at the inorganic–organic interface for all types of colloidal nanocrystals studied, and investigated quantitatively using CdSe nanocrystals as the model system. Carboxylate ligands are coordinated to the surface metal ions and the first monolayer of water molecules is found to bond to the carboxylate groups of alkanoate ligands through hydrogen bonds. Additional monolayer(s) of water molecules can further be adsorbed through hydrogen bonds to the first monolayer of water molecules. The nearly ideal environment for hydrogen bonding at the inorganic–organic interface of alkanoate-coated nanocrystals helps to rapidly and stably enrich the interface-bonded water molecules, most of which are difficult to remove through vacuum treatment, thermal annealing and chemical drying. The water-enriched structure of the inorganic–organic interface of high-quality colloidal nanocrystals must be taken into account in order to understand the synthesis, processing and properties of these novel materials.

A stable Cd(II)-based MOF with efficient CO2 capture and conversion, and fluorescence sensing for ronidazole and dimetridazole

By employing the ligand 2-(isonicotinamido)terephthalic acid (H2L) containing the amide functional groups, a Cd-MOF, {[Cd2L2(H2O)2]·4H2O}n (1) has been constructed by solvothermal synthesis. The dinuclear clusters [Cd2(COO)2] in 1 are linked by the pyridinyl and carboxylate groups of ligands to form a three-dimensional (3D) skeleton, containing 1D channels with the free amide groups. The activated framework shows good stability in water and high selectivity for CO2 over CH4. The open Cd2+ site as Lewis acidic center makes the MOF achieve efficiently catalytic conversion for CO2 cycloaddition with epoxides. Furthermore, 1 also exhibits good chemical stability in water, allowing the detection for ronidazole (RDZ) and dimetridazole (DTZ) with the low detection limit and rapid response.

Three Co/Ni(II)-MOFs with dinuclear metal units constructed by biphenyl-3,3′,5,5′-tetracarboxylic acid and N-donor ligands: Synthesis, structures, and magnetic properties

Three new dinuclear complexes {[Co2(bpta)(2,2′-bipy)(H2O)]·2CH3CN·3H2O}n (M ​= ​Co (1), Ni (2)), and {[Co(H2bpta)(4,4′-bipy)]·H2O}n (3) have been obtained through a mixed-ligands strategy. They were characterized by IR spectroscopy, elemental analysis, single-crystal X-ray diffraction and powder X-ray diffraction analysis. Structural analysis reveals that different dinuclear SBUs are formed by carboxylate groups of H4bpta ligands binding with metal ions in 1−3. The H4bpta ligands act as μ7-κ2:κ2:κ1:κ2 and μ3-κ2:κ0:κ1:κ0 coordination modes, respectively. For 1 and 2, the hexa-coordinated Co/Ni(II) ions are connected to form [M2(OCO)2(μ2-O)] SBUs by syn−syn-OCO− and μ2–oxo carboxylate bridges. The structures show (4,4)-connected 3D net with {42.84}-pts topology by bpta4− ligands linking [M2(OCO)2(μ2-O)] SBUs. Complex 3 possesses penta-coordinate geometry and displays a (2,6)-connected 2D layer formed by H2bpta2− and 4,4′-bipy ligands linking dinuclear [Co2(OCO)2] SBUs. The studies of the magnetic properties of 1−3 in the temperature range 1.8–300 ​K reveal that weak antiferromagnetic interaction exists in the triple and double bridging SBUs of the complexes 1 (J ​= ​−11.32 (6) cm−1) and 3 (J ​= ​−0.84(4) cm−1). Complex 2 exhibits ferromagnetic exchange (J ​= ​1.02(7) cm−1) in dinuclear [Ni2(OCO)2(μ2-O)] units.

Synthesis, characterization, crystal structure, and electrochemical study of zinc(II) metal-organic framework

A zinc(II) metal-organic framework, [Zn (BDC) (MI) (DMF) or Zn-MOF] (BDC=Benzene 1, 4 di-carboxylic acid, MI=Methylimidazole and DMF=N, N-dimethylformamide) has been synthesized by solvothermal method using mixed ligands. The Zn-MOF has been characterized by powder X-ray diffraction, single-crystal X-ray diffraction, Thermo gravimetric analysis, Infrared spectroscopy, and cyclic voltammetry. In Zn-MOF, Zn–N bond lengths were 2.010 (2) and 2.044 (2) Å, Zn–O bond lengths are 1.965 (2) and 1.980 (18) Å and the space group is P-1. These 3 D sheets are connected by Carboxylate groups of bdc and Mi ligands are coordinated to Zn (II) cation in a monodentate manner, forming 3 D frameworks of triclinic geometry. The cyclic voltammetry measurements were performed at different scanning rates (10–100 mVs−1) in the potential range is –0.1–0.1 mVs−1 in 6 M KOH solution.

Synthesis, Thermal, Structural Analyses, and Photoluminescent Properties of a New Family of Malonate-Containing Lanthanide(III) Coordination Polymers.

Five new Lanthanide(III) complexes of malonic acid (HOOC-CH2-COOH); {[Gd(C3H2O4)(H2O)4]·NO3}n (1), {[Tb(C3H2O4)(H2O)4]·NO3}n (2), {[Ho(C3H2O4)(H2O)4]·NO3}n (3), [Er(C3H2O4)(C3H3O4)(H2O)2]n (4), and {[Eu2(C3H2O4)2(C3H3O4)2(H2O)6]·4H2O}n (5) were synthesized and characterized by elemental, infrared spectral, and thermal analyses. The structures of compounds 1–5 were determined by single crystal X-ray diffraction technique. The X-ray analysis reveals that compounds 1, 2, and 3 are isostructural and crystallized in the orthorhombic space group Pmn21. The lanthanide(III) ions are coordinated by four carboxylate and four water oxygen atoms adopting a distorted square antiprism geometry. The LnO8 square antiprisms are linked into infinite layers by malonate (C3H2) dianions sandwiching sheets of nitrate counter ions. Compound 4 contains ErO8 square antiprisms linked into a two-dimensional network by hydrogen malonate (C3H3) anions and malonate dianions. The europium complex, 5 is dinuclear having the two europium(III) ions (Eu1 and Eu2) bridged by carboxylate groups of hydrogen malonate ligands. The europium ions in 5 are nine-coordinate and exhibit a distorted monocapped square antiprism geometry. All the structures are consolidated by O–H⋯ O hydrogen bonds. The photoluminescence spectra of 1–5 exhibit characteristic emissions in the visible region. The IR spectra and thermal data are consistent with the structural results. The room-temperature effective magnetic moments for 1–4 are in good agreement with those expected for the free ions, while the data for 5 indicates that low-lying excited states contribute to the observed moment. The compound 1 was further subjected to quantum computational calculations to explore its optoelectronic properties including; density of states (DOS), dielectric function, refractive index, extinction coefficient, and absorption spectrum, to highlight the possible applications of such materials in the optoelectronics.

Anionic nanoparticle-lipid membrane interactions: the protonation of anionic ligands at the membrane surface reduces membrane disruption.

Monolayer-protected gold nanoparticles (Au NPs) are promising biomedical tools with applications in diagnosis and therapy, thanks to their biocompatibility and versatility. Here we show how the NP surface functionalization can drive the mechanism of interaction with lipid membranes. In particular, we show that the spontaneous protonation of anionic carboxylic groups on the NP surface can make the NP-membrane interaction faster and less disruptive.

Synthesis, crystal structure and magneto-structural studies of 2D copper(II) coordination polymer containing l-alanine amino acid

A 2D coordination polymer of Cu(II) was synthesized by the reaction of CuCl2·2H2O with l-alanine and characterized by elemental analysis, spectroscopic methods and single crystal X-ray studies. X-ray analysis indicated that the compound is a 2D coordination polymer which the carboxylate group of amino acid ligands acts as bridging ligand between Cu(II) ions. The crystal structure of compound is stabilized by intermolecular hydrogen bond interactions. Magnetic susceptibility data of powdered sample between 2 and 300 K were interpreted in terms of a 2D-spin model, with weak antiferromagnetic exchange-coupling through syn-anti carboxylate bridges, with coupling constant J = −0.2 cm−1 between nearest-neighbor Cu(II) ions. The results are compared with those obtained from similar studies in other copper amino acid complexes. DFT studies showed that overlap of magnetic dx2−y2 orbitals of the neighboring Cu(II) ions and the molecular orbitals of bridging carboxylate groups is negligible what makes only weak antiferromagnetic interaction between them. Thermal gravimetric analysis (TGA) indicated that the compound is stable up to 240 °C and it converts to CuO at about 800 °C. Cyclic voltammetry studies showed a quasi-reversible redox and an irreversible peaks which can be attributed to Cu(I)/Cu(II) and Cu(II)/Cu(III) couples, respectively.

Biomimicking Oxidative Bromination and DNA Nuclease Activities of a New Structurally Characterised Oxido-Diperoxidomolybdenum(VI) Complex

A new oxido-diperoxido molybdenum complex, [MoO(O2)2(AA)]PPh4 (AA=anthranilic acid) has been designed and synthesized. The Structural characterisation suggests that the molybdenum centre is heptacoordinated with a slight distorted pentagonal bipyramidal geometry. The pentagonal plane is completed with four oxygen atoms from two peroxido moiety and one oxygen atom from the ligand carboxylate group. Among the two axial positions one is occupied by an oxygen atom of the oxido group and the other is occupied by an oxygen atom from the ligand carboxylate moiety. The biomimicking multifunctionality of this molybdenum(VI) complex has been exhibited by the application of it as a catalyst in peroxidative bromination, whereas the nuclease activity has been established by DNA cleavage. The catalytic studies suggest that the present compound is a good biological peroxidase mimic. The DNA binding of the molybdenum complex has been studied by various physicochemical tools like UV–vis, fluorescence, viscosity. The intrinsic binding constant of the complex with DNA is calculated to be (8.14 ± 0.03) x103 M−1. All the physicochemical studies and the viscosity measurements reveal that the complex is a groove binder to CT-DNA. The extent of ability of the complex to induce DNA cleavage was studied by gel electrophoresis techniques. The complex has been found to exhibit cleavage of pUC19 plasmid DNA with good efficiency.

Electrochemical performance of MIL-53(Fe)@RGO as an Organic Anode Material for Li-ion Batteries

Metal–organic frameworks (MOFs) may be promising multifunctional materials attributing to their large internal surface areas and high porosities that can favor charge transport. In this article, MIL-53(Fe) has been investigated as an anode material for Li-ion batteries. It showed decent performance on account of the redox reaction (Fe3+↔Fe0). However, the carboxylate groups of terephthalate acid ligands did not show electrochemical activity due to the poor electrical conductivity of MIL-53(Fe) and the formation of thick solid electrolyte interphase layer. In this case, reduced graphene oxide (RGO) was then composited to resolve the problem, which named as MIL-53(Fe)@RGO. The composite exhibited better electrochemical performance than the sole MIL-53(Fe). Specifically, a reversible discharge specific capacity of 550mAhg−1 could be still achieved at 100mAg−1 after 100 cycles within the voltage range of 0.01–3.0V, an reversible discharge capacity of about 300mAhg−1 was obtained even at 2Ag−1. These values are much higher than those of currently used graphitic materials. RGO makes it even more possibility for MOFs to be adopted as electrode materials for Li-ion batteries.

NIR luminescence of one-dimensional tartaric acid derivatives neodymium coordination polymers

A series of four neodymium coordination polymers (CPs), namely, {[Nd2L3(CH3OH)3(H2O)4]}n(1), {[Nd2L3(CH3OH)4(H2O)3]·4CH3OH·H2O}n(2), {[Nd2L3(CH3OH)4(H2O)3]·4CH3OH·H2O}n(3) and [NdL'3(CH3OH)3]n(4) have been isolated by facile reactions of ligands (H2L=L-di-2-thenoyltartaric acid and H2L'=L-di-p-toluoyl-tartaric acid) with NdCl3·6H2O at ambient temperature depending on the reaction conditions. X-ray crystallographic analysis reveals that all complexes 1–4 feature one-dimensional (1D) network structure in which the Nd3+ ions are bridged by carboxylate groups of ligands by five types of coordinated modes. Complexes 1–3 feature one-dimensional (1D) ladder-like chain structure and complex 4 features one-dimensional (1D) linear structure owing tothe ligands coordination modes. NIR luminescence analysis reveal that all complexes 1–4 exhibit three characteristic bands around 890, 1054 and 1326nm of Nd3+ ion in which complex 3 shows the longest lifetime and highest quantum yield. The energy transfer processes among ligands, the Nd3+ ion and the auxiliary ligand in complexes 1–4 has been investigated.

A new Cd(II) coordination polymer constructed by a flexible carboxylate ligand

A new two-dimensional Cd(II) coordination polymer, [Cd(dtb)(CH3OH)] n (H 2 DTNB = 5,5′-dithiobis(2-nitrobenzoic acid), has been synthesized by solvothermal method, and characterized by elemental analysis, IR and single-crystal X-ray diffraction analysis. The complex crystallizes in the orthorhombic Pbca space group, with a = 15.1365(19) A, b = 7.6198(10) A, c = 31.761(4) A, β = 90°, V = 3663.2(8) A3, Z = 8, Mr = 538.77, D c = 1.954 g/cm3 and F(000) = 2128. The final R = 0.040 and wR = 0.0866 for 3603 observed reflections with I > 2σ(I). In the complex, the Cd(II) ion is coordinated with six oxygen atoms from four carboxylate groups of distinct DTNB ligands and one methanol molecule. The adjacent Cd centers are interconnected by the flexible carboxylate ligand to form a two-dimensional (2D) structure.

Synthesis, Crystal Structures and Properties of a Series of Lanthanide Adipates [Ln 2(ad)3(H2O)4] (Ln = Y3+, Ho3+, Er3+, Tm3+)

A series of lanthanides adipates [Ln 2(ad)3(H2O)4] [Ln = Y3+ (1), Ho3+ (2), Er3+ (3), Tm3+ (4); ad = adipate] have been hydrothermally synthesized and structurally characterized by elemental analysis, X-ray diffraction, thermogravimetric analysis, UV/Vis and IR spectroscopy. Compounds 1–4 are isostructural and exhibit 2-D polymeric layers constructed by Ln 3+ ions bridged via the carboxylate groups of adipate ligands in two binding modes. The magnetic properties of both 2 and 4 are investigated and their thermal behaviours are also discussed. The Ln 3+ ions (Ln = Y 3+ , Ho 3+ , Er 3+ , Tm 3+ ) bridged by the carboxylate groups of adipate ligands form 2-D polymeric layers.

Vibrational analysis and crystal structure of two new 1D CuII and CoII coordination polymers, involving the ligands 2,5-dihydroxyterephthalate and glutarate

Aiming to obtain metal-organic frameworks with high dimensionality, two new 1D coordination polymers with the general formula {[Co(DHT)(DMF)2(H2O)2]n} (1) and {[Cu(GLU)(DMF)]n} (2) have been obtained, where DHT=2,5-dihydroxyterephthalate; GLU=Glutarate; and DMF=Dimethylformamide. Both coordination compounds involve simple chain formations in which the carboxylate groups from ligands adopt monodentate (for 1) and bidentate (for 2) coordination modes to the metal center. In this work, both polymers synthesized contain solvent molecules coordinated to metal centers, which represent potential open metal sites to allow postsynthetic modifications that may increase the dimensionality of the systems. The dinuclear group formation of type tetrakis (acetate) dicopper complexes, in the case of polymer (2), is worth mentioning. This unit may be categorized as a secondary building unit (SBU) like a paddlewheel formed in situ. Herein, Raman spectroscopy had an important role in its characterization. So, besides X-ray diffraction by single crystals, vibrational spectroscopy had been employed to reinforce the coordination modes analysis, especially through a good approximation of antisymmetric and symmetric shifts of vibrational modes from the carboxylate group of ligands (in comparison to the ionic form of the free ligand). Finally, we propose the removal of solvents coordinated to metal centers by activation for increasing the system dimensionality.

Supramolecular complexes of Co(II), Ni(II) and Zn(II) p-hydroxybenzoates with caffeine: Synthesis, spectral characterization and crystal structure

Three novel complexes Co(II), Ni(II) and Zn(II) containing p-hydroxybenzoates and caffeine ligands were synthesized and characterized by elemental analysis, FT-IR and UV–vis Spectroscopy, molar conductivity and single crystal X-ray diffraction methods. The thermal properties of the synthesized complexes were investigated by TGA/DTA. The general formula of the complexes is [M(HOC6H4COO)2(H2O)4]·2(C8H10N4O2)·8H2O (where: M: Co, Ni and Zn). The IR studies showed that carboxylate groups of p-hydroxybenzoate ligands have monodentate coordination mode. The M2+ ions are octahedrally coordinated by two p-hydroxybenzoate ligands, four water molecules leading to an overall MO6 coordination environment. The medium-strength hydrogen bondings involving the uncoordinated caffeine ligands and water molecules, coordinated and uncoordinated water molecules and p-hydroxybenzoate ligands lead to three-dimensional supramolecular networks in the crystal structures.

2D l-Di-toluoyl-tartaric acid Lanthanide Coordination Polymers: Toward Single-component White-Light and NIR Luminescent Materials.

A series of five l-di-p-toluoyl-tartaric acid (l-DTTA) lanthanide coordination polymers, namely {[Ln4 K(4) L6 (H2O)x ]⋅yH2 O}n , [Ln=Dy (1), x=24, y=12; Ln=Ho (2), x=23, y=12; Ln=Er (3), x=24, y=12; Ln=Yb (4), x=24, y=11; Ln=Lu (5), x=24, y=12] have been isolated by simple reactions of H2L (H2 L= L-DTTA) with LnCl3 ⋅6 H2O at ambient temperature. X-ray crystallographic analysis reveals that complexes 1-5 feature two-dimensional (2D) network structures in which the Ln(3+) ions are bridged by carboxylate groups of ligands in two unique coordinated modes. Luminescent spectra demonstrate that complex 1 realizes single-component white-light emission, while complexes 2-4 exhibit a characteristic near-infrared (NIR) luminescence in the solid state at room temperature.

Hydrothermal Synthesis, Structures and Luminescent of 1D Lanthanide–Metal Organic Frameworks Based on Rigid 5-Nitroisophthalic Acid Linker

1D coordination chain frameworks of [Eu(NIPH)(BDCA)(H2O)2]2(H2O)5 (1), [Sm(NIPH)(BDCA)(H2O)2] (2), [Dy(NIPH)(BDCA)(H2O)2]2 (3), [Gd(HNIPH)(BDCA)(H2O)2](H2O)0.5 (4), [Ce(HNIPH)(BDCA)(H2O)2](H2O)0.5 (5), [Nd(HNIPH)(BDCA)(H2O)2](H2O)0.5 (6), [Dy(NIPH)(ox)0.5(H2O)3](H2O)2 (7) [Er2(NIPH)(ox)0.5(H2O)3](H2O)2 (8), [Y2(NIPH)(ox)0.5(H2O)3](H2O)2 (9), [Eu2(NIPH)(ox)0.5(H2O)3](H2O)2 (10) (H2NIPH = 5-nitroisophthalic acid, H2DBCA = biphenyl-2,2′-dicarboxylic acid, ox = oxalic acid) were synthesized by hydrothermal reaction and characterized by single-crystal X-ray diffraction. These compounds were constructed of [Ln2O2] dimers bridged through the carboxylate groups of H2NIPH ligands. These compounds contain an -Ln–O–C–O–Ln- zigzag chain, which connect to each other through the oxygen atoms of the H2NIPH ligands to form a wave-like layer. In addition, when accretion equiv [Bu4N]F at room temperature the compound 1 emission enhancement.

Potentially bioactive organotin(IV) compounds: Synthesis, characterization, in vitro bioactivities and interaction with SS-DNA

Fourteen new organotin(IV) complexes with general formula R2SnL2 or R3SnL where R = CH3, C2H5, C4H9, C6H5, C6H11, CH2–C6H5, C(CH3)3, C8H17 and L = N-[(2-methoxyphenyl)]-4-oxo-4-[oxy]butanamide were synthesized and characterized by elemental analyses, FT-IR, NMR (1H, 13C and 119Sn), mass spectrometry and single crystal X-ray structural analysis. Crystallographic data for four triorganotin(IV) complexes (R3SnL, R = CH3, C2H5, C4H9, CH2–C6H5) showed the tin has approximate trigonal bipyramidal geometry with the R groups in the trigonal plane. The carboxylate groups of ligands L bridge adjacent tin atoms, resulting in polymeric chains. In case of the diorganotin(IV) derivatives a six-coordinate geometry at the tin atom is proposed from spectroscopic evidence. The Me–Sn–Me bond angle in complex 7 was determined from the 2J[119Sn–1H] value as 166.3° that falls in the range of six-coordinate geometry. The ligand and its complexes (1–14) were screened for their antimicrobial, antitumor, cytotoxic and antileishmanial activities and found to be biologically active. The ligand and its complexes bind to DNA via intercalative interactions resulting in hypochromism and minor bathochromic shifts as confirmed by UV–visible spectroscopy. Based on in vitro studies such as the potato disc method, the synthesized compounds were found to possess significant antitumor activity. Also, from cytotoxicity and DNA interaction studies, these compounds can also be used for the prevention and treatment of cancer. Gel electrophoresis assay was used to investigate the damage to double stranded super coiled plasmid pBR322 DNA by the synthesized compounds and compounds 1 and 7 were found to cause the maximum damage. All the synthesized compounds exhibit strong antileishmanial activity that was even higher than that of Amphotericin B, with significant cytotoxicity. This study, therefore, demonstrated the potential use of these compounds as source of novel agents for the treatment of leishmaniasis.