Introduction. Hydrogen is a promising energy carrier that can achieve net-zero carbon emissions and decrease fossil fuel dependency. However, the importance of the driving forces in hydrogen adaptation and acceptance during the transition to this technology should be emphasised. When assessing hydrogen as a sustainable transportation fuel, defining the success criteria is vital to comprehend the benefits of hydrogen in the transition process. The transport sector is a priority area for the transition to zero emissions, which requires an understanding of the links between the key drivers of hydrogen adoption in transportation. Aim and tasks. This study aims to identify the key drivers of the hydrogen transition and explore the relationship between the transition drivers to hydrogen as a sustainable transport fuel based on a comprehensive literature review and an interpretative structural modelling approach to determine the relationship between the above-mentioned key drivers. Results. This study identified key drivers for the transition to hydrogen as a sustainable transport fuel using the Interpretive Structural Modelling (ISM) approach. This study examines the potential of hydrogen transition, analyses the driving forces, and examines their interrelationships in terms of driving force and dependent force. The role of technological development and transition awareness in achieving the SDGs is revealed. Robust regulatory agendas and supportive strategies, Workforce development and training based on hydrogen deployment, and Industry partnerships and collaboration are the most fundamental drivers for achieving the transition to hydrogen as a sustainable transport fuel. In addition, the advancement of hydrogen technologies in production, storage, and transportation, as well as hydrogen production and use, aligns with environmental aims, which are key factors that depend mainly on the actions of other driving forces. However, the limitations of this study include subjectivity and potential differences in the driving forces across countries and sectors. Conclusions. The deployment of green hydrogen transition for a clean energy source is critical in carbon-intensive sectors of the economy, which are characterised by key drivers and their interlinkages, such as regulatory strategies, workforce development, and industry partnerships. This has increased the flexibility of energy systems with the collaboration of the stakeholders for developing hydrogen technologies and infrastructure, considering the environmental safety, economic efficiency, and social acceptability of hydrogen.